{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:57:26Z","timestamp":1793674646801,"version":"4.5.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01878-0","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:05:56Z","timestamp":1780023956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RBM15 transcription activated by EGR1 stimulates gastric cancer proliferation and metastasis by enhancing m6A modification of RREB1"],"prefix":"10.1007","volume":"26","author":[{"given":"Lu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"issue":"1","key":"1878_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12943-022-01500-4","volume":"21","author":"Y An","year":"2022","unstructured":"An Y, Duan H (2022) The role of m6A RNA methylation in cancer metabolism. Mol Cancer 21(1):14","journal-title":"Mol Cancer"},{"issue":"2","key":"1878_CR36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/sj.cgt.7700896","volume":"13","author":"V Baron","year":"2006","unstructured":"Baron V, Adamson ED, Calogero A, Ragona G, Mercola D (2006) The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther 13(2):115\u2013124","journal-title":"Cancer Gene Ther"},{"key":"1878_CR3","doi-asserted-by":"publisher","first-page":"744839","DOI":"10.3389\/fmed.2021.744839","volume":"8","author":"ZD Chen","year":"2021","unstructured":"Chen ZD, Zhang PF, Xi HQ, Wei B, Chen L, Tang Y (2021) Recent Advances in the Diagnosis, Staging, Treatment, and Prognosis of Advanced Gastric Cancer: A Literature Review. Front Med 8:744839","journal-title":"Front Med"},{"key":"1878_CR41","doi-asserted-by":"publisher","first-page":"1381860","DOI":"10.3389\/fphar.2024.1381860","volume":"15","author":"YN Deng","year":"2024","unstructured":"Deng YN, Chen Y, Gao S, Zhang N, Luo Y, Luo S, Li Q, Fu X, Liang S (2024) RREB1-mediated SUMOylation enhancement promotes chemoresistance partially by transcriptionally upregulating UBC9 in colorectal cancer. Front Pharmacol 15:1381860","journal-title":"Front Pharmacol"},{"issue":"1","key":"1878_CR42","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13046-023-02774-2","volume":"42","author":"Q Dong","year":"2023","unstructured":"Dong Q, Qiu H, Piao C, Li Z, Cui X (2023) LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a\/RREB1 positive feedback loop and a ceRNA network. J experimental Clin cancer research: CR 42(1):209","journal-title":"J experimental Clin cancer research: CR"},{"key":"1878_CR13","doi-asserted-by":"publisher","first-page":"e18761429322420","DOI":"10.2174\/0118761429322420241112051105","volume":"17","author":"S Fatima","year":"2024","unstructured":"Fatima S, Song Y, Zhang Z, Fu Y, Zhao R, Malik K, Zhao L (2024) Exploring the Pharmacological Mechanisms of P-hydroxylcinnamaldehyde for Treating Gastric Cancer: A Pharmacological Perspective with Experimental Confirmation. Curr Mol Pharmacol 17:e18761429322420","journal-title":"Curr Mol Pharmacol"},{"issue":"23","key":"1878_CR22","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1080\/15384101.2021.1987676","volume":"20","author":"Q Gao","year":"2021","unstructured":"Gao Q, Wu Y, Lu C, Kai W, Xie W, Wang Q, Wang L, Liu S, Pan Y (2021) Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer. Cell cycle (Georgetown Tex) 20(23):2465\u20132475","journal-title":"Cell cycle (Georgetown Tex)"},{"issue":"4","key":"1878_CR4","doi-asserted-by":"publisher","first-page":"100817","DOI":"10.1016\/j.bj.2024.100817","volume":"48","author":"JT Hsu","year":"2025","unstructured":"Hsu JT, Lin YN, Chen YF, Kou HW, Wang SY, Chou WC, Wu TR, Yeh TS (2025) A comprehensive overview of gastric cancer management from a surgical point of view. Biomed J 48(4):100817","journal-title":"Biomed J"},{"issue":"20","key":"1878_CR18","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.2217\/fon-2020-0630","volume":"17","author":"JJ Jing","year":"2021","unstructured":"Jing JJ, Zhao X, Li H, Sun LP, Yuan Y (2021) Expression profiles and prognostic roles of m6A writers, erasers and readers in gastric cancer. Future Oncol (London England) 17(20):2605\u20132620","journal-title":"Future Oncol (London England)"},{"issue":"4","key":"1878_CR38","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.7150\/ijbs.90598","volume":"20","author":"Y Jin","year":"2024","unstructured":"Jin Y, Wang C, Zhang B, Sun Y, Ji J, Cai Q, Jiang J, Zhang Z, Zhao L, Yu B et al (2024) Blocking EGR1\/TGF-\u03b21 and CD44s\/STAT3 Crosstalk Inhibits Peritoneal Metastasis of Gastric Cancer. Int