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The causal relationship between intestinal microbiome and PE risk was examined using large-scale genome-wide association studies (GWAS) summary statistics. To be specific, the causal microbial taxa for PE were identified using the two-sample Mendelian randomization (MR) method. The results were verified to be robust through comprehensive sensitive analyses, and the independence of causal relationship was ensured through novel multivariable MR analyses. The possibility of reverse relationships was ruled out through reverse-direction MR analyses. Lastly, the biofunction was explored through enrichment analysis, and a series of validations of PE results in a second GWAS were performed to confirm the results. After correction, four microbial taxa, including\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    genus for PE (FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.085),\n                    <jats:italic>Olsenella<\/jats:italic>\n                    genus for PE (FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.085),\n                    <jats:italic>Enterobacteriales<\/jats:italic>\n                    order for PE (FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.0134), and\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    genus for PE (FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.015), had a causal relationship to diverse joint PE (FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.15). Moreover, when three different methods were employed on basis of the nominal significance (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), five suggestive microbial taxa took on significance. The effect of heterogeneity and horizontal pleiotropy was excluded through sensitive analysis, and the possibility of horizontal pleiotropy of BMI was ruled out through multivariable MR analysis. The protective mechanism of the identified taxa against PE was illustrated through GO enrichment analysis and KEGG pathways. A number of microbial taxa had a causal relationship to PE. The result of this study provides more insights into intestinal microbiome in the pathology of PE.\n                  <\/jats:p>","DOI":"10.1007\/s10142-023-01054-8","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T12:02:29Z","timestamp":1681732949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The causal role of intestinal microbiome in development of pre-eclampsia"],"prefix":"10.1007","volume":"23","author":[{"given":"Zhihui","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"issue":"1","key":"1054_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/1471-0528.12629","volume":"121","author":"E Abalos","year":"2014","unstructured":"Abalos E, Cuesta C, Carroli G, Qureshi Z, Widmer M, Vogel JP, Souza JP (2014) WHO Multicountry Survey on Maternal and Newborn Health Research Network Pre-eclampsia, eclampsia and adverse maternal and perinatal outcomes: a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health. 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