{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:25:39Z","timestamp":1775276739173,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Energy, Science, Technology, Environmental and Climate Change, Malaysia","award":["FP0514B0021-2 (DSTIN)"],"award-info":[{"award-number":["FP0514B0021-2 (DSTIN)"]}]},{"name":"Ministry of Energy, Science, Technology, Environmental and Climate Change, Malaysia","award":["FP0514B0021-2 (DSTIN)"],"award-info":[{"award-number":["FP0514B0021-2 (DSTIN)"]}]},{"name":"Ministry of Energy, Science, Technology, Environmental and Climate Change, Malaysia","award":["FP0514B0021-2 (DSTIN)"],"award-info":[{"award-number":["FP0514B0021-2 (DSTIN)"]}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/2\/2014\/SKK01\/PERDANA\/03\/01"],"award-info":[{"award-number":["FRGS\/2\/2014\/SKK01\/PERDANA\/03\/01"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/2\/2014\/SKK01\/PERDANA\/03\/01"],"award-info":[{"award-number":["FRGS\/2\/2014\/SKK01\/PERDANA\/03\/01"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01553-w","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T11:44:11Z","timestamp":1740397451000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HOXA13 promotes immune evasion in bladder cancer by suppressing antigen processing and presentation, and phagosome pathways"],"prefix":"10.1007","volume":"25","author":[{"given":"Fee-Wai","family":"Chin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Choy","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Ming","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Aik","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azad Hassan","family":"Abdul Razack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khatijah","family":"Yusoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhi","family":"Veerakumarasivam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"1553_CR1","doi-asserted-by":"publisher","first-page":"12716","DOI":"10.1073\/pnas.91.26.12716","volume":"91","author":"MJ Androlewicz","year":"1994","unstructured":"Androlewicz MJ, Ortmann B, Van Endert PM, Spies T, Cresswell P (1994) Characteristics of peptide and major histocompatibility complex class I\/\u03b22-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2). Proc Natl Acad Sci USA 91:12716\u201312720. https:\/\/doi.org\/10.1073\/pnas.91.26.12716","journal-title":"Proc Natl Acad Sci USA"},{"key":"1553_CR2","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.3892\/or.2011.1244","volume":"25","author":"NS Awsare","year":"2011","unstructured":"Awsare NS, Martin TA, Haynes MD, Matthews PN, Jiang WG (2011) Claudin-11 decreases the invasiveness of bladder cancer cells. Oncol Rep 25:1503\u20131509. https:\/\/doi.org\/10.3892\/or.2011.1244","journal-title":"Oncol Rep"},{"key":"1553_CR3","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1158\/1078-0432.CCR-18-3200","volume":"25","author":"ML Axelrod","year":"2019","unstructured":"Axelrod ML, Cook RS, Johnson DB, Balko JM (2019) Biological consequences of MHC-II expression by tumor cells in cancer. Clin Cancer Res 25:2392\u20132402. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-3200","journal-title":"Clin Cancer Res"},{"key":"1553_CR4","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/(sici)1097-0215(19990315)80:6<903::aid-ijc17>3.0.co;2-8","volume":"80","author":"J Bruch","year":"1999","unstructured":"Bruch J, Wohr G, Bruderlein S, Barbi G, Wolter H, Dixkens C, Mattfeldt T, M\u00f6ller P, Paiss T, Hautmann R, Vogel W, Hameister H (1999) Detailed marker chromosome analysis in cell line U-BLC1, established from transitional-cell carcinoma of the bladder. Int J Cancer 80:903\u2013910. https:\/\/doi.org\/10.1002\/(sici)1097-0215(19990315)80:6%3c903::aid-ijc17%3e3.0.co;2-8","journal-title":"Int