{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:02:57Z","timestamp":1785528177052,"version":"3.56.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Key Scientific Research Project of Higher Education of Henan","award":["25A360005"],"award-info":[{"award-number":["25A360005"]}]},{"name":"the Sixth Batch of National Outstanding Clinical Talents in Traditional Chinese Medicine Training Program by the State Administration of Traditional Chinese Medicine","award":["SATCM Document on Personnel and Education No. 256 [2025]"],"award-info":[{"award-number":["SATCM Document on Personnel and Education No. 256 [2025]"]}]},{"name":"Henan Clinical Medical Scientist Program","award":["no. HNCMS202436"],"award-info":[{"award-number":["no. HNCMS202436"]}]},{"name":"the Henan Science and Technology Research and Development Plan Joint Fund","award":["no. 242301420094"],"award-info":[{"award-number":["no. 242301420094"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["grant nos. 81973618 and 81503422"],"award-info":[{"award-number":["grant nos. 81973618 and 81503422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Henan Provincial Special Research Project on Traditional Chinese Medicine","award":["2022JDZX090"],"award-info":[{"award-number":["2022JDZX090"]}]},{"name":"the Natural Science Foundation of Henan","award":["202300410399"],"award-info":[{"award-number":["202300410399"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01991-0","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:01:21Z","timestamp":1785290481000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders"],"prefix":"10.1007","volume":"26","author":[{"given":"Qingpan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"7","key":"1991_CR27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41580-025-00837-0","volume":"26","author":"Y Bai","year":"2025","unstructured":"Bai Y, Pan Y, Liu X (2025) Mechanistic insights into gasdermin-mediated pyroptosis. Nat Rev Mol Cell Biol 26(7):501\u2013521","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"1991_CR30","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","volume":"11","author":"BE Burdette","year":"2021","unstructured":"Burdette BE, Esparza AN, Zhu H, Wang S (2021) Gasdermin D in pyroptosis. Acta Pharm Sinica B 11(9):2768\u20132782","journal-title":"Acta Pharm Sinica B"},{"key":"1991_CR22","doi-asserted-by":"publisher","first-page":"114842","DOI":"10.1016\/j.expneurol.2024.114842","volume":"379","author":"Y Chen","year":"2024","unstructured":"Chen Y, Wei G, Feng X, Lei E, Zhang L (2024) Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat. Exp Neurol 379:114842","journal-title":"Exp Neurol"},{"key":"1991_CR48","doi-asserted-by":"publisher","first-page":"107602","DOI":"10.1016\/j.ntt.2026.107602","volume":"115","author":"B Cheng","year":"2026","unstructured":"Cheng B, He Q, Ge D, Ma S, Luo Y, Wang J (2026) Electroacupuncture mitigates cognitive impairment caused by anesthesia and surgery in aged rats by inhibiting the p38 MAPK signaling pathway. Neurotoxicol Teratol 115:107602","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"1991_CR36","doi-asserted-by":"publisher","first-page":"tfae100","DOI":"10.1093\/toxres\/tfae100","volume":"13","author":"J Ding","year":"2024","unstructured":"Ding J, Zhang K, Wang D, Wang Q (2024) Sevoflurane augments neuroinflammation by regulating DUSP6 via YTHDF1 in postoperative cognitive dysfunction. Toxicol Res 13(4):tfae100","journal-title":"Toxicol Res"},{"issue":"4","key":"1991_CR31","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s13105-022-00909-1","volume":"78","author":"Y Feng","year":"2022","unstructured":"Feng Y, Li M, Yangzhong X, Zhang X, Zu A, Hou Y, Li L, Sun S (2022) Pyroptosis in inflammation-related respiratory disease. J Physiol Biochem 78(4):721\u2013737","journal-title":"J Physiol Biochem"},{"key":"1991_CR47","doi-asserted-by":"publisher","first-page":"1798915","DOI":"10.3389\/fnagi.2026.1798915","volume":"18","author":"B Han","year":"2026","unstructured":"Han B, Jin F, Zhong Y, Teng J (2026) Esketamine ameliorates postoperative cognitive dysfunction