{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:23:20Z","timestamp":1791818600690,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"a research startup funds from the First Affiliated Hospital of Wenzhou Medical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01946-5","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:46:37Z","timestamp":1783129597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-omics integration identifies macrophage senescence driven by the RUNX1-P53 axis as a key mechanism in diabetic foot ulcer"],"prefix":"10.1007","volume":"26","author":[{"given":"Jin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"1946_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1053\/j.semvascsurg.2019.02.001","volume":"31","author":"DF Bandyk","year":"2018","unstructured":"Bandyk DF (2018) The diabetic foot: Pathophysiology, evaluation, and treatment. Semin Vasc Surg 31:43\u201348. https:\/\/doi.org\/10.1053\/j.semvascsurg.2019.02.001","journal-title":"Semin Vasc Surg"},{"key":"1946_CR2","doi-asserted-by":"crossref","unstructured":"Pena G, Armstrong DG, Mills JL, Fitridge R (2020) Pathophysiology and Principles of Management of the Diabetic Foot. In Mechanisms of Vascular Disease: A Textbook for Vascular Specialists. Edited by Fitridge R. Cham: Springer International Publishing; : 563\u2013591","DOI":"10.1007\/978-3-030-43683-4_26"},{"key":"1946_CR3","doi-asserted-by":"publisher","first-page":"10279","DOI":"10.3390\/app122010279","volume":"12","author":"\u00c1 Astasio-Picado","year":"2022","unstructured":"Astasio-Picado \u00c1, Toledano VG, L\u00f3pez-S\u00e1nchez M, Jurado-Palomo J, Cobos-Moreno P, G\u00f3mez-Mart\u00edn B (2022) Management of the Diabetic Foot in People with Diabetes Mellitus Older than 65 Years. Appl Sci 12:10279","journal-title":"Appl Sci"},{"key":"1946_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jcot.2021.01.017","volume":"17","author":"M Edmonds","year":"2021","unstructured":"Edmonds M, Manu C, Vas P (2021) The current burden of diabetic foot disease. J Clin Orthop Trauma 17:88\u201393. https:\/\/doi.org\/10.1016\/j.jcot.2021.01.017","journal-title":"J Clin Orthop Trauma"},{"key":"1946_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1001\/jama.293.2.217","volume":"293","author":"N Singh","year":"2005","unstructured":"Singh N, Armstrong DG, Lipsky BA (2005) Preventing foot ulcers in patients with diabetes. JAMA 293:217\u2013228. https:\/\/doi.org\/10.1001\/jama.293.2.217","journal-title":"JAMA"},{"key":"1946_CR6","doi-asserted-by":"publisher","first-page":"e3651","DOI":"10.1002\/dmrr.3651","volume":"40","author":"SA Bus","year":"2024","unstructured":"Bus SA, Sacco ICN, Monteiro-Soares M, Raspovic A, Paton J, Rasmussen A, Lavery LA, van Netten JJ (2024) Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev 40:e3651. https:\/\/doi.org\/10.1002\/dmrr.3651","journal-title":"Diabetes Metab Res Rev"},{"key":"1946_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12964-024-01663-1","volume":"22","author":"Y Li","year":"2024","unstructured":"Li Y, Tian X, Luo J, Bao T, Wang S, Wu X (2024) Molecular mechanisms of aging and anti-aging strategies. Cell Commun Signal 22:285. https:\/\/doi.org\/10.1186\/s12964-024-01663-1","journal-title":"Cell Commun Signal"},{"key":"1946_CR8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","volume":"8","author":"Z Liu","year":"2023","unstructured":"Liu Z, Liang Q, Ren Y, Guo C, Ge X, Wang L, Cheng Q, Luo P, Zhang Y, Han X (2023) Immunosenescence: molecular mechanisms and diseases. Signal Transduct Target Ther 8:200. https:\/\/doi.org\/10.1038\/s41392-023-01451-2","journal-title":"Signal Transduct Target Ther"},{"key":"1946_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.exger.2017.10.024","volume":"105","author":"G