{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:14:30Z","timestamp":1769271270400,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01700-3","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:33:57Z","timestamp":1758080037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FOXP3 inhibits inflammatory activation of conjunctival epithelial cells in allergic conjunctivitis via the KAT5\/PDCD4 axis"],"prefix":"10.1007","volume":"25","author":[{"given":"Zifeng","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"issue":"4","key":"1700_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/iovs.64.4.5","volume":"64","author":"J Bao","year":"2023","unstructured":"Bao J, Zhang P, Wu B, Wang J, Li S, Li A, Jie Y (2023) Gp130 promotes inflammation via the STAT3\/JAK2 pathway in allergic conjunctivitis. Invest Ophthalmol Vis Sci 64(4):5. https:\/\/doi.org\/10.1167\/iovs.64.4.5","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"1700_CR2","doi-asserted-by":"publisher","first-page":"eaai9297","DOI":"10.1126\/sciimmunol.aai9297","volume":"2","author":"K Bin Dhuban","year":"2017","unstructured":"Bin Dhuban K, d\u2019Hennezel E, Nagai Y, Xiao Y, Shao S, Istomine R, Alvarez F, Ben-Shoshan M, Ochs H, Mazer B, Li B, Sekine C, Berezov A, Hancock W, Torgerson TR, Greene MI, Piccirillo CA (2017) Suppression by human FOXP3(+) regulatory T cells requires FOXP3-TIP60 interactions. Sci Immunol 2(12):eaai9297. https:\/\/doi.org\/10.1126\/sciimmunol.aai9297","journal-title":"Sci Immunol"},{"issue":"5","key":"1700_CR3","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/all.13691","volume":"74","author":"X Chen","year":"2019","unstructured":"Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ (2019) IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy 74(5):910\u2013921. https:\/\/doi.org\/10.1111\/all.13691","journal-title":"Allergy"},{"issue":"3","key":"1700_CR4","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/life14030350","volume":"14","author":"DI Chigbu","year":"2024","unstructured":"Chigbu DI, Karbach NJ, Abu SL, Hehar NK (2024) Cytokines in allergic conjunctivitis: unraveling their pathophysiological roles. Life (Basel) 14(3):350. https:\/\/doi.org\/10.3390\/life14030350","journal-title":"Life (Basel)"},{"key":"1700_CR5","doi-asserted-by":"publisher","first-page":"156013","DOI":"10.1016\/j.phymed.2024.156013","volume":"135","author":"HC Chuang","year":"2024","unstructured":"Chuang HC, Chuang KJ, Cheng PC, Hsieh CL, Fan YY, Lee YL (2024) Indirubin induces tolerogenic dendritic cells via Aryl hydrocarbon receptor activation and ameliorates allergic asthma in a murine model by expanding Foxp3-expressing regulatory T cells. Phytomed 135:156013. https:\/\/doi.org\/10.1016\/j.phymed.2024.156013","journal-title":"Phytomed"},{"key":"1700_CR6","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.3389\/fimmu.2019.02486","volume":"10","author":"G Deng","year":"2019","unstructured":"Deng G, Song X, Fujimoto S, Piccirillo CA, Nagai Y, Greene MI (2019) Foxp3 Post-translational modifications and Treg suppressive activity. Front Immunol 10:2486. https:\/\/doi.org\/10.3389\/fimmu.2019.02486","journal-title":"Front Immunol"},{"issue":"1","key":"1700_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12890-016-0317-y","volume":"16","author":"X Diao","year":"2016","unstructured":"Diao X, Wang J, Zhu H, He B (2016) Overexpression of programmed cell death 5 in a mouse model of ovalbumin-induced allergic asthma. BMC Pulm Med 16(1):149. https:\/\/doi.org\/10.1186\/s12890-016-0317-y","journal-title":"BMC Pulm Med"},{"issue":"3","key":"1700_CR8","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/all.13334","volume":"73","author":"D Elieh Ali Komi","year":"2018","unstructured":"Elieh Ali Komi D, Rambasek T, Bielory L (2018) Clinical implications of mast cell involvement in allergic conjunctivitis. Allergy 73(3):528\u2013539. https:\/\/doi.org\/10.1111\/all.13334","journal-title":"Allergy"},{"key":"1700_CR9","doi-asserted-by":"publisher","first-page":"808475","DOI":"10.3389\/fonc.2022.808475","volume":"12","author":"S Ghafouri-Fard","year":"2022","unstructured":"Ghafouri-Fard S, Hussen BM, Mohaqiq M, Shoorei H, Baniahmad A, Taheri M, Jamali E (2022) Interplay between Non-Coding RNAs and programmed cell death proteins. Front Oncol 12:808475. https:\/\/doi.org\/10.3389\/fonc.2022.808475","journal-title":"Front