aggravated by preoperative acute sleep deprivation in aged mice via the TLR4\/NF-kappaB pathway. Front Aging Neurosci 18:1798915","journal-title":"Front Aging Neurosci"},{"key":"1991_CR32","doi-asserted-by":"crossref","unstructured":"Hao W, Feng C (2023) Research progress on pyroptosis and its effect on the central nervous system. Neurobiol Dis 106333","DOI":"10.1016\/j.nbd.2023.106333"},{"issue":"1","key":"1991_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10863-026-10107-z","volume":"58","author":"L Huang","year":"2026","unstructured":"Huang L, Zheng C, He C, Qiu X, Wei H, Yan J, Cui K, Yang W, Yao L, Wei Y et al (2026) USF1 transcriptionally activates TRIM55 to promote diabetic cardiomyopathy progression by enhancing HSPB1 protein degradation. J Bioenerg Biomembr 58(1):7","journal-title":"J Bioenerg Biomembr"},{"key":"1991_CR35","doi-asserted-by":"publisher","first-page":"107500","DOI":"10.1016\/j.ntt.2025.107500","volume":"110","author":"W Jiang","year":"2025","unstructured":"Jiang W, Fan X, Wu H, Song J, Yang C, Zhao Z (2025) TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy via SYK in BV2 cells. Neurotoxicol Teratol 110:107500","journal-title":"Neurotoxicol Teratol"},{"key":"1991_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.bbrc.2023.01.055","volume":"646","author":"C Kim","year":"2023","unstructured":"Kim C, Wang XD, Jang S, Yu Y (2023) PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage. Biochem Biophys Res Commun 646:78\u201385","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"1991_CR44","doi-asserted-by":"publisher","first-page":"98","DOI":"10.31083\/ph.2017.6788","volume":"72","author":"P Li","year":"2017","unstructured":"Li P, Wang H, Hou M, Li D, Bai H (2017) Upstream stimulating factor1 (USF1) enhances the proliferation of glioblastoma stem cells mainly by activating the transcription of mucin13 (MUC13). Pharmazie 72(2):98\u2013102","journal-title":"Pharmazie"},{"key":"1991_CR9","doi-asserted-by":"publisher","first-page":"110791","DOI":"10.1016\/j.exger.2019.110791","volume":"130","author":"X Lin","year":"2020","unstructured":"Lin X, Chen Y, Zhang P, Chen G, Zhou Y, Yu X (2020) The potential mechanism of postoperative cognitive dysfunction in older people. Exp Gerontol 130:110791","journal-title":"Exp Gerontol"},{"issue":"5","key":"1991_CR17","doi-asserted-by":"publisher","first-page":"167137","DOI":"10.1016\/j.bbadis.2024.167137","volume":"1870","author":"QC Lin","year":"2024","unstructured":"Lin QC, Wang J, Wang XL, Pan C, Jin SW, Char S, Tao YX, Cao H, Li J (2024) Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90\/HSP70 in aged mice. Biochim et Biophys acta Mol basis disease 1870(5):167137","journal-title":"Biochim et Biophys acta Mol basis disease"},{"key":"1991_CR4","doi-asserted-by":"publisher","first-page":"111776","DOI":"10.1016\/j.brainresbull.2026.111776","volume":"237","author":"X Lin","year":"2026","unstructured":"Lin X, Luo Y, Zhu Q (2026) Postoperative cognitive dysfunction and neurodegeneration: From inflammation to precision medicine. Brain Res Bull 237:111776","journal-title":"Brain Res Bull"},{"key":"1991_CR7","doi-asserted-by":"publisher","first-page":"102012","DOI":"10.1016\/j.tice.2022.102012","volume":"81","author":"J Lu","year":"2023","unstructured":"Lu J, Liu Z, Zhao Y, Liu X, He W, Zhang L (2023) FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1alpha\/BDNF\/FNDC5 pathway. Tissue Cell 81:102012","journal-title":"Tissue Cell"},{"issue":"9\u201310","key":"1991_CR15","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s10495-025-02160-7","volume":"30","author":"H Ma","year":"2025","unstructured":"Ma H, Zhu Y, Zhao X, Jiang L, Yang J, Yang T, Liu W (2025) Pyroptosis: inflammatory cell death mechanism and its pathological roles in neurological diseases and injuries. Apoptosis: Int J Program cell death 30(9\u201310):2057\u20132076","journal-title":"Apoptosis: Int J Program cell death"},{"key":"1991_CR28","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.2147\/JIR.S291453","volume":"14","author":"AA Mamun","year":"2021","unstructured":"Mamun