{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:45:12Z","timestamp":1792701912640,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2511002"],"award-info":[{"award-number":["2024YFC2511002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01624-y","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T20:00:37Z","timestamp":1748808037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Functional genomics reveals adipose-kidney crosstalk as a contributor to kidney fibrosis via the OSM-OSMR pathway"],"prefix":"10.1007","volume":"25","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"1624_CR1","doi-asserted-by":"publisher","first-page":"9354","DOI":"10.1038\/s41598-019-45839-z","volume":"9","author":"HM Amemiya","year":"2019","unstructured":"Amemiya HM, Kundaje A, Boyle AP (2019) The ENCODE blacklist: identification of problematic regions of the genome. Sci Rep 9:9354. https:\/\/doi.org\/10.1038\/s41598-019-45839-z","journal-title":"Sci Rep"},{"key":"1624_CR2","doi-asserted-by":"publisher","DOI":"10.3791\/59499","author":"DP Bagchi","year":"2019","unstructured":"Bagchi DP, MacDougald OA (2019) Identification and dissection of diverse mouse adipose depots. J vis Exp. https:\/\/doi.org\/10.3791\/59499","journal-title":"J vis Exp"},{"key":"1624_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrneph.2016.191","volume":"13","author":"NO Camara","year":"2017","unstructured":"Camara NO, Iseki K, Kramer H, Liu ZH, Sharma K (2017) Kidney disease and obesity: epidemiology, mechanisms and treatment. Nat Rev Nephrol 13:181\u2013190. https:\/\/doi.org\/10.1038\/nrneph.2016.191","journal-title":"Nat Rev Nephrol"},{"key":"1624_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrn.2018.7","volume":"19","author":"A Caron","year":"2018","unstructured":"Caron A, Lee S, Elmquist JK, Gautron L (2018) Leptin and brain-adipose crosstalks. Nat Rev Neurosci 19:153\u2013165. https:\/\/doi.org\/10.1038\/nrn.2018.7","journal-title":"Nat Rev Neurosci"},{"key":"1624_CR5","doi-asserted-by":"publisher","first-page":"100784","DOI":"10.1016\/j.xgen.2025.100784","volume":"5","author":"HH Chen","year":"2025","unstructured":"Chen HH, Highland HM, Frankel EG, Scartozzi AC, Zhang X, Roshani R, Sharma P, Kar A, Buchanan VL, Polikowsky HG, Petty LE, Seo J, Anwar MY, Kim D, Graff M, Young KL, Zhu W, Karastergiou K, Shaw DM, Justice AE, Fernandez-Rhodes L, Krishnan M, Gutierrez A, McCormick PJ, Aguilar-Salinas CA, Tusie-Luna MT, Munoz-Hernandez LL, Herrera-Hernandez M, Lee M, Gamazon ER, Cox NJ, Pajukanta P, Fried SK, Gordon-Larsen P, Shah RV, Fisher-Hoch SP, McCormick JB, North KE, Below JE (2025) Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM. Cell Genom 5:100784. https:\/\/doi.org\/10.1016\/j.xgen.2025.100784","journal-title":"Cell Genom"},{"key":"1624_CR6","doi-asserted-by":"publisher","unstructured":"Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C, Cancer Genome Atlas Analysis N, Greenleaf WJ, Chang HY (2018) The chromatin accessibility landscape of primary human cancers. Science 362. https:\/\/doi.org\/10.1126\/science.aav1898","DOI":"10.1126\/science.aav1898"},{"key":"1624_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jcmg.2018.06.025","volume":"12","author":"L Davin","year":"2019","unstructured":"Davin L, Nchimi A, Ilardi F, Dulgheru R, Marchetta S, Gach O, Marechal P, Cimino S, Bruyere PJ, Georgiopoulos A, Dibato JE, d\u2019Amico G, Galderisi M, Parisi V, Oury C, Lancellotti P (2019) Epicardial adipose tissue and myocardial fibrosis in aortic stenosis relationship with symptoms and outcomes: a study using cardiac magnetic resonance imaging. JACC Cardiovasc Imaging 