Pawelec","year":"2018","unstructured":"Pawelec G (2018) Age and immunity: What is immunosenescence? Exp Gerontol 105:4\u20139. https:\/\/doi.org\/10.1016\/j.exger.2017.10.024","journal-title":"Exp Gerontol"},{"key":"1946_CR10","doi-asserted-by":"crossref","unstructured":"Lloberas J, Tur J, Vico T, Celada A (2019) Molecular and Cellular Aspects of Macrophage Aging. In Handbook of Immunosenescence: Basic Understanding and Clinical Implications. Edited by Fulop T, Franceschi C, Hirokawa K, Pawelec G. Cham: Springer International Publishing; : 1631\u20131663","DOI":"10.1007\/978-3-319-99375-1_46"},{"key":"1946_CR11","doi-asserted-by":"publisher","first-page":"114073","DOI":"10.1016\/j.celrep.2024.114073","volume":"43","author":"CE Moss","year":"2024","unstructured":"Moss CE, Johnston SA, Kimble JV, Clements M, Codd V, Hamby S, Goodall AH, Deshmukh S, Sudbery I, Coca D et al (2024) Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Rep 43:114073. https:\/\/doi.org\/10.1016\/j.celrep.2024.114073","journal-title":"Cell Rep"},{"key":"1946_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40842-025-00261-5","volume":"11","author":"NA Supardy","year":"2025","unstructured":"Supardy NA, Kumar RRS (2025) Aging, biofilms, and diabetic foot ulcers: disrupting chronic infections with super-oxidized solutions and addressing age-related vulnerabilities. Cardiovasc Diabetol Endocrinol Rep 11:45. https:\/\/doi.org\/10.1186\/s40842-025-00261-5","journal-title":"Cardiovasc Diabetol Endocrinol Rep"},{"key":"1946_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41368-021-00116-6","volume":"13","author":"Q Wang","year":"2021","unstructured":"Wang Q, Nie L, Zhao P, Zhou X, Ding Y, Chen Q, Wang Q (2021) Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging. Int J Oral Sci 13:11. https:\/\/doi.org\/10.1038\/s41368-021-00116-6","journal-title":"Int J Oral Sci"},{"key":"1946_CR14","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.jdiacomp.2018.01.015","volume":"32","author":"S Basu Mallik","year":"2018","unstructured":"Basu Mallik S, Jayashree BS, Shenoy RR (2018) Epigenetic modulation of macrophage polarization- perspectives in diabetic wounds. J Diabetes Complications 32:524\u2013530. https:\/\/doi.org\/10.1016\/j.jdiacomp.2018.01.015","journal-title":"J Diabetes Complications"},{"key":"1946_CR15","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s43587-023-00455-5","volume":"3","author":"DB Rosoff","year":"2023","unstructured":"Rosoff DB, Mavromatis LA, Bell AS, Wagner J, Jung J, Marioni RE, Davey Smith G, Horvath S, Lohoff FW (2023) Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging. Nat Aging 3:1020\u20131035. https:\/\/doi.org\/10.1038\/s43587-023-00455-5","journal-title":"Nat Aging"},{"key":"1946_CR16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13059-021-02398-9","volume":"22","author":"DL McCartney","year":"2021","unstructured":"McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, Broer L, Guo X, Jeong A, Jung J et al (2021) Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol 22:194. https:\/\/doi.org\/10.1186\/s13059-021-02398-9","journal-title":"Genome Biol"},{"key":"1946_CR17","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1007\/s11357-025-01568-y","volume":"47","author":"SP Wyles","year":"2025","unstructured":"Wyles SP, Yu GT, Ganier C, Tchkonia T, Lynch MD, Kuchel GA, Kirkland JL (2025) SenSkin: a human skin-specific cellular senescence gene set. Geroscience 47:2631\u20132638. https:\/\/doi.org\/10.1007\/s11357-025-01568-y","journal-title":"Geroscience"},{"key":"1946_CR18","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","volume":"13","author":"D Saul","year":"2022","unstructured":"Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y et al (2022) A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun 13:4827. https:\/\/doi.org\/10.1038\/s41467-022-32552-1","journal-title":"Nat Commun"},{"key":"1946_CR19","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1038\/s41588-022-01167-z","volume":"54","author":"MJ Zhang","year":"2022","unstructured":"Zhang MJ, Hou K, Dey KK, Sakaue S, Jagadeesh KA, Weinand K, Taychameekiatchai A, Rao P, Pisco AO, Zou J et al (2022) Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data. Nat Genet 54:1572\u20131580. https:\/\/doi.org\/10.1038\/s41588-022-01167-z","journal-title":"Nat Genet"},{"key":"1946_CR20","doi-asserted-by":"publisher","first-page":"1181016","DOI":"10.3389\/fimmu.2023.1181016","volume":"14","author":"X Guo","year":"2023","unstructured":"Guo X, Khosraviani N, Raju S, Singh J, Farahani NZ, Abramian M, Torres VJ, Howe KL, Fish JE, Kapus A, Lee WL (2023) Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles. Front Immunol 14:1181016. https:\/\/doi.org\/10.3389\/fimmu.2023.1181016","journal-title":"Front Immunol"},{"key":"1946_CR21","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1038\/s41467-024-49545-x","volume":"15","author":"AA Raslan","year":"2024","unstructured":"Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N et al (2024) Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nat Commun 15:5449. https:\/\/doi.org\/10.1038\/s41467-024-49545-x","journal-title":"Nat Commun"},{"key":"1946_CR22","doi-asserted-by":"publisher","unstructured":"Liu Z, Bian X, Luo L, Bjorklund AK, Li L, Zhang L, Chen Y, Guo L, Gao J, Cao C et al Spatiotemporal single-cell roadmap of human skin wound healing. Cell Stem Cell 2025, 32:479\u2013498e478 https:\/\/doi.org\/10.1016\/j.stem.2024.11.013","DOI":"10.1016\/j.stem.2024.11.013"},{"key":"1946_CR23","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10522-024-10092-z","volume":"25","author":"B Diwan","year":"2024","unstructured":"Diwan B, Yadav R, Goyal R, Sharma R (2024) Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome. Biogerontology 25:627\u2013647. https:\/\/doi.org\/10.1007\/s10522-024-10092-z","journal-title":"Biogerontology"},{"key":"1946_CR24","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1074\/jbc.M112.402594","volume":"288","author":"D Wu","year":"2013","unstructured":"Wu D, Ozaki T, Yoshihara Y, Kubo N, Nakagawara A (2013) Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation. J Biol Chem 288:1353\u20131364. https:\/\/doi.org\/10.1074\/jbc.M112.402594","journal-title":"J Biol Chem"},{"key":"1946_CR25","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.2337\/diabetes.48.10.2074","volume":"48","author":"BF Liu","year":"1999","unstructured":"Liu BF, Miyata S, Kojima H, Uriuhara A, Kusunoki H, Suzuki K, Kasuga M (1999) Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products. Diabetes 48:2074\u20132082. https:\/\/doi.org\/10.2337\/diabetes.48.10.2074","journal-title":"Diabetes"},{"key":"1946_CR26","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s12276-021-00561-7","volume":"53","author":"W Rungratanawanich","year":"2021","unstructured":"Rungratanawanich W, Qu Y, Wang X, Essa MM, Song BJ (2021) Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury. Exp Mol Med 53:168\u2013188. https:\/\/doi.org\/10.1038\/s12276-021-00561-7","journal-title":"Exp Mol Med"},{"key":"1946_CR27","doi-asserted-by":"publisher","unstructured":"Hesketh M, Sahin KB, West ZE, Murray RZ (2017) Macrophage phenotypes regulate scar formation and chronic wound healing. Int J Mol Sci 18. https:\/\/doi.org\/10.3390\/ijms18071545","DOI":"10.3390\/ijms18071545"},{"key":"1946_CR28","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cyto.2011.06.016","volume":"56","author":"R Mirza","year":"2011","unstructured":"Mirza R, Koh TJ (2011) Dysregulation of monocyte\/macrophage phenotype in