Oncol"},{"issue":"6","key":"1700_CR10","doi-asserted-by":"publisher","first-page":"344","DOI":"10.21037\/atm-22-982","volume":"10","author":"H Guo","year":"2022","unstructured":"Guo H, Zhang Y, Liao Z, Zhan W, Wang Y, Peng Y, Yang M, Ma X, Yin G, Ye L (2022) MiR-146a upregulates FOXP3 and suppresses inflammation by targeting HIPK3\/STAT3 in allergic conjunctivitis. Ann Transl Med 10(6):344. https:\/\/doi.org\/10.21037\/atm-22-982","journal-title":"Ann Transl Med"},{"issue":"22","key":"1700_CR11","doi-asserted-by":"publisher","first-page":"eadg4993","DOI":"10.1126\/sciadv.adg4993","volume":"9","author":"M Jia","year":"2023","unstructured":"Jia M, Yue X, Sun W, Zhou Q, Chang C, Gong W, Feng J, Li X, Zhan R, Mo K, Zhang L, Qian Y, Sun Y, Wang A, Zou Y, Chen W, Li Y, Huang L, Yang Y, Zhao Y, Cheng X (2023) ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. Sci Adv 9(22):eadg4993. https:\/\/doi.org\/10.1126\/sciadv.adg4993","journal-title":"Sci Adv"},{"issue":"1","key":"1700_CR12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000493328","volume":"178","author":"WE Jiao","year":"2019","unstructured":"Jiao WE, Wei JF, Kong YG, Xu Y, Tao ZZ, Chen SM (2019) Notch signaling promotes development of allergic rhinitis by suppressing Foxp3 expression and Treg cell differentiation. Int Arch Allergy Immunol 178(1):33\u201344. https:\/\/doi.org\/10.1159\/000493328","journal-title":"Int Arch Allergy Immunol"},{"key":"1700_CR13","doi-asserted-by":"publisher","first-page":"119922","DOI":"10.1016\/j.lfs.2021.119922","volume":"284","author":"WE Jiao","year":"2021","unstructured":"Jiao WE, Sun L, Xu S, Deng YQ, Qiao YL, Xi Y, Tao ZZ, Chen SM (2021) Notch2 suppresses the development of allergic rhinitis by promoting FOXP3 expression and Treg cell differentiation. Life Sci 284:119922. https:\/\/doi.org\/10.1016\/j.lfs.2021.119922","journal-title":"Life Sci"},{"issue":"5","key":"1700_CR14","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.anai.2015.08.015","volume":"115","author":"A Krogulska","year":"2015","unstructured":"Krogulska A, Polakowska E, Wasowska-Krolikowska K, Malachowska B, Mlynarski W, Borowiec M (2015) Decreased FOXP3 mRNA expression in children with atopic asthma and IgE-mediated food allergy. Ann Allergy Asthma Immunol 115(5):415\u2013421. https:\/\/doi.org\/10.1016\/j.anai.2015.08.015","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"1700_CR15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.18176\/jiaci.0320","volume":"29","author":"M Kuruvilla","year":"2019","unstructured":"Kuruvilla M, Kalangara J, Lee FEE (2019) Neuropathic pain and itch mechanisms underlying allergic conjunctivitis. J Investig Allergol Clin Immunol 29(5):349\u2013356. https:\/\/doi.org\/10.18176\/jiaci.0320","journal-title":"J Investig Allergol Clin Immunol"},{"key":"1700_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1824-7288-39-18","volume":"39","author":"M La Rosa","year":"2013","unstructured":"La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S, Tomarchio S, Avitabile T, Reibaldi A (2013) Allergic conjunctivitis: a comprehensive review of the literature. Ital J Pediatr 39:18. https:\/\/doi.org\/10.1186\/1824-7288-39-18","journal-title":"Ital J Pediatr"},{"issue":"5","key":"1700_CR17","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3390\/ph15050547","volume":"15","author":"BA Labib","year":"2022","unstructured":"Labib BA, Chigbu DI (2022) Therapeutic targets in allergic conjunctivitis. Pharmaceuticals (Basel) 15(5):547. https:\/\/doi.org\/10.3390\/ph15050547","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"1700_CR18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jaci.2022.01.014","volume":"150","author":"JK Lama","year":"2022","unstructured":"Lama JK, Iijima K, Kobayashi T, Kita H (2022) Blocking the inhibitory receptor programmed cell death 1 prevents allergic immune response and anaphylaxis in mice. J Allergy Clin Immunol 150(1):178\u2013191e179. https:\/\/doi.org\/10.1016\/j.jaci.2022.01.014","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"1700_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s11882-024-01150-0","volume":"24","author":"A Leonardi","year":"2024","unstructured":"Leonardi A, Quintieri L, Presa IJ, JM LL, Montero J, Benitez-Del-Castillo JM, Leston FJS, Gonzalez-Mancebo E, Asero R, Groblewska A, Kuna P (2024) Allergic conjunctivitis management: update on ophthalmic solutions. Curr Allergy Asthma Rep 