12:213\u2013214. https:\/\/doi.org\/10.1016\/j.jcmg.2018.06.025","journal-title":"JACC Cardiovasc Imaging"},{"key":"1624_CR8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12915-021-00977-7","volume":"19","author":"A Duan","year":"2021","unstructured":"Duan A, Wang H, Zhu Y, Wang Q, Zhang J, Hou Q, Xing Y, Shi J, Hou J, Qin Z, Chen Z, Liu Z, Yang J (2021) Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants. BMC Biol 19:38. https:\/\/doi.org\/10.1186\/s12915-021-00977-7","journal-title":"BMC Biol"},{"key":"1624_CR9","doi-asserted-by":"publisher","first-page":"102347","DOI":"10.1016\/j.jbc.2022.102347","volume":"298","author":"A Gupta","year":"2022","unstructured":"Gupta A, Balakrishnan B, Karki S, Slayton M, Jash S, Banerjee S, Grahn THM, Jambunathan S, Disney S, Hussein H, Kong D, Lowell BB, Natarajan P, Reddy UK, Gokce N, Sharma VM, Puri V (2022) Human CIDEC transgene improves lipid metabolism and protects against high-fat diet-induced glucose intolerance in mice. J Biol Chem 298:102347. https:\/\/doi.org\/10.1016\/j.jbc.2022.102347","journal-title":"J Biol Chem"},{"key":"1624_CR10","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1038\/s44318-024-00196-0","volume":"43","author":"YT Hsiao","year":"2024","unstructured":"Hsiao YT, Yoshida Y, Okuda S, Abe M, Mizuno S, Takahashi S, Nakagami H, Morishita R, Kamimura K, Terai S, Aung TM, Li J, Furihata T, Tang JY, Walsh K, Ishigami A, Minamino T, Shimizu I (2024) PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. EMBO J 43:4846\u20134869. https:\/\/doi.org\/10.1038\/s44318-024-00196-0","journal-title":"EMBO J"},{"key":"1624_CR11","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nrendo.2015.58","volume":"11","author":"G Iacobellis","year":"2015","unstructured":"Iacobellis G (2015) Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol 11:363\u2013371. https:\/\/doi.org\/10.1038\/nrendo.2015.58","journal-title":"Nat Rev Endocrinol"},{"key":"1624_CR12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.tem.2011.07.003","volume":"22","author":"G Iacobellis","year":"2011","unstructured":"Iacobellis G, Bianco AC (2011) Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab 22:450\u2013457. https:\/\/doi.org\/10.1016\/j.tem.2011.07.003","journal-title":"Trends Endocrinol Metab"},{"key":"1624_CR13","doi-asserted-by":"publisher","first-page":"e0221477","DOI":"10.1371\/journal.pone.0221477","volume":"14","author":"DV Keulen","year":"2019","unstructured":"Keulen DV, Pouwer MG, Emilsson V, Matic LP, Pieterman EJ, Hedin U, Gudnason V, Jennings LL, Holmstrom K, Nielsen BS, Pasterkamp G, Lindeman JHN, van Gool AJ, SollewijnGelpke MD, Princen HMG, Tempel D (2019) Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans. PLoS One 14:e0221477. https:\/\/doi.org\/10.1371\/journal.pone.0221477","journal-title":"PLoS One"},{"key":"1624_CR14","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim D, Langmead B, Salzberg SL (2015) HISAT: a fast spliced aligner with low memory requirements. Nat Methods 12:357\u2013360. https:\/\/doi.org\/10.1038\/nmeth.3317","journal-title":"Nat Methods"},{"key":"1624_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","volume":"34","author":"S Klein","year":"2022","unstructured":"Klein S, Gastaldelli A, Yki-Jarvinen H, Scherer PE (2022) Why does obesity cause diabetes? Cell Metab 34:11\u201320. https:\/\/doi.org\/10.1016\/j.cmet.2021.12.012","journal-title":"Cell Metab"},{"key":"1624_CR16","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1093\/ndt\/gfw260","volume":"32","author":"CQF Klessens","year":"2017","unstructured":"Klessens CQF, Zandbergen M, Wolterbeek R, Bruijn JA, Rabelink TJ, Bajema IM, IJpelaar DH (2017) Macrophages in diabetic