{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:20:05Z","timestamp":1783480805859,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01912-1","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:09:00Z","timestamp":1783480140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial metabolism\u2013associated biomarkers in oral lichen planus and oral squamous cell carcinoma"],"prefix":"10.1007","volume":"26","author":[{"given":"Qingmei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"issue":"6","key":"1912_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2634-6","volume":"11","author":"E Abu-El-Rub","year":"2020","unstructured":"Abu-El-Rub E, Sareen N, Yan W et al (2020) Hypoxia-induced shift in the phenotype of proteasome from 26S toward immunoproteasome triggers loss of immunoprivilege of mesenchymal stem cells. Cell Death Dis 11(6):419. https:\/\/doi.org\/10.1038\/s41419-020-2634-6","journal-title":"Cell Death Dis"},{"issue":"2","key":"1912_CR2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4103\/0973-029X.185933","volume":"20","author":"R Agarwal","year":"2016","unstructured":"Agarwal R, Chaudhary M, Bohra S, Bajaj S (2016) Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study. J Oral Maxillofac Pathol 20(2):173\u2013177","journal-title":"J Oral Maxillofac Pathol"},{"issue":"1","key":"1912_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-019-0162-0","volume":"24","author":"Y Bao","year":"2019","unstructured":"Bao Y et al (2019) Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer. Cell Mol Biol Lett 24(1):38","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"1912_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2105-12-35","volume":"12","author":"H Chen","year":"2011","unstructured":"Chen H, Boutros PC (2011) VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinforma 12(1):35","journal-title":"BMC Bioinforma"},{"key":"1912_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.922195","volume":"13","author":"Y Chen","year":"2022","unstructured":"Chen Y, Feng Y, Yan F, Zhao Y, Zhao H, Guo Y (2022) A novel immune-related gene signature to identify the tumor microenvironment and prognose disease among patients with oral squamous cell carcinoma patients using ssGSEA: a bioinformatics and biological validation study. Front Immunol 13:922195","journal-title":"Front Immunol"},{"key":"1912_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155833","volume":"132","author":"XJ Ding","year":"2024","unstructured":"Ding XJ et al (2024) Vitexicarpin suppresses malignant progression of colorectal cancer through affecting c-Myc ubiquitination by targeting IMPDH2. Phytomedicine 132:155833. https:\/\/doi.org\/10.1016\/j.phymed.2024.155833","journal-title":"Phytomedicine"},{"issue":"1","key":"1912_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0980-3","volume":"37","author":"S Duan","year":"2018","unstructured":"Duan S et al (2018) IMPDH2 promotes colorectal cancer progression through activation of the PI3K\/AKT\/mTOR and PI3K\/AKT\/FOXO1 signaling pathways. J Exp Clin Cancer Res 37(1):304","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"1912_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.43","volume":"1","author":"Z Gu","year":"2022","unstructured":"Gu Z (2022) Complex heatmap visualization. iMeta 1(3):e43","journal-title":"iMeta"},{"issue":"15","key":"1912_CR9","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","volume":"38","author":"EK Gustavsson","year":"2022","unstructured":"Gustavsson EK, Zhang D, Reynolds RH, Garcia-Ruiz S, Ryten M (2022) ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2. Bioinformatics 38(15):3844\u20133846","journal-title":"Bioinformatics"},{"key":"1912_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59081448","author":"W Huang","year":"2023","unstructured":"Huang W et al (2023) Network pharmacology and molecular docking analysis exploring the mechanism of Tripterygiumwilfordii in the treatment of oral lichen planus. Medicina. https:\/\/doi.org\/10.3390\/medicina59081448","journal-title":"Medicina"},{"key":"1912_CR11","doi-asserted-by":"crossref","unstructured":"John S, Joseph AP, Pillai VBR, Ramani P, Ramalingam K, Pillai VBR Sr (2024) Evaluation of cytotoxic T lymphocytes and natural killer cell distribution in oral squamous cell carcinoma and oral epithelial dysplasia: an immunohistochemical study. Cureus 16(3):e56323","DOI":"10.7759\/cureus.56323"},{"key":"1912_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911695","author":"AA Kobelyatskaya","year":"2022","unstructured":"Kobelyatskaya AA et al (2022) ALDH3A2, ODF2, QSOX2, and MicroRNA-503-5p expression to forecast recurrence in TMPRSS2-ERG-Positive prostate cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms231911695","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1912_CR13","doi-asserted-by":"publisher","first-page":"815","DOI":"10.4103\/ijpm.ijpm_906_21","volume":"66","author":"S Kumar","year":"2023","unstructured":"Kumar S, Chandra A, Agrawal R, Singh P, Pallavi M (2023) Prognostic implications of CD-57 expression in oral squamous cell carcinoma cases. Indian J Pathol Microbiol 66(4):815\u2013818. https:\/\/doi.org\/10.4103\/ijpm.ijpm_906_21","journal-title":"Indian J Pathol Microbiol"},{"issue":"3","key":"1912_CR14","doi-asserted-by":"publisher","first-page":"354","DOI":"10.2174\/1574892818666230602112042","volume":"19","author":"T