{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:34:18Z","timestamp":1780108458179,"version":"3.54.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Office of the Principal Scientific Adviser to Government of India","award":["Prn.SA\/Epilep\/2017(G)"],"award-info":[{"award-number":["Prn.SA\/Epilep\/2017(G)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10142-022-00869-1","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T11:05:41Z","timestamp":1653735941000},"page":"905-917","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcriptomic profiling of nonneoplastic cortical tissues reveals epileptogenic mechanisms in dysembryoplastic neuroepithelial tumors"],"prefix":"10.1007","volume":"22","author":[{"given":"Krishan","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Banerjee Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouzia","family":"Siraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehar Chand","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Lalwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Sarat","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-6067","authenticated-orcid":false,"given":"Jyotirmoy","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"issue":"1\u20132","key":"869_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0169-328X(96)00162-3","volume":"43","author":"MT Akbar","year":"1996","unstructured":"Akbar MT, Rattray M, Powell JF, Meldrum BS (1996) Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats. Brain Res Mol Brain Res 43(1\u20132):105\u2013116","journal-title":"Brain Res Mol Brain Res"},{"issue":"3","key":"869_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1046\/j.0305-1846.2001.00314.x","volume":"27","author":"E Aronica","year":"2001","unstructured":"Aronica E, Yankaya B, Jansen GH, Leenstra S, van Veelen CW, Gorter JA et al (2001) Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy. Neuropathol Appl Neurobiol 27(3):223\u2013237","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"6","key":"869_CR3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1046\/j.1528-1157.2003.54802.x","volume":"44","author":"E Aronica","year":"2003","unstructured":"Aronica E, Gorter JA, Jansen GH, van Veelen CW, van Rijen PC, Ramkema M et al (2003) Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in Taylor-type focal cortical dysplasia. Epilepsia 44(6):785\u2013795","journal-title":"Epilepsia"},{"key":"869_CR4","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1093\/brain\/awp242","volume":"132","author":"S Aubert","year":"2009","unstructured":"Aubert S, Wendling F, Regis J (2009) Local and remote epileptogenicity in focal cortical dysplasias and neurodevelopmental tumours. Brain 132:3072\u20133086","journal-title":"Brain"},{"key":"869_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.eplepsyres.2015.08.007","volume":"117","author":"J Banerjee","year":"2015","unstructured":"Banerjee J, Banerjee Dixit A, Tripathi M, Sarkar C, Gupta YK et al (2015) Enhanced endogenous activation of NMDA receptors in pyramidal neurons of hippocampal tissues from patients with mesial temporal lobe epilepsy: a mechanism of hyper excitation. Epilepsy Res 117:11\u201316","journal-title":"Epilepsy Res"},{"issue":"1","key":"869_CR6","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41598-017-00358-7","volume":"7","author":"J Banerjee","year":"2017","unstructured":"Banerjee J, Dixit AB, Srivastava A, Ramanujam B, Kakkar A, Sarkar C et al (2017) Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. Sci Rep 7(1):319","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"869_CR7","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.eplepsyres.2011.07.004","volume":"97","author":"C Barba","year":"2011","unstructured":"Barba C, Coras R, Giordano F, Buccoliero AM, Genitori L, Bl\u00fcmcke I et al (2011) Intrinsic epileptogenicity of gangliogliomas may be independent from co-occurring focal cortical dysplasia. Epilepsy Res 97(1\u20132):208\u2013213","journal-title":"Epilepsy Res"},{"issue":"6","key":"869_CR8","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1093\/brain\/awx073","volume":"140","author":"G Bar-Klein","year":"2017","unstructured":"Bar-Klein G, Lublinsky S, Kamintsky L, Noyman I, Veksler R, Dalipaj H et al (2017) Imaging blood-brain barrier dysfunction as a biomarker for epileptogenesis. Brain 140(6):1692\u20131705","journal-title":"Brain"},{"key":"869_CR9","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nrneurol.2016.173","volume":"12","author":"I Blumcke","year":"2016","unstructured":"Blumcke I, Aronica E, Becker A, Capper D, Coras R, Honavar M et al (2016) Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification. Nat Rev Neurol 