{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:27:41Z","timestamp":1772429261153,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402038"],"award-info":[{"award-number":["82402038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation Committee","award":["2024A1515013277"],"award-info":[{"award-number":["2024A1515013277"]}]},{"name":"Shenzhen Science Technology Innovation Committee","award":["JCYJ20230807095808017"],"award-info":[{"award-number":["JCYJ20230807095808017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01824-0","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:36:12Z","timestamp":1772422572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated scRNA-seq and bulk transcriptomics identify an amino acid metabolism-associated prognostic signature and highlight FUS as a potential driver in prostate cancer progression"],"prefix":"10.1007","volume":"26","author":[{"given":"Jiangbei","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoqiao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LanJie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2019an","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"1824_CR1","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1200\/jco.22.00193","volume":"40","author":"AJ Armstrong","year":"2022","unstructured":"Armstrong AJ, Azad AA, Iguchi T, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Alcaraz A, Alekseev B, Shore ND, Gomez-Veiga F, Rosbrook B, Zohren F, Yamada S, Haas GP, Stenzl A (2022) Improved survival with enzalutamide in patients with metastatic hormone-sensitive prostate cancer. J Clin Oncol 40:1616\u20131622. https:\/\/doi.org\/10.1200\/jco.22.00193","journal-title":"J Clin Oncol"},{"key":"1824_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305724","volume":"11","author":"X Bian","year":"2024","unstructured":"Bian X, Wang W, Abudurexiti M, Zhang X, Ma W, Shi G, Du L, Xu M, Wang X, Tan C, Sun H, He X, Zhang C, Zhu Y, Zhang M, Ye D, Wang J (2024) Integration analysis of single-cell multi-omics reveals prostate cancer heterogeneity. Adv Sci 11:e2305724. https:\/\/doi.org\/10.1002\/advs.202305724","journal-title":"Adv Sci"},{"key":"1824_CR3","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1200\/jco.22.01649","volume":"41","author":"KN Chi","year":"2023","unstructured":"Chi KN, Rathkopf D, Smith MR, Efstathiou E, Attard G, Olmos D, Lee JY, Small EJ, de Pereira Santana Gomes AJ, Roubaud G, Saad M, Zurawski B, Sakalo V, Mason GE, Francis P, Wang G, Wu D, Diorio B, Lopez-Gitlitz A, Sandhu S (2023) Niraparib and abiraterone acetate for metastatic castration-resistant prostate cancer. J Clin Oncol 41:3339\u20133351. https:\/\/doi.org\/10.1200\/jco.22.01649","journal-title":"J Clin Oncol"},{"key":"1824_CR4","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1159\/000535120","volume":"15","author":"J Cvetkovic","year":"2023","unstructured":"Cvetkovic J, Jacobi RHJ, Miranda-Bedate A, Pham N, Kutmon M, Groot J, van de Garde MDB, Pinelli E (2023) Human monocytes exposed to SARS-CoV-2 display features of innate immune memory producing high levels of CXCL10 upon restimulation. J Innate Immun 15:911\u2013924. https:\/\/doi.org\/10.1159\/000535120","journal-title":"J Innate Immun"},{"key":"1824_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/1878-0261.12844","volume":"15","author":"R Deng","year":"2021","unstructured":"Deng R, Guo Y, Li L, He J, Qiang Z, Zhang H, Chen R, Wang Y, Zhao X, Yu J (2021) BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN. Mol Oncol 15:279\u2013298. https:\/\/doi.org\/10.1002\/1878-0261.12844","journal-title":"Mol Oncol"},{"key":"1824_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200081","volume":"22","author":"Q Fu","year":"2022","unstructured":"Fu Q, Hong R, Zhou H, Li Y, Liu X, Gong J, Wang X, Chen J, Ran H, Wang L, Li F, Yuan J (2022) Proteomics reveals MRPL4 as a high-risk factor and a potential diagnostic biomarker for prostate