{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:13:44Z","timestamp":1792782824914,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Bengbu Medical University Natural Science Program","award":["2023byzd076"],"award-info":[{"award-number":["2023byzd076"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01826-y","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:34:12Z","timestamp":1773110052000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["YTHDF1\u2013ALYREF axis enhances mrna stability and tumor immune evasion in paediatric B-cell acute lymphoblastic leukemia"],"prefix":"10.1007","volume":"26","author":[{"given":"Xu","family":"Sang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"1826_CR1","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1200\/JCO.21.01766","volume":"40","author":"AS Advani","year":"2022","unstructured":"Advani AS, Moseley A, O\u2019Dwyer KM et al (2022) SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia. JCO 40:1574\u20131582","journal-title":"JCO"},{"key":"1826_CR2","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1136\/gutjnl-2022-328845","volume":"72","author":"Y Bao","year":"2023","unstructured":"Bao Y, Zhai J, Chen H et al (2023) Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut 72:1497\u20131509","journal-title":"Gut"},{"key":"1826_CR3","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1001\/jama.2021.0669","volume":"325","author":"PA Brown","year":"2021","unstructured":"Brown PA, Ji L, Xu X et al (2021) Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia. JAMA 325:833","journal-title":"JAMA"},{"key":"1826_CR4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.omto.2021.01.001","volume":"20","author":"P Chen","year":"2021","unstructured":"Chen P, Liu X, Lin X et al (2021) Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism. Molecular Therapy - Oncolytics 20:228\u2013239","journal-title":"Molecular Therapy - Oncolytics"},{"key":"1826_CR5","volume":"1","author":"GS Cowley","year":"2014","unstructured":"Cowley GS, Weir BA, Vazquez F et al (2014) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data 1:1","journal-title":"Sci Data"},{"key":"1826_CR6","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.21037\/tcr-23-2401","volume":"13","author":"Z Dou","year":"2024","unstructured":"Dou Z, Ma X-T, Piao M-N et al (2024) Overview of the interplay between m6A methylation modification and non-coding RNA and their impact on tumor cells. Transl Cancer Res 13:3106\u20133125","journal-title":"Transl Cancer Res"},{"key":"1826_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110868","volume":"124","author":"A Du","year":"2023","unstructured":"Du A, Yang Q, Sun X, Zhao Q (2023) Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression. Int Immunopharmacol 124:110868","journal-title":"Int Immunopharmacol"},{"key":"1826_CR8","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/mc.23330","volume":"60","author":"H Gong","year":"2021","unstructured":"Gong H, Liu L, Cui L et al (2021) ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B. Mol Carcinog 60:644\u2013657","journal-title":"Mol Carcinog"},{"key":"1826_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"W-L Guan","year":"2023","unstructured":"Guan W-L, He Y, Xu R-H (2023) Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol 16:57","journal-title":"J Hematol Oncol"},{"key":"1826_CR10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-0916-x","volume":"566","author":"D Han","year":"2019","unstructured":"Han D, Liu J, Chen C et al (2019) Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 566:270\u2013274","journal-title":"Nature"},{"key":"1826_CR11","doi-asserted-by":"publisher","first-page":"e376","DOI":"10.1016\/j.clml.2021.12.006","volume":"22","author":"NM Hassan","year":"2022","unstructured":"Hassan NM, Abdellateif MS, Radwan EM et al (2022) Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk 22:e376\u2013e385","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"1826_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05268-9","volume":"13","author":"Q Huang","year":"2022","unstructured":"Huang Q, Mo J, Liao Z et al (2022) The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms. Cell Death Dis 13:852","journal-title":"Cell Death Dis"},{"key":"1826_CR13","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ccell.2024.03.003","volume":"42","author":"X Huang","year":"2024","unstructured":"Huang X, Li Y, Zhang J et al (2024) Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia. Cancer Cell 42:552-567.e6","journal-title":"Cancer Cell"},{"key":"1826_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1694","volume":"13","author":"M Kordy\u015b","year":"2021","unstructured":"Kordy\u015b M, Sen R, Warkocki Z (2021) Applications of the versatile CRISPR-Cas13 RNA targeting system. WIREs RNA 13:e1694","journal-title":"WIREs RNA"},{"key":"1826_CR15","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.2147\/JIR.S373776","volume":"15","author":"X-Y Li","year":"2022","unstructured":"Li X-Y, Yang