{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:30:22Z","timestamp":1792801822968,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2024-1-1203"],"award-info":[{"award-number":["2024-1-1203"]}]},{"name":"Dengfeng Talent Support Program of Beijing Municipal Administration of Hospitals","award":["No. DFL20221601"],"award-info":[{"award-number":["No. DFL20221601"]}],"id":[{"id":"https:\/\/ror.org\/04baakq55","id-type":"ROR","asserted-by":"crossref"}]},{"name":"High-level Public Health Technical Personnel Construction Project","award":["Subject leaders-03-21"],"award-info":[{"award-number":["Subject leaders-03-21"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01720-z","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T06:02:29Z","timestamp":1761285749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["C6ORF120 regulates hepatic lipid metabolism through PPAR signaling pathway in metabolic dysfunction-associated steatotic liver disease"],"prefix":"10.1007","volume":"25","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"11","key":"1720_CR1","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1111\/liv.15706","volume":"43","author":"A Caddeo","year":"2023","unstructured":"Caddeo A, Spagnuolo R, Maurotti S (2023) MBOAT7 in liver and extrahepatic diseases. Liver Int 43(11):2351\u20132364","journal-title":"Liver Int"},{"issue":"2","key":"1720_CR2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","volume":"18","author":"E Currie","year":"2013","unstructured":"Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr (2013) Cellular fatty acid metabolism and cancer. Cell Metab 18(2):153\u2013161","journal-title":"Cell Metab"},{"issue":"26","key":"1720_CR3","doi-asserted-by":"publisher","first-page":"E5896","DOI":"10.1073\/pnas.1801745115","volume":"115","author":"J Dai","year":"2018","unstructured":"Dai J, Liang K, Zhao S, Jia W, Liu Y, Wu H et al (2018) Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis. Proc Natl Acad Sci U S A 115(26):E5896\u2013E5905","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"1720_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13612","volume":"24","author":"M Demir","year":"2023","unstructured":"Demir M, Bornstein SR, Mantzoros CS, Perakakis N (2023) Liver fat as risk factor of hepatic and cardiometabolic diseases. Obes Rev 24(10):e13612","journal-title":"Obes Rev"},{"issue":"8","key":"1720_CR5","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3390\/cells8080845","volume":"8","author":"HK Drescher","year":"2019","unstructured":"Drescher HK, Weiskirchen S, Weiskirchen R (2019) Current status in testing for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cells 8(8):845","journal-title":"Cells"},{"issue":"4","key":"1720_CR6","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1172\/JCI88894","volume":"127","author":"V Dubois","year":"2017","unstructured":"Dubois V, Eeckhoute J, Lefebvre P, Staels B (2017) Distinct but complementary contributions of PPAR isotypes to energy homeostasis. J Clin Invest 127(4):1202\u20131214","journal-title":"J Clin Invest"},{"issue":"3","key":"1720_CR7","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","volume":"81","author":"European Association for the Study of the Liver (EASL)","year":"2024","unstructured":"European Association for the Study of the Liver (EASL) (2024) European association for the study of diabetes (EASD); European association for the study of obesity (EASO). EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol 81(3):492\u2013542","journal-title":"J Hepatol"},{"key":"1720_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2147\/HMER.S188991","volume":"11","author":"S Ganguli","year":"2019","unstructured":"Ganguli S, DeLeeuw P, Satapathy SK (2019) A review of current and upcoming treatment modalities in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Hepat Med 11:159\u2013178","journal-title":"Hepat Med"},{"issue":"5","key":"1720_CR9","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s42255-019-0065-4","volume":"1","author":"XM Gong","year":"2019","unstructured":"Gong XM, Li YF, Luo J, Wang JQ, Wei J, Wang JQ et al (2019) Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance. Nat Metab 1(5):570\u2013583","journal-title":"Nat Metab"},{"issue":"1","key":"1720_CR10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nrendo.2016.135","volume":"13","author":"B Gross","year":"2017","unstructured":"Gross B, Pawlak M, Lefebvre P, Staels B (2017) Ppars in obesity-induced T2DM, dyslipidaemia and NAFLD. Nat Rev Endocrinol 13(1):36\u201349","journal-title":"Nat Rev Endocrinol"},{"key":"1720_CR11","doi-asserted-by":"publisher","first-page":"154219","DOI":"10.1016\/j.phymed.2022.154219","volume":"103","author":"Y Gu","year":"2022","unstructured":"Gu Y, Duan S, Ding M, Zheng Q, Fan G, Li X et al (2022) Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPAR\u03b1 and INSIG\/SREBP1c pathway. Phytomedicine 103:154219","journal-title":"Phytomedicine"},{"issue":"1","key":"1720_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbalip.2014.05.001","volume":"1851","author":"P