cancer. Proteomics 22:e2200081. https:\/\/doi.org\/10.1002\/pmic.202200081","journal-title":"Proteomics"},{"key":"1824_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","volume":"4","author":"G Gandaglia","year":"2021","unstructured":"Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, Stattin P, Van Poppel H, La Vecchia C (2021) Epidemiology and prevention of prostate cancer. Eur Urol Oncol 4:877\u2013892. https:\/\/doi.org\/10.1016\/j.euo.2021.09.006","journal-title":"Eur Urol Oncol"},{"key":"1824_CR8","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/ijc.33335","volume":"148","author":"J Hao","year":"2021","unstructured":"Hao J, Ci X, Wang Y, Choi SYC, Sullivan SE, Xue H, Wu R, Dong X, Haegert AM, Collins CC, Lin D, Wang Y (2021) GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells. Int J Cancer 148:469\u2013480. https:\/\/doi.org\/10.1002\/ijc.33335","journal-title":"Int J Cancer"},{"key":"1824_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/jnci\/djab145","volume":"114","author":"JE Hawley","year":"2022","unstructured":"Hawley JE, Pan S, Kandadi H, Chaimowitz MG, Sheikh N, Drake CG (2022) Analysis of circulating immune biomarkers by race in men with metastatic castration-resistant prostate cancer treated with Sipuleucel-T. J Natl Cancer Inst 114:314\u2013317. https:\/\/doi.org\/10.1093\/jnci\/djab145","journal-title":"J Natl Cancer Inst"},{"key":"1824_CR10","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1158\/2767-9764.Crc-24-0112","volume":"4","author":"EI Heath","year":"2024","unstructured":"Heath EI, Thakur A, Chen W, Hwang C, Paller CJ, Cackowski FC, Boerner JL, Heilbrun L, Smith MP, Schalk DL, Schienschang A, Whitaker SA, Polend A, Smith D, Vaishampayan UN, Dickow B, Lum LG (2024) Race-related differences in Sipuleucel-T response among men with metastatic castrate-resistant prostate cancer. Cancer Res Commun 4:1715\u20131725. https:\/\/doi.org\/10.1158\/2767-9764.Crc-24-0112","journal-title":"Cancer Res Commun"},{"key":"1824_CR11","doi-asserted-by":"publisher","unstructured":"Hennrich U, Eder M (2022) [(177)Lu]Lu-PSMA-617 (Pluvicto(TM)): The first FDA-approved radiotherapeutical for treatment of prostate cancer. Pharmaceuticals (Basel) 15. https:\/\/doi.org\/10.3390\/ph15101292","DOI":"10.3390\/ph15101292"},{"key":"1824_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.675935","volume":"8","author":"M Kalafati","year":"2021","unstructured":"Kalafati M, Lenz M, Ertaylan G, Arts ICW, Evelo CT, van Greevenbroek MMJ, Blaak EE, Adriaens M, Kutmon M (2021) Assessing the contribution of relative macrophage frequencies to subcutaneous adipose tissue. Front Nutr 8:675935. https:\/\/doi.org\/10.3389\/fnut.2021.675935","journal-title":"Front Nutr"},{"key":"1824_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.canlet.2022.01.015","volume":"530","author":"J Kang","year":"2022","unstructured":"Kang J, La Manna F, Bonollo F, Sampson N, Alberts IL, Mingels C, Afshar-Oromieh A, Thalmann GN, Karkampouna S (2022) Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer. Cancer Lett 530:156\u2013169. https:\/\/doi.org\/10.1016\/j.canlet.2022.01.015","journal-title":"Cancer Lett"},{"key":"1824_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/life11101099","author":"Z Kaplan","year":"2021","unstructured":"Kaplan Z, Zielske SP, Ibrahim KG, Cackowski FC (2021) Wnt and \u03b2-catenin signaling in the bone metastasis of prostate cancer. Life. https:\/\/doi.org\/10.3390\/life11101099","journal-title":"Life"},{"key":"1824_CR15","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202101250","author":"H Kim","year":"2022","unstructured":"Kim H, Jang S, Lee YS (2022) The m6A(m)-independent role of FTO in regulating WNT signaling pathways. Life Sci Alliance. https:\/\/doi.org\/10.26508\/lsa.202101250","journal-title":"Life Sci Alliance"},{"key":"1824_CR16","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1007\/s11864-024-01215-2","volume":"25","author":"T