{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:58:13Z","timestamp":1781225893015,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573046"],"award-info":[{"award-number":["82573046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01881-5","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:20:09Z","timestamp":1779409209000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The m6A reader IGF2BP3 promotes triple-negative breast cancer metastasis through HOXB9-IL15RA pathway"],"prefix":"10.1007","volume":"26","author":[{"given":"Xinhao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"1881_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/10985549.2025.2560956","author":"K Athanasopoulou","year":"2025","unstructured":"Athanasopoulou K, Adamopoulos PG, Tsiakanikas P, Daneva GN, Prassas I, Yousef GM, Diamandis EP, Scorilas A (2025) Deciphering the m6A epitranscriptomic landscape of mRNAs in breast cancer cells. Mol Cell Biol. https:\/\/doi.org\/10.1080\/10985549.2025.2560956","journal-title":"Mol Cell Biol"},{"issue":"4","key":"1881_CR2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cytogfr.2006.05.001","volume":"17","author":"V Budagian","year":"2006","unstructured":"Budagian V, Bulanova E, Paus R, Bulfone-Paus S (2006) IL-15\/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev 17(4):259\u2013280","journal-title":"Cytokine Growth Factor Rev"},{"issue":"8","key":"1881_CR3","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1080\/15476286.2019.1620060","volume":"16","author":"J Chen","year":"2019","unstructured":"Chen J, Fang X, Zhong P, Song Z, Hu X (2019) N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction. RNA Biol 16(8):991\u20131000","journal-title":"RNA Biol"},{"issue":"8","key":"1881_CR4","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1073\/pnas.1018867108","volume":"109","author":"N Chiba","year":"2012","unstructured":"Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S (2012) Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proc Natl Acad Sci U S A 109(8):2760\u20132765","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"1881_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113299","volume":"12","author":"S Contarelli","year":"2020","unstructured":"Contarelli S, Fedele V, Melisi D (2020) HOX genes family and cancer: a novel role for Homeobox B9 in the resistance to anti-angiogenic therapies. Cancers (Basel) 12(11):3299","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1881_CR6","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.gene.2016.05.009","volume":"590","author":"P Deb","year":"2016","unstructured":"Deb P, Bhan A, Hussain I, Ansari KI, Bobzean SA, Pandita TK, Perrotti LI, Mandal SS (2016) Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo. Gene 590(2):234\u2013243","journal-title":"Gene"},{"key":"1881_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-pathol-042420-093238","volume":"17","author":"F Derakhshan","year":"2022","unstructured":"Derakhshan F, Reis-Filho JS (2022) Pathogenesis of triple-negative breast cancer. Annu Rev Pathol 17:181\u2013204","journal-title":"Annu Rev Pathol"},{"issue":"4","key":"1881_CR8","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.gendis.2020.06.011","volume":"7","author":"X Fang","year":"2020","unstructured":"Fang X, Li M, Yu T, Liu G, Wang J (2020) Reversible N6-methyladenosine of RNA: the regulatory mechanisms on gene expression and implications in physiology and pathology. Genes Dis 7(4):585\u2013597","journal-title":"Genes Dis"},{"key":"1881_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.770428","volume":"11","author":"Y Feng","year":"2021","unstructured":"Feng Y, Zhang T, Wang Y, Xie M, Ji X, Luo X, Huang W, Xia L (2021) Homeobox genes in cancers: from carcinogenesis to recent therapeutic intervention. Front Oncol 11:770428","journal-title":"Front Oncol"},{"issue":"12","key":"1881_CR10","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nrg1723","volume":"6","author":"J Garcia-Fern\u00e0ndez","year":"2005","unstructured":"Garcia-Fern\u00e0ndez J (2005) The genesis and evolution of homeobox gene clusters. Nat Rev Genet 6(12):881\u2013892","journal-title":"Nat Rev Genet"},{"issue":"1","key":"1881_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/wdev.78","volume":"2","author":"PW Holland","year":"2013","unstructured":"Holland PW (2013) Evolution of homeobox genes. Wiley Interdiscip Rev Dev Biol 2(1):31\u201345","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"1","key":"1881_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09857-z","volume":"51","author":"SA Jasim","year":"2024","unstructured":"Jasim SA, Farhan SH, Ahmad I, Hjazi A, Kumar A, Jawad MA, Pramanik A, Altalbawy FMA, Alsaadi SB, Abosaoda MK (2024) Role of homeobox genes in cancer: immune system interactions, long non-coding RNAs, and