{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:26:12Z","timestamp":1790126772621,"version":"4.0.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"name":"This study was supported by the Key Project of Anhui Provincial Department of Education","award":["2022AH051437"],"award-info":[{"award-number":["2022AH051437"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2024byzd062"],"award-info":[{"award-number":["2024byzd062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01683-1","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:04:20Z","timestamp":1756796660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CLDN4 promotes ferroptosis and inflammation involving JAK2\/STAT3 pathway in acute pancreatitis"],"prefix":"10.1007","volume":"25","author":[{"given":"Chuanming","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehe","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"1683_CR1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","volume":"396","author":"L Boxhoorn","year":"2020","unstructured":"Boxhoorn L, Voermans RP, Bouwense SA et al (2020) Acute pancreatitis. Lancet 396:726\u2013734. https:\/\/doi.org\/10.1016\/S0140-6736(20)31310-6","journal-title":"Lancet"},{"key":"1683_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01070-8","volume":"23","author":"M Cao","year":"2023","unstructured":"Cao M, Jin W, Li Y et al (2023) Reversal of H(2)O(2)-induced cell death by knockdown of HOTAIR in HTR-8\/SVneo cells by mediation of miR-106b-5p\/ACSL4 axis. Funct Integr Genomics 23:161. https:\/\/doi.org\/10.1007\/s10142-023-01070-8","journal-title":"Funct Integr Genomics"},{"key":"1683_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-024-01465-1","volume":"24","author":"J Chen","year":"2024","unstructured":"Chen J, Hu C, Lu X et al (2024) ALDH2 alleviates inflammation and facilitates osteogenic differentiation of periodontal ligament stem cells in periodontitis by blocking ferroptosis via activating Nrf2. Funct Integr Genomics 24:184. https:\/\/doi.org\/10.1007\/s10142-024-01465-1","journal-title":"Funct Integr Genomics"},{"key":"1683_CR4","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","volume":"11","author":"E Dai","year":"2020","unstructured":"Dai E, Han L, Liu J et al (2020) Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway. Nat Commun 11:6339. https:\/\/doi.org\/10.1038\/s41467-020-20154-8","journal-title":"Nat Commun"},{"key":"1683_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41419-020-03296-x","volume":"12","author":"X Deng","year":"2021","unstructured":"Deng X, He Y, Miao X et al (2021) ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. Cell Death Dis 12:5. https:\/\/doi.org\/10.1038\/s41419-020-03296-x","journal-title":"Cell Death Dis"},{"key":"1683_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"key":"1683_CR7","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1002\/tox.23126","volume":"36","author":"LH Dong","year":"2021","unstructured":"Dong LH, Huang JJ, Zu P et al (2021) CircKDM4C upregulates P53 by sponging hsa-let-7b-5p to induce ferroptosis in acute myeloid leukemia. Environ Toxicol 36:1288\u20131302. https:\/\/doi.org\/10.1002\/tox.23126","journal-title":"Environ Toxicol"},{"key":"1683_CR8","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1111\/bph.15499","volume":"178","author":"L Gao","year":"2021","unstructured":"Gao L, Dong X, Gong W et al (2021) Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis. Br J Pharmacol 178:3533\u20133552. https:\/\/doi.org\/10.1111\/bph.15499","journal-title":"Br J Pharmacol"},{"key":"1683_CR9","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","volume":"156","author":"PK Garg","year":"2019","unstructured":"Garg PK, Singh VP (2019) Organ failure due to systemic injury in acute pancreatitis. Gastroenterology 156:2008\u20132023. https:\/\/doi.org\/10.1053\/j.gastro.2018.12.041","journal-title":"Gastroenterology"},{"key":"1683_CR10","doi-asserted-by":"publisher","first-page":"968639","DOI":"10.3389\/fimmu.2022.968639","volume":"13","author":"X Han","year":"2022","unstructured":"Han X, Li B, Bao J et al (2022) Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation. Front Immunol 13:968639. https:\/\/doi.org\/10.3389\/fimmu.2022.968639","journal-title":"Front Immunol"},{"key":"1683_CR11","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1007\/s10620-020-06598-4","volume":"66","author":"R Ji","year":"2021","unstructured":"Ji R, Chen Y, Chen W et al (2021) Identification of significant genes and pathways in acute pancreatitis via bioinformatical analysis. Dig Dis Sci 66:3045\u20133053. https:\/\/doi.org\/10.1007\/s10620-020-06598-4","journal-title":"Dig Dis Sci"},{"key":"1683_CR12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1683_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109981","volume":"117","author":"H