{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:46:27Z","timestamp":1772027187874,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s10142-023-01002-6","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T02:02:30Z","timestamp":1678240950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED ARTICLE: Special transcriptome landscape and molecular prognostic signature of non-smoking head and neck cancer patients"],"prefix":"10.1007","volume":"23","author":[{"given":"Yaya","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxia","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"1002_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-T\u00e2n PF et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24\u201335","journal-title":"N Engl J Med"},{"key":"1002_CR2","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/S0140-6736(08)60728-X","volume":"371","author":"A Argiris","year":"2008","unstructured":"Argiris A, Karamouzis MV, Raben D, Ferris RL (2008) Head and neck cancer. Lancet. 371:1695\u20131709","journal-title":"Lancet."},{"key":"1002_CR3","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","volume":"16","author":"VP Balachandran","year":"2015","unstructured":"Balachandran VP, Gonen M, Smith JJ, DeMatteo RP (2015) Nomograms in oncology: more than meets the eye. Lancet Oncol 16:e173\u2013e180","journal-title":"Lancet Oncol"},{"key":"1002_CR4","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M et al (2013) NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res 41:D991\u2013D995","journal-title":"Nucleic Acids Res"},{"key":"1002_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.cell.2018.03.059","volume":"173","author":"A Blum","year":"2018","unstructured":"Blum A, Wang P, Zenklusen JC (2018) SnapShot: TCGA-analyzed tumors. Cell. 173:530","journal-title":"Cell."},{"key":"1002_CR6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ijrobp.2009.10.050","volume":"79","author":"AM Chen","year":"2011","unstructured":"Chen AM, Chen LM, Vaughan A, Sreeraman R, Farwell DG, Luu Q et al (2011) Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome. Int J Radiat Oncol Biol Phys 79:414\u2013419","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1002_CR7","doi-asserted-by":"publisher","first-page":"666371","DOI":"10.3389\/fgene.2021.666371","volume":"12","author":"C Chen","year":"2021","unstructured":"Chen C, Cheng X, Li S, Chen H, Cui M, Bian L et al (2021) A novel signature for predicting prognosis of smoking-related squamous cell Carcinoma. Front Genet 12:666371","journal-title":"Front Genet"},{"key":"1002_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3322\/CA.2007.0004","volume":"58","author":"N Choong","year":"2008","unstructured":"Choong N, Vokes E (2008) Expanding role of the medical oncologist in the management of head and neck cancer. CA Cancer J Clin 58:32\u201353","journal-title":"CA Cancer J Clin"},{"key":"1002_CR9","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.oraloncology.2013.09.003","volume":"50","author":"CH Chung","year":"2014","unstructured":"Chung CH, Bagheri A, D\u2019Souza G (2014) Epidemiology of oral human papillomavirus infection. Oral Oncol 50:364\u2013369","journal-title":"Oral Oncol"},{"key":"1002_CR10","doi-asserted-by":"publisher","first-page":"e107468","DOI":"10.1371\/journal.pone.0107468","volume":"9","author":"P Geeleher","year":"2014","unstructured":"Geeleher P, Cox N, Huang RS (2014) pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One 9:e107468","journal-title":"PLoS One"},{"key":"1002_CR11","doi-asserted-by":"publisher","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","volume":"43","author":"Gene Ontology Consortium","year":"2015","unstructured":"Gene Ontology Consortium (2015) Gene Ontology Consortium: going forward. Nucleic Acids Res 43:D1049\u2013D1056","journal-title":"Nucleic Acids Res"},{"key":"1002_CR12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/jnci\/djk179","volume":"99","author":"M Hashibe","year":"2007","unstructured":"Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP et al (2007) Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst 99:777\u2013789","journal-title":"J Natl Cancer Inst"},{"key":"1002_CR13","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/hed.23052","volume":"35","author":"M Hashibe","year":"2013","unstructured":"Hashibe M, Hunt J, Wei M, Buys S, Gren L, Lee Y-CA (2013) Tobacco, alcohol, body mass index, physical activity, and the risk of