{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:38:31Z","timestamp":1776490711506,"version":"3.51.2"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903001"],"award-info":[{"award-number":["81903001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The talent recruitment initiative of Zhongnan Hospital, Wuhan University","award":["20190101"],"award-info":[{"award-number":["20190101"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01866-4","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:41:15Z","timestamp":1776487275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PSMG3 enhances the proliferation and metastasis of hepatocellular carcinoma via inhibiting HDAC6"],"prefix":"10.1007","volume":"26","author":[{"given":"Shuaihui","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilinigeer","family":"Tayier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunlei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"1866_CR1","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/hep.0000000000001070","volume":"82","author":"K Acu\u00f1a-Pilarte","year":"2025","unstructured":"Acu\u00f1a-Pilarte K, Reichert EC, Green YS, Halberg LM, Golkowski M, Maguire KM, Mimche PN, Kamdem SD, Hu PA, Wright J, Ducker GS, Voth WP, O\u2019Connell RM, McFarland SA, Egal ESA, Chaix A, Summers SA, Reelitz JW, Maschek JA, Cox JE, Evason KJ, Koh MY (2025) HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-\u03baB pathway. Hepatology 82:438\u2013453. https:\/\/doi.org\/10.1097\/hep.0000000000001070","journal-title":"Hepatology"},{"key":"1866_CR2","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1182\/blood-2016-09-687822","volume":"129","author":"R Avellino","year":"2017","unstructured":"Avellino R, Delwel R (2017) Expression and regulation of C\/EBP\u03b1 in normal myelopoiesis and in malignant transformation. Blood 129:2083\u20132091. https:\/\/doi.org\/10.1182\/blood-2016-09-687822","journal-title":"Blood"},{"key":"1866_CR3","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.jhep.2015.03.019","volume":"63","author":"HJ Bae","year":"2015","unstructured":"Bae HJ, Jung KH, Eun JW, Shen Q, Kim HS, Park SJ, Shin WC, Yang HD, Park WS, Lee JY, Nam SW (2015) Microrna-221 governs tumor suppressor HDAC6 to potentiate malignant progression of liver cancer. J Hepatol 63:408\u2013419. https:\/\/doi.org\/10.1016\/j.jhep.2015.03.019","journal-title":"J Hepatol"},{"key":"1866_CR4","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1096\/fj.13-246470","volume":"28","author":"A Balasubramanian","year":"2014","unstructured":"Balasubramanian A, Kawahara G, Gupta VA, Rozkalne A, Beauvais A, Kunkel LM, Gussoni E (2014) Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation. FASEB J 28:2955\u20132969. https:\/\/doi.org\/10.1096\/fj.13-246470","journal-title":"FASEB J"},{"key":"1866_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1146\/annurev-biochem-062917-011931","volume":"87","author":"JAM Bard","year":"2018","unstructured":"Bard JAM, Goodall EA, Greene ER, Jonsson E, Dong KC, Martin A (2018) Structure and function of the 26S proteasome. Annu Rev Biochem 87:697\u2013724. https:\/\/doi.org\/10.1146\/annurev-biochem-062917-011931","journal-title":"Annu Rev Biochem"},{"key":"1866_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1182\/blood.2021013557","volume":"139","author":"L Bullinger","year":"2022","unstructured":"Bullinger L (2022) CEBPA mutations in AML: site matters. Blood 139:6\u20137. https:\/\/doi.org\/10.1182\/blood.2021013557","journal-title":"Blood"},{"key":"1866_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/gutjnl-2024-332902","volume":"74","author":"J Chen","year":"2024","unstructured":"Chen J, Jiang Y, Hou M, Liu C, Liu E, Zong Y, Wang X, Meng Z, Gu M, Su Y, Wang H, Fu J (2024) Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC. Gut 74:128\u2013140. https:\/\/doi.org\/10.1136\/gutjnl-2024-332902","journal-title":"Gut"},{"key":"1866_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03222-5","volume":"43","author":"J Feng","year":"2024","unstructured":"Feng J, Bin JL, Liao XW, Wu Y, Tang Y, Lu PZ, Zhu GZ, Cui QR, Dan YY, Yang GH, Li LX, Deng JH, Peng T, Hooi SC, Zhou J, Lu GD (2024) The prognostic role of ACSL4 in postoperative adjuvant TACE-treated HCC: implications for therapeutic response and mechanistic insights. J Exp Clin Cancer Res 43:306. https:\/\/doi.org\/10.1186\/s13046-024-03222-5","journal-title":"J Exp Clin Cancer Res"},{"key":"1866_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01629-4","volume":"39","author":"J Feng","year":"2020","unstructured":"Feng J, Li J, Wu L, Yu Q, Ji J, Wu J, Dai W, Guo C (2020) Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res 39:126. https:\/\/doi.org\/10.1186\/s13046-020-01629-4","journal-title":"J Exp Clin Cancer Res"},{"key":"1866_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41375-024-02140-x","volume":"38","author":"JA Georgi","year":"2024","unstructured":"Georgi JA, Stasik S, Kramer M, Meggendorfer M, R\u00f6llig