12:732\u2013740","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"869_CR10","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1046\/j.0953-816x.2001.01541.x","volume":"13","author":"V Bruno","year":"2001","unstructured":"Bruno V, Battaglia G, Copani A, Cesp\u00e9des VM, Galindo MF, Ce\u00f1a V et al (2001) An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. Eur J Neurosci 13(8):1469\u20131478","journal-title":"Eur J Neurosci"},{"issue":"9","key":"869_CR11","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.1158\/1078-0432.CCR-04-1912","volume":"11","author":"HJ Chang","year":"2005","unstructured":"Chang HJ, Yoo BC, Lim SB, Jeong SY, Kim WH, Park JG (2005) Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance. Clin Cancer Res 11(9):3288\u20133295","journal-title":"Clin Cancer Res"},{"issue":"Pt 8","key":"869_CR12","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1093\/brain\/123.8.1733","volume":"123","author":"F Chassoux","year":"2000","unstructured":"Chassoux F, Devaux B, Landre E (2000) Stereoelectroencephalography in focal cortical dysplasia: a 3D approach to delineating the dysplastic cortex. Brain 123(Pt 8):1733\u20131751","journal-title":"Brain"},{"issue":"6","key":"869_CR13","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.clinph.2012.11.015","volume":"124","author":"F Chassoux","year":"2013","unstructured":"Chassoux F, Landr\u00e9 E, Mellerio C, Laschet J, Devaux B, Daumas-Duport C (2013) Dysembryoplastic neuroepithelial tumors: epileptogenicity related to histologic subtypes. Clin Neurophysiol 124(6):1068\u20131078","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"869_CR14","doi-asserted-by":"publisher","first-page":"e92765","DOI":"10.1371\/journal.pone.0092765","volume":"9","author":"H Choi","year":"2014","unstructured":"Choi H, Kim YK, Oh SW, Im H-J, Hwang DW, Kang H et al (2014) In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model. PLoS ONE 9(3):e92765","journal-title":"PLoS ONE"},{"issue":"Suppl 9","key":"869_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/epi.12455","volume":"54","author":"M Cossu","year":"2013","unstructured":"Cossu M, Fuschillo D, Bramerio M, Galli C, Gozzo F, Pelliccia V et al (2013) Epilepsy surgery of focal cortical dysplasia-associated tumors. Epilepsia 54(Suppl 9):115\u2013122","journal-title":"Epilepsia"},{"issue":"7","key":"869_CR16","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1212\/WNL.56.7.906","volume":"56","author":"PB Crino","year":"2001","unstructured":"Crino PB, Duhaime AC, Baltuch G, White R (2001) Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia. Neurology 56(7):906\u2013913","journal-title":"Neurology"},{"key":"869_CR17","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1046\/j.1471-4159.1998.71051953.x","volume":"71","author":"LP Daggett","year":"1998","unstructured":"Daggett LP, Johnson EC, Varney MA, Lin FF, Hess SD, Deal CR et al (1998) The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression. J Neurochem 71:1953\u20131968","journal-title":"J Neurochem"},{"issue":"2","key":"869_CR18","first-page":"516","volume":"276","author":"NO Dalby","year":"1996","unstructured":"Dalby NO, Thomsen C (1996) Modulation of seizure activity in mice by metabotropic glutamate receptor ligands. J Pharmacol Exp Ther 276(2):516\u2013522","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"869_CR19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41598-019-56146-y","volume":"10","author":"D Delev","year":"2020","unstructured":"Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D et al (2020) Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course. Sci Rep 10(1):96","journal-title":"Sci Rep"},{"issue":"1","key":"869_CR20","doi-asserted-by":"publisher","first-page":"17976","DOI":"10.1038\/s41598-018-35892-5","volume":"8","author":"AB Dixit","year":"2018","unstructured":"Dixit AB, Sharma D, Tripathi M, Srivastava A, Paul D, Prakash D, Sarkar C, Kumar K, Banerjee J, Chandra PS (2018) Genome-wide DNA methylation and RNAseq analyses identify aberrant signalling pathways in focal cortical dysplasia (FCD) type II. Sci Rep 8(1):17976","journal-title":"Sci Rep"},{"issue":"11","key":"869_CR21","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.1093\/cercor\/bhw249","volume":"26","author":"JM DuBois","year":"2016","unstructured":"DuBois JM, Rousset OG, Guiot MC et al (2016) Metabotropic glutamate receptor type 5 (mGluR5) cortical abnormalities in focal cortical dysplasia Identified In vivo with [11C]ABP688 positron-emission tomography (PET) imaging. Cereb Cortex 26(11):4170\u20134179","journal-title":"Cereb Cortex"},{"key":"869_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.brainres.2008.05.073","volume":"1226","author":"B Ermolinsky","year":"2008","unstructured":"Ermolinsky B, Pacheco