{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:47:31Z","timestamp":1782269251092,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500972"],"award-info":[{"award-number":["82500972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01931-y","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:39:17Z","timestamp":1782268757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["USP37 facilitates hepatocellular carcinoma progression by deubiquitinating RAF1 and activating ERK1\/2 signaling"],"prefix":"10.1007","volume":"26","author":[{"given":"Yuming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruidong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"issue":"10127","key":"1931_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","volume":"391","author":"A Forner","year":"2018","unstructured":"Forner A, Reig M, Bruix J (2018) Hepatocellular carcinoma. Lancet 391(10127):1301\u20131314. https:\/\/doi.org\/10.1016\/S0140-6736(18)30010-2","journal-title":"Lancet"},{"key":"1931_CR2","doi-asserted-by":"publisher","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics. CA: Cancer J Clin. 2023;73(1):17\u201348. https:\/\/doi.org\/10.3322\/caac.21763","DOI":"10.3322\/caac.21763"},{"key":"1931_CR3","doi-asserted-by":"publisher","unstructured":"Piechotta V, Jakob T, Langer P et al (2019) Multiple drug combinations of bortezomib, lenalidomide, and thalidomide for first-line treatment in adults with transplant-ineligible multiple myeloma: a network meta-analysis. Cochrane Database Syst Rev 2019(11). https:\/\/doi.org\/10.1002\/14651858.CD013487","DOI":"10.1002\/14651858.CD013487"},{"issue":"11","key":"1931_CR4","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.jtho.2023.07.006","volume":"18","author":"JM Lee","year":"2023","unstructured":"Lee JM, McNamee CJ, Toloza E et al (2023) Neoadjuvant Targeted Therapy in Resectable NSCLC: Current and Future Perspectives. J Thorac Oncol 18(11):1458\u20131477. https:\/\/doi.org\/10.1016\/j.jtho.2023.07.006","journal-title":"J Thorac Oncol"},{"issue":"16","key":"1931_CR5","doi-asserted-by":"publisher","first-page":"eaax4826","DOI":"10.1126\/sciadv.aax4826","volume":"6","author":"HL Bi","year":"2020","unstructured":"Bi HL, Zhang XL, Zhang YL et al (2020) The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. Sci Adv 6(16):eaax4826. https:\/\/doi.org\/10.1126\/sciadv.aax4826","journal-title":"Sci Adv"},{"key":"1931_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1146\/annurev.biochem.78.082307.091526","volume":"78","author":"FE Reyes-Turcu","year":"2009","unstructured":"Reyes-Turcu FE, Ventii KH, Wilkinson KD (2009) Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem 78:363\u2013397. https:\/\/doi.org\/10.1146\/annurev.biochem.78.082307.091526","journal-title":"Annu Rev Biochem"},{"issue":"4","key":"1931_CR7","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.molcel.2011.03.027","volume":"42","author":"X Huang","year":"2011","unstructured":"Huang X, Summers MK, Pham V et al (2011) Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Mol Cell 42(4):511\u2013523. https:\/\/doi.org\/10.1016\/j.molcel.2011.03.027","journal-title":"Mol Cell"},{"issue":"19","key":"1931_CR8","doi-asserted-by":"publisher","first-page":"11224","DOI":"10.1093\/nar\/gkab842","volume":"49","author":"C Wu","year":"2021","unstructured":"Wu C, Chang Y, Chen J et al (2021) USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM. Nucleic Acids Res 49(19):11224\u201311240. https:\/\/doi.org\/10.1093\/nar\/gkab842","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"1931_CR9","doi-asserted-by":"publisher","first-page":"6919","DOI":"10.1093\/nar\/gkv613","volume":"43","author":"D Typas","year":"2015","unstructured":"Typas D, Luijsterburg MS, Wiegant WW et al (2015) The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80. Nucleic Acids Res 43(14):6919\u20136933. https:\/\/doi.org\/10.1093\/nar\/gkv613","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"1931_CR10","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.1038\/onc.2012.537","volume":"32","author":"WC Yang","year":"2013","unstructured":"Yang WC, Shih HM (2013) The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF\/RARA stability. Oncogene 32(43):5167\u20135175. https:\/\/doi.org\/10.1038\/onc.2012.537","journal-title":"Oncogene"},{"issue":"1","key":"1931_CR11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13046-018-0934-9","volume":"37","author":"T Qin","year":"2018","unstructured":"Qin T, Li B, Feng X et al (2018) Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity. J Exp Clin Cancer Res 37(1):287. https:\/\/doi.org\/10.1186\/s13046-018-0934-9","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"1931_CR12","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12967-023-04126-2","volume":"21","author":"R Chauhan","year":"2023","unstructured":"Chauhan R, Gupta A, Malhotra L et al (2023) Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression. J Translational Med 21(1):286. https:\/\/doi.org\/10.1186\/s12967-023-04126-2","journal-title":"J Translational Med"},{"issue":"6","key":"1931_CR13","first-page":"2323","volume":"13","author":"D Tong","year":"2023","unstructured":"Tong D, Yuan J, Wang Z, Yu E (2023) USP37 promotes angiogenesis and metastasis