{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T14:04:52Z","timestamp":1781964292034,"version":"3.54.5"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s10142-023-01229-3","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T02:02:16Z","timestamp":1695261736000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism"],"prefix":"10.1007","volume":"23","author":[{"given":"Yunhui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiKang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"1229_CR1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.wneu.2019.07.044","volume":"131","author":"NAO Bush","year":"2019","unstructured":"Bush NAO, Hervey-Jumper SL, Berger MSJWN (2019) Management of glioblastoma, present and future. World Neurosurg 131:328\u2013338","journal-title":"World Neurosurg"},{"issue":"1","key":"1229_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10142-021-00812-w","volume":"22","author":"W Chen","year":"2022","unstructured":"Chen W, Wang F, Zhang J, Li C, Hong L (2022) LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI. Funct Integr Genomics 22(1):55\u201364","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"1229_CR3","first-page":"147","volume":"43","author":"J Cheng","year":"2020","unstructured":"Cheng J, Fan YQ, Liu BH, Zhou H, Wang JM, Chen QX (2020) ACSL4 suppresses glioma cells proliferation via activating ferroptosis. Oncol Rep 43(1):147\u2013158","journal-title":"Oncol Rep"},{"issue":"5","key":"1229_CR4","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.3390\/ijms23052509","volume":"23","author":"E Codrici","year":"2022","unstructured":"Codrici E, Popescu ID, Tanase C, Enciu AM (2022) Friends with benefits: chemokines, glioblastoma-associated microglia\/macrophages, and tumor microenvironment. Int J Mol Sci 23(5):2509","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1229_CR5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3892\/or.2012.1813","volume":"28","author":"MC Daroqui","year":"2012","unstructured":"Daroqui MC, Vazquez P, de Kier B, Joff\u00e9 E, Bakin AV, Puricelli LI (2012) TGF-\u03b2 autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression. Oncol Rep 28(2):567\u2013575","journal-title":"Oncol Rep"},{"issue":"570","key":"1229_CR6","doi-asserted-by":"publisher","first-page":"eaav5183","DOI":"10.1126\/scisignal.aav5183","volume":"12","author":"R Derynck","year":"2019","unstructured":"Derynck R, Budi EHJSS (2019) Specificity, versatility, and control of TGF-\u03b2 family signaling. Sci Signal 12(570):eaav5183","journal-title":"Sci Signal"},{"issue":"5","key":"1229_CR7","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.3390\/ijms23052607","volume":"23","author":"Y Esemen","year":"2022","unstructured":"Esemen Y, Awan M, Parwez R, Baig A, Rahman S, Masala I, Franchini S, Giakoumettis D (2022) Molecular pathogenesis of glioblastoma in adults and future perspectives: a systematic review. Int J Mol Sci 23(5):2607","journal-title":"Int J Mol Sci"},{"key":"1229_CR8","doi-asserted-by":"publisher","first-page":"8890452","DOI":"10.1155\/2020\/8890452","volume":"2020","author":"K Guo","year":"2020","unstructured":"Guo K, Song L, Chang J, Cao P, Liu Q (2020) AEBP1 promotes glioblastoma progression and activates the classical NF-\u03baB pathway. Behav Neurol 2020:8890452","journal-title":"Behav Neurol"},{"key":"1229_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s13277-015-4374-2","volume":"37","author":"L Guo","year":"2016","unstructured":"Guo L, Zhang Y, Zhang L, Huang F, Li J, Wang SJTB (2016) MicroRNAs, TGF-\u03b2 signaling, and the inflammatory microenvironment in cancer. Tumour Biol 37:115\u2013125","journal-title":"Tumour