nephropathy in patients with type 2 diabetes. Nephrol Dial Transplant 32:1322\u20131329. https:\/\/doi.org\/10.1093\/ndt\/gfw260","journal-title":"Nephrol Dial Transplant"},{"key":"1624_CR17","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41586-023-05769-3","volume":"619","author":"BB Lake","year":"2023","unstructured":"Lake BB, Menon R, Winfree S, Hu Q, Melo Ferreira R, Kalhor K, Barwinska D, Otto EA, Ferkowicz M, Diep D, Plongthongkum N, Knoten A, Urata S, Mariani LH, Naik AS, Eddy S, Zhang B, Wu Y, Salamon D, Williams JC, Wang X, Balderrama KS, Hoover PJ, Murray E, Marshall JL, Noel T, Vijayan A, Hartman A, Chen F, Waikar SS, Rosas SE, Wilson FP, Palevsky PM, Kiryluk K, Sedor JR, Toto RD, Parikh CR, Kim EH, Satija R, Greka A, Macosko EZ, Kharchenko PV, Gaut JP, Hodgin JB, Consortium K, Eadon MT, Dagher PC, El-Achkar TM, Zhang K, Kretzler M, Jain S (2023) An atlas of healthy and injured cell states and niches in the human kidney. Nature 619:585\u2013594. https:\/\/doi.org\/10.1038\/s41586-023-05769-3","journal-title":"Nature"},{"key":"1624_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pcad.2018.07.005","volume":"61","author":"JI Lakkis","year":"2018","unstructured":"Lakkis JI, Weir MR (2018) Obesity and Kidney Disease. Prog Cardiovasc Dis 61:157\u2013167. https:\/\/doi.org\/10.1016\/j.pcad.2018.07.005","journal-title":"Prog Cardiovasc Dis"},{"key":"1624_CR19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9:357\u2013359. https:\/\/doi.org\/10.1038\/nmeth.1923","journal-title":"Nat Methods"},{"key":"1624_CR20","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.jacc.2016.06.067","volume":"68","author":"JJ Lee","year":"2016","unstructured":"Lee JJ, Pedley A, Hoffmann U, Massaro JM, Fox CS (2016) Association of changes in abdominal fat quantity and quality with incident cardiovascular disease risk factors. J Am Coll Cardiol 68:1509\u20131521. https:\/\/doi.org\/10.1016\/j.jacc.2016.06.067","journal-title":"J Am Coll Cardiol"},{"key":"1624_CR21","doi-asserted-by":"publisher","first-page":"7336","DOI":"10.1038\/s41467-021-27607-8","volume":"12","author":"BY Lee","year":"2021","unstructured":"Lee BY, Hogg EKJ, Below CR, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle JW, Jorgensen C (2021a) Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. Nat Commun 12:7336. https:\/\/doi.org\/10.1038\/s41467-021-27607-8","journal-title":"Nat Commun"},{"key":"1624_CR22","doi-asserted-by":"publisher","unstructured":"Lee BY, Hogg EKJ, Below CR, Kononov A, Blanco-Gomez A, Heider F, Xu JS, Hutton C, Zhang XH, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle JW, Jorgensen C (2021b) Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. Nat Commun 12. https:\/\/doi.org\/10.1038\/s41467-021-27607-8","DOI":"10.1038\/s41467-021-27607-8"},{"key":"1624_CR23","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R, Genome Project Data Processing S (2009) The Sequence Alignment\/Map format and SAMtools. Bioinformatics 25:2078\u20132079. https:\/\/doi.org\/10.1093\/bioinformatics\/btp352","journal-title":"Bioinformatics"},{"key":"1624_CR24","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","volume":"29","author":"C Ling","year":"2019","unstructured":"Ling C, Ronn T (2019) Epigenetics in human obesity and Type 2 diabetes. Cell Metab 29:1028\u20131044. https:\/\/doi.org\/10.1016\/j.cmet.2019.03.009","journal-title":"Cell Metab"},{"key":"1624_CR25","doi-asserted-by":"publisher","unstructured":"Martin M (2011) Cutadapt removes adapter sequences from high-throughput sequencing reads. 