in colorectal cancer by facilitating \u03b2-catenin stability. Am J Cancer Res 13(6):2323\u20132341","journal-title":"Am J Cancer Res"},{"key":"1931_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","volume":"86","author":"I Dikic","year":"2017","unstructured":"Dikic I (2017) Proteasomal and Autophagic Degradation Systems. Annu Rev Biochem 86:193\u2013224. https:\/\/doi.org\/10.1146\/annurev-biochem-061516-044908","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"1931_CR15","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.jhep.2021.09.007","volume":"76","author":"F Foerster","year":"2022","unstructured":"Foerster F, Gairing SJ, Muller L, Galle PR (2022) NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options. J Hepatol 76(2):446\u2013457. https:\/\/doi.org\/10.1016\/j.jhep.2021.09.007","journal-title":"J Hepatol"},{"key":"1931_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/bs.acr.2020.10.002","volume":"149","author":"T Garcia-Lezana","year":"2021","unstructured":"Garcia-Lezana T, Lopez-Canovas JL, Villanueva A (2021) Signaling pathways in hepatocellular carcinoma. Adv Cancer Res 149:63\u2013101. https:\/\/doi.org\/10.1016\/bs.acr.2020.10.002","journal-title":"Adv Cancer Res"},{"issue":"5","key":"1931_CR17","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1111\/cas.15613","volume":"114","author":"J Cao","year":"2023","unstructured":"Cao J, Wang X, Wang S, Chen Z, Tang J (2023) Stabilization of estrogen receptor alpha by USP37 contributes to the progression of breast cancer. Cancer Sci 114(5):2041\u20132052. https:\/\/doi.org\/10.1111\/cas.15613","journal-title":"Cancer Sci"},{"issue":"2","key":"1931_CR18","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4143\/crt.2021.622","volume":"54","author":"MS Kim","year":"2022","unstructured":"Kim MS, Kim SH, Yang SH, Kim MS (2022) miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37. Cancer Res Treat 54(2):445\u2013457. https:\/\/doi.org\/10.4143\/crt.2021.622","journal-title":"Cancer Res Treat"},{"issue":"2","key":"1931_CR19","doi-asserted-by":"publisher","first-page":"700","DOI":"10.7150\/thno.47800","volume":"11","author":"L Wu","year":"2021","unstructured":"Wu L, Zhao N, Zhou Z et al (2021) PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1. Theranostics 11(2):700\u2013714. https:\/\/doi.org\/10.7150\/thno.47800","journal-title":"Theranostics"},{"issue":"23","key":"1931_CR20","doi-asserted-by":"publisher","first-page":"13023","DOI":"10.1073\/pnas.2002567117","volume":"117","author":"K Hong","year":"2020","unstructured":"Hong K, Hu L, Liu X et al (2020) USP37 promotes deubiquitination of HIF2alpha in kidney cancer. Proc Natl Acad Sci U S A 117(23):13023\u201313032. https:\/\/doi.org\/10.1073\/pnas.2002567117","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1931_CR21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.molcel.2004.11.055","volume":"17","author":"MK Dougherty","year":"2005","unstructured":"Dougherty MK, Muller J, Ritt DA et al (2005) Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell 17(2):215\u2013224. https:\/\/doi.org\/10.1016\/j.molcel.2004.11.055","journal-title":"Mol Cell"},{"key":"1931_CR22","doi-asserted-by":"publisher","unstructured":"McTavish CJ, Berube-Janzen W, Wang X et al (2019) Regulation of c-Raf stability through the CTLH complex. Int J Mol Sci 20(4). https:\/\/doi.org\/10.3390\/ijms20040934","DOI":"10.3390\/ijms20040934"},{"key":"1931_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11658-019-0193-6","volume":"25","author":"Q Fan","year":"2020","unstructured":"Fan Q, Wang Q, Cai R, Yuan H, Xu M (2020) The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer. Cell Mol Biol Lett 25:1. https:\/\/doi.org\/10.1186\/s11658-019-0193-6","journal-title":"Cell Mol Biol Lett"},{"issue":"8","key":"1931_CR24","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/s41419-022-05136-6","volume":"13","author":"HB Park","year":"2022","unstructured":"Park HB, Hwang S, Baek KH (2022) USP7 regulates the ERK1\/2 signaling pathway through deubiquitinating Raf-1 in lung adenocarcinoma. Cell Death Dis 13(8):698. https:\/\/doi.org\/10.1038\/s41419-022-05136-6","journal-title":"Cell Death Dis"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01931-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01931-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01931-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:39:18Z","timestamp":1782268758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01931-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1931"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01931-y","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All studies involving human participants were carried out in compliance with the Declaration of Helsinki and received approval from the Ethics Committee of Fudan University Shanghai Cancer Center. Written informed consent was provided by every participant. Animal experiments conformed to the guidelines of the SLAC Guide for the Care and Use of Laboratory Animals and were authorized by the Institutional Animal Care and Use Committee. The study protocol was also reviewed and approved by the Ethics Committee of FUSCC.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"159"}}