{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:56:44Z","timestamp":1794027404815,"version":"4.8.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01993-y","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:02:22Z","timestamp":1785290542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hsa_circ_0006969 aggravates keratinocytes from high-glucose injury by sponging miR-375 to promote USP10 and SCD expression"],"prefix":"10.1007","volume":"26","author":[{"given":"Wenjun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"1","key":"1993_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12890-019-0835-5","volume":"19","author":"MU Bhuiyan","year":"2019","unstructured":"Bhuiyan MU et al (2019) Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children. BMC Pulm Med 19(1):71","journal-title":"BMC Pulm Med"},{"key":"1993_CR27","doi-asserted-by":"crossref","unstructured":"Chen CI et al (2021) Utility of RGNEF in the Prediction of Clinical Prognosis in Patients with Rectal Cancer Receiving Preoperative Concurrent Chemoradiotherapy. Life (Basel) 12(1), 18","DOI":"10.3390\/life12010018"},{"issue":"1","key":"1993_CR30","doi-asserted-by":"publisher","first-page":"e3260549","DOI":"10.1155\/mi\/3260549","volume":"2026","author":"H Chen","year":"2026","unstructured":"Chen H et al (2026) FGFR2 is a Candidate Immune-Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K\/Akt and MAPK Pathways. Mediators Inflamm 2026(1):e3260549","journal-title":"Mediators Inflamm"},{"issue":"3","key":"1993_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41419-022-04612-3","volume":"13","author":"X Cheng","year":"2022","unstructured":"Cheng X et al (2022) The mmu_circRNA_37492\/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis. Cell Death Dis 13(3):207","journal-title":"Cell Death Dis"},{"issue":"32","key":"1993_CR13","doi-asserted-by":"publisher","first-page":"e21478","DOI":"10.1097\/MD.0000000000021478","volume":"99","author":"D Dai","year":"2020","unstructured":"Dai D et al (2020) Weighted gene coexpression network analysis identifies hub genes related to KRAS mutant lung adenocarcinoma. Med (Baltim) 99(32):e21478","journal-title":"Med (Baltim)"},{"key":"1993_CR24","doi-asserted-by":"publisher","first-page":"946447","DOI":"10.3389\/fvets.2022.946447","volume":"9","author":"X Feng","year":"2022","unstructured":"Feng X et al (2022) Weighted Gene Co-expression Network Analysis Revealed That CircMARK3 Is a Potential CircRNA Affects Fat Deposition in Buffalo. Front Vet Sci 9:946447","journal-title":"Front Vet Sci"},{"key":"1993_CR18","doi-asserted-by":"publisher","first-page":"147669","DOI":"10.1016\/j.gene.2023.147669","volume":"883","author":"Z Fu","year":"2023","unstructured":"Fu Z et al (2023) Upregulation of circ_0080968 in diabetic foot ulcer inhibits wound healing via repressing the migration and promoting proliferation of keratinocytes. Gene 883:147669","journal-title":"Gene"},{"issue":"12","key":"1993_CR40","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/1440-1681.13147","volume":"46","author":"RE Garcia-Jacobo","year":"2019","unstructured":"Garcia-Jacobo RE et al (2019) Circulating miR-146a, miR-34a and miR-375 in type 2 diabetes patients, pre-diabetic and normal-glycaemic individuals in relation to beta-cell function, insulin resistance and metabolic parameters. Clin Exp Pharmacol Physiol 46(12):1092\u20131100","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1","key":"1993_CR5","doi-asserted-by":"publisher","first-page":"e70155","DOI":"10.1002\/edm2.70155","volume":"9","author":"AR Ghafourian","year":"2026","unstructured":"Ghafourian AR et al (2026) Circular RNAs in Diabetic Foot Ulcers: A Scoping Review of Clinical, Preclinical, and In Silico Evidence on Diagnostic and Therapeutic Potentials. Endocrinol Diabetes Metab 9(1):e70155","journal-title":"Endocrinol Diabetes Metab"},{"issue":"4","key":"1993_CR33","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1002\/hep.29270","volume":"66","author":"D Han","year":"2017","unstructured":"Han D et al (2017) Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology 66(4):1151\u20131164","journal-title":"Hepatology"},{"issue":"4","key":"1993_CR7","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s10735-021-09996-8","volume":"52","author":"D Han","year":"2021","unstructured":"Han D et al (2021) Circ_PRKDC knockdown promotes skin wound healing by enhancing keratinocyte migration via miR-31\/FBN1 axis. J Mol Histol 52(4):681\u2013691","journal-title":"J Mol Histol"},{"issue":"4","key":"1993_CR19","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1007\/s10528-021-10157-5","volume":"60","author":"Z He","year":"2022","unstructured":"He Z, Xu X (2022) Circ_0084443 Inhibits Wound Healing Via Repressing Keratinocyte Migration Through Targeting the miR-17-3p\/FOXO4 Axis. Biochem Genet 60(4):1236\u20131252","journal-title":"Biochem Genet"},{"issue":"4","key":"1993_CR38","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.metabol.2014.12.003","volume":"64","author":"C Higuchi","year":"2015","unstructured":"Higuchi C et al (2015) Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes. Metabolism 64(4):489\u2013497","journal-title":"Metabolism"},{"issue":"2","key":"1993_CR12","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1002\/jcp.26959","volume":"234","author":"W Hu","year":"2019","unstructured":"Hu W et al (2019) Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185\/TGF-beta1. J Cell Physiol 234(2):1469\u20131476","journal-title":"J Cell Physiol"},{"issue":"36","key":"1993_CR26","doi-asserted-by":"publisher","first-page":"6323","DOI":"10.1038\/s41388-019-0881-8","volume":"38","author":"EG Kleinschmidt","year":"2019","unstructured":"Kleinschmidt EG et al (2019) Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene 38(36):6323\u20136337","journal-title":"Oncogene"},{"issue":"1","key":"1993_CR25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s12276-025-01631-w","volume":"58","author":"J Lee","year":"2026","unstructured":"Lee J et al (2026) Rgnef regulates bone mass through the activation of RhoA and Rac1. Exp Mol Med 58(1):243\u2013253","journal-title":"Exp Mol Med"},{"key":"1993_CR23","doi-asserted-by":"publisher","first-page":"8737","DOI":"10.2147\/IJGM.S335108","volume":"14","author":"M Li","year":"2021","unstructured":"Li M et al (2021) WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs. Int J Gen Med 14:8737\u20138751","journal-title":"Int J Gen Med"},{"key":"1993_CR17","doi-asserted-by":"publisher","first-page":"1019935","DOI":"10.3389\/fendo.2022.1019935","volume":"13","author":"D Li","year":"2022","unstructured":"Li D et al (2022) The progress and challenges of circRNA for diabetic foot ulcers: A mini-review. Front Endocrinol (Lausanne) 13:1019935","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"1993_CR6","doi-asserted-by":"publisher","first-page":"e70047","DOI":"10.1002\/kjm2.70047","volume":"41","author":"CM Li","year":"2025","unstructured":"Li CM et al (2025) Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction. Kaohsiung J Med Sci 41(9):e70047","journal-title":"Kaohsiung J Med Sci"},{"issue":"12","key":"1993_CR42","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1007\/s00125-004-1575-4","volume":"47","author":"CF Liew","year":"2004","unstructured":"Liew CF et al (2004) Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia 47(12):2168\u20132175","journal-title":"Diabetologia"},{"issue":"9","key":"1993_CR9","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1080\/02713683.2020.1722179","volume":"45","author":"X Liu","year":"2020","unstructured":"Liu X et al (2020) Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration. Curr Eye Res 45(9):1173\u20131180","journal-title":"Curr Eye Res"},{"key":"1993_CR44","doi-asserted-by":"crossref","unstructured":"Liu L et al (2021) Isoquercitrin protects HUVECs against high glucoseinduced apoptosis through regulating p53 proteasomal degradation. Int J Mol Med 48(1), 122","DOI":"10.3892\/ijmm.2021.4955"},{"issue":"1","key":"1993_CR11","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12943-022-01653-2","volume":"21","author":"P