J Biol Sci 20(4):1314\u20131331","journal-title":"Int J Biol Sci"},{"issue":"10","key":"1878_CR34","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41419-023-06163-7","volume":"14","author":"R Ji","year":"2023","unstructured":"Ji R, Wu C, Yao J, Xu J, Lin J, Gu H, Fu M, Zhang X, Li Y, Zhang X (2023) IGF2BP2-meidated m(6)A modification of CSF2 reprograms MSC to promote gastric cancer progression. Cell Death Dis 14(10):693","journal-title":"Cell Death Dis"},{"issue":"7","key":"1878_CR40","doi-asserted-by":"publisher","first-page":"e0159899","DOI":"10.1371\/journal.pone.0159899","volume":"11","author":"SH Kim","year":"2016","unstructured":"Kim SH, Park YY, Cho SN, Margalit O, Wang D, DuBois RN (2016) Kr\u00fcppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1. PLoS ONE 11(7):e0159899","journal-title":"PLoS ONE"},{"key":"1878_CR7","doi-asserted-by":"crossref","unstructured":"Kolasseri AE, Tamizhselvi R, Jayanthi S (2025) Decoding the methylome: Insights into the epigenetic regulation of polycystic ovarian syndrome through mitochondrial dna methylation. Curr Genom 26(6):422\u2013433","DOI":"10.2174\/0113892029401274251009070350"},{"key":"1878_CR17","doi-asserted-by":"crossref","unstructured":"Liang T, Ding C, Yang Z, Da M (2025) Clinical significance of RBM15 in gastric cancer: A multi-database validation. Current Medicinal Chemistry 33(6):1212\u20131232","DOI":"10.2174\/0109298673356198250217100226"},{"issue":"5","key":"1878_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41388-024-03220-z","volume":"44","author":"H Li","year":"2025","unstructured":"Li H, Li Y, Zheng X, Chen F, Zhang S, Xu S, Mu Y, Shen W, Tong J, Chen H et al (2025) RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1. Oncogene 44(5):307\u2013321","journal-title":"Oncogene"},{"issue":"1","key":"1878_CR1","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1186\/s12889-024-19104-6","volume":"24","author":"JL Lin","year":"2024","unstructured":"Lin JL, Lin JX, Lin GT, Huang CM, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Li P (2024) Global incidence and mortality trends of gastric cancer and predicted mortality of gastric cancer by 2035. BMC Public Health 24(1):1763","journal-title":"BMC Public Health"},{"issue":"5","key":"1878_CR14","doi-asserted-by":"publisher","first-page":"380","DOI":"10.2174\/0113892029300694240612081006","volume":"25","author":"Q Li","year":"2024","unstructured":"Li Q, Chu Y, Yao Y, Song Q (2024) FAT4 Mutation is Related to Tumor Mutation Burden and Favorable Prognosis in Gastric Cancer. Curr Genom 25(5):380\u2013389","journal-title":"Curr Genom"},{"key":"1878_CR33","doi-asserted-by":"publisher","first-page":"110313","DOI":"10.1016\/j.cellsig.2022.110313","volume":"94","author":"D Liu","year":"2022","unstructured":"Liu D, Xia AD, Wu LP, Li S, Zhang K, Chen D (2022) IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathway. Cell Signal 94:110313","journal-title":"Cell Signal"},{"issue":"11","key":"1878_CR23","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1038\/s41417-022-00482-1","volume":"29","author":"ZL Liu","year":"2022","unstructured":"Liu ZL, Wang SK, Pang L, Meng XW (2022) circXRCC5 foster gastric cancer growth and metastasis by the HNRNPC\/circXRCC5\/miR-655-3p\/RREB1\/UBA2 positive feedback loop. Cancer Gene Ther 29(11):1648\u20131661","journal-title":"Cancer Gene Ther"},{"issue":"1","key":"1878_CR37","doi-asserted-by":"publisher","first-page":"e12922","DOI":"10.1111\/cpr.12922","volume":"54","author":"Z Ma","year":"2021","unstructured":"Ma Z, Gao X, Shuai Y, Wu X, Yan Y, Xing X, Ji J (2021) EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer. Cell Prolif 54(1):e12922","journal-title":"Cell Prolif"},{"key":"1878_CR25","doi-asserted-by":"publisher","first-page":"2333794x1668901","DOI":"10.1177\/2333794X16689011","volume":"4","author":"Y Nakano","year":"2017","unstructured":"Nakano Y, Yamasaki K, Otsuka Y, Ujiro A, Kawakita R, Tamagawa N, Okada K, Fujisaki H, Yorifuji T, Hara J (2017) Acute Myeloid Leukemia With RBM15-MKL1 Presenting as Severe Hepatic Failure. Glob Pediatr Health 4:2333794x16689011","journal-title":"Glob Pediatr Health"},{"issue":"8","key":"1878_CR30","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/cbin.12020","volume":"47","author":"G Nie","year":"2023","unstructured":"Nie G, Tang B, Lv M, Li D, Li T, Ou R, Xu Y, Wen J (2023) HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition. Cell Biol Int 47(8):1327\u20131343","journal-title":"Cell