{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:25:28Z","timestamp":1790259928753,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10142-024-01286-2","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T03:02:08Z","timestamp":1704510128000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RETRACTED ARTICLE: Carnosic acid nanocluster-based framework combined with PD-1 inhibitors impeded tumorigenesis and enhanced immunotherapy in hepatocellular carcinoma"],"prefix":"10.1007","volume":"24","author":[{"given":"Wenhua","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"issue":"10","key":"1286_CR1","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/nrc903","volume":"2","author":"TM Allen","year":"2002","unstructured":"Allen TM (2002) Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2(10):750\u2013763. https:\/\/doi.org\/10.1038\/nrc903","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"1286_CR2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3892\/or.2012.1630","volume":"27","author":"MV Barni","year":"2012","unstructured":"Barni MV, Carlini MJ, Cafferata EG, Puricelli L, Moreno S (2012) Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol Rep 27(4):1041\u20131048. https:\/\/doi.org\/10.3892\/or.2012.1630","journal-title":"Oncol Rep"},{"issue":"5","key":"1286_CR3","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s10142-022-00876-2","volume":"22","author":"F Cheng","year":"2022","unstructured":"Cheng F, Wang L, Yi S, Liu G (2022) Long non-coding RNA SNHG1\/microRNA-195-5p\/Yes-associated protein axis affects the proliferation and metastasis of gastric cancer via the Hippo signaling pathway. Funct Integr Genomics 22(5):1043\u20131055. https:\/\/doi.org\/10.1007\/s10142-022-00876-2","journal-title":"Funct Integr Genomics"},{"issue":"7","key":"1286_CR4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1080\/14712598.2020.1749593","volume":"20","author":"L Chiew Woon","year":"2020","unstructured":"Chiew Woon L, Joycelyn Jie Xin L, Su Pin C (2020) Nivolumab for the treatment of hepatocellular carcinoma. Expert Opin Biol Ther 20(7):687\u2013693. https:\/\/doi.org\/10.1080\/14712598.2020.1749593","journal-title":"Expert Opin Biol Ther"},{"issue":"11","key":"1286_CR5","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/s41423-020-00549-9","volume":"17","author":"R Deng","year":"2020","unstructured":"Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y et al (2020) The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt\/\u03b2-catenin signaling pathway. Cell Mol Immunol 17(11):1163\u20131179. https:\/\/doi.org\/10.1038\/s41423-020-00549-9","journal-title":"Cell Mol Immunol"},{"issue":"10088","key":"1286_CR6","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1016\/s0140-6736(17)31046-2","volume":"389","author":"AB El-Khoueiry","year":"2017","unstructured":"El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C et al (2017) Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1\/2 dose escalation and expansion trial. Lancet 389(10088):2492\u20132502. https:\/\/doi.org\/10.1016\/s0140-6736(17)31046-2","journal-title":"Lancet"},{"issue":"20","key":"1286_CR7","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","volume":"382","author":"RS Finn","year":"2020","unstructured":"Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY et al (2020) Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N Engl J Med 382(20):1894\u20131905. https:\/\/doi.org\/10.1056\/NEJMoa1915745","journal-title":"N Engl J Med"},{"issue":"10127","key":"1286_CR8","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/s0140-6736(18)30010-2","volume":"391","author":"A Forner","year":"2018","unstructured":"Forner A, Reig M, Bruix J (2018) Hepatocellular carcinoma. Lancet 391(10127):1301\u20131314. https:\/\/doi.org\/10.1016\/s0140-6736(18)30010-2","journal-title":"Lancet"},{"issue":"1","key":"1286_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s10142-022-00933-w","volume":"23","author":"B Gao","year":"2022","unstructured":"Gao B, Wang Y, Lu S (2022) Construction and validation of a novel signature based on epithelial-mesenchymal transition-related genes to predict prognosis and immunotherapy response in hepatocellular carcinoma by comprehensive analysis of the tumor microenvironment. Funct Integr Genomics 23(1):6. https:\/\/doi.org\/10.1007\/s10142-022-00933-w","journal-title":"Funct Integr Genomics"},{"issue":"5","key":"1286_CR10","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/jat.3049","volume":"35","author":"Q