{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:54:40Z","timestamp":1785840880546,"version":"3.56.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Graduate Innovation Star\" Doctoral Program of Gansu Province","award":["2025CXZX-767"],"award-info":[{"award-number":["2025CXZX-767"]}]},{"name":"The Key Talent Project of Gansu Province","award":["NO. 2022RCXM016"],"award-info":[{"award-number":["NO. 2022RCXM016"]}]},{"name":"he National Nature Science Foundation of China","award":["NO. 32273091"],"award-info":[{"award-number":["NO. 32273091"]}]},{"DOI":"10.13039\/501100001809","name":"The National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["NO. 32473110"],"award-info":[{"award-number":["NO. 32473110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01741-8","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:42:38Z","timestamp":1761529358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Smeat-seq transcriptomic profiling unveils key regulatory events during Maternal-to-Zygotic transition and supports High-Efficiency culture system development in Tibetan sheep embryos"],"prefix":"10.1007","volume":"25","author":[{"given":"Tianhao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijiu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"issue":"9","key":"1741_CR1","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1080\/10495398.2023.2258953","volume":"34","author":"L An","year":"2023","unstructured":"An L, Li Y, Yaq L, Wang Y, Dai Q, Du S, Ru Y, Zhoucuo Q, Wang J (2023) Transcriptome analysis reveals molecular regulation mechanism of Tibet sheep tolerance to high altitude oxygen environment. Anim Biotechnol 34(9):5097\u20135112","journal-title":"Anim Biotechnol"},{"issue":"1","key":"1741_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02000-z","volume":"11","author":"DA Anzalone","year":"2021","unstructured":"Anzalone DA, Palazzese L, Czernik M, Sabatucci A, Valbonetti L, Capra E, Loi P (2021) Controlled spermatozoa-oocyte interaction improves embryo quality in sheep. Sci Rep 11(1):22629","journal-title":"Sci Rep"},{"issue":"4","key":"1741_CR3","doi-asserted-by":"publisher","first-page":"658","DOI":"10.54203\/scil.2020.wvj79","volume":"10","author":"G Ashour","year":"2020","unstructured":"Ashour G, El-Sayed A, Khalifa M, Ghanem N (2020) Effect of heat stress on developmental competence of in vitro matured oocytes of Camelus dromedaries with different qualities. World\u2019s Veterinary Journal 10(4):658\u2013664","journal-title":"World's Veterinary Journal"},{"key":"1741_CR4","doi-asserted-by":"crossref","unstructured":"Carvalho S, Zea-Redondo L, Tang TCC, Stachel-Braum P, Miller D, Caldas P, Kukalev A, Diecke S, Grosswendt S, Grosso AR, Pombo A (2024) SRRM2 splicing factor modulates cell fate in early development. Biology Open 13(4)","DOI":"10.1242\/bio.060415"},{"key":"1741_CR5","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s10142-022-00893-1","volume":"22","author":"PA de Souza Fonseca","year":"2022","unstructured":"de Souza Fonseca PA, Su\u00e1rez-Vega A, C\u00e1novas A (2022) Unrevealing functional candidate genes for bovine fertility through RNA sequencing meta-analysis and regulatory elements networks of co-expressed genes and LncRNAs. Funct Integr Genomics 22:1361\u20131376","journal-title":"Funct Integr Genomics"},{"key":"1741_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.theriogenology.2022.12.025","volume":"198","author":"MC Fabra","year":"2023","unstructured":"Fabra MC, Anchordoquy JP, Carranza-Mart\u00edn AC, Farnetano N, Anchordoquy JM, Furnus CC, Nikoloff N (2023) Alpha-lipoic acid improves bovine preimplantation blastocyst quality and cryotolerance. Theriogenology 198:61\u201368","journal-title":"Theriogenology"},{"issue":"5","key":"1741_CR7","doi-asserted-by":"publisher","first-page":"260","DOI":"10.5306\/wjco.v11.i5.260","volume":"11","author":"MT Fernandes","year":"2020","unstructured":"Fernandes MT, Calado SM, Mendes-Silva L, Bragan\u00e7a J (2020) CITED2 and the modulation of the hypoxic response in cancer. World J Clin Oncol 11(5):260\u2013274","journal-title":"World