Otalora LF, Arshadmansab MF, Zarei MM, Garrido-Sanabria ER (2008) Differential changes in mGlu2 and mGlu3 gene expression following pilocarpine-induced status epilepticus: a comparative real-time PCR analysis. Brain Res 1226:173\u2013180","journal-title":"Brain Res"},{"key":"869_CR23","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1111\/j.1528-1167.2006.00619.x","volume":"47","author":"C Ferrier","year":"2006","unstructured":"Ferrier C, Aronica E, Leijten FSS, Spliet WGM, Van Huffelen AC, Van Rijen PC et al (2006) Electrocorticographic discharge patterns in glioneuronal tumors and focal cortical dysplasia. Epilepsia 47:1477\u20131486","journal-title":"Epilepsia"},{"issue":"4","key":"869_CR24","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.pjnns.2018.06.001","volume":"52","author":"ED Goldstein","year":"2018","unstructured":"Goldstein ED, Feyissa AM (2018) Brain tumor related-epilepsy. Neurol Neurochir Pol 52(4):436\u2013447","journal-title":"Neurol Neurochir Pol"},{"issue":"32","key":"869_CR25","doi-asserted-by":"publisher","first-page":"8388","DOI":"10.1523\/JNEUROSCI.2285-06.2006","volume":"26","author":"L Iacovelli","year":"2006","unstructured":"Iacovelli L, Arcella A, Battaglia G, Pazzaglia S, Aronica E, Spinsanti P et al (2006) Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas. J Neurosci 26(32):8388\u20138397","journal-title":"J Neurosci"},{"issue":"33","key":"869_CR26","doi-asserted-by":"publisher","first-page":"12010","DOI":"10.1073\/pnas.0805574105","volume":"105","author":"K Iijima","year":"2008","unstructured":"Iijima K, Abe H, Okazawa M, Moriyoshi K, Nakanishi S (2008) Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures. Proc Natl Acad Sci USA 105(33):12010\u201312015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"24","key":"869_CR27","doi-asserted-by":"publisher","first-page":"7859","DOI":"10.1523\/JNEUROSCI.16-24-07859.1996","volume":"16","author":"H Kadotani","year":"1996","unstructured":"Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M et al (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci 16(24):7859\u20137867","journal-title":"J Neurosci"},{"issue":"7","key":"869_CR28","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1158\/0008-5472.CAN-05-1608","volume":"66","author":"MS Kim","year":"2006","unstructured":"Kim MS, Yamashita K, Baek JH, Park HL, Carvalho AL, Osada M et al (2006) N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer. Cancer Res 66(7):3409\u20133418","journal-title":"Cancer Res"},{"issue":"29","key":"869_CR29","doi-asserted-by":"publisher","first-page":"7696","DOI":"10.1523\/JNEUROSCI.4572-06.2007","volume":"27","author":"T Kirschstein","year":"2007","unstructured":"Kirschstein T, Bauer M, Muller L, R\u00fcschenschmidt C, Reitze M, Becker AJ et al (2007) Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci 27(29):7696\u20137704","journal-title":"J Neurosci"},{"key":"869_CR30","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.braindev.2008.10.002","volume":"31","author":"J Lee","year":"2009","unstructured":"Lee J, Lee BL, Joo EY, Seo DW, Hong SB, Hong S-C et al (2009) Dysembryoplastic neuroepithelial tumors in pediatric patients. Brain Dev 31:671\u2013681","journal-title":"Brain Dev"},{"issue":"1","key":"869_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/1531-8249(200001)47:1<26::AID-ANA7>3.0.CO;2-P","volume":"47","author":"AA Lie","year":"2000","unstructured":"Lie AA, Becker A, Behle K, Beck H, Malitschek B, Conn PJ et al (2000) Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann Neurol 47(1):26\u201335","journal-title":"Ann Neurol"},{"issue":"3","key":"869_CR32","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/0304-3940(95)11454-5","volume":"189","author":"R Marianowski","year":"1995","unstructured":"Marianowski R, Pollard H, Moreau J, Despr\u00e9s G, Ben Ari Y, Tran Ba Huy P et al (1995) N-Methyl-D-aspartate receptor subunits NR1 and NR2C are overexpressed in the inferior colliculus of audiogenic mice. Neurosci Lett 189(3):190\u2013194","journal-title":"Neurosci Lett"},{"issue":"1","key":"869_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/physiolgenomics.2001.5.1.21","volume":"5","author":"JM Markert","year":"2001","unstructured":"Markert JM, Fuller CM, Gillespie GY, Bubien JK, McLean LA, Hong RL et al (2001) Differential gene expression profiling in human brain tumors. Physiol Genomics 5(1):21\u201333","journal-title":"Physiol Genomics"},{"issue":"1\u20132","key":"869_CR34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0920-1211(98)00048-5","volume":"32","author":"GW Mathern","year":"1998","unstructured":"Mathern GW, Pretorius JK, Leite JP, Kornblum HI, Mendoza D, Lozada A, Bertram EH 3rd (1998) Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Epilepsy