Karagianni","year":"2015","unstructured":"Karagianni P, Talianidis I (2015) Transcription factor networks regulating hepatic fatty acid metabolism. Biochim Biophys Acta 1851(1):2\u20138","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"1720_CR13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151895","volume":"132","author":"S Kawamura","year":"2022","unstructured":"Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y et al (2022) Inhibiting SCAP\/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. J Clin Invest 132(11):e151895","journal-title":"J Clin Invest"},{"issue":"21","key":"1720_CR14","first-page":"3560","volume":"124","author":"X Li","year":"2011","unstructured":"Li X, Qiao Y, Chang LS, Xiao F, Lu LH, Hao XH et al (2011) Role of C6ORF120, an N-glycosylated protein, is implicated in apoptosis of CD4\u207a T lymphocytes. Chin Med J (Engl) 124(21):3560\u20133567","journal-title":"Chin Med J (Engl)"},{"key":"1720_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-025-01682-w","author":"Y Lin","year":"2025","unstructured":"Lin Y, Wang X, Cui X, Zhu N, Li Y, Li X (2025) C6orf120 deficiency inhibits hepatic stellate cell activation by upregulating RAR\u03b2 signaling. Cell Biochem Biophys. https:\/\/doi.org\/10.1007\/s12013-025-01682-w","journal-title":"Cell Biochem Biophys"},{"issue":"1","key":"1720_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10142-023-00993-6","volume":"23","author":"K Lu","year":"2023","unstructured":"Lu K, Wu J, Zhang Y, Zhuang W, Liang XF (2023) Role of phosphoenolpyruvate carboxykinase 1 (pck1) in mediating nutrient metabolism in zebrafish. Funct Integr Genomics 23(1):67","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"1720_CR17","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s10142-025-01544-x","volume":"25","author":"RM Mansour","year":"2025","unstructured":"Mansour RM, Abdel Mageed SS, Abulsoud AI, Sayed GA, Lutfy RH, Awad FA et al (2025) From fatty liver to fibrosis: the impact of MiRNAs on NAFLD and NASH. Funct Integr Genomics 25(1):30","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"1720_CR18","doi-asserted-by":"publisher","first-page":"214","DOI":"10.2337\/db20-0619","volume":"70","author":"Z Mao","year":"2021","unstructured":"Mao Z, Feng M, Li Z, Zhou M, Xu L, Pan K et al (2021) ETV5 regulates hepatic fatty acid metabolism through PPAR signaling pathway. Diabetes 70(1):214\u2013226","journal-title":"Diabetes"},{"issue":"11","key":"1720_CR19","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.cmet.2022.09.023","volume":"34","author":"M Martin-Perez","year":"2022","unstructured":"Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA (2022) The role of lipids in cancer progression and metastasis. Cell Metab 34(11):1675\u20131699","journal-title":"Cell Metab"},{"key":"1720_CR20","doi-asserted-by":"crossref","unstructured":"Ng IC, Zhang L, Shen NNYY, Soong YT, Ng CW, Koh PKS et al (2021) Isolation of primary rat hepatocytes with multiparameter perfusion control. J Vis Exp 17010.3791\/62289","DOI":"10.3791\/62289-v"},{"issue":"1","key":"1720_CR21","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/s41467-022-29846-9","volume":"13","author":"Z Ning","year":"2022","unstructured":"Ning Z, Guo X, Liu X, Lu C, Wang A, Wang X et al (2022) Usp22 regulates lipidome accumulation by stabilizing PPAR\u03b3 in hepatocellular carcinoma. Nat Commun 13(1):2187","journal-title":"Nat Commun"},{"issue":"6","key":"1720_CR22","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.bbalip.2018.06.018","volume":"1864","author":"P Pingitore","year":"2019","unstructured":"Pingitore P, Romeo S (2019) The role of PNPLA3 in health and disease. Biochim Biophys Acta Mol Cell Biol Lipids 1864(6):900\u2013906","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"10290","key":"1720_CR23","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","volume":"397","author":"EE Powell","year":"2021","unstructured":"Powell EE, Wong VW, Rinella M (2021) Non-alcoholic fatty liver disease. Lancet 397(10290):2212\u20132224","journal-title":"Lancet"},{"issue":"3","key":"1720_CR24","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10142-023-01131-y","volume":"23","author":"J Qiao","year":"2023","unstructured":"Qiao J, Li H, Jinxiang C, Shi Y, Li N, Zhu P et al (2023) Mulberry fruit repairs alcoholic liver injury by modulating lipid metabolism and the expression of miR-155 and PPAR\u03b1 in rats. Funct Integr Genomics 23(3):261","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"1720_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2023.101133","volume":"29","author":"ME Rinella","year":"2024","unstructured":"Rinella ME, Lazarus JV, Ratziu V (2024) A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Ann Hepatol 29(1):101133","journal-title":"Ann Hepatol"},{"issue":"11","key":"1720_CR26","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nrc.2016.89","volume":"16","author":"F R\u00f6hrig","year":"2016","unstructured":"R\u00f6hrig F, Schulze A (2016) The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer 16(11):732\u2013749","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1720_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cmet.2017.08.002","volume":"27","author":"VT Samuel","year":"2018","unstructured":"Samuel VT, Shulman GI (2018) Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases. Cell Metab 27(1):22\u201341","journal-title":"Cell Metab"},{"issue":"12","key":"1720_CR28","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nrendo.2017.91","volume":"13","author":"H Shimano","year":"2017","unstructured":"Shimano H, Sato R (2017) SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat Rev Endocrinol 13(12):710\u2013730","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"1720_CR29","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1002\/hep.28415","volume":"63","author":"MD Wang","year":"2016","unstructured":"Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L (2016) Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients. Hepatology 63(4):1272\u20131286","journal-title":"Hepatology"},{"issue":"1","key":"1720_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01716-9","volume":"21","author":"P Wang","year":"2022","unstructured":"Wang P, Wang Y, Liu H, Han X, Yi Y, Wang X et al (2022) Role of triglycerides as a predictor of autoimmune hepatitis with cirrhosis. Lipids Health Dis 21(1):108","journal-title":"Lipids Health Dis"},{"issue":"7","key":"1720_CR31","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1111\/jgh.16538","volume":"39","author":"X Wang","year":"2024","unstructured":"Wang X, Liu H, Wang Y, Wang P, Yi Y, Lin Y et al (2024) Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K\/Akt\/mTOR pathway. J Gastroenterol Hepatol 39(7):1422\u20131430","journal-title":"J Gastroenterol Hepatol"},{"key":"1720_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104467","volume":"371","author":"YN Wu","year":"2022","unstructured":"Wu YN, Zhang R, Song XC, Han XX, Zhang J, Li X (2022) C6orf120 gene knockout in rats mitigates concanavalin A\u2013induced autoimmune hepatitis via regulating NKT cells. Cell Immunol 371:104467","journal-title":"Cell Immunol"},{"issue":"2","key":"1720_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01010-6","volume":"23","author":"Z Yu","year":"2023","unstructured":"Yu Z, Zhou Y, Li Y, Dong Z (2023) Integration of clinical and spatial data to explore lipid metabolism-related genes for predicting prognosis and immune microenvironment in gliomas. Funct Integr Genomics 23(2):82","journal-title":"Funct Integr Genomics"},{"key":"1720_CR34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cellimm.2018.04.017","volume":"331","author":"MK Zhang","year":"2018","unstructured":"Zhang MK, Ma HM, Zhang J, Song XC, Ye XH, Li YF et al (2018) Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin a. Cell Immunol 331:9\u201315","journal-title":"Cell Immunol"},{"issue":"6","key":"1720_CR35","first-page":"1626","volume":"18","author":"J Zhang","year":"2020","unstructured":"Zhang J, Zhang MK, Ma HM, Song XC, Wu YN, Zhang R et al (2020) C6orf120 gene deficiency may be vulnerable to carbon tetrachloride induced acute hepatic injury in rats. Arch Med Sci 18(6):1626\u20131637","journal-title":"Arch Med Sci"},{"key":"1720_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.824776","volume":"8","author":"HB Zhang","year":"2022","unstructured":"Zhang HB, Su W, Xu H (2022) HSD17B13: a potential therapeutic target for NAFLD. Front Mol Biosci 8:824776","journal-title":"Front Mol Biosci"},{"issue":"4","key":"1720_CR37","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/hep.30702","volume":"70","author":"F Zhou","year":"2019","unstructured":"Zhou F, Zhou J, Wang W, Zhang XJ, Ji YX, Zhang P et al (2019) Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta-analysis. Hepatology 70(4):1119\u20131133","journal-title":"Hepatology"},{"issue":"5","key":"1720_CR38","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/hep.31150","volume":"71","author":"J Zhou","year":"2020","unstructured":"Zhou J, Zhou F, Wang W, Zhang XJ, Ji YX, Zhang P et al (2020) Epidemiological features of NAFLD from 1999 to 2018 in China. Hepatology 71(5):1851\u20131864","journal-title":"Hepatology"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01720-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01720-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01720-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:10:30Z","timestamp":1769155830000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01720-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1720"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01720-z","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"17 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee of Beijing Ditan Hospital, Capital Medical University (no. DTEC-KY2023-23-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All of the authors have consented to the publication of this research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no conflict of interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"221"}}