{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:56:58Z","timestamp":1781074618321,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01927-8","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:59:40Z","timestamp":1781071180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent fasting synergizes with GCN5 inhibition to suppress RBM5-AS1\/GCN5\/PGC-1\u03b1\u2013driven Warburg metabolism in ovarian cancer"],"prefix":"10.1007","volume":"26","author":[{"given":"Gayathiri","family":"Gunasangkaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saradhadevi","family":"Muthukrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"R.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiva","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali K.","family":"Ravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Anand","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Arockianathan","family":"Pushpam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"23","key":"1927_CR2","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.3390\/cancers16234095","volume":"16","author":"S Chouhan","year":"2024","unstructured":"Chouhan S, Kumar A, Muhammad N, Usmani D, Khan TH (2024) Sirtuins as key regulators in pancreatic cancer: insights into signaling mechanisms and therapeutic implications. Cancers 16(23):4095","journal-title":"Cancers"},{"issue":"2","key":"1927_CR1","doi-asserted-by":"publisher","first-page":"100569","DOI":"10.1016\/j.phyplu.2024.100569","volume":"4","author":"AR Cinthamony","year":"2024","unstructured":"Cinthamony AR, Palanirajan A, Raju MV, Chandrasekaran MK, Ahalliya RM, Dugganaboyana G, Kanniappan GV (2024) Biochemical and Histoarchitectural evaluation of 4-Vinylcyclohexane induced ovarian cancer against Alpinia purpurata (Vieill). K. Schum. Phytomedicine Plus 4(2):100569","journal-title":"Phytomedicine Plus"},{"issue":"8","key":"1927_CR3","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/j.immuni.2024.05.021","volume":"57","author":"RB Delconte","year":"2024","unstructured":"Delconte RB, Owyong M, Santosa EK, Srpan K, Sheppard S, McGuire TJ, Sun JC (2024) Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity. Immunity 57(8):1923\u20131938","journal-title":"Immunity"},{"issue":"1","key":"1927_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12986-024-00866-0","volume":"21","author":"K Fang","year":"2024","unstructured":"Fang K, Xu H, Yuan S, Li X, Chen X, Fan X, Zhu X (2024) LncRNA mediated metabolic reprogramming: The chief culprits of solid tumor malignant progression: An update review. Nutr Metabolism 21(1):89","journal-title":"Nutr Metabolism"},{"issue":"1","key":"1927_CR5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s11033-025-10800-z","volume":"52","author":"G Gunasangkaran","year":"2025","unstructured":"Gunasangkaran G, Muthukrishnan S, Ravi AK, Arumugam VA, Shanmugam V, Sakthivel KM, Kaliyaperumal A (2025) Targeting the lncRNA RBM5-AS1\/GCN5 axis under fasting conditions reprograms Glycolysis and induces apoptosis in ovarian cancer cells. Mol Biol Rep 52(1):691","journal-title":"Mol Biol Rep"},{"issue":"14","key":"1927_CR6","doi-asserted-by":"publisher","first-page":"4890","DOI":"10.18632\/aging.102082","volume":"11","author":"T Guo","year":"2019","unstructured":"Guo T, Li B, Gu C, Chen X, Han M, Liu X, Xu C (2019) GCN-5\/PGC-1\u03b1 signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer. Aging 11(14):4890\u20134899","journal-title":"Aging"},{"issue":"1","key":"1927_CR7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12957-025-03770-w","volume":"23","author":"X Huo","year":"2025","unstructured":"Huo X, Tian T, Zhang X, Zhou N (2025) Comparative effectiveness and safety of treatment regimens for recurrent advanced ovarian cancer: a systematic review and network meta-analysis. World J Surg Oncol 23(1):134","journal-title":"World J Surg Oncol"},{"issue":"4","key":"1927_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10616-025-00809-4","volume":"77","author":"R Kumar","year":"2025","unstructured":"Kumar R, Muthukrishnan S, Rathinavel A, Rajendran K, Gunasangkaran G, Ravi AK, Packiaraj G (2025) Chitosan-encapsulated Gloriosa superba nanoparticles suppress cervical cancer by inhibiting SKA3-mediated PI3K\/AKT\/mTOR pathway. Cytotechnology 77(4):143","journal-title":"Cytotechnology"},{"issue":"6","key":"1927_CR9","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.cmet.2006.04.013","volume":"3","author":"C Lerin","year":"2006","unstructured":"Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P (2006) GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1\u03b1. Cell Metabol 3(6):429\u2013438","journal-title":"Cell Metabol"},{"issue":"4","key":"1927_CR10","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/s42255-024-01011-0","volume":"6","author":"X