AA, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J (2021) Role of Pyroptosis in Diabetes and Its Therapeutic Implications. J Inflamm Res 14:2187\u20132206","journal-title":"J Inflamm Res"},{"issue":"7","key":"1991_CR33","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","volume":"28","author":"D Moujalled","year":"2021","unstructured":"Moujalled D, Strasser A, Liddell JR (2021) Molecular mechanisms of cell death in neurological diseases. Cell Death Differ 28(7):2029\u20132044","journal-title":"Cell Death Differ"},{"key":"1991_CR34","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.bbi.2024.02.001","volume":"117","author":"A Oladapo","year":"2024","unstructured":"Oladapo A, Jackson T, Menolascino J, Periyasamy P (2024) Role of pyroptosis in the pathogenesis of various neurological diseases. Brain Behav Immun 117:428\u2013446","journal-title":"Brain Behav Immun"},{"issue":"10","key":"1991_CR20","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.3390\/cells9102286","volume":"9","author":"E Paldino","year":"2020","unstructured":"Paldino E, D\u2019Angelo V, Laurenti D, Angeloni C, Sancesario G, Fusco FR (2020) Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6\/2 Mouse Model of Huntington\u2019s Disease. Cells 9(10):2286","journal-title":"Cells"},{"issue":"10","key":"1991_CR11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2174\/1566524023666221118140523","volume":"23","author":"W Peng","year":"2023","unstructured":"Peng W, Lu W, Jiang X, Xiong C, Chai H, Cai L, Lan Z (2023) Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update. Curr Mol Med 23(10):1077\u20131086","journal-title":"Curr Mol Med"},{"issue":"3","key":"1991_CR46","doi-asserted-by":"publisher","first-page":"232","DOI":"10.2174\/1567202617666200513085403","volume":"17","author":"J Qin","year":"2020","unstructured":"Qin J, Ma Q, Ma D (2020) Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K\/AKT Pathway. Curr Neurovasc Res 17(3):232\u2013240","journal-title":"Curr Neurovasc Res"},{"issue":"12","key":"1991_CR25","doi-asserted-by":"publisher","first-page":"100286","DOI":"10.1016\/j.lddd.2026.100286","volume":"22","author":"P Sahu","year":"2025","unstructured":"Sahu P, Satapathy A, Satapathy A, Satapathy T (2025) Single-cell multi-omics for biomarker discovery: Technologies, molecular mechanisms, applications and translational challenges. Lett Drug Des Discovery 22(12):100286","journal-title":"Lett Drug Des Discovery"},{"issue":"2","key":"1991_CR38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12017-019-08578-y","volume":"22","author":"W Su","year":"2020","unstructured":"Su W, Xie M, Li Y, Gong X, Li J (2020) Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromol Med 22(2):227\u2013238","journal-title":"Neuromol Med"},{"issue":"12","key":"1991_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.31083\/j.jin2312224","volume":"23","author":"J Sun","year":"2024","unstructured":"Sun J, Du X, Chen Y (2024) Current Progress on Postoperative Cognitive Dysfunction: An Update. J Integr Neurosci 23(12):224","journal-title":"J Integr Neurosci"},{"key":"1991_CR29","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.ibneur.2025.09.012","volume":"19","author":"H Sun","year":"2025","unstructured":"Sun H, Cai R, Zhao M, Shan Y, Ma K, Qian M (2025) Beyond apoptosis: Exploring necroptosis, ferroptosis, and pyroptosis in sevoflurane- and isoflurane-associated PNDs. IBRO Neurosci Rep 19:688\u2013698","journal-title":"IBRO Neurosci Rep"},{"issue":"3","key":"1991_CR26","doi-asserted-by":"publisher","first-page":"e14406","DOI":"10.1111\/acel.14406","volume":"24","author":"Z Suo","year":"2025","unstructured":"Suo Z, Xiao T, Qu Y, Zheng Y, Xu W, Zhou B, Yang J, Yu J, Zheng H, Ni C (2025) Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment. Aging Cell 24(3):e14406","journal-title":"Aging Cell"},{"issue":"7","key":"1991_CR2","doi-asserted-by":"publisher","first-page":"afae160","DOI":"10.1093\/ageing\/afae160","volume":"53","author":"P Suraarunsumrit","year":"2024","unstructured":"Suraarunsumrit P, Srinonprasert V, Kongmalai T, Suratewat S, Chaikledkaew U, Rattanasiri