J Cancer"},{"key":"1553_CR5","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.semcancer.2012.03.003","volume":"22","author":"J Bukur","year":"2012","unstructured":"Bukur J, Jasinski S, Seliger B (2012) The role of classical and non-classical HLA class I antigens in human tumors. Semin Cancer Biol 22:350\u2013358. https:\/\/doi.org\/10.1016\/j.semcancer.2012.03.003","journal-title":"Semin Cancer Biol"},{"key":"1553_CR6","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/ijc.28518","volume":"134","author":"J Calderaro","year":"2014","unstructured":"Calderaro J, Rebouissou S, de Koning L, Masmoudi A, H\u00e9rault A, Dubois T, Maille P, Soyeux P, Sibony M, de la Taille A, Vordos D, Lebret T, Radvanyi F, Allory Y (2014) PI3K\/AKT pathway activation in bladder carcinogenesis. Int J Cancer 134:1776\u20131784. https:\/\/doi.org\/10.1002\/ijc.28518","journal-title":"Int J Cancer"},{"key":"1553_CR7","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.3390\/ijms19092531","volume":"19","author":"H Chi","year":"2018","unstructured":"Chi H, Yang R, Zheng X, Zhang L, Jiang R, Chen J (2018) LncRNA RP11\u201379H233 functions as a competing endogenous RNA to regulate PTEN expression through sponging hsa-miR-107 in the development of bladder cancer. Int J Mol Sci 19:2531. https:\/\/doi.org\/10.3390\/ijms19092531","journal-title":"Int J Mol Sci"},{"key":"1553_CR8","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.3390\/diagnostics13162636","volume":"13","author":"FW Chin","year":"2023","unstructured":"Chin FW, Hussin H, Chau DM, Ong TA, Yunus R, Abdul Razack AH, Yusoff K, Chan SC, Veerakumarasivam A (2023) Differential protein expression patterns of HOXA13 and HOXB13 are associated with bladder cancer progression. Diagnostics 13:2636. https:\/\/doi.org\/10.3390\/diagnostics13162636","journal-title":"Diagnostics"},{"key":"1553_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/2051013614525375","volume":"2","author":"JD Comber","year":"2014","unstructured":"Comber JD, Philip R (2014) MHC class I antigen presentation and implications for developing a new generation of therapeutic vaccines. Ther Adv Vaccines 2:77\u201389. https:\/\/doi.org\/10.1177\/2051013614525375","journal-title":"Ther Adv Vaccines"},{"key":"1553_CR10","unstructured":"Cooper GM (2000) Endocytosis. In: The cell: a molecular approach, 2nd ed. Sunderland (MA): Sinauer Associates"},{"key":"1553_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00262-019-02443-4","volume":"69","author":"PL Crispen","year":"2020","unstructured":"Crispen PL, Kusmartsev S (2020) Mechanisms of immune evasion in bladder cancer. Cancer Immunol Immunother 69:3\u201314. https:\/\/doi.org\/10.1007\/s00262-019-02443-4","journal-title":"Cancer Immunol Immunother"},{"key":"1553_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1084\/jem.179.1.335","volume":"179","author":"FV Cromme","year":"1994","unstructured":"Cromme FV, Airey J, Heemels MT, Ploegh HL, Keating PJ, Stern PL, Meijer CJLM, Walboomers JMM (1994) Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J Exp Med 179:335\u2013340. https:\/\/doi.org\/10.1084\/jem.179.1.335","journal-title":"J Exp Med"},{"key":"1553_CR13","doi-asserted-by":"publisher","first-page":"27778","DOI":"10.18632\/oncotarget.4813","volume":"6","author":"R Duan","year":"2015","unstructured":"Duan R, Han L, Wang Q, Wei J, Chen L, Zhang J, Kang C, Wang L (2015) HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-\u03b2 pathways. Oncotarget 6:27778\u201327793. https:\/\/doi.org\/10.18632\/oncotarget.4813","journal-title":"Oncotarget"},{"key":"1553_CR14","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3389\/fimmu.2015.00459","volume":"6","author":"FV