17:3. https:\/\/doi.org\/10.14806\/ej.17.1.200","DOI":"10.14806\/ej.17.1.200"},{"key":"1624_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.metabol.2012.08.012","volume":"62","author":"K Michalakis","year":"2013","unstructured":"Michalakis K, Mintziori G, Kaprara A, Tarlatzis BC, Goulis DG (2013) The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism 62:457\u2013478. https:\/\/doi.org\/10.1016\/j.metabol.2012.08.012","journal-title":"Metabolism"},{"key":"1624_CR27","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s41591-019-0415-5","volume":"25","author":"MA Niewczas","year":"2019","unstructured":"Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS (2019) A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes. Nat Med 25:805\u2013813. https:\/\/doi.org\/10.1038\/s41591-019-0415-5","journal-title":"Nat Med"},{"key":"1624_CR28","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.jacc.2018.03.509","volume":"71","author":"M Packer","year":"2018","unstructured":"Packer M (2018) Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium. J Am Coll Cardiol 71:2360\u20132372. https:\/\/doi.org\/10.1016\/j.jacc.2018.03.509","journal-title":"J Am Coll Cardiol"},{"key":"1624_CR29","doi-asserted-by":"publisher","first-page":"717","DOI":"10.2337\/db17-0755","volume":"67","author":"Y Pan","year":"2018","unstructured":"Pan Y, Jiang S, Hou Q, Qiu D, Shi J, Wang L, Chen Z, Zhang M, Duan A, Qin W, Zen K, Liu Z (2018) Dissection of glomerular transcriptional profile in patients with diabetic nephropathy: SRGAP2a protects podocyte structure and function. Diabetes 67:717\u2013730. https:\/\/doi.org\/10.2337\/db17-0755","journal-title":"Diabetes"},{"key":"1624_CR30","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1038\/nprot.2016.095","volume":"11","author":"M Pertea","year":"2016","unstructured":"Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL (2016) Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown. Nat Protoc 11:1650\u20131667. https:\/\/doi.org\/10.1038\/nprot.2016.095","journal-title":"Nat Protoc"},{"key":"1624_CR31","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.kint.2020.02.019","volume":"98","author":"S Ranjit","year":"2020","unstructured":"Ranjit S, Henriksen K, Dvornikov A, Delsante M, Rosenberg A, Levi M, Gratton E (2020) Phasor approach to autofluorescence lifetime imaging FLIM can be a quantitative biomarker of chronic renal parenchymal injury. Kidney Int 98:1341\u20131346. https:\/\/doi.org\/10.1016\/j.kint.2020.02.019","journal-title":"Kidney Int"},{"key":"1624_CR32","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.2174\/1389450123666220811101032","volume":"23","author":"TR Rankouhi","year":"2022","unstructured":"Rankouhi TR, Keulen DV, Tempel D, Venhorst J (2022) Oncostatin M: risks and benefits of a novel therapeutic target for atherosclerosis. Curr Drug Targets 23:1345\u20131369. https:\/\/doi.org\/10.2174\/1389450123666220811101032","journal-title":"Curr Drug Targets"},{"key":"1624_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mcna.2012.10.001","volume":"97","author":"AT Reutens","year":"2013","unstructured":"Reutens AT (2013) Epidemiology of diabetic kidney disease. Med Clin North Am 97:1\u201318. https:\/\/doi.org\/10.1016\/j.mcna.2012.10.001","journal-title":"Med Clin North Am"},{"key":"1624_CR34","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature10730","volume":"481","author":"CS Ross-Innes","year":"2012","unstructured":"Ross-Innes CS, Stark R, Teschendorff AE, Holmes KA, Ali HR, Dunning MJ, Brown GD, Gojis O, Ellis IO, Green AR, Ali S, Chin SF, Palmieri C, Caldas C, Carroll JS (2012) Differential oestrogen receptor binding is associated with clinical outcome in breast cancer. Nature 