X-T (2022) Correlation between the RNA methylation genes and immune infiltration and prognosis of patients with hepatocellular carcinoma: a pan-cancer analysis. JIR 15:3941\u20133956","journal-title":"JIR"},{"key":"1826_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1080\/15384047.2020.1740054","volume":"21","author":"H Li","year":"2020","unstructured":"Li H, Tian X, Wang P et al (2020) LINC01128 resisted acute myeloid leukemia through regulating miR-4260\/NR3C2. Cancer Biol Ther 21:615\u2013622","journal-title":"Cancer Biol Ther"},{"key":"1826_CR17","doi-asserted-by":"publisher","first-page":"25426","DOI":"10.18632\/aging.203760","volume":"13","author":"Y Li","year":"2021","unstructured":"Li Y, Lu T, Wang J et al (2021) YTHDC1 gene polymorphisms and neuroblastoma susceptibility in Chinese children. Aging 13:25426\u201325439","journal-title":"Aging"},{"key":"1826_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115891","volume":"169","author":"Y Li","year":"2023","unstructured":"Li Y, Yan B, He S (2023) Advances and challenges in the treatment of lung cancer. Biomed Pharmacother 169:115891","journal-title":"Biomed Pharmacother"},{"key":"1826_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41467-022-35710-7","volume":"14","author":"W Lin","year":"2023","unstructured":"Lin W, Chen L, Zhang H et al (2023) Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation. Nat Commun 14:265","journal-title":"Nat Commun"},{"key":"1826_CR20","doi-asserted-by":"publisher","first-page":"5447","DOI":"10.7150\/jca.35053","volume":"10","author":"L Liu","year":"2019","unstructured":"Liu L, Liu X, Dong Z et al (2019) N6-methyladenosine-related genomic targets are altered in breast cancer tissue and associated with poor survival. J Cancer 10:5447\u20135459","journal-title":"J Cancer"},{"key":"1826_CR21","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s12943-022-01680-z","volume":"21","author":"Z Liu","year":"2022","unstructured":"Liu Z, Zou H, Dang Q et al (2022) Biological and pharmacological roles of m6A modifications in cancer drug resistance. Mol Cancer 21:220","journal-title":"Mol Cancer"},{"key":"1826_CR22","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1001\/jama.2021.0987","volume":"325","author":"F Locatelli","year":"2021","unstructured":"Locatelli F, Zugmaier G, Rizzari C et al (2021) Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia. JAMA 325:843","journal-title":"JAMA"},{"key":"1826_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00404-3","volume":"8","author":"C L\u00f3pez","year":"2022","unstructured":"L\u00f3pez C, Burkhardt B, Chan JKC et al (2022) Burkitt lymphoma. Nat Rev Dis Primers 8:78","journal-title":"Nat Rev Dis Primers"},{"key":"1826_CR24","doi-asserted-by":"publisher","first-page":"9189","DOI":"10.2147\/CMAR.S335925","volume":"13","author":"A Luo","year":"2021","unstructured":"Luo A, Yang L, Li M et al (2021) Genetic Variants in METTL14 are Associated with the Risk of Acute Lymphoblastic Leukemia in Southern Chinese Children: A Five-Center Case-Control Study. CMAR 13:9189\u20139200","journal-title":"CMAR"},{"key":"1826_CR25","doi-asserted-by":"publisher","first-page":"7476","DOI":"10.18632\/oncotarget.23554","volume":"9","author":"Y Nishizawa","year":"2017","unstructured":"Nishizawa Y, Konno M, Asai A et al (2017) Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer. Oncotarget 9:7476\u20137486","journal-title":"Oncotarget"},{"key":"1826_CR26","doi-asserted-by":"publisher","first-page":"17122","DOI":"10.18632\/aging.103653","volume":"12","author":"M Qian","year":"2020","unstructured":"Qian M, Ling W, Ruan Z (2020) Long non-coding RNA SNHG12 promotes immune escape of ovarian cancer cells through their crosstalk with M2 macrophages. Aging 12:17122\u201317136","journal-title":"Aging"},{"key":"1826_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s12859-023-05379-w","volume":"24","author":"W Qian","year":"2023","unstructured":"Qian W, Zhou J, Shou S (2023) Exploration of m6A methylation regulators as epigenetic targets for immunotherapy in advanced sepsis. BMC Bioinformatics 24:257","journal-title":"BMC Bioinformatics"},{"key":"1826_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1681","volume":"13","author":"ER Satterwhite","year":"2021","unstructured":"Satterwhite ER, Mansfield KD (2021) RNA methyltransferase METTL16: targets and function. Wiley Interdiscip Rev RNA 13:e1681","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"1826_CR29","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1182\/blood.2020007932","volume":"139","author":"A Sipol","year":"2022","unstructured":"Sipol A, Hameister E, Xue B et al (2022) MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress. Blood 139:1184\u20131197","journal-title":"Blood"},{"key":"1826_CR30","first-page":"88","volume":"49","author":"CA Tirado","year":"2023","unstructured":"Tirado CA, Dobin S, Eastwood K et al (2023) A B-ALL Pediatric Patient with a Cryptic IGH Rearrangement Within the Context of a Complex Karyotype. J Assoc Genet Technol 