Biol Int"},{"issue":"5","key":"1878_CR12","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2174\/0113892029300608240531111743","volume":"25","author":"Z Peng","year":"2024","unstructured":"Peng Z, Fang C, Tong Z, Rao Q, Ren Z, Hu K (2024) Crosstalk Between Cancer-associated Fibroblasts and Myeloid Cells Shapes the Heterogeneous Microenvironment of Gastric Cancer. Curr Genom 25(5):390\u2013411","journal-title":"Curr Genom"},{"issue":"1","key":"1878_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40364-024-00720-8","volume":"13","author":"N Qin","year":"2025","unstructured":"Qin N, Fan Y, Yang T, Yang Z, Fan D (2025) The burden of Gastric Cancer and possible risk factors from 1990 to 2021, and projections until 2035: findings from the Global Burden of Disease Study 2021. Biomark Res 13(1):5","journal-title":"Biomark Res"},{"issue":"2","key":"1878_CR39","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1158\/0008-5472.CAN-25-0252","volume":"86","author":"ZY Qin","year":"2026","unstructured":"Qin ZY, Che LR, Tian S, Li X, Du XY, Li J, Liu Q, Liu KW, Chu Z, Han M et al (2026) TRIM49 Deficiency Stabilizes a Galectin-3\/EGR1 Transcriptional Complex That Drives Invasiveness of Gastric Adenocarcinoma. Cancer Res 86(2):402\u2013420","journal-title":"Cancer Res"},{"issue":"1","key":"1878_CR8","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12943-024-02148-y","volume":"23","author":"Y Qiu","year":"2024","unstructured":"Qiu Y, Man C, Zhu L, Zhang S, Wang X, Gong D, Fan Y (2024) R-loops\u2019 m6A modification and its roles in cancers. Mol Cancer 23(1):232","journal-title":"Mol Cancer"},{"issue":"8","key":"1878_CR11","doi-asserted-by":"publisher","first-page":"100138","DOI":"10.1016\/j.lddd.2025.100138","volume":"22","author":"M Su","year":"2025","unstructured":"Su M, Chen W, Luo J, Li X, Ye D, Han D, Fu G (2025) METTL14-induced N6-methyladenosine modification on TPX2 mRNA inhibits tumor progression in clear cell renal cell carcinoma. Lett Drug Des Discovery 22(8):100138","journal-title":"Lett Drug Des Discovery"},{"issue":"12","key":"1878_CR6","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s13238-021-00846-7","volume":"13","author":"L Sun","year":"2022","unstructured":"Sun L, Zhang H, Gao P (2022) Metabolic reprogramming and epigenetic modifications on the path to cancer. Protein Cell 13(12):877\u2013919","journal-title":"Protein Cell"},{"key":"1878_CR10","doi-asserted-by":"publisher","first-page":"108613","DOI":"10.1016\/j.biopha.2019.108613","volume":"112","author":"T Sun","year":"2019","unstructured":"Sun T, Wu R, Ming L (2019) The role of m6A RNA methylation in cancer. Biomed pharmacotherapy = Biomedecine pharmacotherapie 112:108613","journal-title":"Biomed pharmacotherapy = Biomedecine pharmacotherapie"},{"issue":"3","key":"1878_CR16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2174\/0109298665350654250111144722","volume":"32","author":"Q Suyila","year":"2025","unstructured":"Suyila Q, Li X, Su X (2025) Anti-Cancer Bioactive Peptide Induces Apoptosis in Gastric Cancer Cells through TP53 Signaling Cascade. Protein Pept Lett 32(3):194\u2013205","journal-title":"Protein Pept Lett"},{"issue":"8","key":"1878_CR5","doi-asserted-by":"publisher","first-page":"100127","DOI":"10.1016\/j.lddd.2025.100127","volume":"22","author":"L Tao","year":"2025","unstructured":"Tao L, Zeng P, Yuan X, Chen M, Ying J, Wei Q, Li J, Yu X, Xu Q (2025) The application of immunoprotein inhibitor treatment regimens based on PD-L1: A retrospective analysis after the progression of advanced gastric cancer. Lett Drug Des Discovery 22(8):100127","journal-title":"Lett Drug Des Discovery"},{"issue":"1","key":"1878_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s41065-025-00530-4","volume":"162","author":"E Tian","year":"2025","unstructured":"Tian E, Gao L, Wu L, Qin L (2025) RBM15 promotes COAD progression by regulating the m6A modification of TMC5. Hereditas 162(1):177","journal-title":"Hereditas"},{"key":"1878_CR19","doi-asserted-by":"publisher","first-page":"642547","DOI":"10.3389\/fonc.2021.642547","volume":"11","author":"B Wang","year":"2021","unstructured":"Wang B, Guo H, Yu H, Chen Y, Xu H, Zhao G (2021) The Role of the Transcription Factor EGR1 in Cancer. Front Oncol 11:642547","journal-title":"Front Oncol"},{"issue":"5","key":"1878_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1615\/CritRevEukaryotGeneExpr.2024052205","volume":"34","author":"R