481:389-U177. https:\/\/doi.org\/10.1038\/nature10730","journal-title":"Nature"},{"key":"1624_CR35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","volume":"185","author":"A Sakers","year":"2022","unstructured":"Sakers A, De Siqueira MK, Seale P, Villanueva CJ (2022) Adipose-tissue plasticity in health and disease. Cell 185:419\u2013446. https:\/\/doi.org\/10.1016\/j.cell.2021.12.016","journal-title":"Cell"},{"key":"1624_CR36","doi-asserted-by":"publisher","first-page":"E217","DOI":"10.1210\/jc.2013-3555","volume":"99","author":"D Sanchez-Infantes","year":"2014","unstructured":"Sanchez-Infantes D, White UA, Elks CM, Morrison RF, Gimble JM, Considine RV, Ferrante AW, Ravussin E, Stephens JM (2014) Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes. J Clin Endocrinol Metab 99:E217-225. https:\/\/doi.org\/10.1210\/jc.2013-3555","journal-title":"J Clin Endocrinol Metab"},{"key":"1624_CR37","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature13138","volume":"507","author":"S Smemo","year":"2014","unstructured":"Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, G\u00f3mez-Mar\u00edn C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, N\u00f3brega MA (2014) Obesity-associated variants within form long-range functional connections with IRX3. Nature 507:371. https:\/\/doi.org\/10.1038\/nature13138","journal-title":"Nature"},{"issue":"1888\u20131902","key":"1624_CR38","doi-asserted-by":"publisher","first-page":"e1821","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM 3rd, Hao Y, Stoeckius M, Smibert P, Satija R (2019) Comprehensive Integration of Single-Cell Data. Cell 177(1888\u20131902):e1821. https:\/\/doi.org\/10.1016\/j.cell.2019.05.031","journal-title":"Cell"},{"key":"1624_CR39","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1172\/JCI45887","volume":"121","author":"K Sun","year":"2011","unstructured":"Sun K, Kusminski CM, Scherer PE (2011a) Adipose tissue remodeling and obesity. J Clin Invest 121:2094\u20132101. https:\/\/doi.org\/10.1172\/JCI45887","journal-title":"J Clin Invest"},{"key":"1624_CR40","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.5858\/arpa.2010-0549-OA","volume":"135","author":"Y Sun","year":"2011","unstructured":"Sun Y, Yu H, Zheng D, Cao Q, Wang Y, Harris D, Wang Y (2011b) Sudan black B reduces autofluorescence in murine renal tissue. Arch Pathol Lab Med 135:1335\u20131342. https:\/\/doi.org\/10.5858\/arpa.2010-0549-OA","journal-title":"Arch Pathol Lab Med"},{"key":"1624_CR41","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3978\/j.issn.2223-3652.2014.11.05","volume":"4","author":"AH Talman","year":"2014","unstructured":"Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK, Wong DT (2014) Epicardial adipose tissue: far more than a fat depot. Cardiovasc Diagn Ther 4:416\u2013429. https:\/\/doi.org\/10.3978\/j.issn.2223-3652.2014.11.05","journal-title":"Cardiovasc Diagn Ther"},{"key":"1624_CR42","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","volume":"16","author":"SCW Tang","year":"2020","unstructured":"Tang SCW, Yiu WH (2020) Innate immunity in diabetic kidney disease. Nat Rev Nephrol 16:206\u2013222. https:\/\/doi.org\/10.1038\/s41581-019-0234-4","journal-title":"Nat Rev Nephrol"},{"key":"1624_CR43","doi-asserted-by":"publisher","unstructured":"Till A, Fries C, Fenske WK (2022) Brain-to-BAT - and Back?: crosstalk between the central nervous system and thermogenic adipose tissue in development and therapy of obesity. Brain Sci 12. https:\/\/doi.org\/10.3390\/brainsci12121646","DOI":"10.3390\/brainsci12121646"},{"key":"1624_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41591-020-1116-9","volume":"27","author":"R Wagner","year":"2021","unstructured":"Wagner R, Heni M, Tabak