Lan","year":"2024","unstructured":"Lan T et al (2024) Integrated single-cell and bulk RNA sequencing analysis cross talk between ferroptosis-related genes and prognosis in oral cavity squamous cell carcinoma. Recent Pat Anticancer Drug Discov 19(3):354\u2013372. https:\/\/doi.org\/10.2174\/1574892818666230602112042","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"1912_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1088943","volume":"13","author":"H Li","year":"2022","unstructured":"Li H, Gao L, Du J, Ma T, Ye Z, Li Z (2022) Differentially expressed gene profiles and associated ceRNA network in ATG7-Deficient lens epithelial cells under oxidative stress. Front Genet 13:1088943","journal-title":"Front Genet"},{"key":"1912_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.711020","volume":"11","author":"L Liang","year":"2021","unstructured":"Liang L et al (2021) Integration of scRNA-Seq and bulk RNA-Seq to analyse the heterogeneity of ovarian cancer immune cells and establish a molecular risk model. Front Oncol 11:711020","journal-title":"Front Oncol"},{"key":"1912_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.682002","volume":"9","author":"TT Liu","year":"2021","unstructured":"Liu TT et al (2021) Identification of CDK2-related immune forecast model and ceRNA in lung adenocarcinoma, a pan-cancer analysis. Front Cell Dev Biol 9:682002","journal-title":"Front Cell Dev Biol"},{"issue":"19","key":"1912_CR18","doi-asserted-by":"publisher","first-page":"12769","DOI":"10.18632\/aging.205707","volume":"16","author":"R Liu","year":"2024","unstructured":"Liu R, Wang W, Li W (2024) Bezafibrate mitigates cardiac injury against coronary microembolization by preventing activation of p38 MAPK\/NF-\u03baB signaling. Aging (Albany NY) 16(19):12769","journal-title":"Aging (Albany NY)"},{"issue":"8","key":"1912_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166841","volume":"1869","author":"Y Lu","year":"2023","unstructured":"Lu Y, Fujioka H, Wang W, Zhu X (2023) Bezafibrate confers neuroprotection in the 5xFAD mouse model of Alzheimer\u2019s disease. Biochimica et Biophysica Acta (BBA) 1869(8):166841","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"1912_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1144430","volume":"13","author":"C Meng","year":"2023","unstructured":"Meng C, Sun Y, Liu G (2023) Establishment of a prognostic model for ovarian cancer based on mitochondrial metabolism-related genes. Front Oncol 13:1144430","journal-title":"Front Oncol"},{"key":"1912_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102943","volume":"59","author":"S Missiroli","year":"2020","unstructured":"Missiroli S, Perrone M, Genovese I, Pinton P, Giorgi C (2020) Cancer metabolism and mitochondria: finding novel mechanisms to fight tumours. EBioMedicine 59:102943","journal-title":"EBioMedicine"},{"key":"1912_CR22","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1038\/s41587-024-02480-0","volume":"42","author":"B Nature","year":"2024","unstructured":"Nature B (2024) What will it take to get miRNA therapies to market. Nat Biotechnol 42:1623\u20131624. https:\/\/doi.org\/10.1038\/s41587-024-02480-0","journal-title":"Nat Biotechnol"},{"key":"1912_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.782699","volume":"12","author":"S Nersisyan","year":"2021","unstructured":"Nersisyan S, Novosad V, Engibaryan N, Ushkaryov Y, Nikulin S, Tonevitsky A (2021) ECM\u2013receptor regulatory network and its prognostic role in colorectal cancer. Front Genet 12:782699","journal-title":"Front Genet"},{"issue":"4","key":"1912_CR24","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.3892\/or.2014.2999","volume":"31","author":"J Poljakov\u00e1","year":"2014","unstructured":"Poljakov\u00e1 J, Groh T, Gudino ZO et al (2014) Hypoxia-mediated histone acetylation and expression of N-myc transcription factor dictate aggressiveness of neuroblastoma cells. Oncol Rep 31(4):1928\u20131934. https:\/\/doi.org\/10.3892\/or.2014.2999","journal-title":"Oncol Rep"},{"issue":"7","key":"1912_CR25","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47\u2013e47","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1912_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/ani12010060","volume":"12","author":"LE Robles-Jimenez","year":"2021","unstructured":"Robles-Jimenez LE et al (2021) worldwide traceability of antibiotic residues from livestock in wastewater and soil: a systematic review. Animals 12(1):60","journal-title":"Animals"},{"issue":"11","key":"1912_CR27","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498","journal-title":"Genome Res"},{"issue":"3","key":"1912_CR28","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911589","volume":"12","author":"H Steele","year":"2020","unstructured":"Steele H et al (2020) Metabolic effects of bezafibrate in mitochondrial disease. EMBO Mol Med 12(3):EMMM201911589","journal-title":"EMBO Mol Med"},{"issue":"6","key":"1912_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.14715\/cmb\/2023.69.6.31","volume":"69","author":"J Su","year":"2023","unstructured":"Su J, Zhou W, Yuan H, Wang H, Zhang H (2023) Identification and functional analysis of novel biomarkers in adenoid cystic carcinoma. Cell Mol Biol Paris (Noisy-le-grand) 