head and neck cancer in the prostate, lung, colorectal, and ovarian (PLCO) cohort. Head Neck 35:914\u2013922","journal-title":"Head Neck"},{"key":"1002_CR14","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/hed.23944","volume":"38","author":"JL Hatcher","year":"2016","unstructured":"Hatcher JL, Sterba KR, Tooze JA, Day TA, Carpenter MJ, Alberg AJ et al (2016) Tobacco use and surgical outcomes in patients with head and neck cancer. Head Neck 38:700\u2013706","journal-title":"Head Neck"},{"key":"1002_CR15","doi-asserted-by":"publisher","first-page":"107789","DOI":"10.1016\/j.intimp.2021.107789","volume":"98","author":"F He","year":"2021","unstructured":"He F, Chen Z, Deng W, Zhan T, Huang X, Zheng Y et al (2021) Development and validation of a novel ferroptosis-related gene signature for predicting prognosis and immune microenvironment in head and neck squamous cell carcinoma. Int Immunopharmacol 98:107789","journal-title":"Int Immunopharmacol"},{"key":"1002_CR17","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","volume":"26","author":"A Iasonos","year":"2008","unstructured":"Iasonos A, Schrag D, Raj GV, Panageas KS (2008) How to build and interpret a nomogram for cancer prognosis. J Clin Oncol 26:1364\u20131370","journal-title":"J Clin Oncol"},{"key":"1002_CR18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10555-017-9689-6","volume":"36","author":"AR Jethwa","year":"2017","unstructured":"Jethwa AR, Khariwala SS (2017) Tobacco-related carcinogenesis in head and neck cancer. Cancer Metastasis Rev 36:411\u2013423","journal-title":"Cancer Metastasis Rev"},{"key":"1002_CR19","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41591-018-0136-1","volume":"24","author":"P Jiang","year":"2018","unstructured":"Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X et al (2018) Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med 24:1550\u20131558","journal-title":"Nat Med"},{"key":"1002_CR20","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2017","unstructured":"Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K (2017) KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 45:D353\u2013D361","journal-title":"Nucleic Acids Res"},{"key":"1002_CR22","doi-asserted-by":"publisher","first-page":"1904573","DOI":"10.1080\/2162402X.2021.1904573","volume":"10","author":"Y Kim","year":"2021","unstructured":"Kim Y, Kang JW, Kang J, Kwon EJ, Ha M, Kim YK et al (2021) Novel deep learning-based survival prediction for oral cancer by analyzing tumor-infiltrating lymphocyte profiles through CIBERSORT. Oncoimmunology. 10:1904573","journal-title":"Oncoimmunology."},{"key":"1002_CR23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neunet.2019.07.015","volume":"119","author":"Y Liu","year":"2019","unstructured":"Liu Y, Gao X, Gao Q, Shao L, Han J (2019) Adaptive robust principal component analysis. Neural Netw 119:85\u201392","journal-title":"Neural Netw"},{"key":"1002_CR24","doi-asserted-by":"publisher","first-page":"489","DOI":"10.4065\/83.4.489","volume":"83","author":"S Marur","year":"2008","unstructured":"Marur S, Forastiere AA (2008) Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proc 83:489\u2013501","journal-title":"Mayo Clin Proc"},{"key":"1002_CR25","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1158\/1078-0432.CCR-18-0871","volume":"25","author":"S Miyauchi","year":"2019","unstructured":"Miyauchi S, Kim SS, Pang J, Gold KA, Gutkind JS, Califano JA et al (2019) Immune modulation of head and neck squamous cell carcinoma and the tumor microenvironment by conventional therapeutics. Clin Cancer Res 25:4211\u20134223","journal-title":"Clin Cancer Res"},{"key":"1002_CR26","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cancergen.2021.05.011","volume":"256\u2013257","author":"BW Papenberg","year":"2021","unstructured":"Papenberg BW, Ingles J, Gao S, Feng J, Allen JL, Markwell SM et al (2021) Copy number alterations identify a smoking-associated expression signature predictive of poor outcome in head and neck squamous cell carcinoma. Cancer Gene Ther 256\u2013257:136\u2013148","journal-title":"Cancer Gene Ther"},{"key":"1002_CR27","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.3390\/cancers13133126","volume":"13","author":"V Perrotti","year":"2021","unstructured":"Perrotti V, Caponio VCA, Mascitti M, Lo Muzio L, Piattelli A, Rubini C et al (2021) Therapeutic potential of antibody-drug conjugate-based therapy in head and neck cancer: a systematic