J Clin Oncol"},{"issue":"2","key":"1741_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020497","volume":"9","author":"M Gabut","year":"2020","unstructured":"Gabut M, Bourdelais F, Durand S (2020) Ribosome and translational control in stem cells. Cells 9(2):497","journal-title":"Cells"},{"issue":"5","key":"1741_CR9","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1093\/biolre\/ioac160","volume":"107","author":"S Ghorbani","year":"2022","unstructured":"Ghorbani S, Eyni H, Norahan MH, Zarrintaj P, Urban N, Mohammadzadeh A, Mostafavi E, Sutherland DS (2022) Advanced bioengineering of female germ cells to preserve fertility. Biol Reprod 107(5):1177\u20131204","journal-title":"Biol Reprod"},{"key":"1741_CR10","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10142-025-01689-9","volume":"25","author":"H Hu","year":"2025","unstructured":"Hu H, Sun J, Meng F, Gong F, Lin G, Leng L (2025) A novel PADI6 splice-site variant induces non-canonical GC-AG splicing and embryonic arrest in humans. Funct Integr Genomics 25:171","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"1741_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-024-10480-2","volume":"25","author":"Q Ji","year":"2024","unstructured":"Ji Q, Zhang F, Su Q, He T, Wu Z, Zhu K, Chen X, Wang Z, Hou S, Gui L (2024) Effect of supplementing lysins and methionine to low-protein diets on growth performance, hepatic antioxidant capacity, immune status, and glycolytic activity of Tibetan sheep. BMC Genomics 25(1):557","journal-title":"BMC Genomics"},{"issue":"7","key":"1741_CR12","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1017\/S0007114519003222","volume":"123","author":"X Jing","year":"2020","unstructured":"Jing X, Wang W, Degen A, Guo Y, Kang J, Liu P, Ding L, Shang Z, Fievez V, Zhou J (2020) Tibetan sheep have a high capacity to absorb and to regulate metabolism of SCFA in the rumen epithelium to adapt to low energy intake. Br J Nutr 123(7):721\u2013736","journal-title":"Br J Nutr"},{"issue":"3","key":"1741_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.animal.2020.100162","volume":"15","author":"XP Jing","year":"2021","unstructured":"Jing XP, Wang WJ, Degen AA, Guo YM, Kang JP, Liu PP, Ding LM, Shang ZH, Zhou JW, Long RJ (2021) Energy substrate metabolism in skeletal muscle and liver when consuming diets of different energy levels: comparison between Tibetan and Small-tailed Han sheep. Anim 15(3):100162","journal-title":"Anim"},{"issue":"21","key":"1741_CR14","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1016\/j.devcel.2021.10.008","volume":"56","author":"S Krishna","year":"2021","unstructured":"Krishna S, Arrojo e Drigo R, Capitanio JS, Ramachandra R, Ellisman M, Hetzer MW (2021) Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain. Dev Cell 56(21):2952\u20132965e9","journal-title":"Dev Cell"},{"issue":"7","key":"1741_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072448","volume":"21","author":"T Li","year":"2020","unstructured":"Li T, Zhang H, Wang X, Yin D, Chen N, Kang L, Zhao X, Ma Y (2020) Cloning, molecular characterization and expression patterns of DMRTC2 implicated in germ cell development of male Tibetan sheep. Int J Mol Sci 21(7):2448","journal-title":"Int J Mol Sci"},{"key":"1741_CR16","doi-asserted-by":"crossref","unstructured":"Li C, He X, Zhang Z, Ren C, Chu M (2021) Pineal gland transcriptomic profiling reveals the differential regulation of LncRNA and mRNA related to prolificacy in STH sheep with two FecB genotypes. BMC Genomic Data 22(1)","DOI":"10.1186\/s12863-020-00957-w"},{"issue":"21","key":"1741_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ani14213117","volume":"14","author":"Y Li","year":"2024","unstructured":"Li Y, Yang Y, Yu B, Gao R, Wang X (2024) Transcriptome and metabolome analyses reveal high-altitude adaptation mechanism of epididymis sperm maturation in Tibetan sheep. Animals 14(21):3117","journal-title":"Animals"},{"key":"1741_CR18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2322291121","author":"X Liang","year":"2024","unstructured":"Liang X, Duan Q, Li