Kulasegaran","year":"2024","unstructured":"Kulasegaran T, Oliveira N (2024) Metastatic castration-resistant prostate cancer: advances in treatment and symptom management. Curr Treat Options Oncol 25:914\u2013931. https:\/\/doi.org\/10.1007\/s11864-024-01215-2","journal-title":"Curr Treat Options Oncol"},{"key":"1824_CR17","doi-asserted-by":"publisher","first-page":"4424","DOI":"10.7150\/ijbs.99716","volume":"20","author":"L Li","year":"2024","unstructured":"Li L, Chao Z, Peng H, Hu Z, Wang Z, Zeng X (2024) Tumor ABCC4-mediated release of PGE2 induces CD8(+) T cell dysfunction and impairs PD-1 blockade in prostate cancer. Int J Biol Sci 20:4424\u20134437. https:\/\/doi.org\/10.7150\/ijbs.99716","journal-title":"Int J Biol Sci"},{"key":"1824_CR18","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.molimm.2025.04.006","volume":"182","author":"Z Li","year":"2025","unstructured":"Li Z, Shao Y, Liu X, Wan X, Xiong P, Wang L, Yuan J (2025) Steap3 is a key node in regulating the phagosome escape of Listeria monocytogenes. Mol Immunol 182:96\u2013106. https:\/\/doi.org\/10.1016\/j.molimm.2025.04.006","journal-title":"Mol Immunol"},{"key":"1824_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00053","volume":"14","author":"JYW Liu","year":"2020","unstructured":"Liu JYW, Dzurova N, Al-Kaaby B, Mills K, Sisodiya SM, Thom M (2020) Granule cell dispersion in human temporal lobe epilepsy: proteomics investigation of neurodevelopmental migratory pathways. Front Cell Neurosci 14:53. https:\/\/doi.org\/10.3389\/fncel.2020.00053","journal-title":"Front Cell Neurosci"},{"key":"1824_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051118","author":"F Lorenzin","year":"2022","unstructured":"Lorenzin F, Demichelis F (2022) Past, current, and future strategies to target ERG fusion-positive prostate cancer. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers14051118","journal-title":"Cancers (Basel)"},{"key":"1824_CR21","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/bs.acr.2024.04.007","volume":"161","author":"S Maji","year":"2024","unstructured":"Maji S, Kumar A, Emdad L, Fisher PB, Das SK (2024) Molecular landscape of prostate cancer bone metastasis. Adv Cancer Res 161:321\u2013365. https:\/\/doi.org\/10.1016\/bs.acr.2024.04.007","journal-title":"Adv Cancer Res"},{"key":"1824_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17040645","author":"H Ofner","year":"2025","unstructured":"Ofner H, Kramer G, Shariat SF, Hassler MR (2025) TP53 deficiency in the natural history of prostate cancer. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers17040645","journal-title":"Cancers (Basel)"},{"key":"1824_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00243-0","volume":"7","author":"RJ Rebello","year":"2021","unstructured":"Rebello RJ, Oing C, Knudsen KE, Loeb S, Johnson DC, Reiter RE, Gillessen S, Van der Kwast T, Bristow RG (2021) Prostate cancer. Nat Rev Dis Primers 7:9. https:\/\/doi.org\/10.1038\/s41572-020-00243-0","journal-title":"Nat Rev Dis Primers"},{"key":"1824_CR24","doi-asserted-by":"publisher","first-page":"T109","DOI":"10.1530\/erc-21-0073","volume":"28","author":"ML Sandoval","year":"2021","unstructured":"Sandoval ML, Dohm A, Yamoah K (2021) Management of early-stage metastatic prostate cancer: appraisal of locoregional treatments and radiation therapy, with or without immunomodulation. Endocr Relat Cancer 28:T109-t120. https:\/\/doi.org\/10.1530\/erc-21-0073","journal-title":"Endocr Relat Cancer"},{"key":"1824_CR25","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/s41418-021-00913-w","volume":"29","author":"Q Shi","year":"2022","unstructured":"Shi Q, Jin X, Zhang P, Li Q, Lv Z, Ding Y, He H, Wang Y, He Y, Zhao X, Zhao SM, Li Y, Gao K, Wang C (2022) SPOP mutations promote p62\/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer. Cell Death Differ 29:1228\u20131239. https:\/\/doi.org\/10.1038\/s41418-021-00913-w","journal-title":"Cell Death