Biol"},{"key":"1229_CR10","doi-asserted-by":"publisher","first-page":"107066","DOI":"10.1016\/j.compbiomed.2023.107066","volume":"161","author":"S Guo","year":"2023","unstructured":"Guo S, Liu X, Zhang J, Huang Z, Ye P, Shi J, Stalin A, Wu C, Lu S, Zhang F, Gao Y, Jin Z, Tao X, Huang J, Zhai Y, Shi R, Guo F, Zhou W, Wu J (2023) Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels T cell-related prognostic risk model and tumor immune microenvironment modulation in triple-negative breast cancer. Comput. Biol Med 161:107066","journal-title":"Comput. Biol Med"},{"issue":"1","key":"1229_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4149\/neo_2017_108","volume":"64","author":"L He","year":"2017","unstructured":"He L, Deng HJN (2017) Decreased expression of MS4A12 inhibits differentiation and predicts early stage survival in colon cancer. Neoplasma 64(1):65\u201373","journal-title":"Neoplasma"},{"issue":"5","key":"1229_CR12","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s10142-022-00858-4","volume":"22","author":"D Hong","year":"2022","unstructured":"Hong D, Zang A, Wang Z, Yang L, Ren G, Zhang C, Zhang L, Hou W, Wei Y (2022) Elevation of microRNA-365 impedes malignant behaviors of gastric cancer cells by inhibiting PAX6. Funct Integr Genomics 22(5):825\u2013834","journal-title":"Funct Integr Genomics"},{"key":"1229_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cyto.2017.12.032","volume":"118","author":"BV Howley","year":"2019","unstructured":"Howley BV, Howe PH (2019) TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1. Cytokine 118:19\u201326","journal-title":"Cytokine"},{"key":"1229_CR14","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3389\/fimmu.2018.00727","volume":"9","author":"CI Jan","year":"2018","unstructured":"Jan CI, Tsai WC, Harn HJ, Shyu WC, Liu MC, Lu HM, Chiu SC, Cho DY (2018) Predictors of response to autologous dendritic cell therapy in glioblastoma multiforme. Front Immunol 9:727","journal-title":"Front Immunol"},{"key":"1229_CR15","doi-asserted-by":"publisher","first-page":"107721","DOI":"10.1016\/j.pharmthera.2020.107721","volume":"220","author":"E Kunadis","year":"2021","unstructured":"Kunadis E, Lakiotaki E, Korkolopoulou P, Piperi C (2021) Targeting post-translational histone modifying enzymes in glioblastoma. Pharmacol Ther 220:107721","journal-title":"Pharmacol Ther"},{"issue":"17","key":"1229_CR16","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.2217\/epi-2021-0217","volume":"13","author":"H Li","year":"2021","unstructured":"Li H, Yang W, Zhang M, He T, Zhou FJGH, Hu L, Guo M (2021) Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer. Epigenomics 13(17):1403\u20131419","journal-title":"Epigenomics"},{"issue":"6","key":"1229_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/tox.22905","volume":"35","author":"Y Lu","year":"2020","unstructured":"Lu Y, Li L, Chen L, Gao Y, Chen X, Cao Y (2020) TRIB3 confers glioma cell stemness via interacting with \u03b2-catenin. Environ Toxicol 35(6):697\u2013706","journal-title":"Environ Toxicol"},{"key":"1229_CR18","doi-asserted-by":"publisher","first-page":"8097872","DOI":"10.1155\/2020\/8097872","volume":"2020","author":"AF Majdalawieh","year":"2020","unstructured":"Majdalawieh AF, Massri M, Ro HS (2020) AEBP1 is a novel oncogene: mechanisms of action and signaling pathways. J Oncol 2020:8097872","journal-title":"J Oncol"},{"issue":"9","key":"1229_CR19","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.it.2021.07.002","volume":"42","author":"I Mattiola","year":"2021","unstructured":"Mattiola I, Mantovani A, Locati MJTII (2021) The tetraspan MS4A family in homeostasis, immunity, and disease. Trends Immunol 42(9):764\u2013781","journal-title":"Trends