tumor progression. Mol Biol Rep 51(1):964","journal-title":"Mol Biol Rep"},{"issue":"11","key":"1881_CR13","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200751RR","volume":"36","author":"T Jiang","year":"2022","unstructured":"Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L (2022) RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression. FASEB J 36(11):e22618","journal-title":"FASEB J"},{"issue":"17","key":"1881_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70842","volume":"29","author":"GW Li","year":"2025","unstructured":"Li GW, Jin YP, Sheng MF (2025) The miR-192-EGR1\/HOXB9 loop regulates glioma cell stemness and malignant phenotypes by promoting their mesenchymal transition. J Cell Mol Med 29(17):e70842","journal-title":"J Cell Mol Med"},{"issue":"6","key":"1881_CR15","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.molmed.2023.03.005","volume":"29","author":"Y Liu","year":"2023","unstructured":"Liu Y, Yang D, Liu T, Chen J, Yu J, Yi P (2023) N6-methyladenosine-mediated gene regulation and therapeutic implications. Trends Mol Med 29(6):454\u2013467","journal-title":"Trends Mol Med"},{"issue":"2","key":"1881_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020273","volume":"11","author":"C Mancarella","year":"2021","unstructured":"Mancarella C, Morrione A, Scotlandi K (2021) Novel regulators of the IGF system in cancer. Biomolecules 11(2):273","journal-title":"Biomolecules"},{"issue":"17","key":"1881_CR17","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.1158\/0008-5472.CAN-14-0637","volume":"74","author":"P Marra","year":"2014","unstructured":"Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A (2014) IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res 74(17):4908\u20134921","journal-title":"Cancer Res"},{"issue":"5","key":"1881_CR18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","volume":"15","author":"KD Meyer","year":"2014","unstructured":"Meyer KD, Jaffrey SR (2014) The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol 15(5):313\u2013326","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1881_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.cell.2009.04.030","volume":"138","author":"DX Nguyen","year":"2009","unstructured":"Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagu\u00e9 J (2009) WNT\/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138(1):51\u201362","journal-title":"Cell"},{"issue":"9","key":"1881_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.715","volume":"5","author":"Y Qu","year":"2024","unstructured":"Qu Y, Gao N, Zhang S, Gao L, He B, Wang C, Gong C, Shi Q, Li Z, Yang S, Xiao Y (2024) Role of N6-methyladenosine RNA modification in cancer. MedComm 5(9):e715","journal-title":"MedComm"},{"key":"1881_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2024.102206","volume":"86","author":"RJ Rabelo-Fern\u00e1ndez","year":"2024","unstructured":"Rabelo-Fern\u00e1ndez RJ, Yuen M, Batista PJ (2024) The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing. Curr Opin Genet Dev 86:102206","journal-title":"Curr Opin Genet Dev"},{"issue":"Pt 3","key":"1881_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.semcancer.2022.05.009","volume":"86","author":"D Ramesh-Kumar","year":"2022","unstructured":"Ramesh-Kumar D, Guil S (2022) The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer. Semin Cancer Biol 86(Pt 3):18\u201331","journal-title":"Semin Cancer Biol"},{"issue":"6","key":"1881_CR23","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1245\/s10434-012-2295-5","volume":"19","author":"H Seki","year":"2012","unstructured":"Seki H, Hayashida T, Jinno H, Hirose S, Sakata M, Takahashi M, Maheswaran S, Mukai M, Kitagawa Y (2012) HOXB9 expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients. Ann Surg Oncol 19(6):1831\u20131840","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"1881_CR24","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/s12032-025-03066-9","volume":"42","author":"D Sood","year":"2025","unstructured":"Sood D, Kaur C, Kumar N, Kumar R, Singh G (2025) Triple-negative breast cancer: challenges, advances, and promising therapeutic interventions. Med Oncol 42(11):506","journal-title":"Med Oncol"},{"issue":"7","key":"1881_CR25","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.7150\/ijbs.70458","volume":"18","author":"CY Sun","year":"2022","unstructured":"Sun CY, Cao D, Du BB, Chen CW, Liu D (2022) The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m(6)A readers in cancer. Int J Biol Sci 18(7):2744\u20132758","journal-title":"Int J Biol Sci"},{"issue":"17","key":"1881_CR26","doi-asserted-by":"publisher","first-page":"18114","DOI":"10.1021\/acs.jmedchem.5c01570","volume":"68","author":"H Tang","year":"2025","unstructured":"Tang H, Zhang R, Zhang A (2025) Small-molecule inhibitors targeting RNA m(6)A modifiers