C, Haferlach T, Valk P, Linch D, Herold T, Duployez N, Taube F, Middeke JM, Platzbecker U, Serve H, Baldus CD, Muller-Tidow C, Haferlach C, Koch S, Berdel WE, Woermann BJ, Krug U, Braess J, Hiddemann W, Spiekermann K, Boertjes EL, Hills RK, Burnett A, Ehninger G, Metzeler K, Rothenberg-Thurley M, Dufour A, Dombret H, Pautas C, Preudhomme C, Fenwarth L, Bornh\u00e4user M, Gale R, Thiede C (2024) Prognostic impact of CEBPA mutational subgroups in adult AML. Leukemia 38:281\u2013290. https:\/\/doi.org\/10.1038\/s41375-024-02140-x","journal-title":"Leukemia"},{"key":"1866_CR11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cbic.200400313","volume":"6","author":"M Groll","year":"2005","unstructured":"Groll M, Bochtler M, Brandstetter H, Clausen T, Huber R (2005) Molecular machines for protein degradation. Chembiochem 6:222\u2013256. https:\/\/doi.org\/10.1002\/cbic.200400313","journal-title":"Chembiochem"},{"key":"1866_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/cr.2010.183","volume":"21","author":"G He","year":"2011","unstructured":"He G, Karin M (2011) NF-\u03baB and STAT3 - key players in liver inflammation and cancer. Cell Res 21:159\u2013168. https:\/\/doi.org\/10.1038\/cr.2010.183","journal-title":"Cell Res"},{"key":"1866_CR13","doi-asserted-by":"publisher","first-page":"15799","DOI":"10.1038\/s41598-022-20232-5","volume":"12","author":"YD Heryanto","year":"2022","unstructured":"Heryanto YD, Katayama K, Imoto S (2022) Analyzing integrated network of methylation and gene expression profiles in lung squamous cell carcinoma. Sci Rep 12:15799. https:\/\/doi.org\/10.1038\/s41598-022-20232-5","journal-title":"Sci Rep"},{"key":"1866_CR14","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.molcel.2006.11.015","volume":"24","author":"Y Hirano","year":"2006","unstructured":"Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S (2006) Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Mol Cell 24:977\u2013984. https:\/\/doi.org\/10.1016\/j.molcel.2006.11.015","journal-title":"Mol Cell"},{"key":"1866_CR15","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1038\/nature04106","volume":"437","author":"Y Hirano","year":"2005","unstructured":"Hirano Y, Hendil KB, Yashiroda H, Iemura S, Nagane R, Hioki Y, Natsume T, Tanaka K, Murata S (2005) A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature 437:1381\u20131385. https:\/\/doi.org\/10.1038\/nature04106","journal-title":"Nature"},{"key":"1866_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28280-6","volume":"8","author":"H Huang","year":"2018","unstructured":"Huang H, Zheng J, Shen N, Wang G, Zhou G, Fang Y, Lin J, Zhao J (2018) Identification of pathways and genes associated with synovitis in osteoarthritis using bioinformatics analyses. Sci Rep 8:10050. https:\/\/doi.org\/10.1038\/s41598-018-28280-6","journal-title":"Sci Rep"},{"key":"1866_CR17","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.molcel.2007.06.025","volume":"27","author":"B Le Tallec","year":"2007","unstructured":"Le Tallec B, Barrault MB, Courbeyrette R, Gu\u00e9rois R, Marsolier-Kergoat MC, Peyroche A (2007) 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol Cell 27:660\u2013674. https:\/\/doi.org\/10.1016\/j.molcel.2007.06.025","journal-title":"Mol Cell"},{"key":"1866_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","volume":"8","author":"T Luedde","year":"2011","unstructured":"Luedde T, Schwabe RF (2011) NF-\u03baB in the liver\u2013linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 8:108\u2013118. https:\/\/doi.org\/10.1038\/nrgastro.2010.213","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1866_CR19","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1002\/mc.22345","volume":"55","author":"Z Lv","year":"2016","unstructured":"Lv Z, Weng X, Du C, Zhang C, Xiao H, Cai X, Ye S, Cheng J, Ding C, Xie H, Zhou L, Wu J, Zheng S (2016) Downregulation of HDAC6 promotes angiogenesis in hepatocellular carcinoma cells and predicts poor prognosis in liver transplantation patients. Mol Carcinog 55:1024\u20131033. https:\/\/doi.org\/10.1002\/mc.22345","journal-title":"Mol Carcinog"},{"key":"1866_CR20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nrm2630","volume":"10","author":"S Murata","year":"2009","unstructured":"Murata S, Yashiroda H, Tanaka K (2009) Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 10:104\u2013115. https:\/\/doi.org\/10.1038\/nrm2630","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1866_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/hep.27388","volume":"61","author":"B Njei","year":"2015","unstructured":"Njei B, Rotman Y, Ditah I, Lim JK (2015) Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology 61:191\u2013199. https:\/\/doi.org\/10.1002\/hep.27388","journal-title":"Hepatology"},{"key":"1866_CR22","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s12325-008-0113-z","volume":"25","author":"P Roxburgh","year":"2008","unstructured":"Roxburgh P, Evans TR (2008) Systemic therapy of hepatocellular