Liu","year":"2024","unstructured":"Liu X, Li S, Cui Q, Guo B, Ding W, Liu J, Xiao RP (2024) Activation of GPR81 by lactate drives tumour-induced cachexia. Nat Metabolism 6(4):708\u2013723","journal-title":"Nat Metabolism"},{"issue":"1","key":"1927_CR11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1186\/s12885-025-13806-9","volume":"25","author":"X Liu","year":"2025","unstructured":"Liu X, Meng Q, Fan W, Ning L, Ge L (2025) The effects of intermittent fasting on anthropometric indices, glycemic profile, chemotherapy-related toxicity, and subjective perception in gynecological and breast cancer patients: a systematic review and meta-analysis. BMC Cancer 25(1):419","journal-title":"BMC Cancer"},{"issue":"3","key":"1927_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2021.10382","volume":"22","author":"J Ma","year":"2021","unstructured":"Ma J, Cheng Y, Su Q, Ai W, Gong L, Wang Y, Chen K (2021) Effects of intermittent fasting on liver physiology and metabolism in mice. Experimental therapeutic Med 22(3):1\u201310","journal-title":"Experimental therapeutic Med"},{"issue":"1","key":"1927_CR13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/cancers11010033","volume":"11","author":"Y Ma","year":"2018","unstructured":"Ma Y, Wang W, Idowu MO, Oh U, Wang XY, Temkin SM, Fang X (2018) Ovarian cancer relies on glucose transporter 1 to fuel glycolysis and growth: anti-tumor activity of BAY-876. Cancers 11(1):33","journal-title":"Cancers"},{"key":"1927_CR14","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1007\/s12668-024-01532-8","volume":"14","author":"S Muthukrishnan","year":"2024","unstructured":"Muthukrishnan S, Gunasangkaran G, Ravi AK, Amirthalakshmi SR, Gandhi D, Arumugam VA, Muthukrishnan A (2024) Molecular mechanism of novel PAMAM dendrimer decorated Tectona grandis and Lactobacillus plantarum nanoparticles on Autophagy-Induced apoptosis in TNBC cells. BioNanoScience 14:2940\u20132963","journal-title":"BioNanoScience"},{"issue":"1","key":"1927_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40170-024-00354-2","volume":"12","author":"AO Ogunleye","year":"2024","unstructured":"Ogunleye AO, Gayen N, Rauth S, Marimuthu S, Nimmakayala RK, Alsafwani ZW, Ponnusamy MP (2024) PAF1\/HIF1\u03b1 axis rewires the glycolytic metabolism to fuel aggressiveness of pancreatic cancer. Cancer Metabolism 12(1):26","journal-title":"Cancer Metabolism"},{"issue":"10","key":"1927_CR16","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.3390\/ijms26104821","volume":"26","author":"M Perez-Medina","year":"2025","unstructured":"Perez-Medina M, Benito-Lopez JJ, Aguilar-Cazares D, Lopez-Gonzalez JS (2025) A comprehensive review of long non-coding RNAs in the cancer\u2013immunity cycle: mechanisms and therapeutic implications. Int J Mol Sci 26(10):4821","journal-title":"Int J Mol Sci"},{"key":"1927_CR17","doi-asserted-by":"publisher","first-page":"1041010","DOI":"10.3389\/fimmu.2022.1041010","volume":"13","author":"V Plackoska","year":"2022","unstructured":"Plackoska V, Shaban D, Nijnik A (2022) Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression. Front Immunol 13:1041010","journal-title":"Front Immunol"},{"issue":"3","key":"1927_CR18","doi-asserted-by":"publisher","first-page":"100708","DOI":"10.1016\/j.senol.2025.100708","volume":"38","author":"AK Ravi","year":"2025","unstructured":"Ravi AK, Muthukrishnan S, Abirami S, Gunasangkaran G, Arumugam VA, Shanmugam V, Kaliyaperumal A (2025a) Synergistic effects of vitamin D3 and 5-aza-2\u2032-deoxycytidine on VDR methylation and breast cancer progression. Revista de Senolog\u00eda y Patolog\u00eda Mamaria 38(3):100708","journal-title":"Revista de Senolog\u00eda y Patolog\u00eda Mamaria"},{"issue":"1","key":"1927_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s12032-025-03141-1","volume":"43","author":"AK Ravi","year":"2025","unstructured":"Ravi AK, Muthukrishnan S, Gunasangkaran G, Pushpam MA, Arumugam VA, Sakthivel KM (2025b) Long non-coding RNA Nkx2-2as\/BTG2 axis attenuates breast cancer progression by targeting Wnt\/\u03b2-catenin signaling. Med Oncol 43(1):12","journal-title":"Med Oncol"},{"issue":"7","key":"1927_CR20","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.7150\/thno.104858","volume":"15","author":"C Sun","year":"2025","unstructured":"Sun C, Li X, Teng Q, Liu X, Song L, Schi\u00f6th HB, Kong B (2025) Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation. Theranostics 15(7):3055\u20133075","journal-title":"Theranostics"},{"issue":"2","key":"1927_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S2221-6189(13)60117-1","volume":"2","author":"S Thangarajan","year":"2013","unstructured":"Thangarajan S, Perumal S, Chinthamony AR, Paramasivam R, Balasubramanian