Duraes","year":"2015","unstructured":"Duraes FV, Niven J, Dubrot J, Hugues S, Gannag\u00e9 M (2015) Macroautophagy in endogenous processing of self- and pathogen-derived antigens for MHC class II presentation. Front Immunol 6:459. https:\/\/doi.org\/10.3389\/fimmu.2015.00459","journal-title":"Front Immunol"},{"key":"1553_CR15","doi-asserted-by":"publisher","first-page":"20574","DOI":"10.1038\/srep20574","volume":"6","author":"H Egawa","year":"2016","unstructured":"Egawa H, Jingushi K, Hirono T, Ueda Y, Kitae K, Nakata W, Fujita K, Uemura M, Nonomura N, Tsujikawa K (2016) The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN. Sci Rep 6:20574. https:\/\/doi.org\/10.1038\/srep20574","journal-title":"Sci Rep"},{"key":"1553_CR16","doi-asserted-by":"publisher","first-page":"e48057","DOI":"10.1371\/journal.pone.0048057","volume":"7","author":"O Filhol","year":"2012","unstructured":"Filhol O, Ciais D, Lajaunie C, Charbonnier P, Foveau N, Vert JP, Vandenbrouck Y (2012) DSIR: assessing the design of highly potent siRNA by testing a set of cancer-relevant target genes. PLoS ONE 7:e48057. https:\/\/doi.org\/10.1371\/journal.pone.0048057","journal-title":"PLoS ONE"},{"key":"1553_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1146\/annurev.ge.20.120186.001051","volume":"20","author":"WJ Gehring","year":"1986","unstructured":"Gehring WJ, Hiromi Y (1986) Homeotic genes and the homeobox. Annu Rev Genet 20:147\u2013173. https:\/\/doi.org\/10.1146\/annurev.ge.20.120186.001051","journal-title":"Annu Rev Genet"},{"key":"1553_CR18","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/s0022-5347(17)45139-1","volume":"136","author":"HB Grossman","year":"1986","unstructured":"Grossman HB, Wedemeyer G, Ren L, Wilson GN, Cox B (1986) Improved growth of human urothelial carcinoma cell cultures. J Urol 136:953\u2013959. https:\/\/doi.org\/10.1016\/s0022-5347(17)45139-1","journal-title":"J Urol"},{"key":"1553_CR19","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1158\/0008-5472.CAN-08-4546","volume":"69","author":"ZD Gu","year":"2009","unstructured":"Gu ZD, Shen LY, Wang H, Chen XM, Li Y, Ning T, Chen KN (2009) HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. Cancer Res 69:4969\u20134973. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-4546","journal-title":"Cancer Res"},{"key":"1553_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/978-1-4939-7471-9_16","volume":"1706","author":"H Han","year":"2018","unstructured":"Han H (2018) RNA interference to knock down gene expression. Methods Mol Biol 1706:293\u2013302. https:\/\/doi.org\/10.1007\/978-1-4939-7471-9_16","journal-title":"Methods Mol Biol"},{"key":"1553_CR21","doi-asserted-by":"publisher","first-page":"e243","DOI":"10.1016\/j.juro.2013.02.1990","volume":"189","author":"T Hayashi","year":"2013","unstructured":"Hayashi T, Gust KM, Jaeger W, Awrey S, Li N, Altamirano-Dimas M, Buttyan R, Li E, Fazli L, Black PC, Canada V (2013) Specific inhibiton of Notch-2 as a novel therapy for invasive bladder cancer. J Urol 189:e243. https:\/\/doi.org\/10.1016\/j.juro.2013.02.1990","journal-title":"J Urol"},{"key":"1553_CR22","doi-asserted-by":"publisher","first-page":"258","DOI":"10.26355\/eurrev_202205_28830","volume":"21","author":"YX He","year":"2017","unstructured":"He YX, Song XH, Zhao ZY, Zhao H (2017) HOXA13 upregulation in gastric cancer is associated with enhanced cancer cell invasion and epithelial-to-mesenchymal transition. Eur Rev Med Pharmacol Sci 21:258\u2013265. https:\/\/doi.org\/10.26355\/eurrev_202205_28830","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1553_CR23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1093\/carcin\/bgt348","volume":"35","author":"I Hsu","year":"2014","unstructured":"Hsu I, Chuang KL, Slavin S, Da