B, Wang Y, Bu Y, Zhang Y, Kuang Z, Mao L, An X, Wang H, Yang X, Wan N, Feng Z, Shen W, Miao W, Chen J, Liu S, Storz JF, Liu J, Li K (2024) Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep. Proc Natl Acad Sci U S A. https:\/\/doi.org\/10.1073\/pnas.2322291121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1741_CR19","doi-asserted-by":"crossref","unstructured":"Liu X, Hao Y, Li Z, Zhou J, Zhu H, Bu G, Liu Z, Hou X, Zhang X, Miao Y-L (2020) Maternal cytokines CXCL12, VEGFA, and WNT5A promote Porcine oocyte maturation via MAPK activation and canonical WNT Inhibition. Front Cell Dev Biology 8","DOI":"10.3389\/fcell.2020.00578"},{"key":"1741_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01008-0","volume":"23","author":"K Liu","year":"2023","unstructured":"Liu K, Peng X, Luo L (2023) Mir-322 promotes the differentiation of embryonic stem cells into cardiomyocytes. Funct Integr Genomics 23:87","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"1741_CR21","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.22168","volume":"24","author":"A Lorenzo-Torres","year":"2023","unstructured":"Lorenzo-Torres A, Rangel-Santos R, Ru\u00edz-Flores A, Ambr\u00edz-Garc\u00eda DA (2023) In vitro embryo production from ewes at different physiological stages. J Vet Sci 24(1):e10","journal-title":"J Vet Sci"},{"issue":"2","key":"1741_CR22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.devcel.2021.12.022","volume":"57","author":"JL Rossant","year":"2022","unstructured":"Rossant JL, Tam PPL (2022) Early human embryonic development: blastocyst formation to gastrulation. Dev Cell 57(2):152\u2013165","journal-title":"Dev Cell"},{"key":"1741_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1280797","author":"T Ma","year":"2024","unstructured":"Ma T, Zhou S, Xie X, Chen J, Wang J, Zhang G (2024) A case report of a family with developmental arrest of human prokaryotic stage zygote. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2024.1280797","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"1741_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061458","volume":"10","author":"A Mastrorocco","year":"2021","unstructured":"Mastrorocco A, Cacopardo L, Lamanna D, Temerario L, Brunetti G, Carluccio A, Robbe D, Dell\u2019Aquila ME (2021) Bioengineering approaches to improve in vitro performance of prepubertal lamb oocytes. Cells 10(6):1458","journal-title":"Cells"},{"issue":"6","key":"1741_CR26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.fmre.2022.08.011","volume":"2","author":"J Mu","year":"2022","unstructured":"Mu J, Zhou Z, Sang Q, Wang L (2022) The physiological and pathological mechanisms of early embryonic development. Fundam Res 2(6):859\u2013872","journal-title":"Fundam Res"},{"issue":"3","key":"1741_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/genes14030569","volume":"14","author":"M N\u00f5mm","year":"2023","unstructured":"N\u00f5mm M, Ivask M, P\u00e4rn P, Reimann E, K\u00f5ks S, Jaakma \u00dc (2023) Detecting embryo developmental potential by single blastomere RNA-Seq. Genes 14(3):569","journal-title":"Genes"},{"key":"1741_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1014498","volume":"10","author":"D Pladevall-Morera","year":"2022","unstructured":"Pladevall-Morera D, Zylicz JJ (2022) Chromatin as a sensor of metabolic changes during early development. Front Cell Dev Biol 10:1014498","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"1741_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0290689","volume":"18","author":"MB Rabaglino","year":"2023","unstructured":"Rabaglino MB, Forde N, Besenfelder U, Havlicek V, Blum H, Graf A, Wolf E, Lonergan P (2023) Maternal metabolic status and in-vitro culture conditions during embryonic genome activation deregulate the expression of energy-related genes in the bovine 16-cells embryo. PLoS ONE 18(8):e0290689","journal-title":"PLoS ONE"},{"key":"1741_CR30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58641","volume":"9","author":"KW Rogers","year":"2020","unstructured":"Rogers KW, ElGamacy M, Jordan BM, M\u00fcller P (2020) Optogenetic