69(6):203\u2013207. https:\/\/doi.org\/10.14715\/cmb\/2023.69.6.31","journal-title":"Cell Mol Biol Paris (Noisy-le-grand)"},{"issue":"43","key":"1912_CR30","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceed Natl Acad Sci 102(43):15545\u201315550","journal-title":"Proceed Natl Acad Sci"},{"key":"1912_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155637","volume":"263","author":"V Vijayarangam","year":"2024","unstructured":"Vijayarangam V et al (2024) Ferroptosis as a hero against oral cancer. Pathol Res Pract 263:155637. https:\/\/doi.org\/10.1016\/j.prp.2024.155637","journal-title":"Pathol Res Pract"},{"issue":"1","key":"1912_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/ptr.6825","volume":"35","author":"W Wang","year":"2021","unstructured":"Wang W et al (2021) Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer. Phytother Res 35(1):463\u2013476. https:\/\/doi.org\/10.1002\/ptr.6825","journal-title":"Phytother Res"},{"key":"1912_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2023.107846","volume":"104","author":"XM Wang","year":"2023","unstructured":"Wang XM, Chen G, Dang YW, Li J, Li P, Li ZY (2023) A comprehensive investigation regarding the clinical significance of ITGB4 in oral squamous cell carcinoma combining immunohistochemistry, RNA-seq, and microarray data. Comput Biol Chem 104:107846. https:\/\/doi.org\/10.1016\/j.compbiolchem.2023.107846","journal-title":"Comput Biol Chem"},{"issue":"1","key":"1912_CR34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s13058-025-02135-1","volume":"27","author":"D Wang","year":"2025","unstructured":"Wang D, Luo S, Yu R, Wen D, Jiang H, Xu K, Di X, Zhang S (2025) ALDH3A2 targets arachidonic acid to promote cell metastasis in TNBC via AMPK\/m-TOR signaling pathway. Breast Cancer Res 27(1):217. https:\/\/doi.org\/10.1186\/s13058-025-02135-1","journal-title":"Breast Cancer Res"},{"issue":"5","key":"1912_CR35","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3892\/ol.2020.12082","volume":"20","author":"H Xu","year":"2020","unstructured":"Xu H, Ma H, Zha L, Li Q, Yang G, Pan H, Fei X, Xu X, Xing C, Zhang L (2020) IMPDH2 promotes cell proliferation and epithelial-mesenchymal transition of non-small cell lung cancer by activating the Wnt\/\u03b2-catenin signaling pathway. Oncol Lett 20(5):219. https:\/\/doi.org\/10.3892\/ol.2020.12082","journal-title":"Oncol Lett"},{"issue":"1","key":"1912_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1938890","volume":"10","author":"Z Yang","year":"2021","unstructured":"Yang Z et al (2021) YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration. Oncoimmunology 10(1):1938890","journal-title":"Oncoimmunology"},{"issue":"1","key":"1912_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02936-w","volume":"23","author":"S Yao","year":"2023","unstructured":"Yao S et al (2023) CD79A work as a potential target for the prognosis of patients with OSCC: Analysis of immune cell infiltration in oral squamous cell carcinoma based on the CIBERSORTx deconvolution algorithm. BMC Oral Health 23(1):411","journal-title":"BMC Oral Health"},{"key":"1912_CR38","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-1-0716-0301-7_11","volume":"2117","author":"G Yu","year":"2020","unstructured":"Yu G (2020) Gene ontology semantic similarity analysis using GOSemSim. Methods Mol Biol 2117:207\u2013215. https:\/\/doi.org\/10.1007\/978-1-0716-0301-7_11","journal-title":"Methods Mol Biol"},{"issue":"5","key":"1912_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. Omics: J Integr Biol 16(5):284\u2013287","journal-title":"Omics: J Integr Biol"},{"issue":"1","key":"1912_CR40","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/1471-2105-14-244","volume":"14","author":"H Zhang","year":"2013","unstructured":"Zhang H, Meltzer P, Davis S (2013) RCircos: an R package for Circos 2D track plots. BMC Bioinform 14(1):244","journal-title":"BMC Bioinform"},{"key":"1912_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.106597","volume":"154","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Zhu H, Wang X, Lin S, Ruan C, Wang Q (2023) A novel basement membrane-related gene signature for prognosis of lung adenocarcinomas. Comput Biol Med 154:106597. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.106597","journal-title":"Comput Biol Med"},{"issue":"6","key":"1912_CR42","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.7150\/jca.92489","volume":"15","author":"J Zheng","year":"2024","unstructured":"Zheng J, Chen K, Cai L, Pan Y, Zeng Y (2024) A potential biomarker for the early diagnosis of OSCC: saliva and serum PrPC. J Cancer 15(6):1593","journal-title":"J Cancer"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01912-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01912-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01912-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:09:09Z","timestamp":1783480149000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01912-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1912"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01912-1","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted with approval from the Ethics Committee of Fujian Medical University Union Hospital (No. 2025\u201391). This study was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"180"}}