Immunol"},{"issue":"1","key":"1229_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/cancers9010005","volume":"9","author":"P McAnena","year":"2017","unstructured":"McAnena P, Brown JA, Kerin MJ (2017) Circulating nucleosomes and nucleosome modifications as biomarkers in cancer. Cancers 9(1):5","journal-title":"Cancers"},{"issue":"2","key":"1229_CR21","first-page":"455","volume":"59","author":"CS Melincovici","year":"2018","unstructured":"Melincovici CS, Bo\u015fca AB, \u015eu\u015fman S, M\u0103rginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM (2018) Vascular endothelial growth factor (VEGF) \u2014 key factor in normal and pathological angiogenesis. Romanian Jo Morphol Embryol = Rev Roum de Morphol Embryol 59(2):455\u2013467","journal-title":"Romanian Jo Morphol Embryol = Rev Roum de Morphol Embryol"},{"issue":"11","key":"1229_CR22","doi-asserted-by":"publisher","first-page":"e78943","DOI":"10.1371\/journal.pone.0078943","volume":"8","author":"T Oike","year":"2013","unstructured":"Oike T, Suzuki Y, Sugawara K, Shirai K, Noda SE, Tamaki T, Nagaishi M, Yokoo H, Nakazato Y, Nakano T (2013) Radiotherapy plus concomitant adjuvant temozolomide for glioblastoma: Japanese mono-institutional results. PLoS One 8(11):e78943","journal-title":"PLoS One"},{"issue":"3","key":"1229_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s11060-014-1675-z","volume":"121","author":"P Pathak","year":"2015","unstructured":"Pathak P, Jha P, Purkait S, Sharma V, Suri V, Sharma MC, Faruq M, Suri A, Sarkar C (2015) Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM. J Neuro-Oncol 121(3):489\u2013497","journal-title":"J Neuro-Oncol"},{"issue":"5","key":"1229_CR24","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1007\/s12010-022-04234-7","volume":"195","author":"R Ren","year":"2023","unstructured":"Ren R, Wang H, Xie L, Muthupandian S, Yang X (2023) Identify potential urine biomarkers for bladder cancer prognosis using NGS data analysis and experimental validation. Appl Biochem Biotechnol 195(5):2947\u20132964","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"1229_CR25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13148-023-01446-4","volume":"15","author":"AJ Roura","year":"2023","unstructured":"Roura AJ, Szadkowska P, Poleszak K, Dabrowski MJ, Ellert-Miklaszewska A, Wojnicki K, Ciechomska IA, Stepniak K, Kaminska B, Wojtas B (2023) Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications. Clin Epigenetics 15(1):29","journal-title":"Clin Epigenetics"},{"issue":"4","key":"1229_CR26","doi-asserted-by":"publisher","first-page":"424","DOI":"10.6004\/jnccn.2013.0057","volume":"11","author":"U Shah","year":"2013","unstructured":"Shah U, Morrison TJJOTNCCN (2013) A review of the symptomatic management of malignant gliomas in adults. J Natl Compr Canc Netw 11(4):424\u20139","journal-title":"J Natl Compr Canc Netw"},{"issue":"12","key":"1229_CR27","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s13238-021-00846-7","volume":"13","author":"L Sun","year":"2022","unstructured":"Sun L, Zhang H, Gao P (2022) Metabolic reprogramming and epigenetic modifications on the path to cancer. Protein Cell 13(12):877\u2013919","journal-title":"Protein Cell"},{"key":"1229_CR28","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1515\/med-2018-0028","volume":"13","author":"L Sun","year":"2018","unstructured":"Sun L, Zhang Y, Zhang C (2018) Distinct expression and prognostic value of MS4A in gastric cancer. Open Med (Warsaw, Poland) 13:178\u2013188","journal-title":"Open Med (Warsaw, Poland)"},{"issue":"3","key":"1229_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"1229_CR30","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3390\/cancers11050726","volume":"11","author":"S