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UKB has approval from the North West Multi-center Research Ethics Committee (MREC) as a Research Tissue Bank (RTB) approval. This approval means that separate ethical approval is waived and that researchers can operate under the RTB approval. All participants enrolled in the cohorts investigated in the present study provided written informed consent in accordance with their approved protocols. All research conformed to the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"194"}}