investigation of BMP target gene expression diversity. eLife 9:e58641","journal-title":"eLife"},{"key":"1741_CR31","doi-asserted-by":"crossref","unstructured":"Sadeesh EM, Lahamge MS (2025) Unveiling the tissue-specific landscape of nuclear-encoded mitochondrial genes involved in amino acid metabolism in Buffalo. Amino Acids 57(1):17","DOI":"10.1007\/s00726-025-03447-4"},{"key":"1741_CR32","doi-asserted-by":"publisher","unstructured":"Sadeesh EM, Lahamge MS, Kumari S, Singh P (2025a) Tissue-specific diversity of nuclear-encoded mitochondrial genes related to lipid and carbohydrate metabolism in Buffalo. Mol Biotechnol. Advance online publication.\u00a0https:\/\/doi.org\/10.1007\/s12033-025-01386-9","DOI":"10.1007\/s12033-025-01386-9"},{"key":"1741_CR33","doi-asserted-by":"crossref","unstructured":"Sadeesh EM, Lahamge MS, Malik A, Ampadi AN (2025b) Nuclear Genome-Encoded mitochondrial OXPHOS complex I genes in female Buffalo show tissue-specific differences. Mol Biotechnol 67(6):2411\u20132427","DOI":"10.1007\/s12033-024-01206-6"},{"key":"1741_CR34","doi-asserted-by":"crossref","unstructured":"Sadeesh EM, Lahamge MS, Malik A, Ampadi AN (2025c) Differential expression of nuclear-encoded mitochondrial protein genes of ATP synthase across different tissues of female Buffalo. Mol Biotechnol 67(2):705\u2013722","DOI":"10.1007\/s12033-024-01085-x"},{"issue":"6","key":"1741_CR35","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1007\/s10616-016-0022-y","volume":"68","author":"EM Sadeesh","year":"2016","unstructured":"Sadeesh EM, Sikka P, Balhara AK, Balhara S (2016) Developmental competence and expression profile of genes in Buffalo (Bubalus bubalis) oocytes and embryos collected under different environmental stress. Cytotechnology 68(6):2271\u20132285","journal-title":"Cytotechnology"},{"key":"1741_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.theriogenology.2021.07.010","volume":"173","author":"\u00c9CD Santos","year":"2021","unstructured":"Santos \u00c9CD, Fonseca Junior AM, D, Lima CB, Ispada J, Silva JVAD, Milazzotto MP (2021) Less is more: reduced nutrient concentration during in vitro culture improves embryo production rates and morphophysiology of bovine embryos. Theriogenology 173:37\u201347","journal-title":"Theriogenology"},{"issue":"11","key":"1741_CR37","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1016\/j.cell.2021.04.020","volume":"184","author":"H Shen","year":"2021","unstructured":"Shen H, Yang M, Li S, Zhang J, Peng B, Wang C, Chang Z, Ong J, Du P (2021) Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell 184(11):2843-2859e20","journal-title":"Cell"},{"issue":"1","key":"1741_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09146-2","volume":"24","author":"H Shi","year":"2023","unstructured":"Shi H, Li T, Su M, Wang H, Li Q, Lang X, Ma Y (2023) Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep. BMC Genomics 24(1):50","journal-title":"BMC Genomics"},{"issue":"22","key":"1741_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ani14223212","volume":"14","author":"Y Song","year":"2024","unstructured":"Song Y, Yuan C, An X, Guo T, Zhang W, Lu Z, Liu J (2024) Genome-wide selection signals reveal candidate genes associated with plateau adaptation in Tibetan sheep. Animals 14(22):3212","journal-title":"Animals"},{"issue":"7","key":"1741_CR40","doi-asserted-by":"publisher","first-page":"991","DOI":"10.5713\/ab.22.0432","volume":"36","author":"D Tian","year":"2023","unstructured":"Tian D, Han B, Li X, Liu D, Zhou B, Zhao C, Zhang N, Wang L, Pei Q, Zhao K (2023) Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing. Anim Biosci 36(7):991\u20131002","journal-title":"Anim Biosci"},{"issue":"19","key":"1741_CR41","doi-asserted-by":"publisher","first-page":"10648","DOI":"10.1093\/nar\/gkaa757","volume":"48","author":"AC Vind","year":"2020","unstructured":"Vind AC, Genzor AV, Bekker-Jensen S (2020) Ribosomal stress-surveillance: three pathways is a magic number. Nucleic Acids Res 48(19):10648\u201310661","journal-title":"Nucleic Acids