Liu","year":"2022","unstructured":"Liu P et al (2022) The FUS\/circEZH2\/KLF5\/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition. Mol Cancer 21(1):198","journal-title":"Mol Cancer"},{"issue":"3","key":"1993_CR35","doi-asserted-by":"publisher","first-page":"e0150900","DOI":"10.1371\/journal.pone.0150900","volume":"11","author":"F Ochoa-Gonzalez","year":"2016","unstructured":"Ochoa-Gonzalez F et al (2016) Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients. PLoS ONE 11(3):e0150900","journal-title":"PLoS ONE"},{"issue":"5","key":"1993_CR39","first-page":"2189","volume":"24","author":"LJ Pu","year":"2020","unstructured":"Pu LJ et al (2020) Relationship between miR-375 regulating Ndrg2\/IL-6\/STAT3 signaling pathway and diabetic retinopathy in rats. Eur Rev Med Pharmacol Sci 24(5):2189\u20132195","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"1993_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","volume":"365","author":"S Qu","year":"2015","unstructured":"Qu S et al (2015) Circular RNA: A new star of noncoding RNAs. Cancer Lett 365(2):141\u2013148","journal-title":"Cancer Lett"},{"issue":"5","key":"1993_CR29","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.2337\/db20-1008","volume":"70","author":"H Qu","year":"2021","unstructured":"Qu H et al (2021) Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing. Diabetes 70(5):1170\u20131184","journal-title":"Diabetes"},{"key":"1993_CR28","doi-asserted-by":"crossref","unstructured":"Sugiwaki H et al (2023) Effects of Schumann resonance on the proliferation and migration of normal human epidermal keratinocytes and the expression of DEFB1 and SIRT1. J Cosmet Dermatol","DOI":"10.1111\/jocd.15988"},{"issue":"8","key":"1993_CR31","doi-asserted-by":"publisher","first-page":"151649","DOI":"10.1016\/j.acthis.2020.151649","volume":"122","author":"X Sun","year":"2020","unstructured":"Sun X et al (2020) Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway. Acta Histochem 122(8):151649","journal-title":"Acta Histochem"},{"issue":"3","key":"1993_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/iwj.13535","volume":"18","author":"M Tian","year":"2021","unstructured":"Tian M et al (2021) Identification of potential circRNAs and circRNA-miRNA-mRNA regulatory network in the development of diabetic foot ulcers by integrated bioinformatics analysis. Int Wound J 18(3):323\u2013331","journal-title":"Int Wound J"},{"issue":"3","key":"1993_CR41","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.bbrc.2005.05.013","volume":"332","author":"J Wang","year":"2005","unstructured":"Wang J et al (2005) Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun 332(3):735\u2013742","journal-title":"Biochem Biophys Res Commun"},{"issue":"21","key":"1993_CR43","doi-asserted-by":"publisher","first-page":"13372","DOI":"10.1074\/jbc.M115.643767","volume":"290","author":"W Wang","year":"2015","unstructured":"Wang W et al (2015) TRAF Family Member-associated NF-kappaB Activator (TANK) Inhibits Genotoxic Nuclear Factor kappaB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem 290(21):13372\u201313385","journal-title":"J Biol Chem"},{"issue":"4","key":"1993_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1089\/wound.2019.0956","volume":"9","author":"A Wang","year":"2020","unstructured":"Wang A et al (2020) Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation. Adv Wound Care (New Rochelle) 9(4):145\u2013160","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"1","key":"1993_CR22","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1186\/s12864-023-09612-x","volume":"24","author":"Y Wang","year":"2023","unstructured":"Wang Y et al (2023) Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs. BMC Genomics 24(1):477","journal-title":"BMC Genomics"},{"issue":"24","key":"1993_CR1","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.4103\/0366-6999.171350","volume":"128","author":"JP Weng","year":"2015","unstructured":"Weng JP, Bi Y (2015) Epidemiological Status of Chronic Diabetic Complications in China. Chin Med J (Engl) 