24(7):347\u2013360. https:\/\/doi.org\/10.1007\/s11882-024-01150-0","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"1700_CR20","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s42003-024-06086-9","volume":"7","author":"C Liu","year":"2024","unstructured":"Liu C, Gui Z, An C, Sun F, Gao X, Ge S (2024) STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-beta-catenin axis. Commun Biol 7(1):396. https:\/\/doi.org\/10.1038\/s42003-024-06086-9","journal-title":"Commun Biol"},{"issue":"4","key":"1700_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"5","key":"1700_CR22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.63.5.4","volume":"63","author":"F Luo","year":"2022","unstructured":"Luo F, Tao Y, Wang M, Yang L, Su R, Pan Z, Tan X (2022) The protective effects of KAT5 Inhibition on ocular inflammation by mediating the PI3K\/AKT pathway in a murine model of allergic conjunctivitis. Invest Ophthalmol Vis Sci 63(5):4. https:\/\/doi.org\/10.1167\/iovs.63.5.4","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1700_CR23","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.2147\/COPD.S208977","volume":"14","author":"ZJ Meng","year":"2019","unstructured":"Meng ZJ, Wu JH, Zhou M, Sun SW, Miao SY, Han HL, Chen L, Xiong XZ (2019) Peripheral blood CD4\u2009+\u2009T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 14:1669\u20131680. https:\/\/doi.org\/10.2147\/COPD.S208977","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"4","key":"1700_CR24","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.alit.2020.06.004","volume":"69","author":"D Miyazaki","year":"2020","unstructured":"Miyazaki D, Fukagawa K, Okamoto S, Fukushima A, Uchio E, Ebihara N, Shoji J, Namba K, Shimizu Y (2020) Epidemiological aspects of allergic conjunctivitis. Allergol Int 69(4):487\u2013495. https:\/\/doi.org\/10.1016\/j.alit.2020.06.004","journal-title":"Allergol Int"},{"issue":"3","key":"1700_CR25","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.jaci.2016.06.003","volume":"138","author":"M Noval Rivas","year":"2016","unstructured":"Noval Rivas M, Chatila TA (2016) Regulatory T cells in allergic diseases. J Allergy Clin Immunol 138(3):639\u2013652. https:\/\/doi.org\/10.1016\/j.jaci.2016.06.003","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1700_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s12291-019-00853-w","volume":"36","author":"R Pandey","year":"2021","unstructured":"Pandey R, Prakash V (2021) Expression of FOXP3 and GATA3 transcription factors among bronchial asthmatics in Northern population. Indian J Clin Biochem 36(1):88\u201393. https:\/\/doi.org\/10.1007\/s12291-019-00853-w","journal-title":"Indian J Clin Biochem"},{"issue":"D1","key":"1700_CR27","doi-asserted-by":"publisher","first-page":"D174","DOI":"10.1093\/nar\/gkad1059","volume":"52","author":"I Rauluseviciute","year":"2024","unstructured":"Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A (2024) JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res 52(D1):D174\u2013D182. https:\/\/doi.org\/10.1093\/nar\/gkad1059","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 2","key":"1700_CR28","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1097\/ICL.0000000000000688","volume":"2","author":"N Roy","year":"2020","unstructured":"Roy N, Levanon S, Asbell PA (2020) Potential biomarkers for allergic conjunctival diseases. Eye Contact Lens 46 Suppl 2(Suppl 2):S109\u2013S121. https:\/\/doi.org\/10.1097\/ICL.0000000000000688","journal-title":"Eye Contact Lens 46 Suppl"},{"issue":"4","key":"1700_CR29","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/all.15144","volume":"77","author":"S Tagkareli","year":"2022","unstructured":"Tagkareli S, Salagianni M, Galani IE, Manioudaki M, Pavlos E, Thanopoulou K, Andreakos E (2022) CD103 integrin identifies a high IL-10-producing FoxP3(+) regulatory T-cell population suppressing allergic airway inflammation. Allergy 77(4):1150\u20131164. https:\/\/doi.org\/10.1111\/all.15144","journal-title":"Allergy"},{"issue":"9","key":"1700_CR30","doi-asserted-by":"publisher","first-page":"e202201732","DOI":"10.26508\/lsa.202201732","volume":"6","author":"C Tan","year":"2023","unstructured":"Tan C, Shi W, Zhang Y, Liu C, Hu T, Chen D, Huang J (2023) MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model. Life Sci Alliance 6(9):e202201732. https:\/\/doi.org\/10.26508\/lsa.202201732","journal-title":"Life Sci