S, McKay G, Attia J, Thakkinstian A (2024) Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis. Age Ageing 53(7):afae160","journal-title":"Age Ageing"},{"issue":"1","key":"1991_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s40520-024-02779-7","volume":"36","author":"HA Varpaei","year":"2024","unstructured":"Varpaei HA, Farhadi K, Mohammadi M, Khafaee Pour Khamseh A, Mokhtari T (2024) Postoperative cognitive dysfunction: a concept analysis. Aging Clin Exp Res 36(1):133","journal-title":"Aging Clin Exp Res"},{"issue":"1","key":"1991_CR37","first-page":"293","volume":"11","author":"B Wang","year":"2018","unstructured":"Wang B, Zhu C, Zhang N, Li L, Sun L, Xu J (2018) Nampt\/RelB pathway protects learning and memory ability in aged rats after general anesthesia with sevoflurane and nitrous oxide. Int J Clin Exp Pathol 11(1):293\u2013303","journal-title":"Int J Clin Exp Pathol"},{"key":"1991_CR6","doi-asserted-by":"publisher","first-page":"702231","DOI":"10.3389\/fnagi.2021.702231","volume":"13","author":"CM Wang","year":"2021","unstructured":"Wang CM, Chen WC, Zhang Y, Lin S, He HF (2021) Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction. Front Aging Neurosci 13:702231","journal-title":"Front Aging Neurosci"},{"key":"1991_CR14","doi-asserted-by":"publisher","first-page":"1480502","DOI":"10.3389\/fnagi.2024.1480502","volume":"16","author":"T Wang","year":"2024","unstructured":"Wang T, Sun G, Tao B (2024) Updated insights into the NLRP3 inflammasome in postoperative cognitive dysfunction: emerging mechanisms and treatments. Front Aging Neurosci 16:1480502","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"1991_CR8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10565-024-09964-4","volume":"41","author":"Y Wang","year":"2024","unstructured":"Wang Y, Li N, Chen X, Zhao Y, Qu L, Cai D (2024) Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1\/Nrf2 signaling axis in aged rats. Cell Biol Toxicol 41(1):13","journal-title":"Cell Biol Toxicol"},{"key":"1991_CR40","doi-asserted-by":"crossref","unstructured":"Xu L, Ma Y, Ji Y, Ma Y, Wang Y, Zhao X, Ge S (2023) Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1\/NAD(+)\/SIRT1 axis through oxidative stress. Exp Gerontol :112320","DOI":"10.1016\/j.exger.2023.112320"},{"key":"1991_CR23","doi-asserted-by":"publisher","first-page":"114738","DOI":"10.1016\/j.bbr.2023.114738","volume":"458","author":"J Xu","year":"2024","unstructured":"Xu J, Chen X, Liu S, Wei Z, Xu M, Jiang L, Han X, Peng L, Gu X, Xia T (2024) Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice. Behav Brain Res 458:114738","journal-title":"Behav Brain Res"},{"issue":"4","key":"1991_CR12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41423-025-01275-w","volume":"22","author":"W Xu","year":"2025","unstructured":"Xu W, Huang Y, Zhou R (2025) NLRP3 inflammasome in neuroinflammation and central nervous system diseases. Cell Mol Immunol 22(4):341\u2013355","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"1991_CR45","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/febs.13650","volume":"283","author":"T Yamanaka","year":"2016","unstructured":"Yamanaka T, Tosaki A, Kurosawa M, Shimogori T, Hattori N, Nukina N (2016) Genome-wide analyses in neuronal cells reveal that upstream transcription factors regulate lysosomal gene expression. FEBS J 283(6):1077\u20131087","journal-title":"FEBS J"},{"issue":"11\u201312","key":"1991_CR18","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1007\/s00018-016-2202-5","volume":"73","author":"Y Ying","year":"2016","unstructured":"Ying Y, Padanilam BJ (2016) Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis? Cell Mol Life Sci 73(11\u201312):2309\u20132324","journal-title":"Cell Mol Life Sci"},{"key":"1991_CR13","doi-asserted-by":"crossref","unstructured":"Yuan G, Lei M, Dedong X: Mechanism of Pyroptosis in Postoperative Cognitive Dysfunction Rats and \u03b17-nicotinic Receptor Agonist Regulating NLRP3 Inflammasome Activation. Letters in Drug Design & Discovery 2024, 