{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:56:58Z","timestamp":1773903418723,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01846-8","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:12:56Z","timestamp":1773889976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis-related ceRNA axis regulates the apoptosis and proliferation of uveal melanoma cells through MAPRE2"],"prefix":"10.1007","volume":"26","author":[{"given":"Hai-Bo","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Hui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"1846_CR1","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/ceo.14214","volume":"51","author":"H Bai","year":"2023","unstructured":"Bai H, Bosch JJ, Heindl LM (2023) Current management of uveal melanoma: a review. Clin Exp Ophthalmol 51:484\u2013494. https:\/\/doi.org\/10.1111\/ceo.14214","journal-title":"Clin Exp Ophthalmol"},{"key":"1846_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010134","volume":"14","author":"K Bilmin","year":"2021","unstructured":"Bilmin K, Synoradzki KJ, Czarnecka AM, Spa\u0142ek MJ, Kujawska T, Solnik M et al (2021) New perspectives for eye-sparing treatment strategies in primary uveal melanoma. Cancers (Basel) 14:134. https:\/\/doi.org\/10.3390\/cancers14010134","journal-title":"Cancers (Basel)"},{"key":"1846_CR3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41571-022-00714-1","volume":"20","author":"RD Carvajal","year":"2023","unstructured":"Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW et al (2023) Advances in the clinical management of uveal melanoma. Nat Rev Clin Oncol 20:99\u2013115. https:\/\/doi.org\/10.1038\/s41571-022-00714-1","journal-title":"Nat Rev Clin Oncol"},{"key":"1846_CR5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"key":"1846_CR6","doi-asserted-by":"publisher","first-page":"14775","DOI":"10.3390\/ijms232314775","volume":"23","author":"L Dong","year":"2022","unstructured":"Dong L, Tian X, Zhao Y, Tu H, Wong A, Yang Y (2022) The roles of miRNAs (MicroRNAs) in melanoma immunotherapy. Int J Mol Sci 23:14775. https:\/\/doi.org\/10.3390\/ijms232314775","journal-title":"Int J Mol Sci"},{"key":"1846_CR7","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3390\/biomedicines10081987","volume":"10","author":"M-B Firnau","year":"2022","unstructured":"Firnau M-B, Brieger A (2022) CK2 and the hallmarks of cancer. Biomedicines 10:1987. https:\/\/doi.org\/10.3390\/biomedicines10081987","journal-title":"Biomedicines"},{"key":"1846_CR8","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3390\/antiox10060986","volume":"10","author":"KM Fujihara","year":"2021","unstructured":"Fujihara KM, Zhang BZ, Clemons NJ (2021) Opportunities for ferroptosis in cancer therapy. Antioxid (Basel) 10:986. https:\/\/doi.org\/10.3390\/antiox10060986","journal-title":"Antioxid (Basel)"},{"key":"1846_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00461","volume":"10","author":"L Gong","year":"2020","unstructured":"Gong L, Xiao M, He D, Hu Y, Zhu Y, Xiang L et al (2020) WDHD1 leads to cisplatin resistance by promoting MAPRE2 ubiquitination in lung adenocarcinoma. Front Oncol 10:461. https:\/\/doi.org\/10.3389\/fonc.2020.00461","journal-title":"Front Oncol"},{"key":"1846_CR10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ygyno.2021.02.004","volume":"161","author":"M Hashemipour","year":"2021","unstructured":"Hashemipour M, Boroumand H, Mollazadeh S, Tajiknia V, Nourollahzadeh Z, Rohani Borj M et al (2021) Exosomal microRNAs and exosomal long non-coding RNAs in gynecologic cancers. Gynecol Oncol 161:314\u2013327. https:\/\/doi.org\/10.1016\/j.ygyno.2021.02.004","journal-title":"Gynecol Oncol"},{"key":"1846_CR11","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.ajhg.2015.10.014","volume":"97","author":"M Isrie","year":"2015","unstructured":"Isrie M, Breuss M, Tian G, Hansen AH, Cristofoli F, Morandell J et al (2015) Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. Am J Hum Genet 97:790\u2013800. https:\/\/doi.org\/10.1016\/j.ajhg.2015.10.014","journal-title":"Am J Hum Genet"},{"key":"1846_CR12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1846_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030349","volume":"12","author":"A