Res 32(1\u20132):154\u2013171","journal-title":"Epilepsy Res"},{"issue":"Suppl 6","key":"869_CR35","first-page":"62","volume":"41","author":"GW Mathern","year":"2000","unstructured":"Mathern GW, Cepeda C, Hurst RS, Flores-Hernandez J, Mendoza D, Levine MS (2000) Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia. Epilepsia 41(Suppl 6):62\u201367","journal-title":"Epilepsia"},{"key":"869_CR36","doi-asserted-by":"publisher","first-page":"8868","DOI":"10.1038\/s41598-018-27293-5","volume":"8","author":"AT McKenzie","year":"2018","unstructured":"McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A et al (2018) Brain cell type specific gene expression and co-expression network architectures. Sci Rep 8:8868","journal-title":"Sci Rep"},{"issue":"1","key":"869_CR37","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1152\/jn.00579.2001","volume":"87","author":"LR Merlin","year":"2002","unstructured":"Merlin LR (2002) Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts. J Neurophysiol 87(1):621\u2013625","journal-title":"J Neurophysiol"},{"issue":"3","key":"869_CR38","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/epi.14005","volume":"59","author":"CS Metcalf","year":"2018","unstructured":"Metcalf CS, Klein BD, Smith MD, Ceusters M, Lavreysen H, Pype S et al (2018) Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model. Epilepsia 59(3):724\u2013735","journal-title":"Epilepsia"},{"issue":"W1","key":"869_CR39","doi-asserted-by":"publisher","first-page":"W566","DOI":"10.1093\/nar\/gkv468","volume":"43","author":"T Metsalu","year":"2015","unstructured":"Metsalu T, Vilo J (2015) ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap. Nucleic Acids Res 43(W1):W566\u2013W570","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"869_CR40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2005.03.042","volume":"1046","author":"G Moddel","year":"2005","unstructured":"Moddel G, Jacobson B, Ying Z, Janigro D, Bingaman W, Gonz\u00e1lez-Mart\u00ednez J, Kellinghaus C, Prayson RA, Najm IM (2005) The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. Brain Res 1046(1\u20132):10\u201323","journal-title":"Brain Res"},{"key":"869_CR41","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1528-1157.1998.tb01378.x","volume":"39","author":"HH Morris","year":"1998","unstructured":"Morris HH, Matkovic Z, Estes ML, Prayson RA, Comair YG, Turnbull J et al (1998) Ganglioglioma and intractable epilepsy: clinical and neurophysiologic features and predictors of outcome after surgery. Epilepsia 39:307\u2013313","journal-title":"Epilepsia"},{"key":"869_CR42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.eplepsyres.2018.11.006","volume":"149","author":"V Navarrete-Modesto","year":"2019","unstructured":"Navarrete-Modesto V, Orozco-Su\u00e1rez S, Feria-Romero IA, Rocha L (2019) The molecular hallmarks of epigenetic effects mediated by antiepileptic drugs. Epilepsy Res 149:53\u201365","journal-title":"Epilepsy Res"},{"key":"869_CR43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","volume":"50","author":"CM Niswender","year":"2010","unstructured":"Niswender CM, Conn PJ (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 50:295\u2013322","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"244","key":"869_CR44","doi-asserted-by":"publisher","first-page":"244ra89","DOI":"10.1126\/scitranslmed.3008065","volume":"6","author":"J Pallud","year":"2014","unstructured":"Pallud J, Le Van QM, Bielle F, Pellegrino C, Varlet P, Cresto N et al (2014) Cortical GABAergic excitation contributes to epileptic activities around human glioma. Sci Transl Med 6(244):244ra89","journal-title":"Sci Transl Med"},{"key":"869_CR45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1684\/j.1950-6945.2002.tb00480.x","volume":"4","author":"B Pasquier","year":"2002","unstructured":"Pasquier B, P\u00e9oc\u2019 HM, Fabre-Bocquentin B, Bensaadi L, Pasquier D, Hoffmann D et al (2002) Surgical pathology of drug-resistant partial epilepsy. A 10-year-experience with a series of 327 consecutive resections. Epileptic Disord 4:99\u2013119","journal-title":"Epileptic Disord"},{"issue":"3","key":"869_CR46","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.nbd.2007.03.003","volume":"26","author":"J Pitsch","year":"2007","unstructured":"Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ (2007) Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. Neurobiol Dis 26(3):623\u2013633","journal-title":"Neurobiol Dis"},{"issue":"2","key":"869_CR47","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","volume":"14","author":"J Reimand","year":"2019","unstructured":"Reimand J, Isserlin R, Voisin V, Kucera M, Tannus-Lopes C, Rostamianfar A et al (2019) Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA Cytoscape and EnrichmentMap. Nat Protoc 14(2):482\u2013517","journal-title":"Nat Protoc"},{"issue":"6","key":"869_CR48","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3(6):1101\u20131108","journal-title":"Nat Protoc"},{"key":"869_CR49","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00418-009-0613-1","volume":"132","author":"A Stepulak","year":"2009","unstructured":"Stepulak A, Luksch H, Gebhardt C, Uckermann O, Marzahn J, Sifringer M et al (2009) Expression of glutamate receptor subunits in human cancers. Histochem Cell Biol 132:435\u2013445","journal-title":"Histochem Cell Biol"},{"issue":"1","key":"869_CR50","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00401-017-1773-z","volume":"135","author":"TJ Stone","year":"2018","unstructured":"Stone TJ, Keeley A, Virasami A, Harkness W, Tisdall M, Izquierdo Delgado E et al (2018) Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours. Acta Neuropathol 135(1):115\u2013129","journal-title":"Acta Neuropathol"},{"issue":"43","key":"869_CR51","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci USA"},{"key":"869_CR52","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/1471-2407-11-220","volume":"11","author":"H Tamura","year":"2011","unstructured":"Tamura H, Suzuki M, Moriya Y, Hoshino H, Okamoto T, Yoshida S et al (2011) Aberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma. BMC Cancer 11:220","journal-title":"BMC Cancer"},{"issue":"3","key":"869_CR53","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1684\/epd.2010.0327","volume":"12","author":"L Tassi","year":"2010","unstructured":"Tassi L, Garbelli R, Colombo N, Bramerio M, Lo Russo G, Deleo F et al (2010) Type I focal cortical dysplasia: surgical outcome is related to histopathology. Epileptic Disord 12(3):181\u2013191","journal-title":"Epileptic Disord"},{"issue":"1","key":"869_CR54","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.eplepsyres.2009.12.007","volume":"89","author":"M Tripathi","year":"2010","unstructured":"Tripathi M, Garg A, Gaikwad S, Bal CS, Chitra S, Prasad K et al (2010) Intra-operative electrocorticography in lesional epilepsy. Epilepsy Res 89(1):133\u2013141","journal-title":"Epilepsy Res"},{"issue":"4","key":"869_CR55","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.cell.2015.04.012","volume":"161","author":"HS Venkatesh","year":"2015","unstructured":"Venkatesh HS, Johung TB, Caretti V et al (2015) Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell 161(4):803\u2013816","journal-title":"Cell"},{"issue":"3","key":"869_CR56","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1684\/epd.2014.0675","volume":"16","author":"T Yang","year":"2014","unstructured":"Yang T, Hakimian S, Schwartz TH (2014) Intraoperative ElectroCorticoGraphy (ECog): indications, techniques, and utility in epilepsy surgery. Epileptic Disord 16(3):271\u2013279","journal-title":"Epileptic Disord"},{"issue":"1","key":"869_CR57","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/00005072-199801000-00007","volume":"57","author":"Z Ying","year":"1998","unstructured":"Ying Z, Babb TL, Comair YG, Bingaman W, Bushey M, Touhalisky K (1998) Induced expression of NMDAR2 proteins and differential expression of NMDAR1 splice variants in dysplastic neurons of human epileptic neocortex. J Neuropathol Exp Neurol 57(1):47\u201362","journal-title":"J Neuropathol Exp Neurol"},{"issue":"36","key":"869_CR58","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O\u2019Keeffe S et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34(36):11929\u201311947","journal-title":"J Neurosci"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-022-00869-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-022-00869-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-022-00869-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:55:24Z","timestamp":1727312124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-022-00869-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,28]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["869"],"URL":"https:\/\/doi.org\/10.1007\/s10142-022-00869-1","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,28]]},"assertion":[{"value":"19 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was pre-approved by the institutional human ethics committee (IHEC) of the All India Institute of Medical Sciences, New Delhi, and all the methods were performed in accordance with the relevant guidelines and regulations. A prior Informed written consent was obtained from all subjects, their parents, or legal guardians if the subjects were minor. We declare that we have followed the tenets of the Declaration of Helsinki in our study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}