J, Lim WX, Pang ST, O\u2019Brien JH, Yeh S (2014) Suppression of ER\u03b2 signaling via ER\u03b2 knockout or antagonist protects against bladder cancer development. Carcinogenesis 35:651\u2013661. https:\/\/doi.org\/10.1093\/carcin\/bgt348","journal-title":"Carcinogenesis"},{"key":"1553_CR24","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00508-016-1108-4","volume":"129","author":"HY Hu","year":"2017","unstructured":"Hu HY, Chen YB, Cheng S, Li GH, Zhang ZG (2017) Dysregulated expression of homebox gene HOXA13 is correlated with the poor prognosis in bladder cancer. Wien Klin Wochenschr 129:391\u2013397. https:\/\/doi.org\/10.1007\/s00508-016-1108-4","journal-title":"Wien Klin Wochenschr"},{"key":"1553_CR25","doi-asserted-by":"publisher","first-page":"9185","DOI":"10.1158\/0008-5472.CAN-04-1330","volume":"64","author":"CY Jung","year":"2004","unstructured":"Jung CY, Kim RS, Zhang HJ, Lee SJ, Jeng MH (2004) HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. Cancer Res 64:9185\u20139192. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-1330","journal-title":"Cancer Res"},{"key":"1553_CR26","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1038\/sj.bjc.6602631","volume":"92","author":"C Jung","year":"2005","unstructured":"Jung C, Kim RS, Zhang H, Lee SJ, Sheng H, Loehrer PJ, Gardner TA, Jeng MH, Kao C (2005) HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. Br J Cancer 92:2233\u20132239. https:\/\/doi.org\/10.1038\/sj.bjc.6602631","journal-title":"Br J Cancer"},{"key":"1553_CR27","doi-asserted-by":"crossref","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res 28:27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27","DOI":"10.1093\/nar\/28.1.27"},{"key":"1553_CR28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3892\/or.2013.2416","volume":"30","author":"EC Kauffman","year":"2013","unstructured":"Kauffman EC, Robinson BD, Downes M, Marcinkiewicz K, Vourganti S, Scherr DS, Gudas LJ, Mongan NP (2013) Estrogen receptor-\u03b2 expression and pharmacological targeting in bladder cancer. Oncol Rep 30:131\u2013138. https:\/\/doi.org\/10.3892\/or.2013.2416","journal-title":"Oncol Rep"},{"key":"1553_CR29","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/355641a0","volume":"355","author":"A Kelly","year":"1992","unstructured":"Kelly A, Powis SH, Kerr LA, Mockridge I, Elliott T, Bastin J, Uchanska-Ziegler B, Ziegler A, Trowsdale J, Townsend A (1992) Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature 355:641\u2013644. https:\/\/doi.org\/10.1038\/355641a0","journal-title":"Nature"},{"key":"1553_CR30","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.urology.2005.07.062","volume":"66","author":"Z Kirkali","year":"2005","unstructured":"Kirkali Z, Chan T, Manoharan M, Algaba F, Busch C, Cheng L, Kiemeney L, Kriegmair M, Montironi R, Murphy WM, Sesterhenn IA, Tachibana M, Weider J (2005) Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 66:4\u201334. https:\/\/doi.org\/10.1016\/j.urology.2005.07.062","journal-title":"Urology"},{"key":"1553_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","volume":"78","author":"R Krumlauf","year":"1994","unstructured":"Krumlauf R (1994) Hox genes in vertebrate development. Cell 78:191\u2013201. https:\/\/doi.org\/10.1016\/0092-8674(94)90290-9","journal-title":"Cell"},{"key":"1553_CR32","first-page":"3997","volume":"44","author":"AA Kyriazis","year":"1984","unstructured":"Kyriazis AA, Kyriazis AP, McCombs WB, Peterson WD (1984) Morphological, biological, and biochemical characteristics of human bladder transitional cell carcinomas grown in tissue culture and in nude mice. Cancer Res 44:3997\u20134005","journal-title":"Cancer Res"},{"key":"1553_CR33","volume-title":"Cancer cell culture: methods and