Jiang","year":"2023","unstructured":"Jiang A, Ye J, Zhou Y, Zhu B, Lu J, Ge S et al (2023) Copper death inducer, FDX1, as a prognostic biomarker reshaping tumor immunity in clear cell renal cell carcinoma. Cells 12:349. https:\/\/doi.org\/10.3390\/cells12030349","journal-title":"Cells"},{"key":"1846_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.685120","volume":"9","author":"Y Jin","year":"2021","unstructured":"Jin Y, Wang Z, He D, Zhu Y, Gong L, Xiao M et al (2021) Analysis of ferroptosis-mediated modification patterns and tumor immune microenvironment characterization in uveal melanoma. Front Cell Dev Biol 9:685120. https:\/\/doi.org\/10.3389\/fcell.2021.685120","journal-title":"Front Cell Dev Biol"},{"key":"1846_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-022-01211-1","volume":"15","author":"S Lei","year":"2022","unstructured":"Lei S, Zhang Y (2022) Integrative analysis identifies key genes related to metastasis and a robust gene-based prognostic signature in uveal melanoma. BMC Med Genomics 15:61. https:\/\/doi.org\/10.1186\/s12920-022-01211-1","journal-title":"BMC Med Genomics"},{"key":"1846_CR16","doi-asserted-by":"publisher","first-page":"15033","DOI":"10.1080\/21655979.2023.2184317","volume":"13","author":"P Lei","year":"2022","unstructured":"Lei P, Xue L, Wu Y, Zhong J (2022) MicroRNA-592 serves as a novel tumor suppressor in uveal melanoma: bioinformatics analysis and in vitro cell function verification. Bioengineered 13:15033\u201315044. https:\/\/doi.org\/10.1080\/21655979.2023.2184317","journal-title":"Bioengineered"},{"key":"1846_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111402","volume":"137","author":"M Li","year":"2021","unstructured":"Li M, Yu X, Zheng Q, Zhang Q, He Y, Guo W (2021) Promising role of long non-coding RNA PCAT6 in malignancies. Biomed Pharmacother 137:111402. https:\/\/doi.org\/10.1016\/j.biopha.2021.111402","journal-title":"Biomed Pharmacother"},{"key":"1846_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113135","volume":"416","author":"Y-Y Li","year":"2022","unstructured":"Li Y-Y, Lei W-L, Zhang C-F, Sun S-M, Zhao B-W, Xu K et al (2022) MAPRE2 regulates the first meiotic progression in mouse oocytes. Exp Cell Res 416:113135. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113135","journal-title":"Exp Cell Res"},{"key":"1846_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22116167","volume":"22","author":"C Liaci","year":"2021","unstructured":"Liaci C, Camera M, Caslini G, Rando S, Contino S, Romano V et al (2021) Neuronal cytoskeleton in intellectual disability: from systems biology and modeling to therapeutic opportunities. Int J Mol Sci 22:6167. https:\/\/doi.org\/10.3390\/ijms22116167","journal-title":"Int J Mol Sci"},{"key":"1846_CR20","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s10238-021-00697-w","volume":"21","author":"Y Liu","year":"2021","unstructured":"Liu Y, Guo F, Guo W, Wang Y, Song W, Fu T (2021) Ferroptosis-related genes are potential prognostic molecular markers for patients with colorectal cancer. Clin Exp Med 21:467\u2013477. https:\/\/doi.org\/10.1007\/s10238-021-00697-w","journal-title":"Clin Exp Med"},{"key":"1846_CR21","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.1038\/s41388-022-02370-2","volume":"41","author":"Y Liu","year":"2022","unstructured":"Liu Y, Ouyang L, Mao C, Chen Y, Li T, Liu N et al (2022) PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma. Oncogene 41:3570\u20133583. https:\/\/doi.org\/10.1038\/s41388-022-02370-2","journal-title":"Oncogene"},{"key":"1846_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020219","volume":"11","author":"H Luo","year":"2021","unstructured":"Luo H, Ma C (2021) A novel ferroptosis-associated gene signature to predict prognosis in patients with uveal melanoma. Diagnostics 11:219. https:\/\/doi.org\/10.3390\/diagnostics11020219","journal-title":"Diagnostics"},{"key":"1846_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154690","volume":"248","author":"HM Midan","year":"2023","unstructured":"Midan HM, Helal GK, Abulsoud AI, Elshaer SS, El-Husseiny AA, Fathi D et al (2023) The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma - a focus on signaling pathways interplay. Pathol Res Pract 248:154690. https:\/\/doi.org\/10.1016\/j.prp.2023.154690","journal-title":"Pathol Res Pract"},{"key":"1846_CR24","doi-asserted-by":"publisher","first-page":"252","DOI":"10.18502\/jovr.v15i2.6744","volume":"15","author":"JK Ndulue","year":"2020","unstructured":"Ndulue JK, Mashayekhi A, Shields CL (2020) Ciliary body seeding after pars plana transvitreal fine-needle aspiration biopsy of choroidal melanoma. J Ophthalmic Vis Res 15:252\u2013255. https:\/\/doi.org\/10.18502\/jovr.v15i2.6744","journal-title":"J Ophthalmic Vis Res"},{"key":"1846_CR25","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.3390\/biomedicines9101319","volume":"9","author":"LC Nguyen","year":"2021","unstructured":"Nguyen LC, Naulaerts S, Bruna A, Ghislat G, Ballester PJ (2021) Predicting cancer drug response in vivo by learning an optimal feature selection of tumour molecular profiles. Biomedicines 9:1319. https:\/\/doi.org\/10.3390\/biomedicines9101319","journal-title":"Biomedicines"},{"key":"1846_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106845","volume":"87","author":"K Nie","year":"2020","unstructured":"Nie K, Zheng Z, Wen Y, Pan J, Liu Y, Jiang X et al (2020) A novel ceRNA axis involves in regulating immune infiltrates and macrophage polarization in gastric cancer. Int Immunopharmacol 87:106845. https:\/\/doi.org\/10.1016\/j.intimp.2020.106845","journal-title":"Int Immunopharmacol"},{"key":"1846_CR27","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.trecan.2023.03.003","volume":"9","author":"U Sen","year":"2023","unstructured":"Sen U, Coleman C, Sen T (2023) Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis. Trends Cancer 9:480\u2013489. https:\/\/doi.org\/10.1016\/j.trecan.2023.03.003","journal-title":"Trends Cancer"},{"key":"1846_CR28","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1111\/febs.16034","volume":"289","author":"L Shi","year":"2022","unstructured":"Shi L, Liu Y, Li M, Luo Z (2022) Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity. FEBS J 289:3655\u20133665. https:\/\/doi.org\/10.1111\/febs.16034","journal-title":"FEBS J"},{"key":"1846_CR29","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ctrv.2012.01.002","volume":"38","author":"F Spagnolo","year":"2012","unstructured":"Spagnolo F, Caltabiano G, Queirolo P (2012) Uveal melanoma. Cancer Treat Rev 38:549\u2013553. https:\/\/doi.org\/10.1016\/j.ctrv.2012.01.002","journal-title":"Cancer Treat Rev"},{"key":"1846_CR30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo C-J, Chen L-L, Huarte M (2021) Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol 22:96\u2013118. https:\/\/doi.org\/10.1038\/s41580-020-00315-9","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1846_CR31","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/hep.28548","volume":"64","author":"Y Takashima","year":"2016","unstructured":"Takashima Y et al (2016) Suppression of lethal-7b and miR-125a\/b maturation by Lin28b enables maintenance of stem cell properties in hepatoblasts. Hepatology 64(1):245\u201360","journal-title":"Hepatology"},{"key":"1846_CR32","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12887","volume":"53","author":"C Tu","year":"2020","unstructured":"Tu C, Yang K, Wan L, He J, Qi L, Wang W et al (2020) The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression. Cell Prolif 53:e12887. https:\/\/doi.org\/10.1111\/cpr.12887","journal-title":"Cell Prolif"},{"key":"1846_CR33","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.18632\/oncotarget.27559","volume":"11","author":"A Vashishtha","year":"2020","unstructured":"Vashishtha A, Lee TJ, Sharma A, Wallbillich JJ (2020) Changes in microRNA expression associated with metastasis and survival in patients with uveal melanoma. Oncotarget 11:1435\u20131447. https:\/\/doi.org\/10.18632\/oncotarget.27559","journal-title":"Oncotarget"},{"key":"1846_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13184594","volume":"13","author":"J Wang","year":"2021","unstructured":"Wang J, Chen Y, Li X, Zou X (2021) Perineural invasion and associated pain