{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:30:44Z","timestamp":1793817044419,"version":"4.6.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2022MH155"],"award-info":[{"award-number":["ZR2022MH155"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2023MH382"],"award-info":[{"award-number":["ZR2023MH382"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Qilu hygiene and health outstanding youth project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10142-025-01748-1","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T01:26:32Z","timestamp":1763774792000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["LETM2 regulates mitochondrial function and autophagy in diabetic foot ulcers: implications for oxidative stress and therapeutic targeting"],"prefix":"10.1007","volume":"25","author":[{"given":"Nan","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchen","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanya","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"issue":"2","key":"1748_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s12015-020-10014-9","volume":"17","author":"T An","year":"2021","unstructured":"An T, Chen Y, Tu Y, Lin P (2021) Mesenchymal stromal cell-derived extracellular vesicles in the treatment of diabetic foot ulcers: application and challenges. Stem Cell Rev Rep 17(2):369\u2013378","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"1748_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01965-7","volume":"22","author":"Y An","year":"2023","unstructured":"An Y, Xu BT, Wan SR, Ma XM, Long Y, Xu Y et al (2023) The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol 22(1):237","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"1748_CR3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/jama.2023.10578","volume":"330","author":"DG Armstrong","year":"2023","unstructured":"Armstrong DG, Tan TW, Boulton AJM, Bus SA (2023) Diabetic foot ulcers: a review. JAMA 330(1):62\u201375","journal-title":"JAMA"},{"issue":"781","key":"1748_CR4","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adn8699","volume":"17","author":"LL Bao","year":"2025","unstructured":"Bao LL, Yu YQ, Gonz\u00e1lez-Acera M, Patankar JV, Giessl A, Sturm G (2025) Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease. Sci Transl Med 17(781):eadn8699","journal-title":"Sci Transl Med"},{"issue":"9","key":"1748_CR5","doi-asserted-by":"publisher","first-page":"696","DOI":"10.4239\/wjd.v13.i9.696","volume":"13","author":"R Chakraborty","year":"2022","unstructured":"Chakraborty R, Borah P, Dutta PP, Sen S (2022) Evolving spectrum of diabetic wound: mechanistic insights and therapeutic targets. World J Diabetes 13(9):696\u2013716","journal-title":"World J Diabetes"},{"issue":"2","key":"1748_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ajhg.2015.12.013","volume":"98","author":"C Cheng","year":"2016","unstructured":"Cheng C, Zhou Y, Li H, Xiong T, Li S, Bi Y et al (2016) Whole-genome sequencing reveals diverse models of structural variations in esophageal squamous cell carcinoma. Am J Hum Genet 98(2):256\u2013274","journal-title":"Am J Hum Genet"},{"issue":"6","key":"1748_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020351","volume":"6","author":"A Dutt","year":"2011","unstructured":"Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T et al (2011) Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS ONE 6(6):e20351","journal-title":"PLoS ONE"},{"key":"1748_CR8","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.2147\/JIR.S504001","volume":"18","author":"S Fang","year":"2025","unstructured":"Fang S, Zhang H, Liu W, Li S, Chen Z, Min J et al (2025) Analysis and validation of Mitophagy-Related genes in diabetic foot ulcers. J Inflamm Res 18:4367\u20134379","journal-title":"J Inflamm Res"},{"key":"1748_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.933474","volume":"10","author":"J Flournoy","year":"2022","unstructured":"Flournoy J, Ashkanani S, Chen Y (2022) Mechanical regulation of signal transduction in angiogenesis. Front Cell Dev Biol 10:933474","journal-title":"Front Cell Dev Biol"},{"key":"1748_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae023","volume":"12","author":"L Guo","year":"2024","unstructured":"Guo L, Xiao D, Xing H, Yang G, Yang X (2024) Engineered exosomes as a prospective therapy for diabetic foot ulcers. Burns Trauma 12:tkae023","journal-title":"Burns Trauma"},{"key":"1748_CR11","doi-asserted-by":"crossref","unstructured":"Gyimesi G, Hediger MA (2020) Sequence features of mitochondrial transporter protein families. Biomolecules. ;10(12)","DOI":"10.3390\/biom10121611"},{"issue":"2","key":"1748_CR12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1080\/15548627.2016.1256520","volume":"13","author":"J Hu","year":"2017","unstructured":"Hu J, Meng Y, Zhang Z, Yan Q, Jiang X, Lv Z et al (2017) MARCH5 RNA promotes autophagy, migration, and invasion of ovarian cancer cells. Autophagy 13(2):333\u2013344","journal-title":"Autophagy"},{"issue":"6","key":"1748_CR13","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1080\/15548627.2016.1166318","volume":"12","author":"Q Huang","year":"2016","unstructured":"Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X et al (2016) Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways. Autophagy 12(6):999\u20131014","journal-title":"Autophagy"},{"key":"1748_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8098135","author":"MZ Huang","year":"2019","unstructured":"Huang MZ, Yang YJ, Liu XW, Qin Z, Li JY (2019) Aspirin Eugenol ester reduces H(2)O(2)-Induced oxidative stress of HUVECs via Mitochondria-Lysosome axis. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/8098135","journal-title":"Oxid Med Cell Longev"},{"key":"1748_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1136098","volume":"14","author":"M Jiang","year":"2023","unstructured":"Jiang M, Jiang X, Li H, Zhang C, Zhang Z, Wu C et al (2023a) The role of mesenchymal stem cell-derived EVs in diabetic wound healing. Front Immunol 14:1136098","journal-title":"Front Immunol"},{"issue":"7","key":"1748_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23407","volume":"37","author":"G Jiang","year":"2023","unstructured":"Jiang G, Jiang T, Chen J, Yao H, Mao R, Yang X et al (2023b) Mitochondrial dysfunction and oxidative stress in diabetic wound. J Biochem Mol Toxicol 37(7):e23407","journal-title":"J Biochem Mol Toxicol"},{"key":"1748_CR17","doi-asserted-by":"crossref","unstructured":"Kowalczyk P, Sulejczak D, Kleczkowska P, Bukowska-O\u015bko I, Kucia M, Popiel M et al (2021) Mitochondrial oxidative Stress-A causative factor and therapeutic target in many diseases. Int J Mol Sci. ;22(24)","DOI":"10.3390\/ijms222413384"},{"key":"1748_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102530","volume":"58","author":"S Li","year":"2022","unstructured":"Li S, Deng J, Sun D, Chen S, Yao X, Wang N et al (2022) FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition. Redox Biol 58:102530","journal-title":"Redox Biol"},{"key":"1748_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154915","volume":"118","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang S, Jin G, Gao K, Wang S, Zhang X et al (2023) Network pharmacology-based study on the mechanism of ShenKang injection in diabetic kidney disease through Keap1\/Nrf2\/Ho-1 signaling pathway. Phytomedicine 118:154915","journal-title":"Phytomedicine"},{"issue":"2","key":"1748_CR20","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu Y, Li Z, Zhang S, Zhang T, Liu Y, Zhang L (2023) Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics 13(2):736\u2013766","journal-title":"Theranostics"},{"issue":"1","key":"1748_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bbrc.2017.06.094","volume":"500","author":"M Noguchi","year":"2018","unstructured":"Noguchi M, Kasahara A (2018) Mitochondrial dynamics coordinate cell differentiation. Biochem Biophys Res Commun 500(1):59\u201364","journal-title":"Biochem Biophys Res Commun"},{"key":"1748_CR22","doi-asserted-by":"crossref","unstructured":"Okonkwo UA, DiPietro LA (2017) Diabetes and wound angiogenesis. Int J Mol Sci. ;18(7)","DOI":"10.3390\/ijms18071419"},{"key":"1748_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2024.102674","volume":"93","author":"E Qaed","year":"2025","unstructured":"Qaed E, Almoiliqy M, Liu W, Wang J, Al-Mashriqi HS, Aldahmash W et al (2025) Phosphocreatine-mediated enhancement of mitochondrial function for accelerated healing of diabetic foot ulcers through the PGC-1\u03b1-NRF-1 signaling pathway. Tissue Cell 93:102674","journal-title":"Tissue Cell"},{"key":"1748_CR24","doi-asserted-by":"publisher","first-page":"476969","DOI":"10.1155\/2010\/476969","volume":"2010","author":"O Seitz","year":"2010","unstructured":"Seitz O, Sch\u00fcrmann C, Hermes N, M\u00fcller E, Pfeilschifter J, Frank S et al (2010) Wound healing in mice with high-fat diet- or Ob gene-induced diabetes-obesity syndromes: a comparative study. Exp Diabetes Res 2010:476969","journal-title":"Exp Diabetes Res"},{"issue":"1","key":"1748_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-025-01587-0","volume":"25","author":"Y Sun","year":"2025","unstructured":"Sun Y, Shan X, Li M, Niu Y, Sun Z, Ma X et al (2025) Autoimmune mechanisms and inflammation in obesity-associated type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver disease. Funct Integr Genomics 25(1):84","journal-title":"Funct Integr Genomics"},{"issue":"Pt 4","key":"1748_CR26","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1242\/jcs.099234","volume":"125","author":"SW Tait","year":"2012","unstructured":"Tait SW, Green DR (2012) Mitochondria and cell signalling. J Cell Sci 125(Pt 4):807\u2013815","journal-title":"J Cell Sci"},{"key":"1748_CR27","doi-asserted-by":"crossref","unstructured":"Tan CT, Liang K, Ngo ZH, Dube CT, Lim CY (2020) Application of 3D Bioprinting technologies to the management and treatment of diabetic foot ulcers. Biomedicines. ;8(10)","DOI":"10.3390\/biomedicines8100441"},{"issue":"9","key":"1748_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06112-4","volume":"14","author":"J Wang","year":"2023","unstructured":"Wang