protocols","author":"SP Langdon","year":"2004","unstructured":"Langdon SP (2004) Cancer cell culture: methods and protocols. Humana Press, New Jersey"},{"key":"1553_CR34","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1182\/blood.V85.3.692.bloodjournal853692","volume":"85","author":"MC Lill","year":"1995","unstructured":"Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC (1995) The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation. Blood 85:692\u2013697","journal-title":"Blood"},{"key":"1553_CR35","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"1553_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.molimm.2021.12.013","volume":"142","author":"I Mantel","year":"2022","unstructured":"Mantel I, Sadiq BA, Blander JM (2022) Spotlight on TAP and its vital role in antigen presentation and cross-presentation. Mol Immunol 142:105\u2013119. https:\/\/doi.org\/10.1016\/j.molimm.2021.12.013","journal-title":"Mol Immunol"},{"key":"1553_CR37","first-page":"833","volume":"20","author":"L Marra","year":"2013","unstructured":"Marra L, Cantile M, Scognamiglio G, Marra L, Perdona S, La Mantia E, Cerrone M, Gigantino V, Cillo C, Caraglia M, Pignata S, Facchini G, Botti G, Chieffi S, Chieffi P, Franco R (2013) Deregulation of HOX B13 expression in urinary bladder cancer progression. Curr Med Chem 20:833\u2013839","journal-title":"Curr Med Chem"},{"key":"1553_CR38","first-page":"3630","volume":"46","author":"JRW Masters","year":"1986","unstructured":"Masters JRW, Hepburn PJ, Walker L, Highman WJ, Trejdosiewicz LK, Povey S, Parkar M, Hill BT, Riddle PR, Franks LM (1986) Tissue culture model of transitional cell carcinoma: characterization of twenty-two human urothelial cell lines. Cancer Res 46:3630\u20133636","journal-title":"Cancer Res"},{"key":"1553_CR39","doi-asserted-by":"publisher","first-page":"17093","DOI":"10.1073\/pnas.0707938104","volume":"104","author":"JY Miao","year":"2007","unstructured":"Miao JY, Wang ZC, Provencher H, Muir B, Dahiya S, Carney E, Leong CO, Sgroi DC, Orsulic S (2007) HOXB13 promotes ovarian cancer progression. Proc Natl Acad Sci 104:17093\u201317098. https:\/\/doi.org\/10.1073\/pnas.0707938104","journal-title":"Proc Natl Acad Sci"},{"key":"1553_CR40","doi-asserted-by":"publisher","first-page":"66","DOI":"10.4274\/jus.1070","volume":"3","author":"KF Narter","year":"2016","unstructured":"Narter KF, Sabuncu K (2016) Invasion mechanisms of bladder cancer: a molecular review. J Urol Surg 3:66\u201373. https:\/\/doi.org\/10.4274\/jus.1070","journal-title":"J Urol Surg"},{"key":"1553_CR41","doi-asserted-by":"publisher","first-page":"165776","DOI":"10.1016\/j.bbadis.2020.165776","volume":"1866","author":"K Nesteruk","year":"2020","unstructured":"Nesteruk K, Janmaat VT, Liu H, Ten Hagen TL, Peppelenbosch MP, Fuhler GM (2020) Forced expression of HOXA13 confers oncogenic hallmarks to esophageal keratinocytes. Biochim Biophys Acta Mol Basis Dis 1866:165776. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165776","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1553_CR42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/onc.2016.172","volume":"36","author":"ML Nickerson","year":"2017","unstructured":"Nickerson ML, Witte N, Im KM, Turan S, Owens C, Misner K, Tsang SX, Cai Z, Wu S, Dean M, Costello JC, Theodorescu D (2017) Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response. Oncogene 36:35\u201346. https:\/\/doi.org\/10.1038\/onc.2016.172","journal-title":"Oncogene"},{"key":"1553_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13070\/mm.en.3.197","volume":"3","author":"EP O\u2019Keefe","year":"2013","unstructured":"O\u2019Keefe EP (2013) siRNAs and shRNAs: tools for protein knockdown by gene silencing. Mater Methods 