Res"},{"key":"1741_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.gep.2021.119218","volume":"43","author":"H Wang","year":"2022","unstructured":"Wang H, Wang X, Li T, An X, Yin D, Chen N, Ma Y (2022) Regulation of GDF9 and CDKN1B expression in Tibetan sheep testes during different stages of maturity. Gene Expr Patterns 43:119218","journal-title":"Gene Expr Patterns"},{"issue":"4","key":"1741_CR43","first-page":"509","volume":"27","author":"HJ Wang","year":"2024","unstructured":"Wang HJ, Ma L, Yu Q (2024) Cited2 inhibited hypoxia-induced proliferation and migration of PASMCs via the TGF-\u03b21\/Cited2\/PPAR\u03b3 pathway. Iran J Basic Med Sci 27(4):509\u2013517","journal-title":"Iran J Basic Med Sci"},{"issue":"2","key":"1741_CR44","first-page":"43","volume":"14","author":"Y Xu","year":"2025","unstructured":"Xu Y, Sha Y, Chen X, Chen Q, Liu X, He Y, Huang W, He Y, Gao X (2025) Interaction between rumen microbiota and epithelial mitochondrial dynamics in Tibetan sheep: elucidating the mechanism of rumen. Epithel Energy Metabolism BioTech 14(2):43","journal-title":"Epithel Energy Metabolism BioTech"},{"key":"1741_CR45","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.theriogenology.2020.09.039","volume":"158","author":"S Yaacobi-Artzi","year":"2020","unstructured":"Yaacobi-Artzi S, Shimoni C, Kalo D, Hansen PJ, Roth Z (2020) Melatonin slightly alleviates the effect of heat shock on bovine oocytes and resulting blastocysts. Theriogenology 158:477\u2013489","journal-title":"Theriogenology"},{"issue":"7801","key":"1741_CR46","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41586-020-2105-3","volume":"580","author":"Y Yin","year":"2020","unstructured":"Yin Y, Lu JY, Zhang X, Shao W, Xu Y, Li P, Hong Y, Cui L, Shan G, Tian B (2020) U1 snRNP regulates chromatin retention of noncoding RNAs. Nature 580(7801):147\u2013150","journal-title":"Nature"},{"issue":"4","key":"1741_CR47","doi-asserted-by":"publisher","first-page":"64","DOI":"10.15586\/aei.v50i4.628","volume":"50","author":"X Zhang","year":"2022","unstructured":"Zhang X, Chen W, Liu W, Li D, Shen W (2022) CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-\u03baB pathway. Allergol Immunopathol 50(4):64\u201370","journal-title":"Allergol Immunopathol"},{"issue":"7","key":"1741_CR48","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.5713\/ab.22.0402","volume":"36","author":"T Zhang","year":"2023","unstructured":"Zhang T, Zhang J, Li R (2023) p66Shc in sheep preimplantation embryos: expression and regulation of oxidative stress through the manganese superoxide dismutase-reactive oxygen species metabolic pathway. Anim Biosci 36(7):1022\u20131033","journal-title":"Anim Biosci"},{"issue":"1","key":"1741_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/ani12010058","volume":"12","author":"P Zhao","year":"2021","unstructured":"Zhao P, He Z, Xi Q, Sun H, Luo Y, Wang J, Liu X, Zhao Z, Li S (2021) Variations in HIF-1\u03b1 contributed to high altitude hypoxia adaptation via affected oxygen metabolism in Tibetan sheep. Animals 12(1):58","journal-title":"Animals"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01741-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01741-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01741-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:06:29Z","timestamp":1769155589000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01741-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1741"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01741-8","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"7 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animals were subjected to the relevant animal welfare protocols approved by the Gansu Agricultural University College of Veterinary Medicine (Approval No. GSAU-Eth-vwc-2022-009, approved on March 10, 2022). A total of 1, 350 ovaries from healthy Tibetan sheep (30 ovaries collected daily over 45 consecutive days) were used in this study. Clinical trial number: not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no conflicts of interest related to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"228"}}