Differ"},{"key":"1824_CR26","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adf6724","volume":"15","author":"W Shi","year":"2023","unstructured":"Shi W, Wang Y, Zhao Y, Kim JJ, Li H, Meng C, Chen F, Zhang J, Mak DH, Van V, Leo J, St Croix B, Aparicio A, Zhao D (2023) Immune checkpoint B7-H3 is a therapeutic vulnerability in prostate cancer harboring PTEN and TP53 deficiencies. Sci Transl Med 15:eadf6724. https:\/\/doi.org\/10.1126\/scitranslmed.adf6724","journal-title":"Sci Transl Med"},{"key":"1824_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01841","volume":"9","author":"A Siddiqa","year":"2018","unstructured":"Siddiqa A, Cirillo E, Tareen SHK, Ali A, Kutmon M, Eijssen LMT, Ahmad J, Evelo CT, Coort SL (2018) Biological pathways leading from ANGPTL8 to diabetes mellitus-a co-expression network based analysis. Front Physiol 9:1841. https:\/\/doi.org\/10.3389\/fphys.2018.01841","journal-title":"Front Physiol"},{"key":"1824_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00178-6","volume":"10","author":"JA Siddiqui","year":"2022","unstructured":"Siddiqui JA, Seshacharyulu P, Muniyan S, Pothuraju R, Khan P, Vengoji R, Chaudhary S, Maurya SK, Lele SM, Jain M, Datta K, Nasser MW, Batra SK (2022) GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation. Bone Res 10:6. https:\/\/doi.org\/10.1038\/s41413-021-00178-6","journal-title":"Bone Res"},{"key":"1824_CR29","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1158\/0008-5472.Can-24-0932","volume":"84","author":"H Song","year":"2024","unstructured":"Song H, Lu T, Han D, Zhang J, Gan L, Xu C, Liu S, Li P, Zhang K, Hu Z, Li H, Li Y, Zhao X, Zhang J, Xing N, Shi C, Wen W, Yang F, Qin W (2024) YAP1 inhibition induces phenotype switching of cancer-associated fibroblasts to tumor suppressive in prostate cancer. Cancer Res 84:3728\u20133742. https:\/\/doi.org\/10.1158\/0008-5472.Can-24-0932","journal-title":"Cancer Res"},{"key":"1824_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1079037","volume":"13","author":"C Stevens","year":"2023","unstructured":"Stevens C, Hightower A, Buxbaum SG, Falzarano SM, Rhie SK (2023) Genomic, epigenomic, and transcriptomic signatures of prostate cancer between African American and European American patients. Front Oncol 13:1079037. https:\/\/doi.org\/10.3389\/fonc.2023.1079037","journal-title":"Front Oncol"},{"key":"1824_CR31","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-077738","volume":"386","author":"S Vaccarella","year":"2024","unstructured":"Vaccarella S, Li M, Bray F, Kvale R, Serraino D, Lorenzoni V, Auvinen A, Dal Maso L (2024) Prostate cancer incidence and mortality in Europe and implications for screening activities: population based study. BMJ 386:e077738. https:\/\/doi.org\/10.1136\/bmj-2023-077738","journal-title":"BMJ"},{"key":"1824_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1517679","volume":"15","author":"J Wang","year":"2024","unstructured":"Wang J, Zhao F, Zhang Q, Sun Z, Xiahou Z, Wang C, Liu Y, Yu Z (2024) Unveiling the NEFH+ malignant cell subtype: insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions. Front Immunol 15:1517679. https:\/\/doi.org\/10.3389\/fimmu.2024.1517679","journal-title":"Front Immunol"},{"key":"1824_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214257","author":"S Wasim","year":"2022","unstructured":"Wasim S, Lee SY, Kim J (2022) Complexities of prostate cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232214257","journal-title":"Int J Mol Sci"},{"key":"1824_CR34","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.bbadis.2014.04.018","volume":"1842","author":"Z Yan","year":"2014","unstructured":"Yan Z, Jin S, Wei Z, Huilian H, Zhanhai Y, Yue T, Juan L, Jing L, Libo Y, Xu L (2014) Discoidin domain receptor 2 facilitates prostate cancer bone metastasis via regulating parathyroid hormone-related protein. Biochim Biophys Acta 1842:1350\u20131363. https:\/\/doi.org\/10.1016\/j.bbadis.2014.04.018","journal-title":"Biochim