3:1\u201315. https:\/\/doi.org\/10.13070\/mm.en.3.197","journal-title":"Mater Methods"},{"key":"1553_CR44","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1038\/sj.onc.1209200","volume":"25","author":"H Okuda","year":"2006","unstructured":"Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada M, Tokino T, Shuin T (2006) Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma. Oncogene 25:1733\u20131742. https:\/\/doi.org\/10.1038\/sj.onc.1209200","journal-title":"Oncogene"},{"key":"1553_CR45","unstructured":"Qiagen (2010) Flexible RNAi technologies you can rely on. https:\/\/www.qiagen.com\/us\/resources\/resourcedetail?id=0489bb98-dc9a-4b3a-9f12-e9e94cd7218f&lang=en. Accessed 27 Dec 2019"},{"key":"1553_CR46","first-page":"1234","volume":"21","author":"L Qu","year":"2017","unstructured":"Qu L, Zhong Y, Zheng Z, Zhao R (2017) CDH17 is a downstream effector of HOXA13 in modulating the Wnt\/\u03b2-catenin signaling pathway in gastric cancer. Eur Rev Med Pharmacol Sci 21:1234\u20131241","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1553_CR47","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/labinvest.2017.107","volume":"98","author":"L Quagliata","year":"2018","unstructured":"Quagliata L, Quintavalle C, Lanzafame M, Matter MS, Novello C, di Tommaso L, Pressiani T, Rimassa L, Tornillo L, Roncalli M, Cillo C, Pallante P, Piscuoglio S, Ng CK, Terracciano LM (2018) High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models. Lab Investig 98:95\u2013105. https:\/\/doi.org\/10.1038\/labinvest.2017.107","journal-title":"Lab Investig"},{"key":"1553_CR48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/imm.12675","volume":"150","author":"E Reeves","year":"2016","unstructured":"Reeves E, James E (2016) Antigen processing and immune regulation in the response to tumours. Immunology 150:16\u201324. https:\/\/doi.org\/10.1111\/imm.12675","journal-title":"Immunology"},{"key":"1553_CR49","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/bf03401948","volume":"7","author":"U Ritz","year":"2001","unstructured":"Ritz U, Seliger B (2001) The transporter associated with antigen processing (TAP): structural integrity, expression, function, and its clinical relevance. Mol Med 7:149\u2013158. https:\/\/doi.org\/10.1007\/bf03401948","journal-title":"Mol Med"},{"key":"1553_CR50","doi-asserted-by":"crossref","unstructured":"Sandberg JK, Glas R (2001) Antigen processing. In: Encyclopedia of Life Sciences. Nature Publishing Group, pp 1\u20136","DOI":"10.1038\/npg.els.0001228"},{"key":"1553_CR51","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1002\/cncr.21945","volume":"106","author":"SS Shen","year":"2006","unstructured":"Shen SS, Smith CL, Hsieh JT, Yu J, Kim IY, Jian W, Sonpavde G, Ayala GE, Younes M, Lerner SP (2006) Expression of estrogen receptors-\u03b1 and -\u03b2 in bladder cancer cell lines and human bladder tumor tissue. Am Cancer Soc 106:2610\u20132616. https:\/\/doi.org\/10.1002\/cncr.21945","journal-title":"Am Cancer Soc"},{"key":"1553_CR52","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00345-009-0395-z","volume":"27","author":"KD Sievert","year":"2009","unstructured":"Sievert KD, Amend B, Nagele U, Schilling D, Bedke J, Horstmann M, Hennenlotter J, Kruck S, Stenzl A (2009) Economic aspects of bladder cancer: what are the benefits and costs? World J Urol 27:295\u2013300. https:\/\/doi.org\/10.1007\/s00345-009-0395-z","journal-title":"World J Urol"},{"key":"1553_CR53","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/MOU.0b013e32830b8925","volume":"18","author":"A Stenzl","year":"2008","unstructured":"Stenzl A, Hennenlotter J, Schilling D (2008) Can we still afford bladder cancer? Curr Opin Urol 18:488\u2013492. https:\/\/doi.org\/10.1097\/MOU.0b013e32830b8925","journal-title":"Curr