for cancer therapeutics: latest advances and future perspectives. J Med Chem 68(17):18114\u201318142","journal-title":"J Med Chem"},{"issue":"22","key":"1881_CR27","doi-asserted-by":"publisher","first-page":"10662","DOI":"10.1093\/nar\/gkw808","volume":"44","author":"J Wan","year":"2016","unstructured":"Wan J, Xu W, Zhan J, Ma J, Li X, Xie Y, Wang J, Zhu WG, Luo J, Zhang H (2016) PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6. Nucleic Acids Res 44(22):10662\u201310675","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"1881_CR28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3724\/abbs.2024153","volume":"57","author":"D Wu","year":"2024","unstructured":"Wu D, Wang Z, Zhang Y, Yang Y, Yang Y, Zu G, Yu X, Chen W, Qin Y, Xu X, Chen X (2024) IL15RA-STAT3-GPX4\/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer. Acta Biochim Biophys Sin (Shanghai) 57(3):389\u2013402","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"1881_CR29","first-page":"1","volume":"35","author":"Z Wu","year":"2024","unstructured":"Wu Z, Smith AR, Qian Z, Zheng G (2024) Patent landscape of small molecule inhibitors of METTL3 (2020-present). Expert Opin Ther Pat 35:1\u201316","journal-title":"Expert Opin Ther Pat"},{"key":"1881_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1666126","volume":"15","author":"DL Xiang","year":"2025","unstructured":"Xiang DL, Yue X (2025) Research progress of molecular typing and targeted therapy for triple-negative breast cancer. Front Oncol 15:1666126","journal-title":"Front Oncol"},{"issue":"1","key":"1881_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08038-5","volume":"16","author":"T Xia","year":"2025","unstructured":"Xia T, Zhao J, Zhang Z, Lu W, Wang Y, Dong X, Sang M, Ju L, Zhang X, Wei J, Ding Q (2025) The deubiquitinase USP9X and E3 ligase WWP1 orchestrate IGF2BP2 ubiquitination homeostasis to drive TNBC progression and cisplatin sensitivity. Cell Death Dis 16(1):703","journal-title":"Cell Death Dis"},{"issue":"1","key":"1881_CR33","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1186\/s12967-024-05771-x","volume":"22","author":"G Zhang","year":"2024","unstructured":"Zhang G, Cheng C, Wang X, Wang S (2024) N6-Methyladenosine methylation modification in breast cancer: current insights. J Transl Med 22(1):971","journal-title":"J Transl Med"},{"issue":"4","key":"1881_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/path.6091","volume":"260","author":"J Zhang","year":"2023","unstructured":"Zhang J, Chen B, Wang Y, Liu X, Yan H, Wong KY, Chan AK, Cheung AH, Chow C, Xu D, Wang S, Huang B, Liang L, Ke H, Wong CC, Wu WK, Cheng AS, Yu J, Lo KW, To KF, Kang W (2023) The E2F1-HOXB9\/PBX2-CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer. J Pathol 260(4):402\u2013416","journal-title":"J Pathol"},{"key":"1881_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-025-01280-8","author":"L Zhang","year":"2025","unstructured":"Zhang L, Wei J, Zou Z, He C (2025) RNA modification systems as therapeutic targets. Nat Rev Drug Discov. https:\/\/doi.org\/10.1038\/s41573-025-01280-8","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"1881_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaf006","volume":"46","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Li Q, Lan J, Xie G, Zhang G, Cui J, Leng P, Wang Y (2025) Triple-negative breast cancer molecular subtypes and potential detection targets for biological therapy indications. Carcinogenesis 46(2):bgaf006","journal-title":"Carcinogenesis"},{"issue":"1","key":"1881_CR36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s40364-021-00295-8","volume":"9","author":"F Zheng","year":"2021","unstructured":"Zheng F, Du F, Zhao J, Wang X, Si Y, Jin P, Qian H, Xu B, Yuan P (2021) The emerging role of RNA N6-methyladenosine methylation in breast cancer. Biomark Res 9(1):39","journal-title":"Biomark Res"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01881-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01881-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01881-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:09:54Z","timestamp":1781222994000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01881-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1881"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01881-5","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent: The use of clinical samples was in line with the principles of the Declaration of Helsinki, and approved by the Ethics Committee of Fourth Military Medical University (Xi\u2019an, China; protocol ID: KY20224226). Registry and the registration No. of the study: All animal study protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of Fourth Military Medical University (Xi\u2019an, China; protocol ID: 20220956).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"107"}}