Gao","year":"2015","unstructured":"Gao Q, Liu H, Yao Y, Geng L, Zhang X, Jiang L et al (2015) Carnosic acid induces autophagic cell death through inhibition of the Akt\/mTOR pathway in human hepatoma cells. J Appl Toxicol 35(5):485\u2013492. https:\/\/doi.org\/10.1002\/jat.3049","journal-title":"J Appl Toxicol"},{"key":"1286_CR11","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.biopha.2017.01.084","volume":"89","author":"NN Han","year":"2017","unstructured":"Han NN, Zhou Q, Huang Q, Liu KJ (2017) Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo. Biomed Pharmacother 89:827\u2013837. https:\/\/doi.org\/10.1016\/j.biopha.2017.01.084","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"1286_CR12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1053\/j.semdp.2016.12.011","volume":"34","author":"J Hartke","year":"2017","unstructured":"Hartke J, Johnson M, Ghabril M (2017) The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol 34(2):153\u2013159. https:\/\/doi.org\/10.1053\/j.semdp.2016.12.011","journal-title":"Semin Diagn Pathol"},{"key":"1286_CR13","doi-asserted-by":"publisher","unstructured":"Hasei S, Yamamotoya T, Nakatsu Y, Ohata Y, Itoga S, Nonaka Y et al (2021) Carnosic acid and carnosol activate AMPK, suppress expressions of gluconeogenic and lipogenic genes, and inhibit proliferation of HepG2 cells. Int J Mol Sci 22(8). https:\/\/doi.org\/10.3390\/ijms22084040","DOI":"10.3390\/ijms22084040"},{"issue":"5","key":"1286_CR14","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/hep.27246","volume":"60","author":"T Hato","year":"2014","unstructured":"Hato T, Goyal L, Greten TF, Duda DG, Zhu AX (2014) Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions. Hepatology 60(5):1776\u20131782. https:\/\/doi.org\/10.1002\/hep.27246","journal-title":"Hepatology"},{"key":"1286_CR15","doi-asserted-by":"publisher","unstructured":"He W, Wang S, Yan J, Qu Y, Jin L, Sui F et al (2019a) Self-assembly of therapeutic peptide into stimuli-responsive clustered nanohybrids for cancer-targeted therapy. Adv Funct Mater 29(10). https:\/\/doi.org\/10.1002\/adfm.201807736","DOI":"10.1002\/adfm.201807736"},{"key":"1286_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.biomaterials.2019.03.026","volume":"206","author":"W He","year":"2019","unstructured":"He W, Yan J, Wang L, Lei B, Hou P, Lu W et al (2019b) A lanthanide-peptide-derived bacterium-like nanotheranostic with high tumor-targeting, -imaging and -killing properties. Biomaterials 206:13\u201324. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.03.026","journal-title":"Biomaterials"},{"key":"1286_CR17","doi-asserted-by":"publisher","unstructured":"Ho TTB, Nasti A, Seki A, Komura T, Inui H, Kozaka T et al (2020) Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis. J Immunother Cancer 8(2). https:\/\/doi.org\/10.1136\/jitc-2020-001367","DOI":"10.1136\/jitc-2020-001367"},{"issue":"7652","key":"1286_CR18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/nature22079","volume":"545","author":"AC Huang","year":"2017","unstructured":"Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S et al (2017) T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545(7652):60\u201365. https:\/\/doi.org\/10.1038\/nature22079","journal-title":"Nature"},{"key":"1286_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.radonc.2021.06.034","volume":"162","author":"Y Huang","year":"2021","unstructured":"Huang Y, Sheng H, Xiao Y, Hu W, Zhang Z, Chen Y et al (2021) Wnt\/\u03b2-catenin inhibitor ICG-001 enhances the antitumor efficacy of radiotherapy by increasing radiation-induced DNA damage and improving tumor immune microenvironment in hepatocellular carcinoma. Radiother Oncol 162:34\u201344. https:\/\/doi.org\/10.1016\/j.radonc.2021.06.034","journal-title":"Radiother Oncol"},{"key":"1286_CR20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2016.05.020","volume":"97","author":"KJ Jung","year":"2016","unstructured":"Jung KJ, Min KJ, Park JW, Park KM, Kwon TK (2016) Carnosic acid attenuates unilateral ureteral obstruction-induced kidney fibrosis via inhibition of Akt-mediated Nox4 expression. Free Radic Biol Med 97:50\u201357. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.05.020","journal-title":"Free Radic Biol Med"},{"key":"1286_CR21","doi-asserted-by":"publisher","unstructured":"Khella KF, Abd El Maksoud AI, Hassan A, Abdel-Ghany SE, Elsanhoty RM, Aladhadh MA et al (2022) Carnosic acid encapsulated in albumin nanoparticles induces apoptosis in breast and colorectal cancer cells. Molecules 27(13). https:\/\/doi.org\/10.3390\/molecules27134102","DOI":"10.3390\/molecules27134102"},{"issue":"12","key":"1286_CR22","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1158\/2159-8290.cd-12-0329","volume":"2","author":"M Labelle","year":"2012","unstructured":"Labelle M, Hynes RO (2012) The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov 2(12):1091\u20131099. https:\/\/doi.org\/10.1158\/2159-8290.cd-12-0329","journal-title":"Cancer Discov"},{"key":"1286_CR23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.biopha.2016.04.064","volume":"82","author":"H Li","year":"2016","unstructured":"Li H, Sun JJ, Chen GY, Wang WW, Xie ZT, Tang GF et al (2016) Carnosic acid nanoparticles suppress liver ischemia\/reperfusion injury by inhibition of ROS, caspases and NF-\u03baB signaling pathway in mice. Biomed Pharmacother 82:237\u2013246. https:\/\/doi.org\/10.1016\/j.biopha.2016.04.064","journal-title":"Biomed Pharmacother"},{"issue":"37","key":"1286_CR24","doi-asserted-by":"publisher","first-page":"62780","DOI":"10.18632\/oncotarget.19376","volume":"8","author":"Z Liang","year":"2017","unstructured":"Liang Z, Li T, Jiang S, Xu J, Di W, Yang Z et al (2017) AMPK: a novel target for treating hepatic fibrosis. Oncotarget 8(37):62780\u201362792. https:\/\/doi.org\/10.18632\/oncotarget.19376","journal-title":"Oncotarget"},{"issue":"12","key":"1286_CR25","doi-asserted-by":"publisher","first-page":"8708","DOI":"10.1021\/acs.nanolett.9b03414","volume":"19","author":"J Liu","year":"2019","unstructured":"Liu J, Yan J, Yan S, Wang Y, Zhang R, Hou P et al (2019) Biomimetic and self-assembled nanoclusters targeting \u03b2-catenin for potent anticancer therapy and enhanced immunotherapy. Nano Lett 19(12):8708\u20138715. https:\/\/doi.org\/10.1021\/acs.nanolett.9b03414","journal-title":"Nano Lett"},{"key":"1286_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/s0065-2571(00)00013-3","volume":"41","author":"H Maeda","year":"2001","unstructured":"Maeda H (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 41:189\u2013207. https:\/\/doi.org\/10.1016\/s0065-2571(00)00013-3","journal-title":"Adv Enzyme Regul"},{"issue":"4","key":"1286_CR27","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrc3239","volume":"12","author":"DM Pardoll","year":"2012","unstructured":"Pardoll DM (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12(4):252\u2013264. https:\/\/doi.org\/10.1038\/nrc3239","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"1286_CR28","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nrgastro.2015.173","volume":"12","author":"J Prieto","year":"2015","unstructured":"Prieto J, Melero I, Sangro B (2015) Immunological landscape and immunotherapy of hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 12(12):681\u2013700. https:\/\/doi.org\/10.1038\/nrgastro.2015.173","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1286_CR29","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.semcancer.2017.09.009","volume":"50","author":"F Shi","year":"2018","unstructured":"Shi F, Li T, Liu Z, Qu K, Shi C, Li Y et al (2018) FOXO1: another avenue for treating digestive malignancy? Semin Cancer Biol 50:124\u2013131. https:\/\/doi.org\/10.1016\/j.semcancer.2017.09.009","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"1286_CR30","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.apsb.2021.06.005","volume":"12","author":"D Sun","year":"2022","unstructured":"Sun D, Zou Y, Song L, Han S, Yang H, Chu D et al (2022) A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer. Acta Pharm Sin B 12(1):378\u2013393. https:\/\/doi.org\/10.1016\/j.apsb.2021.06.005","journal-title":"Acta Pharm Sin B"},{"key":"1286_CR31","doi-asserted-by":"publisher","first-page":"675870","DOI":"10.3389\/fonc.2021.675870","volume":"11","author":"M Sun","year":"2021","unstructured":"Sun M, Ding H, Zhu Z, Wang S, Gu X, Xia L et al (2021) Identifying optimal surgical intervention-based chemotherapy for gastric cancer patients with liver metastases. Front. Oncol 11:675870. https:\/\/doi.org\/10.3389\/fonc.2021.675870","journal-title":"Oncol"},{"key":"1286_CR32","doi-asserted-by":"publisher","first-page":"6401","DOI":"10.2147\/ijn.s101285","volume":"11","author":"B Tang","year":"2016","unstructured":"Tang B, Tang F, Wang Z, Qi G, Liang X, Li B et al (2016) Upregulation of Akt\/NF-\u03baB-regulated inflammation and