review. Cancers (Basel) 13:3126","journal-title":"Cancers (Basel)"},{"key":"1002_CR28","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.csbj.2021.01.046","volume":"19","author":"W Qiang","year":"2021","unstructured":"Qiang W, Dai Y, Xing X, Sun X (2021) Identification and validation of a prognostic signature and combination drug therapy for immunotherapy of head and neck squamous cell carcinoma. Comput Struct Biotechnol J 19:1263\u20131276","journal-title":"Comput Struct Biotechnol J"},{"key":"1002_CR29","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47","journal-title":"Nucleic Acids Res"},{"key":"1002_CR30","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1158\/1078-0432.CCR-05-2017","volume":"12","author":"RJC Slebos","year":"2006","unstructured":"Slebos RJC, Yi Y, Ely K, Carter J, Evjen A, Zhang X et al (2006) Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 12:701\u2013709","journal-title":"Clin Cancer Res"},{"key":"1002_CR31","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/nar\/gkg034","volume":"31","author":"C von Mering","year":"2003","unstructured":"von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P, Snel B (2003) STRING: a database of predicted functional associations between proteins. Nucleic Acids Res 31:258\u2013261","journal-title":"Nucleic Acids Res"},{"key":"1002_CR32","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1002\/ijc.29649","volume":"137","author":"G Wichmann","year":"2015","unstructured":"Wichmann G, Rosolowski M, Krohn K, Kreuz M, Boehm A, Reiche A et al (2015) The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer. Int J Cancer 137:2846\u20132857","journal-title":"Int J Cancer"},{"key":"1002_CR34","doi-asserted-by":"publisher","first-page":"711433","DOI":"10.3389\/fimmu.2021.711433","volume":"12","author":"Q Xu","year":"2021","unstructured":"Xu Q, Chen S, Hu Y, Huang W (2021) Landscape of immune microenvironment under immune cell infiltration pattern in breast cancer. Front Immunol 12:711433","journal-title":"Front Immunol"},{"key":"1002_CR35","doi-asserted-by":"publisher","first-page":"D955","DOI":"10.1093\/nar\/gks1111","volume":"41","author":"W Yang","year":"2013","unstructured":"Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S et al (2013) Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res 41:D955\u2013D961","journal-title":"Nucleic Acids Res"},{"key":"1002_CR36","doi-asserted-by":"publisher","first-page":"e000444","DOI":"10.1136\/jitc-2019-000444","volume":"8","author":"Y Yao","year":"2020","unstructured":"Yao Y, Yan Z, Lian S, Wei L, Zhou C, Feng D et al (2020) Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma. J Immunother Cancer 8:e000444","journal-title":"J Immunother Cancer"},{"key":"1002_CR37","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1093\/bib\/bby073","volume":"20","author":"F Yu","year":"2019","unstructured":"Yu F, Quan F, Xu J, Zhang Y, Xie Y, Zhang J et al (2019) Breast cancer prognosis signature: linking risk stratification to disease subtypes. Brief Bioinform 20:2130\u20132140","journal-title":"Brief Bioinform"},{"key":"1002_CR38","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1186\/s12885-020-07489-7","volume":"20","author":"F Zhang","year":"2020","unstructured":"Zhang F, Liu Y, Yang Y, Yang K (2020) Development and validation of a fourteen- innate immunity-related gene pairs signature for predicting prognosis head and neck squamous cell carcinoma. BMC Cancer 20:1015","journal-title":"BMC Cancer"}],"updated-by":[{"DOI":"10.1007\/s10142-024-01367-2","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"record-id":"53875"},{"DOI":"10.1007\/s10142-024-01367-2","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000}}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-023-01002-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-023-01002-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-023-01002-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:01:49Z","timestamp":1715562109000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-023-01002-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["1002"],"URL":"https:\/\/doi.org\/10.1007\/s10142-023-01002-6","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"27 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2024","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10142-024-01367-2","URL":"https:\/\/doi.org\/10.1007\/s10142-024-01367-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}