J, Chen A, Xue Z, Liu J, He Y, Liu G et al (2023) BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma. Cell Death Dis 14(9):585","journal-title":"Cell Death Dis"},{"issue":"4","key":"1748_CR29","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/med.22020","volume":"44","author":"F Wang","year":"2024","unstructured":"Wang F, Zhang X, Zhang J, Xu Q, Yu X, Xu A et al (2024) Recent advances in the adjunctive management of diabetic foot ulcer: focus on noninvasive technologies. Med Res Rev 44(4):1501\u20131544","journal-title":"Med Res Rev"},{"issue":"3","key":"1748_CR30","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41418-020-00657-z","volume":"28","author":"H Xian","year":"2021","unstructured":"Xian H, Liou YC (2021) Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy. Cell Death Differ 28(3):827\u2013842","journal-title":"Cell Death Differ"},{"issue":"12","key":"1748_CR31","doi-asserted-by":"publisher","first-page":"14059","DOI":"10.1021\/acsami.1c24569","volume":"14","author":"Z Xu","year":"2022","unstructured":"Xu Z, Liu Y, Ma R, Chen J, Qiu J, Du S et al (2022) Thermosensitive hydrogel incorporating Prussian blue nanoparticles promotes diabetic wound healing via ROS scavenging and mitochondrial function restoration. ACS Appl Mater Interfaces 14(12):14059\u201314071","journal-title":"ACS Appl Mater Interfaces"},{"issue":"8055","key":"1748_CR32","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/s41586-025-08590-2","volume":"639","author":"T Yamada","year":"2025","unstructured":"Yamada T, Ikeda A, Murata D, Wang H, Zhang C, Khare P et al (2025) Dual regulation of mitochondrial fusion by Parkin-PINK1 and OMA1. Nature 639(8055):776\u2013783","journal-title":"Nature"},{"issue":"10","key":"1748_CR33","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1080\/15548627.2020.1871204","volume":"17","author":"M Yazdankhah","year":"2021","unstructured":"Yazdankhah M, Ghosh S, Shang P, Stepicheva N, Hose S, Liu H et al (2021) Bnip3l-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes. Autophagy 17(10):3140\u20133159","journal-title":"Autophagy"},{"issue":"1","key":"1748_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-025-01617-x","volume":"25","author":"J Yuan","year":"2025","unstructured":"Yuan J, Li L, Lv Y, Yang W (2025) N4-acetylcytidine modification of LncRNA GFOD1-AS1 promotes high glucose-induced dysfunction in human dermal microvascular endothelial cells through stabilization of DNMT1 protein. Funct Integr Genomics 25(1):107","journal-title":"Funct Integr Genomics"},{"issue":"2","key":"1748_CR35","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.tips.2022.11.004","volume":"44","author":"E Zacharioudakis","year":"2023","unstructured":"Zacharioudakis E, Gavathiotis E (2023) Mitochondrial dynamics proteins as emerging drug targets. Trends Pharmacol Sci 44(2):112\u2013127","journal-title":"Trends Pharmacol Sci"},{"issue":"7","key":"1748_CR36","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.3390\/cimb44070218","volume":"44","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhao Y, Yu M, Qin J, Ye B, Wang Q (2022) Mitochondrial dysfunction and chronic liver disease. Curr Issues Mol Biol 44(7):3156\u20133165","journal-title":"Curr Issues Mol Biol"},{"issue":"12","key":"1748_CR37","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1007\/s00204-023-03599-w","volume":"97","author":"X Zhang","year":"2023","unstructured":"Zhang X, Zhou H, Chang X (2023) Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury. Arch Toxicol 97(12):3023\u20133035","journal-title":"Arch Toxicol"},{"key":"1748_CR38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/cancers14194722","volume":"14","author":"S Zhou","year":"2022","unstructured":"Zhou S, Zhong Z, Lu Y, Li Y, Yao H, Zhao Y et al (2022) A LETM2-Regulated PI3K-Akt signaling axis reveals a prognostic and therapeutic target in pancreatic cancer. Cancers (Basel) 14:19","journal-title":"Cancers (Basel)"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01748-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-025-01748-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-025-01748-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:26:48Z","timestamp":1770092808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-025-01748-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,22]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1748"],"URL":"https:\/\/doi.org\/10.1007\/s10142-025-01748-1","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,22]]},"assertion":[{"value":"7 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version of this paper was updated because the affiliation numbers have changed due to the deletion of affiliation 3.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The validation cohort consisted of independent sequencing data previously approved by the ethics committee of Qilu Hospital of Shandong University (ethics number 2021071, approved on May 13, 2021), which included 10 diabetic control samples and 10 DFU samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"251"}}