transmission in pancreatic cancer. Cancers (Basel) 13:4594. https:\/\/doi.org\/10.3390\/cancers13184594","journal-title":"Cancers (Basel)"},{"key":"1846_CR35","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2388709","volume":"56","author":"Y Wang","year":"2024","unstructured":"Wang Y, Sun X, Lu J, Zhong L, Yang Z (2024) Construction and evaluation of a mortality prediction model for patients with acute kidney injury undergoing continuous renal replacement therapy based on machine learning algorithms. Ann Med 56:2388709. https:\/\/doi.org\/10.1080\/07853890.2024.2388709","journal-title":"Ann Med"},{"key":"1846_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107553","volume":"211","author":"C Xu","year":"2025","unstructured":"Xu C, Wen S, Du X, Zou X, Leung E-H, Zhou G et al (2025) Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy. Pharmacol Res 211:107553. https:\/\/doi.org\/10.1016\/j.phrs.2024.107553","journal-title":"Pharmacol Res"},{"key":"1846_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100997","volume":"8","author":"X Yao","year":"2021","unstructured":"Yao X, Li W, Fang D, Xiao C, Wu X, Li M et al (2021) Emerging roles of energy metabolism in ferroptosis regulation of tumor cells. Adv Sci 8:e2100997. https:\/\/doi.org\/10.1002\/advs.202100997","journal-title":"Adv Sci"},{"key":"1846_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010080","volume":"15","author":"Q Ye","year":"2022","unstructured":"Ye Q, Li Z, Li Y, Li Y, Zhang Y, Gui R et al (2022) Exosome-derived microRNA: implications in melanoma progression, diagnosis and treatment. Cancers (Basel) 15:80. https:\/\/doi.org\/10.3390\/cancers15010080","journal-title":"Cancers (Basel)"},{"key":"1846_CR39","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.bbrc.2019.11.133","volume":"522","author":"B Zhang","year":"2020","unstructured":"Zhang B, Wu H, Hao J, Wu Y, Yang B (2020) Inhibition of DNA-PKcs activity re-sensitizes uveal melanoma cells to radio- and chemotherapy. Biochem Biophys Res Commun 522:639\u2013646. https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.133","journal-title":"Biochem Biophys Res Commun"},{"key":"1846_CR40","doi-asserted-by":"publisher","first-page":"151776","DOI":"10.1016\/j.acthis.2021.151776","volume":"123","author":"D Zhang","year":"2021","unstructured":"Zhang D, Li C, Cheng N, Sun L, Zhou X, Pan G et al (2021a) CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression. Acta Histochem 123:151776. https:\/\/doi.org\/10.1016\/j.acthis.2021.151776","journal-title":"Acta Histochem"},{"key":"1846_CR41","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/med.21734","volume":"41","author":"J Zhang","year":"2021","unstructured":"Zhang J, Duan D, Song Z-L, Liu T, Hou Y, Fang J (2021b) Small molecules regulating reactive oxygen species homeostasis for cancer therapy. Med Res Rev 41:342\u2013394. https:\/\/doi.org\/10.1002\/med.21734","journal-title":"Med Res Rev"},{"key":"1846_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04370-6","volume":"21","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Fan X, Zhang X, Ju S (2023) Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs. J Transl Med 21:514. https:\/\/doi.org\/10.1186\/s12967-023-04370-6","journal-title":"J Transl Med"},{"key":"1846_CR43","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cac2.12250","volume":"42","author":"L Zhao","year":"2022","unstructured":"Zhao L, Zhou X, Xie F, Zhang L, Yan H, Huang J et al (2022) Ferroptosis in cancer and cancer immunotherapy. Cancer Commun 42:88\u2013116. https:\/\/doi.org\/10.1002\/cac2.12250","journal-title":"Cancer Commun"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01846-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01846-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01846-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:12:58Z","timestamp":1773889978000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01846-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1846"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01846-8","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"12 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}