AG, Machann J, Schick F, Randrianarisoa E, Hrabe de Angelis M, Birkenfeld AL, Stefan N, Peter A, Haring HU, Fritsche A (2021) Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat Med 27:49\u201357. https:\/\/doi.org\/10.1038\/s41591-020-1116-9","journal-title":"Nat Med"},{"key":"1624_CR45","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38:e164. https:\/\/doi.org\/10.1093\/nar\/gkq603","journal-title":"Nucleic Acids Res"},{"key":"1624_CR46","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nm.4307","volume":"23","author":"NR West","year":"2017","unstructured":"West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Gortz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Muller-Newen G, Owens RJ, Kuhl AA, Maloy KJ, Plevy SE, Oxford IBDCI, Keshav S, Travis SPL, Powrie F (2017) Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med 23:579\u2013589. https:\/\/doi.org\/10.1038\/nm.4307","journal-title":"Nat Med"},{"key":"1624_CR47","doi-asserted-by":"publisher","first-page":"5253","DOI":"10.1038\/s41467-022-32972-z","volume":"13","author":"PC Wilson","year":"2022","unstructured":"Wilson PC, Muto Y, Wu H, Karihaloo A, Waikar SS, Humphreys BD (2022) Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Nat Commun 13:5253. https:\/\/doi.org\/10.1038\/s41467-022-32972-z","journal-title":"Nat Commun"},{"key":"1624_CR48","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1038\/ncomms2469","volume":"4","author":"J Yang","year":"2013","unstructured":"Yang J, Sung E, Donlin-Asp PG, Corces VG (2013) A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins. Nat Commun 4:1464. https:\/\/doi.org\/10.1038\/ncomms2469","journal-title":"Nat Commun"},{"key":"1624_CR49","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS (2008) Model-based analysis of ChIP-Seq (MACS). Genome Biol 9:R137. https:\/\/doi.org\/10.1186\/gb-2008-9-9-r137","journal-title":"Genome Biol"},{"key":"1624_CR50","doi-asserted-by":"publisher","first-page":"114172","DOI":"10.1016\/j.yexcr.2024.114172","volume":"441","author":"CJ Zhang","year":"2024","unstructured":"Zhang CJ, Wang Y, Jin YQ, Zhu YW, Zhu SG, Wang QM, Jing MR, Zhang YX, Cai CB, Feng ZF, Ji XY, Wu DD (2024a) Recent advances in the role of hydrogen sulfide in age-related diseases. Exp Cell Res 441:114172. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114172","journal-title":"Exp Cell Res"},{"key":"1624_CR51","doi-asserted-by":"publisher","unstructured":"Zhang J, Guo Y, Gong L, Xia L, Liu Q, Wang K, Wang Q, Liu Z, Qin Z, Shi S, Yang J (2024) Locus-specific stratification and prioritization unveil high risk genes underlying hyperuricemia. medRxiv:2024.2003.2006.24303846. https:\/\/doi.org\/10.1101\/2024.03.06.24303846","DOI":"10.1101\/2024.03.06.24303846"},{"key":"1624_CR52","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nrneph.2017.157","volume":"14","author":"Q Zhu","year":"2018","unstructured":"Zhu Q, Scherer PE (2018) Immunologic and endocrine functions of adipose tissue: implications for kidney disease. Nat Rev Nephrol 14:105\u2013120. https:\/\/doi.org\/10.1038\/nrneph.2017.157","journal-title":"Nat Rev Nephrol"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01624-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01624-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01624-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:08:38Z","timestamp":1769155718000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01624-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1624"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01624-y","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"20 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"114"}}