V, Martin S, Gopalakrishnan VK (2013) Chemomodulatory effects of Ichnocarpus frutescens R. Br against 4-vinylcyclohexane induced ovarian cancer in swiss albino mice. J Acute Disease 2(2):151\u2013155","journal-title":"J Acute Disease"},{"key":"1927_CR22","doi-asserted-by":"crossref","unstructured":"Udumula MP, Singh H, Rashid F, Poisson L, Tiwari N, Dimitrova I, Rattan R (2023) Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response. Iscience 26(10):107839","DOI":"10.1016\/j.isci.2023.107839"},{"issue":"2","key":"1927_CR23","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.3390\/ijms24021723","volume":"24","author":"C Vidoni","year":"2023","unstructured":"Vidoni C, Ferraresi A, Vallino L, Salwa A, Ha JH, Seca C, Isidoro C (2023) Glycolysis inhibition of autophagy drives malignancy in ovarian cancer: exacerbation by IL-6 and attenuation by resveratrol. Int J Mol Sci 24(2):1723","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1927_CR24","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12885-018-4271-3","volume":"18","author":"F Wang","year":"2018","unstructured":"Wang F, Liu H, Hu L, Liu Y, Duan Y, Cui R, Tian W (2018) The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells. BMC Cancer 18(1):360","journal-title":"BMC Cancer"},{"issue":"1","key":"1927_CR25","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12943-024-01967-3","volume":"23","author":"L Wang","year":"2024","unstructured":"Wang L, Wang X, Zhu X, Zhong L, Jiang Q, Wang Y, Zou D (2024) Drug resistance in ovarian cancer: from mechanism to clinical trial. Mol Cancer 23(1):66","journal-title":"Mol Cancer"},{"issue":"1","key":"1927_CR26","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1186\/s40001-025-03133-x","volume":"30","author":"S Wang","year":"2025","unstructured":"Wang S, Xie N, Zha P, Li Y, Wei M, Bai J, Zhao X (2025) EMSY enhances glycolysis in ovarian cancer cells. Eur J Med Res 30(1):890","journal-title":"Eur J Med Res"},{"issue":"4","key":"1927_CR27","doi-asserted-by":"publisher","first-page":"101041","DOI":"10.1016\/j.gendis.2023.06.013","volume":"11","author":"Y Wei","year":"2024","unstructured":"Wei Y, Zhang D, Shi H, Qian H, Chen H, Zeng Q, Chen T (2024) PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1\u03b1. Genes Dis 11(4):101041","journal-title":"Genes Dis"},{"issue":"11","key":"1927_CR28","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3390\/biom14111437","volume":"14","author":"Y Xie","year":"2024","unstructured":"Xie Y, Ye H, Liu Z, Liang Z, Zhu J, Zhang R, Li Y (2024) Fasting as an adjuvant therapy for cancer: mechanism of action and clinical practice. Biomolecules 14(11):1437","journal-title":"Biomolecules"},{"issue":"1","key":"1927_CR29","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12902-025-01952-x","volume":"25","author":"S Zhang","year":"2025","unstructured":"Zhang S, Sun B, Sun L, Zou S, Chen Q (2025) Effect of intermittent fasting on obesity and metabolic indices in patients with metabolic syndrome: a systematic review and meta analysis. BMC Endocr Disorders 25(1):130","journal-title":"BMC Endocr Disorders"},{"issue":"4","key":"1927_CR30","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/cr.2007.11","volume":"17","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Ba Y, Liu C, Sun G, Ding L, Gao S, Zhang CY (2007) PGC-1\u03b1 induces apoptosis in human epithelial ovarian cancer cells through a PPAR\u03b3-dependent pathway. Cell Res 17(4):363\u2013373","journal-title":"Cell Res"},{"issue":"2","key":"1927_CR31","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/hep.31280","volume":"73","author":"Q Zuo","year":"2021","unstructured":"Zuo Q, He J, Zhang S, Wang H, Jin G, Jin H, Qin W (2021) PPAR\u03b3 coactivator-1\u03b1 suppresses metastasis of hepatocellular carcinoma by inhibiting Warburg effect by PPAR\u03b3\u2013dependent WNT\/\u03b2\u2010catenin\/pyruvate dehydrogenase kinase isozyme 1 Axis. Hepatology 73(2):644\u2013660","journal-title":"Hepatology"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01927-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01927-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01927-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:59:42Z","timestamp":1781071182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01927-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1927"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01927-8","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"9 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for the study was obtained from the Institutional Animal Ethics Committee (IAEC), Bharathiar University (Approval No: BU\/BT\/IAEC\/2025\/1\u20131; dated 20.02.2025).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"131"}}