Biophys Acta"},{"key":"1824_CR35","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.eururo.2022.08.002","volume":"82","author":"T Yanagisawa","year":"2022","unstructured":"Yanagisawa T, Rajwa P, Thibault C, Gandaglia G, Mori K, Kawada T, Fukuokaya W, Shim SR, Mostafaei H, Motlagh RS, Quhal F, Laukhtina E, Pallauf M, Pradere B, Kimura T, Egawa S, Shariat SF (2022) Androgen receptor signaling inhibitors in addition to docetaxel with androgen deprivation therapy for metastatic hormone-sensitive prostate cancer: a systematic review and meta-analysis. Eur Urol 82:584\u2013598. https:\/\/doi.org\/10.1016\/j.eururo.2022.08.002","journal-title":"Eur Urol"},{"key":"1824_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7279243","volume":"2023","author":"J Ye","year":"2023","unstructured":"Ye J, Wu M, He L, Chen P, Liu H, Yang H (2023) Glutathione-S-transferase p1 gene promoter methylation in cell-free DNA as a diagnostic and prognostic tool for prostate cancer: a systematic review and meta-analysis. Int J Endocrinol 2023:7279243. https:\/\/doi.org\/10.1155\/2023\/7279243","journal-title":"Int J Endocrinol"},{"key":"1824_CR37","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00738-19","volume":"88","author":"J Yuan","year":"2020","unstructured":"Yuan J, Zheng Z, Wang L, Ran H, Tang X, Xie X, Li F, Liu F, Wang X, Zhang J, Zhang J, Huang Y, Xia X, Wan Y (2020) The Dynll1-Cox4i1 complex regulates intracellular pathogen clearance via release of mitochondrial reactive oxygen species. Infect Immun 88:e00738-00719. https:\/\/doi.org\/10.1128\/iai.00738-19","journal-title":"Infect Immun"},{"key":"1824_CR38","doi-asserted-by":"publisher","unstructured":"Zanvit P, van Dyk D, Fazenbaker C, McGlinchey K, Luo W, Pezold JM, Meekin J, Chang CY, Carrasco RA, Breen S, Cheung CS, Endlich-Frazier A, Clark B, Chu NJ, Vantellini A, Martin PL, Hoover CE, Riley K, Sweet SM, Chain D, Kim YJ, Tu E, Harder N, Phipps S, Damschroder M, Gilbreth RN, Cobbold M, Moody G, Bosco EE (2023) Antitumor activity of AZD0754, a dnTGF\u03b2RII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer. J Clin Invest 133. https:\/\/doi.org\/10.1172\/jci169655","DOI":"10.1172\/jci169655"},{"key":"1824_CR39","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41585-021-00442-8","volume":"18","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Mo M, Wei Y, Wu J, Pan J, Freedland SJ, Zheng Y, Ye D (2021) Epidemiology and genomics of prostate cancer in Asian men. Nat Rev Urol 18:282\u2013301. https:\/\/doi.org\/10.1038\/s41585-021-00442-8","journal-title":"Nat Rev Urol"},{"key":"1824_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2022.103771","volume":"123","author":"H Zou","year":"2022","unstructured":"Zou H, Wang JY, Ma GM, Xu MM, Luo F, Zhang L, Wang WY (2022) The function of FUS in neurodevelopment revealed by the brain and spinal cord organoids. Mol Cell Neurosci 123:103771. https:\/\/doi.org\/10.1016\/j.mcn.2022.103771","journal-title":"Mol Cell Neurosci"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01824-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01824-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01824-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:36:15Z","timestamp":1772422575000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01824-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1824"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01824-0","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"18 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study utilized human tissue samples and clinical data, which were collected in accordance with the ethical guidelines approved by the Institutional Review Board (IRB) of Zhejiang Provincial People's Hospital, approval No. 2025\u2013154. All participants provided informed consent, and patients' names were anonymized in accordance with ethical and legal standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"55"}}