21(18):4429\u20134438","DOI":"10.2174\/0115701808340483241119064321"},{"issue":"17","key":"1991_CR21","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1523\/JNEUROSCI.2321-22.2023","volume":"43","author":"M Zhang","year":"2023","unstructured":"Zhang M, Yang K, Wang QH, Xie L, Liu Q, Wei R, Tao Y, Zheng HL, Lin N, Xu H et al (2023) The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons. J neuroscience: official J Soc Neurosci 43(17):3009\u20133027","journal-title":"J neuroscience: official J Soc Neurosci"},{"issue":"1","key":"1991_CR42","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s10020-024-00798-8","volume":"30","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Guo Q, Ma C, Zhao Z, Shi Q, Yu H, Rao L, Li M (2024) USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5\/Smad2\/3 axis. Mol Med (Cambridge Mass) 30(1):32","journal-title":"Mol Med (Cambridge Mass)"},{"issue":"6","key":"1991_CR24","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2174\/0113892029387405250921211549","volume":"26","author":"L Zhang","year":"2025","unstructured":"Zhang L, Shang J, Kong X, Li F, Liu J (2025) Two-Stage Multi-View Graph Spectural Clustering for Single-Cell RNASeq Data. Curr Genom 26(6):673\u2013689","journal-title":"Curr Genom"},{"key":"1991_CR10","doi-asserted-by":"publisher","first-page":"1613378","DOI":"10.3389\/fcell.2025.1613378","volume":"13","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Yin Z, Zou Z, Feng S, Xu H (2025) Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles. Front cell Dev biology 13:1613378","journal-title":"Front cell Dev biology"},{"key":"1991_CR1","doi-asserted-by":"publisher","first-page":"1328790","DOI":"10.3389\/fnbeh.2024.1328790","volume":"18","author":"Q Zhao","year":"2024","unstructured":"Zhao Q, Wan H, Pan H, Xu Y (2024) Postoperative cognitive dysfunction-current research progress. Front Behav Neurosci 18:1328790","journal-title":"Front Behav Neurosci"},{"issue":"5","key":"1991_CR39","doi-asserted-by":"publisher","first-page":"871","DOI":"10.33549\/physiolres.935577","volume":"74","author":"C Zhao","year":"2025","unstructured":"Zhao C, Liu J, Zhao S, Liu P, Li Z, Li Y, Dong R, Wang XL (2025) Role of Esketamine in Attenuating Neuroinflammation and Improving Postoperative Cognitive Function via Autophagy Activation Through PARP1 Targeting. Physiol Res 74(5):871\u2013884","journal-title":"Physiol Res"},{"key":"1991_CR16","doi-asserted-by":"publisher","first-page":"109725","DOI":"10.1016\/j.intimp.2023.109725","volume":"116","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Zhang Y, Wang H, Zhang X, Chen Y, Chen G (2023) Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway. Int Immunopharmacol 116:109725","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"1991_CR41","doi-asserted-by":"publisher","first-page":"159581","DOI":"10.1016\/j.bbalip.2024.159581","volume":"1870","author":"S Zhuang","year":"2025","unstructured":"Zhuang S, Fu J, Wu L, Xu X, Guo C (2025) Role of USF1 in activating CYBA transcription and influencing NADPH-ROS-mediated oxidative stress and lipid accumulation in non-alcoholic fatty liver disease. Biochim et Biophys acta Mol cell biology lipids 1870(2):159581","journal-title":"Biochim et Biophys acta Mol cell biology lipids"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01991-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01991-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01991-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:19:16Z","timestamp":1785521956000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01991-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1991"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01991-0","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"9 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animal research was approved by the Animal Ethics Committee of the First Affiliated Hospital of Henan University of Chinese Medicine (Approval No. IACUC-202407009). Animals were cared for according to the relevant guidelines and regulations of Care and Use of Laboratory Animals of the National Institutes of Health (NIH).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"208"}}