Akt\/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle. Int J Nanomedicine 11:6401\u20136420. https:\/\/doi.org\/10.2147\/ijn.s101285","journal-title":"Int J Nanomedicine"},{"issue":"7528","key":"1286_CR33","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nature13954","volume":"515","author":"PC Tumeh","year":"2014","unstructured":"Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L et al (2014) PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515(7528):568\u2013571. https:\/\/doi.org\/10.1038\/nature13954","journal-title":"Nature"},{"issue":"1","key":"1286_CR34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3109\/1061186x.2012.725405","volume":"21","author":"SR Vaka","year":"2013","unstructured":"Vaka SR, Shivakumar HN, Repka MA, Murthy SN (2013) Formulation and evaluation of carnosic acid nanoparticulate system for upregulation of neurotrophins in the brain upon intranasal administration. J Drug Target 21(1):44\u201353. https:\/\/doi.org\/10.3109\/1061186x.2012.725405","journal-title":"J Drug Target"},{"key":"1286_CR35","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3389\/fphar.2018.00370","volume":"9","author":"LC Wang","year":"2018","unstructured":"Wang LC, Wei WH, Zhang XW, Liu D, Zeng KW, Tu PF (2018) An integrated proteomics and bioinformatics approach reveals the anti-inflammatory mechanism of carnosic acid. Front Pharmacol 9:370. https:\/\/doi.org\/10.3389\/fphar.2018.00370","journal-title":"Front Pharmacol"},{"key":"1286_CR36","doi-asserted-by":"publisher","first-page":"129141","DOI":"10.1016\/j.cej.2021.129141","volume":"416","author":"J Yan","year":"2021","unstructured":"Yan J, He W, Li X, You W, Liu X, Lin S et al (2021) Carnosic acid-induced co-self-assembly of metal-peptide complexes into a nanocluster-based framework with tumor-specific accumulation for augmented immunotherapy. Chem Eng J 416:129141. https:\/\/doi.org\/10.1016\/j.cej.2021.129141","journal-title":"Chem Eng J"},{"issue":"4","key":"1286_CR37","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41419-022-04765-1","volume":"13","author":"W Yi-Bin","year":"2022","unstructured":"Yi-Bin W, Xiang L, Bing Y, Qi Z, Fei-Tong J, Minghong W et al (2022) Inhibition of the CEBP\u03b2-NF\u03baB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer's disease model. Cell Death Dis 13(4):318. https:\/\/doi.org\/10.1038\/s41419-022-04765-1","journal-title":"Cell Death Dis"},{"issue":"4","key":"1286_CR38","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1021\/acsnano.0c00708","volume":"14","author":"Z Yu","year":"2020","unstructured":"Yu Z, Guo J, Hu M, Gao Y, Huang L (2020) Icaritin exacerbates mitophagy and synergizes with doxorubicin to induce immunogenic cell death in hepatocellular carcinoma. ACS Nano 14(4):4816\u20134828. https:\/\/doi.org\/10.1021\/acsnano.0c00708","journal-title":"ACS Nano"},{"issue":"8","key":"1286_CR39","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s00125-015-3622-8","volume":"58","author":"D Zheng","year":"2015","unstructured":"Zheng D, Ma J, Yu Y, Li M, Ni R, Wang G et al (2015) Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL\/6 mice. Diabetologia 58(8):1949\u20131958. https:\/\/doi.org\/10.1007\/s00125-015-3622-8","journal-title":"Diabetologia"}],"updated-by":[{"DOI":"10.1007\/s10142-025-01558-5","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"record-id":"63950"},{"DOI":"10.1007\/s10142-025-01558-5","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000}}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-024-01286-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-024-01286-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-024-01286-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T06:12:55Z","timestamp":1740723175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-024-01286-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,6]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1286"],"URL":"https:\/\/doi.org\/10.1007\/s10142-024-01286-2","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,6]]},"assertion":[{"value":"18 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10142-025-01558-5","URL":"https:\/\/doi.org\/10.1007\/s10142-025-01558-5","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments were approved and supervised by the Animal Ethics Committee of the Second Affiliated Hospital of Xi\u2019an Jiaotong University. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare there are no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"5"}}