Jin","year":"2023","unstructured":"Jin H, Zhao K, Li J et al (2023) Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2\/SIRT3\/PGC1\u03b1 pathway. Int Immunopharmacol 117:109981. https:\/\/doi.org\/10.1016\/j.intimp.2023.109981","journal-title":"Int Immunopharmacol"},{"key":"1683_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cca.2020.10.013","volume":"511","author":"W Kimita","year":"2020","unstructured":"Kimita W, Petrov MS (2020) Iron metabolism and the exocrine pancreas. Clin Chim Acta 511:167\u2013176. https:\/\/doi.org\/10.1016\/j.cca.2020.10.013","journal-title":"Clin Chim Acta"},{"key":"1683_CR15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","volume":"16","author":"PJ Lee","year":"2019","unstructured":"Lee PJ, Papachristou GI (2019) New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol 16:479\u2013496. https:\/\/doi.org\/10.1038\/s41575-019-0158-2","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1683_CR16","doi-asserted-by":"publisher","first-page":"1868691","DOI":"10.1080\/2162402X.2020.1868691","volume":"10","author":"J Liu","year":"2021","unstructured":"Liu J, Dai E, Kang R et al (2021) The dark side of ferroptosis in pancreatic cancer. Oncoimmunology 10:1868691. https:\/\/doi.org\/10.1080\/2162402X.2020.1868691","journal-title":"Oncoimmunology"},{"key":"1683_CR17","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jcmgh.2021.09.008","volume":"13","author":"K Liu","year":"2022","unstructured":"Liu K, Liu J, Zou B et al (2022) Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice. Cell Mol Gastroenterol Hepatol 13:483\u2013500. https:\/\/doi.org\/10.1016\/j.jcmgh.2021.09.008","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1683_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01086-0","volume":"23","author":"S Liu","year":"2023","unstructured":"Liu S, Zhao Y, Zhang J et al (2023) Application of single-cell RNA sequencing analysis of novel breast cancer phenotypes based on the activation of ferroptosis-related genes. Funct Integr Genomics 23:173. https:\/\/doi.org\/10.1007\/s10142-023-01086-0","journal-title":"Funct Integr Genomics"},{"key":"1683_CR19","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1113\/EP088112","volume":"105","author":"J Luo","year":"2020","unstructured":"Luo J, Wang H, Chen H et al (2020) CLDN4 silencing promotes proliferation and reduces chemotherapy sensitivity of gastric cancer cells through activation of the PI3K\/Akt signalling pathway. Exp Physiol 105:979\u2013988. https:\/\/doi.org\/10.1113\/EP088112","journal-title":"Exp Physiol"},{"key":"1683_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3892\/etm.2022.11120","volume":"23","author":"V Padureanu","year":"2022","unstructured":"Padureanu V, Florescu DN, Padureanu R et al (2022) Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review). Exp Ther Med 23:197. https:\/\/doi.org\/10.3892\/etm.2022.11120","journal-title":"Exp Ther Med"},{"key":"1683_CR21","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141108","author":"E Palathingal Bava","year":"2022","unstructured":"Palathingal Bava E, George J, Tarique M et al (2022) Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.141108","journal-title":"JCI Insight"},{"key":"1683_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.redox.2015.01.014","volume":"5","author":"S Perez","year":"2015","unstructured":"Perez S, Pereda J, Sabater L et al (2015) Redox signaling in acute pancreatitis. Redox Biol 5:1\u201314. https:\/\/doi.org\/10.1016\/j.redox.2015.01.014","journal-title":"Redox Biol"},{"key":"1683_CR23","first-page":"1773","volume":"132","author":"P Puolakkainen","year":"2016","unstructured":"Puolakkainen P, Kylanpaa L (2016) Etiology of acute pancreatitis. Duodecim 132:1773\u20131779","journal-title":"Duodecim"},{"key":"1683_CR24","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1007\/s00108-021-01158-y","volume":"62","author":"M Sendler","year":"2021","unstructured":"Sendler M, Algul H (2021) [Pathogenesis of acute pancreatitis]. Internist (Berl) 62:1034\u20131043. https:\/\/doi.org\/10.1007\/s00108-021-01158-y","journal-title":"Internist (Berl)"},{"key":"1683_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3892\/ijmm.2022.5144","volume":"50","author":"Y Shan","year":"2022","unstructured":"Shan Y, Li J, Zhu A et al (2022) Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2\/HO\u20131\u2013mediated ferroptosis pathway. Int J Mol Med 50:89. https:\/\/doi.org\/10.3892\/ijmm.2022.5144","journal-title":"Int J Mol Med"},{"key":"1683_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00304-1","volume":"8","author":"YX Song","year":"2017","unstructured":"Song YX, Sun JX, Zhao JH et al (2017) Non-coding RNAs participate in the regulatory network of CLDN4 via CeRNA mediated miRNA evasion. Nat Commun 8:289. https:\/\/doi.org\/10.1038\/s41467-017-00304-1","journal-title":"Nat Commun"},{"key":"1683_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050657","author":"L Swentek","year":"2021","unstructured":"Swentek L, Chung D, Ichii H (2021) Antioxidant therapy in pancreatitis. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10050657","journal-title":"Antioxidants"},{"key":"1683_CR28","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s40265-022-01766-4","volume":"82","author":"P Szatmary","year":"2022","unstructured":"Szatmary P, Grammatikopoulos T, Cai W et al (2022) Acute pancreatitis: diagnosis and treatment. Drugs 82:1251\u20131276. https:\/\/doi.org\/10.1007\/s40265-022-01766-4","journal-title":"Drugs"},{"key":"1683_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1051497","volume":"12","author":"DW Wang","year":"2022","unstructured":"Wang DW, Zhang WH, Danil G et al (2022) The role and mechanism of claudins in cancer. Front Oncol 12:1051497. https:\/\/doi.org\/10.3389\/fonc.2022.1051497","journal-title":"Front Oncol"},{"key":"1683_CR30","doi-asserted-by":"publisher","first-page":"887","DOI":"10.4103\/1673-5374.382252","volume":"19","author":"Y Wu","year":"2024","unstructured":"Wu Y, Sun J, Lin Q et al (2024) Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen\/glucose deprivation-induced injury to neurovascular units. Neural Regen Res 19:887\u2013894. https:\/\/doi.org\/10.4103\/1673-5374.382252","journal-title":"Neural Regen Res"},{"key":"1683_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.778221","volume":"13","author":"X Yang","year":"2022","unstructured":"Yang X, Geng H, You L et al (2022) Rhein protects against severe acute pancreatitis in vitro and in vivo by regulating the JAK2\/STAT3 pathway. Front Pharmacol 13:778221. https:\/\/doi.org\/10.3389\/fphar.2022.778221","journal-title":"Front Pharmacol"},{"key":"1683_CR32","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y et al (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16:284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"OMICS"},{"key":"1683_CR33","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s13577-023-00894-7","volume":"36","author":"Z Zhirong","year":"2023","unstructured":"Zhirong Z, Li H, Yi L et al (2023) Ferroptosis in pancreatic diseases: potential opportunities and challenges that require attention. Hum Cell 36:1233\u20131243. https:\/\/doi.org\/10.1007\/s13577-023-00894-7","journal-title":"Hum Cell"},{"key":"1683_CR34","doi-asserted-by":"publisher","first-page":"9947047","DOI":"10.1155\/2021\/9947047","volume":"2021","author":"J Zhou","year":"2021","unstructured":"Zhou J, Zhou P, Zhang Y et al (2021) Signal pathways and markers involved in acute lung injury induced by acute pancreatitis. Dis Markers 2021:9947047. https:\/\/doi.org\/10.1155\/2021\/9947047","journal-title":"Dis Markers"},{"key":"1683_CR35","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3389\/fimmu.2019.01441","volume":"10","author":"L Zhu","year":"2019","unstructured":"Zhu L, Han J, Li L et al (2019) Claudin family participates in the pathogenesis of inflammatory bowel diseases and colitis-associated colorectal cancer. Front Immunol 10:1441. https:\/\/doi.org\/10.3389\/fimmu.2019.01441","journal-title":"Front Immunol"},{"key":"1683_CR36","doi-asserted-by":"publisher","first-page":"4187398","DOI":"10.1155\/2021\/4187398","volume":"2021","author":"Q Zhu","year":"2021","unstructured":"Zhu Q, Hao L, Shen Q et al (2021) CaMK II Inhibition attenuates ROS dependent necroptosis in acinar cells and protects against acute pancreatitis in mice. Oxid Med Cell Longev 2021:4187398. https:\/\/doi.org\/10.1155\/2021\/4187398","journal-title":"Oxid Med Cell Longev"},{"key":"1683_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111013","volume":"395","author":"HT Zhu","year":"2024","unstructured":"Zhu HT, Luo J, Peng Y et al (2024) Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation. Chemico-Biological Interactions 395:111013. https:\/\/doi.org\/10.1016\/j.cbi.2024.111013","journal-title":"Chemico-Biological Interactions"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01683-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01683-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01683-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:09:45Z","timestamp":1769155785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01683-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1683"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01683-1","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Animal Research Ethics Committee of the First Affiliated Hospital of Bengbu Medical College (Approve number: 2023419; Approve date: 2023-05-26).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"184"}}