carcinoma: are we making progress? Adv Ther 25:1089\u20131104. https:\/\/doi.org\/10.1007\/s12325-008-0113-z","journal-title":"Adv Ther"},{"key":"1866_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219926","volume":"14","author":"A Sewda","year":"2019","unstructured":"Sewda A, Agopian AJ, Goldmuntz E, Hakonarson H, Morrow BE, Taylor D, Mitchell LE (2019) Gene-based genome-wide association studies and meta-analyses of conotruncal heart defects. PLoS One 14:e0219926. https:\/\/doi.org\/10.1371\/journal.pone.0219926","journal-title":"PLoS One"},{"key":"1866_CR24","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.7150\/thno.99633","volume":"14","author":"Y Su","year":"2024","unstructured":"Su Y, Li Z, Li Q, Guo X, Zhang H, Li Y, Meng Z, Huang S, Hu Z (2024) Oncofetal TRIM71 drives liver cancer carcinogenesis through remodeling CEBPA-mediated serine\/glycine metabolism. Theranostics 14:4948\u20134966. https:\/\/doi.org\/10.7150\/thno.99633","journal-title":"Theranostics"},{"key":"1866_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"1866_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217420","volume":"611","author":"C Wang","year":"2024","unstructured":"Wang C, Dong D, Zhao N, Liu Y, Bai C, Hua J, Cui R, Wei X, Zhao T, Ji N, Yang S, Zhao J, Li H, Li Y (2024) Tumor-derived CCL15 regulates RNA m(6)A methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth. Cancer Lett 611:217420. https:\/\/doi.org\/10.1016\/j.canlet.2024.217420","journal-title":"Cancer Lett"},{"key":"1866_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.7150\/ijms.78590","volume":"20","author":"DTM Xuan","year":"2023","unstructured":"Xuan DTM, Yeh IJ, Su CY, Liu HL, Ta HDK, Anuraga G, Chiao CC, Wang CY, Yen MC (2023) Prognostic and immune infiltration value of proteasome assembly chaperone (PSMG) family genes in lung adenocarcinoma. Int J Med Sci 20:87\u2013101. https:\/\/doi.org\/10.7150\/ijms.78590","journal-title":"Int J Med Sci"},{"key":"1866_CR28","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1002\/hep.30657","volume":"70","author":"HD Yang","year":"2019","unstructured":"Yang HD, Kim HS, Kim SY, Na MJ, Yang G, Eun JW, Wang HJ, Cheong JY, Park WS, Nam SW (2019) HDAC6 suppresses let-7i-5p to elicit TSP1\/CD47-mediated anti-tumorigenesis and phagocytosis of hepatocellular carcinoma. Hepatology 70:1262\u20131279. https:\/\/doi.org\/10.1002\/hep.30657","journal-title":"Hepatology"},{"key":"1866_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nsmb.1386","volume":"15","author":"H Yashiroda","year":"2008","unstructured":"Yashiroda H, Mizushima T, Okamoto K, Kameyama T, Hayashi H, Kishimoto T, Niwa S, Kasahara M, Kurimoto E, Sakata E, Takagi K, Suzuki A, Hirano Y, Murata S, Kato K, Yamane T, Tanaka K (2008) Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat Struct Mol Biol 15:228\u2013236. https:\/\/doi.org\/10.1038\/nsmb.1386","journal-title":"Nat Struct Mol Biol"},{"key":"1866_CR30","doi-asserted-by":"publisher","first-page":"7082","DOI":"10.3892\/ol.2018.9504","volume":"16","author":"Z Yin","year":"2018","unstructured":"Yin Z, Xu W, Xu H, Zheng J, Gu Y (2018) Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt\/\u03b2-catenin signaling pathway in hepatocellular carcinoma. Oncol Lett 16:7082\u20137090. https:\/\/doi.org\/10.3892\/ol.2018.9504","journal-title":"Oncol Lett"},{"key":"1866_CR31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s12094-024-03580-8","volume":"27","author":"M Zheng","year":"2025","unstructured":"Zheng M, Chen X, Xu Z, Ye Z, Zhong L, Chen Z, Chen G, Cai B (2025) Comprehensive analysis of PSMG3 in pan-cancer and validation of its role in hepatocellular carcinoma. Clin Transl Oncol 27:319\u2013332. https:\/\/doi.org\/10.1007\/s12094-024-03580-8","journal-title":"Clin Transl Oncol"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01866-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01866-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01866-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:41:21Z","timestamp":1776487281000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01866-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1866"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01866-4","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"19 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and with all applicable local and national regulations. All animal experiments were conducted in adherence to the procedures approved by the Institutional Animal Care and Use Committee (IACUC) of Zhongnan Hospital of Wuhan University (IACUC approval number: WP20241063). All the liver tissue samples in this study were obtained from Zhongnan Hospital of Wuhan University. Informed consent was obtained from all patients prior to the collection and use of liver tissue samples in this study. This research was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University (ethical approval number: 2020004).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"84"}}