Alliance"},{"issue":"6","key":"1700_CR31","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/life14060650","volume":"14","author":"F Tariq","year":"2024","unstructured":"Tariq F (2024) Allergic conjunctivitis: review of current types, treatments, and trends. Life (Basel) 14(6):650. https:\/\/doi.org\/10.3390\/life14060650","journal-title":"Life (Basel)"},{"issue":"3","key":"1700_CR32","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.3390\/ijms24032113","volume":"24","author":"K Tominaga","year":"2023","unstructured":"Tominaga K, Sakashita E, Kasashima K, Kuroiwa K, Nagao Y, Iwamori N, Endo H (2023) Tip60\/KAT5 histone acetyltransferase is required for maintenance and neurogenesis of embryonic neural stem cells. Int J Mol Sci 24(3):2113. https:\/\/doi.org\/10.3390\/ijms24032113","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1700_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jdermsci.2024.05.002","volume":"115","author":"X Tong","year":"2024","unstructured":"Tong X, Kim SH, Che L, Park J, Lee J, Kim TG (2024) Foxp3(+) Treg control allergic skin inflammation by restricting IFN-gamma-driven neutrophilic infiltration and NETosis. J Dermatol Sci 115(1):2\u201312. https:\/\/doi.org\/10.1016\/j.jdermsci.2024.05.002","journal-title":"J Dermatol Sci"},{"issue":"1","key":"1700_CR34","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","volume":"27","author":"P Wan","year":"2020","unstructured":"Wan P, Su W, Zhang Y, Li Z, Deng C, Li J, Jiang N, Huang S, Long E, Zhuo Y (2020) LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury. Cell Death Differ 27(1):176\u2013191. https:\/\/doi.org\/10.1038\/s41418-019-0351-4","journal-title":"Cell Death Differ"},{"issue":"3","key":"1700_CR35","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.tips.2024.01.010","volume":"45","author":"J White","year":"2024","unstructured":"White J, Derheimer FA, Jensen-Pergakes K, O\u2019Connell S, Sharma S, Spiegel N, Paul TA (2024) Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy. Trends Pharmacol Sci 45(3):243\u2013254. https:\/\/doi.org\/10.1016\/j.tips.2024.01.010","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"1700_CR36","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/all.13304","volume":"73","author":"G Yang","year":"2018","unstructured":"Yang G, Cheng BH, Yang SB, Liu ZQ, Qiu SQ, Yang LT, Xie RD, Geng XR, Li MG, Gao L, Liu ZG, Yang PC (2018) Targeting histone-acetyltransferase Tat-interactive protein 60 inhibits intestinal allergy. Allergy 73(2):387\u2013394. https:\/\/doi.org\/10.1111\/all.13304","journal-title":"Allergy"},{"key":"1700_CR37","doi-asserted-by":"publisher","first-page":"121484","DOI":"10.1016\/j.biomaterials.2022.121484","volume":"284","author":"Z Yu","year":"2022","unstructured":"Yu Z, Wen Y, Jiang N, Li Z, Guan J, Zhang Y, Deng C, Zhao L, Zheng SG, Zhu Y, Su W, Zhuo Y (2022) TNF-alpha stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3\/miR-21a-5p axis. Biomaterials 284:121484. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121484","journal-title":"Biomaterials"},{"issue":"6","key":"1700_CR38","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1189\/jlb.3A0313-136RRR","volume":"96","author":"B Zhong","year":"2014","unstructured":"Zhong B, Yang X, Sun Q, Liu L, Lan X, Tian J, He Q, Hou W, Liu H, Jiang C, Gao N, Lu S (2014) Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation. J Leukoc Biol 96(6):1065\u20131075. https:\/\/doi.org\/10.1189\/jlb.3A0313-136RRR","journal-title":"J Leukoc Biol"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01700-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01700-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01700-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:02:38Z","timestamp":1769191358000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01700-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1700"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01700-3","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"assertion":[{"value":"20 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All participants provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"This study was approved by the Ethics Committee of Hunan Children\u2019s Hospital (Approval Number: HCHLL-2024-45, Approval Date: 2024-03-11) and conducted in accordance with ethical guideline.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics statement"}}],"article-number":"193"}}