128(24):3267\u20133269","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"1993_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S2213-8587(16)00051-6","volume":"4","author":"Z Xu","year":"2016","unstructured":"Xu Z, Ran X (2016) Diabetic foot care in China: challenges and strategy. Lancet Diabetes Endocrinol 4(4):297\u2013298","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"1993_CR36","first-page":"2368","volume":"19","author":"S Xu","year":"2019","unstructured":"Xu S et al (2019) Screening and preliminary validation of T lymphocyte immunoregulation\u2013associated long non\u2013coding RNAs in diabetic foot ulcers. Mol Med Rep 19(3):2368\u20132376","journal-title":"Mol Med Rep"},{"issue":"4","key":"1993_CR15","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41419-022-04732-w","volume":"13","author":"J Yang","year":"2022","unstructured":"Yang J et al (2022) Hsa_circRNA_0088036 acts as a ceRNA to promote bladder cancer progression by sponging miR-140-3. Cell Death Dis 13(4):322","journal-title":"Cell Death Dis"},{"issue":"1","key":"1993_CR21","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1186\/s12864-022-08911-z","volume":"23","author":"X Yang","year":"2022","unstructured":"Yang X et al (2022) A genome-wide landscape of mRNAs, lncRNAs, circRNAs and miRNAs during intramuscular adipogenesis in cattle. BMC Genomics 23(1):691","journal-title":"BMC Genomics"},{"issue":"1","key":"1993_CR10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41420-023-01448-4","volume":"9","author":"Y Zeng","year":"2023","unstructured":"Zeng Y et al (2023) Hsa_circ_0060467 promotes breast cancer liver metastasis by complexing with eIF4A3 and sponging miR-1205. Cell Death Discov 9(1):153","journal-title":"Cell Death Discov"},{"issue":"2","key":"1993_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1124\/jpet.115.229369","volume":"356","author":"E Zhang","year":"2016","unstructured":"Zhang E et al (2016) Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K\/Akt\/mTOR Signaling Pathway and Benefits Wound Healing in Genetically Diabetic Mice. J Pharmacol Exp Ther 356(2):324\u2013332","journal-title":"J Pharmacol Exp Ther"},{"key":"1993_CR34","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3389\/fbioe.2019.00222","volume":"7","author":"Y Zhang","year":"2019","unstructured":"Zhang Y et al (2019) Systematic Characterization of Circular RNA-Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer\u2019s Disease. Front Bioeng Biotechnol 7:222","journal-title":"Front Bioeng Biotechnol"},{"key":"1993_CR32","doi-asserted-by":"publisher","first-page":"tkab031","DOI":"10.1093\/burnst\/tkab031","volume":"9","author":"J Zhang","year":"2021","unstructured":"Zhang J et al (2021) Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction. Burns Trauma 9:tkab031","journal-title":"Burns Trauma"},{"issue":"3","key":"1993_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11655-023-3607-2","volume":"30","author":"Y Zhang","year":"2024","unstructured":"Zhang Y et al (2024) Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF\/EGFR and PI3K\/AKT Pathways and Circ_0084443. Chin J Integr Med 30(3):213\u2013221","journal-title":"Chin J Integr Med"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01993-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01993-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01993-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:16:23Z","timestamp":1785521783000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01993-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1993"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01993-y","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"assertion":[{"value":"6 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of the Third Xiangya Hospital of Central South University (Approval number: 25033) and in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants.","order":1,"name":"Ethics","label":"Human Ethics and Consent to Participate declarations","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"207"}}