Wang","year":"2024","unstructured":"Wang R, Tan W (2024) RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer. Crit Rev Eukaryot Gene Expr 34(5):15\u201329","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"1","key":"1878_CR32","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12935-022-02452-x","volume":"22","author":"S Wang","year":"2022","unstructured":"Wang S, Lv W, Li T, Zhang S, Wang H, Li X, Wang L, Ma D, Zang Y, Shen J et al (2022) Dynamic regulation and functions of mRNA m6A modification. Cancer Cell Int 22(1):48","journal-title":"Cancer Cell Int"},{"key":"1878_CR29","doi-asserted-by":"publisher","first-page":"936658","DOI":"10.3389\/fgene.2022.936658","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang X, Xu K, Liao X, Rao J, Huang K, Gao J, Xu G, Wang D (2022) Construction of a survival nomogram for gastric cancer based on the cancer genome atlas of m6A-related genes. Front Genet 13:936658","journal-title":"Front Genet"},{"issue":"1","key":"1878_CR21","doi-asserted-by":"publisher","first-page":"e70016","DOI":"10.1002\/mog2.70016","volume":"4","author":"Z Wang","year":"2025","unstructured":"Wang Z, Xie F, Zhou F (2025) RREB1: A Critical Transcription Factor, Integrates TGF-\u03b2 and RAS Signals to Drive Cancer Metastasis via Regulation of Enhancers. MedComm \u2013 Oncol 4(1):e70016","journal-title":"MedComm \u2013 Oncol"},{"issue":"1","key":"1878_CR15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12672-024-00994-2","volume":"15","author":"S Wu","year":"2024","unstructured":"Wu S, Li C, Zhou H, Yang Y, Liang N, Fu Y, Luo Q, Zhan Y (2024) The regulatory mechanism of m6A modification in gastric cancer. Discover Oncol 15(1):283","journal-title":"Discover Oncol"},{"issue":"11","key":"1878_CR27","doi-asserted-by":"publisher","first-page":"e70014","DOI":"10.1002\/jbt.70014","volume":"38","author":"H Zhang","year":"2024","unstructured":"Zhang H, Li Y, Zhou Y, Xu Q, Liao B, Qiu X, Liu J (2024) RNA methylase RBM15 facilitates malignant progression of colorectal cancer through regulating E2F2 in an m6A modification-dependent manner. J Biochem Mol Toxicol 38(11):e70014","journal-title":"J Biochem Mol Toxicol"},{"issue":"5","key":"1878_CR35","doi-asserted-by":"publisher","first-page":"11541","DOI":"10.1080\/21655979.2022.2068920","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Xing Y, Gao W, Yang L, Shi J, Song W, Li T (2022) N(6)-methyladenosine (m(6)A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1. Bioengineered 13(5):11541\u201311550","journal-title":"Bioengineered"},{"issue":"4","key":"1878_CR20","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1440-1827.2010.02512.x","volume":"60","author":"L Zheng","year":"2010","unstructured":"Zheng L, Pu J, Jiang G, Weng M, He J, Mei H, Hou X, Tong Q (2010) Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription. Pathol Int 60(4):268\u2013277","journal-title":"Pathol Int"},{"issue":"5","key":"1878_CR24","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3892\/ol.2021.13036","volume":"22","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Yang J, Tian Z, Zeng J, Shen W (2021) Research progress concerning m(6)A methylation and cancer. Oncol Lett 22(5):775","journal-title":"Oncol Lett"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01878-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01878-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01878-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:06:01Z","timestamp":1780023961000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01878-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1878"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01878-0","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"4 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All human disease tissue research was approved by the Institutional Review Board of the First Affiliated Hospital of Henan University of Medicine [Approval Number: 20230826D], and complied with the Declaration of Helsinki. Written informed consent was obtained from all patients, and all samples were de-identified to protect patient privacy.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Animal studies were performed in compliance with the ARRIVE guidelines and the Basel Declaration. All animals received humane care according to the National Institutes of Health (USA) guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal studies"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"114"}}