Opin Urol"},{"key":"1553_CR54","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/j.1365-2559.2011.03856.x","volume":"58","author":"CH Sun","year":"2011","unstructured":"Sun CH, Chang YH, Pan CC (2011) Activation of the PI3K\/Akt\/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. Histopathology 58:1054\u20131063. https:\/\/doi.org\/10.1111\/j.1365-2559.2011.03856.x","journal-title":"Histopathology"},{"key":"1553_CR55","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.3390\/ijms17122142","volume":"17","author":"M Tellez-Gabriel","year":"2016","unstructured":"Tellez-Gabriel M, Ory B, Lamoureux F, Heymann MF, Heymann D (2016) Tumour heterogeneity: the key advantages of single-cell analysis. Int J Mol Sci 17:2142. https:\/\/doi.org\/10.3390\/ijms17122142","journal-title":"Int J Mol Sci"},{"key":"1553_CR56","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/S0002-9440(10)64396-9","volume":"161","author":"MJ Urist","year":"2002","unstructured":"Urist MJ, Di Como CJ, Lu ML, Charytonowicz E, Verbel D, Crum CP, Ince TA, McKeon FD, Cordon-Cardo C (2002) Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol 161:1199\u20131206. https:\/\/doi.org\/10.1016\/S0002-9440(10)64396-9","journal-title":"Am J Pathol"},{"key":"1553_CR57","doi-asserted-by":"publisher","first-page":"38531","DOI":"10.1038\/srep38531","volume":"6","author":"J Warrick","year":"2016","unstructured":"Warrick J, Walter V, Yamashita H, Chung E, Shuman L, Amponsa VO, Zheng Z, Chan W, Whitcomb TL, Yue F, Iyyanki T, Kawasawa YI, Kaag M, Guo W, Raman JD, Park JS, DeGraff DJ (2016) FOXA1, GATA3 and PPARI cooperate to drive luminal subtype in bladder cancer: a molecular analysis of established human cell lines. Sci Rep 6:38531. https:\/\/doi.org\/10.1038\/srep38531","journal-title":"Sci Rep"},{"key":"1553_CR58","unstructured":"World Health Organization (2024) Bladder cancer. In: International Agency for Research in Cancer. https:\/\/www.iarc.who.int\/cancer-type\/bladder-cancer\/. Accessed 11 Dec 2024"},{"key":"1553_CR59","first-page":"6919","volume":"8","author":"LL Zhai","year":"2015","unstructured":"Zhai LL, Wu Y, Cai CY, Tang ZG (2015) Overexpression of homeobox B-13 correlates with angiogenesis, aberrant expression of EMT markers, aggressive characteristics and poor prognosis in pancreatic carcinoma. Int J Clin Exp Pathol 8:6919\u20136927","journal-title":"Int J Clin Exp Pathol"},{"key":"1553_CR60","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12935-019-1056-y","volume":"19","author":"PB Zhang","year":"2019","unstructured":"Zhang PB, Huang ZL, Xu YH, Huang J, Huang XY, Huang XY (2019) Systematic analysis of gene expression profiles reveals prognostic stratification and underlying mechanisms for muscle-invasive bladder cancer. Cancer Cell Int 19:337. https:\/\/doi.org\/10.1186\/s12935-019-1056-y","journal-title":"Cancer Cell Int"},{"key":"1553_CR61","first-page":"2925","volume":"7","author":"JY Zhu","year":"2014","unstructured":"Zhu JY, Sun QK, Wang W, Jia WD (2014) High-level expression of HOXB13 is closely associated with tumor angiogenesis and poor prognosis of hepatocellular carcinoma. Int J Clin Exp Pathol 7:2925\u20132933","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01553-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01553-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01553-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:13:12Z","timestamp":1769155992000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01553-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1553"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01553-w","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"11 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}