49:88\u201392","journal-title":"J Assoc Genet Technol"},{"key":"1826_CR31","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","volume":"161","author":"X Wang","year":"2015","unstructured":"Wang X, Zhao BS, Roundtree IA et al (2015) N6-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 161:1388\u20131399","journal-title":"Cell"},{"key":"1826_CR32","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1038\/s41388-021-01820-7","volume":"40","author":"F Wang","year":"2021","unstructured":"Wang F, Liao Y, Zhang M et al (2021) N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma. Oncogene 40:3885\u20133898","journal-title":"Oncogene"},{"key":"1826_CR33","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.jhep.2023.06.021","volume":"79","author":"L Wang","year":"2023","unstructured":"Wang L, Zhu L, Liang C et al (2023) Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis. J Hepatol 79:1185\u20131200","journal-title":"J Hepatol"},{"key":"1826_CR34","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2024.2333590","author":"Y Wang","year":"2024","unstructured":"Wang Y, Peng L, Wang F (2024) M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma. Cancer Biol Ther. https:\/\/doi.org\/10.1080\/15384047.2024.2333590","journal-title":"Cancer Biol Ther"},{"key":"1826_CR35","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","volume":"26","author":"MD Wilkerson","year":"2010","unstructured":"Wilkerson MD, Hayes DN (2010) ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Bioinformatics 26:1572\u20131573","journal-title":"Bioinformatics"},{"key":"1826_CR36","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s10495-023-01846-0","volume":"28","author":"S Wu","year":"2023","unstructured":"Wu S, Chi C, Weng S et al (2023) IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD\u2009+\u2009acute myeloid leukemia. Apoptosis 28:1035\u20131047","journal-title":"Apoptosis"},{"key":"1826_CR37","doi-asserted-by":"publisher","first-page":"870816","DOI":"10.3389\/fmicb.2022.870816","volume":"13","author":"Y Yanagi","year":"2022","unstructured":"Yanagi Y, Watanabe T, Hara Y et al (2022) EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle. Front. Microbiol. 13:870816","journal-title":"Front. Microbiol."},{"key":"1826_CR38","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/cr.2017.55","volume":"27","author":"X Yang","year":"2017","unstructured":"Yang X, Yang Y, Sun B-F et al (2017) 5-methylcytosine promotes mRNA export \u2014 NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res 27:606\u2013625","journal-title":"Cell Res"},{"key":"1826_CR39","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","volume":"20","author":"S Zaccara","year":"2019","unstructured":"Zaccara S, Ries RJ, Jaffrey SR (2019) Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol 20:608\u2013624","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1826_CR40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","volume":"21","author":"C Zhang","year":"2022","unstructured":"Zhang C, Liu X, Jin S et al (2022) Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer 21:47","journal-title":"Mol Cancer"},{"key":"1826_CR41","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s12276-022-00735-x","volume":"54","author":"N Zhang","year":"2022","unstructured":"Zhang N, Shen Y, Li H et al (2022b) The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability. Exp Mol Med 54:194\u2013205","journal-title":"Exp Mol Med"},{"key":"1826_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201724","volume":"10","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Ji M, Xia Y et al (2022) Silencing of IRF8 mediated by m6A modification promotes the progression of T-cell acute lymphoblastic leukemia. Adv Sci 10:2201724","journal-title":"Adv Sci"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01826-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:56:20Z","timestamp":1773118580000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01826-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1826"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01826-y","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"17 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study utilized publicly available data from the TARGET database and the Gene Expression Omnibus (GEO), which provide fully anonymized data without any identifiable personal information. According to the Declaration of Helsinki, research using such publicly accessible and anonymized datasets does not require additional ethical approval. In addition, the collection and use of peripheral blood samples from pediatric B-ALL patients were reviewed and approved by the Clinical Ethics Committee of The First Affiliated Hospital of Bengbu Medical University (Approval No. 198). All animal experiments adhered to the ARRIVE guidelines and were approved by the Animal Ethics Committee of The First Affiliated Hospital of Bengbu Medical University (Approval No. 302).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"61"}}