Suriyamurthy","year":"2019","unstructured":"Suriyamurthy S, Baker D, Ten Dijke P, Iyengar PVJC (2019) Epigenetic reprogramming of TGF-\u03b2 signaling in breast cancer. Cancers (Basel) 11(5):726","journal-title":"Cancers (Basel)"},{"issue":"3","key":"1229_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s10142-023-01210-0","volume":"23","author":"J Wang","year":"2023","unstructured":"Wang J, Li S, Guo Y, Zhao C, Chen Y, Ning W, Yang J, Zhang H (2023) Cuproptosis-related gene SLC31A1 expression correlates with the prognosis and tumor immune microenvironment in glioma. Funct Integr Genomics 23(3):279","journal-title":"Funct Integr Genomics"},{"issue":"41","key":"1229_CR32","doi-asserted-by":"publisher","first-page":"70035","DOI":"10.18632\/oncotarget.19550","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Zhang Y, Herman JG, Linghu E, Guo M (2017) Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development. Oncotarget 8(41):70035\u201370048","journal-title":"Oncotarget"},{"issue":"10","key":"1229_CR33","doi-asserted-by":"publisher","first-page":"5352","DOI":"10.3390\/ijms22105352","volume":"22","author":"T Watanabe","year":"2021","unstructured":"Watanabe T (2021) The tumor microenvironment in follicular lymphoma: its pro-malignancy role with therapeutic potential. Int J Mol Sci 22(10):5352","journal-title":"Int J Mol Sci"},{"key":"1229_CR34","doi-asserted-by":"crossref","unstructured":"Yan X, Feng L, Xu Z, Chen W, Yan H, Wu P, Ding C, Zhu X, Lu Y (2023) Histone acetylation gene-based biomarkers as novel markers of the immune microenvironment in glioblastoma. J Gene Med 25:e3511","DOI":"10.1002\/jgm.3511"},{"issue":"9","key":"1229_CR35","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/s41419-020-03000-z","volume":"11","author":"W Yang","year":"2020","unstructured":"Yang W, Xiu Z, He Y, Huang W, Li Y, Sun T (2020) Bip inhibition in glioma stem cells promotes radiation-induced immunogenic cell death. Cell Death Dis 11(9):786","journal-title":"Cell Death Dis"},{"issue":"14","key":"1229_CR36","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.2174\/0929867328666211108105214","volume":"29","author":"S Zaib","year":"2022","unstructured":"Zaib S, Rana N, Khan I (2022) Histone modifications and their role in epigenetics of cancer. Curr Med Chem 29(14):2399\u20132411","journal-title":"Curr Med Chem"},{"key":"1229_CR37","doi-asserted-by":"publisher","first-page":"795844","DOI":"10.3389\/fgene.2022.795844","volume":"13","author":"Y Zeng","year":"2022","unstructured":"Zeng Y, Tan P, Ren C, Gao L, Chen Y, Hu S, Tang N, Chen C, Du S (2022) Comprehensive analysis of expression and prognostic value of MS4As in glioma. Front Genet 13:795844","journal-title":"Front Genet"},{"key":"1229_CR38","doi-asserted-by":"publisher","first-page":"1184250","DOI":"10.3389\/fphar.2023.1184250","volume":"14","author":"H Zhou","year":"2023","unstructured":"Zhou H, Ke J, Liu C, Zhu M, Xiao B, Wang Q, Hou R, Zheng Y, Wu Y, Zhou X, Chen X, Pan H (2023) Potential prognostic and immunotherapeutic value of calponin 1: a pan-cancer analysis. Front Pharmacol 14:1184250","journal-title":"Front Pharmacol"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-023-01229-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-023-01229-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-023-01229-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T14:07:49Z","timestamp":1702476469000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-023-01229-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["1229"],"URL":"https:\/\/doi.org\/10.1007\/s10142-023-01229-3","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"30 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"307"}}