wounds of diabetic mice. Cytokine 56:256\u2013264. https:\/\/doi.org\/10.1016\/j.cyto.2011.06.016","journal-title":"Cytokine"},{"key":"1946_CR29","doi-asserted-by":"publisher","first-page":"e9539","DOI":"10.1371\/journal.pone.0009539","volume":"5","author":"S Khanna","year":"2010","unstructured":"Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S (2010) Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS ONE 5:e9539. https:\/\/doi.org\/10.1371\/journal.pone.0009539","journal-title":"PLoS ONE"},{"key":"1946_CR30","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.2337\/db12-1450","volume":"62","author":"RE Mirza","year":"2013","unstructured":"Mirza RE, Fang MM, Ennis WJ, Koh TJ (2013) Blocking interleukin-1beta induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes 62:2579\u20132587. https:\/\/doi.org\/10.2337\/db12-1450","journal-title":"Diabetes"},{"key":"1946_CR31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1524-475X.2012.00772.x","volume":"20","author":"M Miao","year":"2012","unstructured":"Miao M, Niu Y, Xie T, Yuan B, Qing C, Lu S (2012) Diabetes-impaired wound healing and altered macrophage activation: a possible pathophysiologic correlation. Wound Repair Regen 20:203\u2013213. https:\/\/doi.org\/10.1111\/j.1524-475X.2012.00772.x","journal-title":"Wound Repair Regen"},{"key":"1946_CR32","doi-asserted-by":"publisher","first-page":"e2122607","DOI":"10.1001\/jamanetworkopen.2021.22607","volume":"4","author":"YY Huang","year":"2021","unstructured":"Huang YY, Lin CW, Cheng NC, Cazzell SM, Chen HH, Huang KF, Tung KY, Huang HL, Lin PY, Perng CK et al (2021) Effect of a Novel Macrophage-Regulating Drug on Wound Healing in Patients With Diabetic Foot Ulcers: A Randomized Clinical Trial. JAMA Netw Open 4:e2122607. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.22607","journal-title":"JAMA Netw Open"},{"key":"1946_CR33","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s10565-022-09748-8","volume":"39","author":"K Geng","year":"2023","unstructured":"Geng K, Ma X, Jiang Z, Gu J, Huang W, Wang W, Xu Y, Xu Y (2023) WDR74 facilitates TGF-beta\/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice. Cell Biol Toxicol 39:1577\u20131591. https:\/\/doi.org\/10.1007\/s10565-022-09748-8","journal-title":"Cell Biol Toxicol"},{"key":"1946_CR34","doi-asserted-by":"publisher","first-page":"155828","DOI":"10.1016\/j.cyto.2022.155828","volume":"153","author":"K Matsushima","year":"2022","unstructured":"Matsushima K, Yang D, Oppenheim JJ (2022) Interleukin-8: An evolving chemokine. Cytokine 153:155828. https:\/\/doi.org\/10.1016\/j.cyto.2022.155828","journal-title":"Cytokine"},{"key":"1946_CR35","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s11033-022-07144-3","volume":"49","author":"V Rai","year":"2022","unstructured":"Rai V, Moellmer R, Agrawal DK (2022) The role of CXCL8 in chronic nonhealing diabetic foot ulcers and phenotypic changes in fibroblasts: a molecular perspective. Mol Biol Rep 49:1565\u20131572. https:\/\/doi.org\/10.1007\/s11033-022-07144-3","journal-title":"Mol Biol Rep"},{"key":"1946_CR36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.7150\/ijbs.78046","volume":"19","author":"S Yang","year":"2023","unstructured":"Yang S, Wang S, Chen L, Wang Z, Chen J, Ni Q, Guo X, Zhang L, Xue G (2023) Neutrophil Extracellular Traps Delay Diabetic Wound Healing by Inducing Endothelial-to-Mesenchymal Transition via the Hippo pathway. Int J Biol Sci 19:347\u2013361. https:\/\/doi.org\/10.7150\/ijbs.78046","journal-title":"Int J Biol Sci"},{"key":"1946_CR37","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10456-007-9084-y","volume":"10","author":"L Xu","year":"2007","unstructured":"Xu L, Ashkenazi A, Chaudhuri A (2007) Duffy antigen\/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis 10:307\u2013318. https:\/\/doi.org\/10.1007\/s10456-007-9084-y","journal-title":"Angiogenesis"},{"key":"1946_CR38","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1042\/BST0341005","volume":"34","author":"M Pruenster","year":"2006","unstructured":"Pruenster M, Rot A (2006) Throwing light on DARC. Biochem Soc Trans 34:1005\u20131008. https:\/\/doi.org\/10.1042\/BST0341005","journal-title":"Biochem Soc Trans"},{"key":"1946_CR39","doi-asserted-by":"publisher","first-page":"188715","DOI":"10.1016\/j.bbcan.2022.188715","volume":"1877","author":"TC Lin","year":"2022","unstructured":"Lin TC (2022) RUNX1 and cancer. Biochim Biophys Acta Rev Cancer 1877:188715. https:\/\/doi.org\/10.1016\/j.bbcan.2022.188715","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"1946_CR40","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/14728222.2021.1915991","volume":"25","author":"F Gonzales","year":"2021","unstructured":"Gonzales F, Barthelemy A, Peyrouze P, Fenwarth L, Preudhomme C, Duployez N, Cheok MH (2021) Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications. Expert Opin Ther Targets 25:299\u2013309. https:\/\/doi.org\/10.1080\/14728222.2021.1915991","journal-title":"Expert Opin Ther Targets"},{"key":"1946_CR41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.14348\/molcells.2019.0295","volume":"43","author":"Y Na","year":"2020","unstructured":"Na Y, Huang G, Wu J (2020) The Role of RUNX1 in NF1-Related Tumors and Blood Disorders. Mol Cells 43:153\u2013159. https:\/\/doi.org\/10.14348\/molcells.2019.0295","journal-title":"Mol Cells"},{"key":"1946_CR42","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1038\/onc.2009.101","volume":"28","author":"K Wolyniec","year":"2009","unstructured":"Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, Stocking C, Cameron E, Neil JC (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene 28:2502\u20132512. https:\/\/doi.org\/10.1038\/onc.2009.101","journal-title":"Oncogene"},{"key":"1946_CR43","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.molimm.2015.08.012","volume":"68","author":"WF Wong","year":"2015","unstructured":"Wong WF, Kohu K, Nagashima T, Funayama R, Matsumoto M, Movahed E, Tan GM, Yeow TC, Looi CY, Kurokawa M et al (2015) The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4(+) T lymphocytes. Mol Immunol 68:223\u2013233. https:\/\/doi.org\/10.1016\/j.molimm.2015.08.012","journal-title":"Mol Immunol"},{"key":"1946_CR44","doi-asserted-by":"publisher","first-page":"7867","DOI":"10.1111\/jcmm.16704","volume":"25","author":"D Zhang","year":"2021","unstructured":"Zhang D, Liang C, Li P, Yang L, Hao Z, Kong L, Tian X, Guo C, Dong J, Zhang Y, Du B (2021) Runt-related transcription factor 1 (Runx1) aggravates pathological cardiac hypertrophy by promoting p53 expression. J Cell Mol Med 25:7867\u20137877. https:\/\/doi.org\/10.1111\/jcmm.16704","journal-title":"J Cell Mol Med"},{"key":"1946_CR45","doi-asserted-by":"publisher","unstructured":"Nagasaka M, Miyajima C, Aoki H, Aoyama M, Morishita D, Inoue Y, Hayashi H (2022) Insights into Regulators of p53 Acetylation. Cells 11. https:\/\/doi.org\/10.3390\/cells11233825","DOI":"10.3390\/cells11233825"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01946-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01946-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01946-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:46:44Z","timestamp":1783129604000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01946-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1946"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01946-5","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]},"assertion":[{"value":"2 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}}],"article-number":"174"}}