{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:03:55Z","timestamp":1785528235868,"version":"3.56.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82504221"],"award-info":[{"award-number":["No. 82504221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1111030003"],"award-info":[{"award-number":["2023B1111030003"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-01996-9","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:40:20Z","timestamp":1785375620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis"],"prefix":"10.1007","volume":"26","author":[{"given":"Yuntao","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaican","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"3","key":"1996_CR40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10456-024-09910-2","volume":"27","author":"M Ackermann","year":"2024","unstructured":"Ackermann M, Werlein C, Plucinski E et al (2024) The role of vasculature and angiogenesis in respiratory diseases. Angiogenesis 27(3):293\u2013310","journal-title":"Angiogenesis"},{"issue":"4","key":"1996_CR14","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1161\/ATVBAHA.118.312254","volume":"39","author":"P Bai","year":"2019","unstructured":"Bai P, Lyu L, Yu T et al (2019) Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2\/TGF (Transforming Growth Factor)-\u03b21 Signaling. Arterioscler Thromb Vasc Biol 39(4):e130\u2013e145","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"1996_CR47","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1161\/ATVBAHA.118.312254","volume":"39","author":"P Bai","year":"2019","unstructured":"Bai P, Lyu L, Yu T et al (2019) Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2\/TGF (Transforming Growth Factor)-\u03b21 Signaling. Arterioscler Thromb Vasc Biol 39(4):e130\u2013e145","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"1996_CR41","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/qjmed\/hcu012","volume":"107","author":"S Barratt","year":"2014","unstructured":"Barratt S, Millar A (2014) Vascular remodelling in the pathogenesis of idiopathic pulmonary fibrosis. QJM 107(7):515\u2013519","journal-title":"QJM"},{"issue":"Suppl 3","key":"1996_CR3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.rxeng.2022.10.009","volume":"64","author":"M Benegas Urteaga","year":"2022","unstructured":"Benegas Urteaga M, Ram\u00edrez Ruz J, S\u00e1nchez Gonz\u00e1lez M (2022) Idiopathic pulmonary fibrosis. Radiologia (Engl Ed) 64(Suppl 3):227\u2013239","journal-title":"Radiologia (Engl Ed)"},{"key":"1996_CR9","unstructured":"Brief (ed) Endothelial-to-mesenchymal transition - PubMed [Internet]. [cited 2025 Apr 1];Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/26446982\/"},{"key":"1996_CR13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2407-10-17","volume":"10","author":"JJ Briggs","year":"2010","unstructured":"Briggs JJ, Haugen MH, Johansen HT et al (2010) Cystatin E\/M suppresses legumain activity and invasion of human melanoma. BMC Cancer 10:17","journal-title":"BMC Cancer"},{"issue":"2","key":"1996_CR28","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/jcp.10395","volume":"198","author":"C B\u00fcttner","year":"2004","unstructured":"B\u00fcttner C, Skupin A, Rieber EP (2004) Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin-4: analysis of the functional collagen promoter sequences. J Cell Physiol 198(2):248\u2013258","journal-title":"J Cell Physiol"},{"issue":"18","key":"1996_CR43","doi-asserted-by":"publisher","first-page":"e183970","DOI":"10.1172\/JCI183970","volume":"134","author":"O Burgy","year":"2024","unstructured":"Burgy O, K\u00f6nigshoff M (2024) Teatime: epigallocatechin gallate targets fibroblast-epithelial cell crosstalk to combat lung fibrosis. J Clin Invest 134(18):e183970","journal-title":"J Clin Invest"},{"issue":"4","key":"1996_CR23","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin SA, Benes V, Garson JA et al (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55(4):611\u2013622","journal-title":"Clin Chem"},{"issue":"6","key":"1996_CR26","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1183\/09031936.00044911","volume":"39","author":"CM Costello","year":"2012","unstructured":"Costello CM, McCullagh B, Howell K et al (2012) A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease. Eur Respir J 39(6):1415\u20131424","journal-title":"Eur Respir J"},{"issue":"10","key":"1996_CR33","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1111\/bph.70304","volume":"183","author":"D D\u2019Avino","year":"2026","unstructured":"D\u2019Avino D, Cerqua I, Maruccio L et al (2026) Sex-related susceptibility to pulmonary fibrosis development in mice. Br J Pharmacol 183(10):2391\u20132405","journal-title":"Br J Pharmacol"},{"issue":"175","key":"1996_CR34","doi-asserted-by":"publisher","first-page":"240080","DOI":"10.1183\/16000617.0080-2024","volume":"34","author":"J Dietrich","year":"2025","unstructured":"Dietrich J, Kang A, Tielemans B et al (2025) The role of vascularity and the fibrovascular interface in interstitial lung diseases. Eur Respir Rev 34(175):240080","journal-title":"Eur Respir Rev"},{"key":"1996_CR10","unstructured":"E D, H B. Structure and function of legumain in health and disease. Biochimie [Internet] 2016 [cited 2026 Apr 12];122. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/26403494\/"},{"issue":"13","key":"1996_CR39","doi-asserted-by":"publisher","first-page":"e2414601","DOI":"10.1002\/adma.202414601","volume":"37","author":"Y-F Fang","year":"2025","unstructured":"Fang Y-F, Zhang C, Han M-M et al (2025) Engineered MSCs Break Endothelial-Myofibroblast Crosstalk in Pulmonary Fibrosis: Reconstructing the Vascular Niche. Adv Mater 37(13):e2414601","journal-title":"Adv Mater"},{"issue":"1","key":"1996_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1165\/rcmb.2010-0365TR","volume":"45","author":"L Farkas","year":"2011","unstructured":"Farkas L, Gauldie J, Voelkel NF, Kolb M (2011) Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors. Am J Respir Cell Mol Biol 45(1):1\u201315","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"1996_CR32","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1080\/17476348.2020.1795832","volume":"14","author":"AV Gaikwad","year":"2020","unstructured":"Gaikwad AV, Eapen MS, McAlinden KD et al (2020) Endothelial to mesenchymal transition (EndMT) and vascular remodeling in pulmonary hypertension and idiopathic pulmonary fibrosis. Expert Rev Respir Med 14(10):1027\u20131043","journal-title":"Expert Rev Respir Med"},{"issue":"4","key":"1996_CR49","doi-asserted-by":"publisher","first-page":"e1008692","DOI":"10.1371\/journal.pgen.1008692","volume":"16","author":"C Goda","year":"2020","unstructured":"Goda C, Balli D, Black M et al (2020) Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. PLoS Genet 16(4):e1008692","journal-title":"PLoS Genet"},{"issue":"7835","key":"1996_CR1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","volume":"587","author":"NC Henderson","year":"2020","unstructured":"Henderson NC, Rieder F, Wynn TA (2020) Fibrosis: from mechanisms to medicines. Nature 587(7835):555\u2013566","journal-title":"Nature"},{"issue":"12","key":"1996_CR5","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/S1470-2045(25)00515-7","volume":"26","author":"Z Hou","year":"2025","unstructured":"Hou Z, Dong B, Yao Q et al (2025) Pirfenidone for grade 2 and grade 3 radiation-induced lung injury: a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol 26(12):1552\u20131562","journal-title":"Lancet Oncol"},{"key":"1996_CR16","unstructured":"Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma - PubMed [Internet]. [cited 2026 Feb 11];Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/37858339\/"},{"issue":"52","key":"1996_CR48","doi-asserted-by":"publisher","first-page":"43000","DOI":"10.1074\/jbc.M510441200","volume":"280","author":"N Khalil","year":"2005","unstructured":"Khalil N, Xu YD, O\u2019Connor R, Duronio V (2005) Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK. J Biol Chem 280(52):43000\u201343009","journal-title":"J Biol Chem"},{"key":"1996_CR21","doi-asserted-by":"crossref","unstructured":"P B, L L, T Y, et al. Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2\/TGF (Transforming Growth Factor)-\u03b21 Signaling. Arterioscler Thromb Vasc Biol [Internet] 2019 [cited 2026 Apr 11];39(4). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30676070\/","DOI":"10.1161\/ATVBAHA.118.312254"},{"issue":"2","key":"1996_CR18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s13402-019-00486-4","volume":"43","author":"X Li","year":"2020","unstructured":"Li X, Tang M, Zhu Q, Wang X, Lin Y, Wang X (2020) The exosomal integrin \u03b15\u03b21\/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration. Cell Oncol (Dordr) 43(2):263\u2013277","journal-title":"Cell Oncol (Dordr)"},{"issue":"585","key":"1996_CR38","doi-asserted-by":"publisher","first-page":"eaba2927","DOI":"10.1126\/scitranslmed.aba2927","volume":"13","author":"FJ Li","year":"2021","unstructured":"Li FJ, Surolia R, Li H et al (2021) Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med 13(585):eaba2927","journal-title":"Sci Transl Med"},{"key":"1996_CR19","doi-asserted-by":"publisher","first-page":"e20635","DOI":"10.1002\/advs.202520635","volume":"13","author":"M Liu","year":"2026","unstructured":"Liu M, Han Y, Xie B et al (2026) Legumain Restrains Granuloma Formation by Inhibiting mTORC1\/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis. Adv Sci (Weinh) 13:e20635","journal-title":"Adv Sci (Weinh)"},{"issue":"8","key":"1996_CR11","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1172\/JCI27648","volume":"116","author":"Y Luo","year":"2006","unstructured":"Luo Y, Zhou H, Krueger J et al (2006) Targeting tumor-associated macrophages as a novel strategy against breast cancer. J Clin Invest 116(8):2132\u20132141","journal-title":"J Clin Invest"},{"key":"1996_CR7","doi-asserted-by":"publisher","first-page":"111327","DOI":"10.1016\/j.ecoenv.2020.111327","volume":"205","author":"K Ma","year":"2020","unstructured":"Ma K, Li C, Xu J et al (2020) LncRNA Gm16410 regulates PM2.5-induced lung Endothelial-Mesenchymal Transition via the TGF-\u03b21\/Smad3\/p-Smad3 pathway. Ecotoxicol Environ Saf 205:111327","journal-title":"Ecotoxicol Environ Saf"},{"issue":"2","key":"1996_CR42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1165\/rcmb.2023-0449OC","volume":"72","author":"P Mart\u00edn-Vicente","year":"2025","unstructured":"Mart\u00edn-Vicente P, L\u00f3pez-Mart\u00ednez C, L\u00f3pez-Alonso I et al (2025) Mechanical Stretch Induces Senescence of Lung Epithelial Cells and Drives Fibroblast Activation by Paracrine Mechanisms. Am J Respir Cell Mol Biol 72(2):195\u2013205","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"7","key":"1996_CR30","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1164\/rccm.200810-1534OC","volume":"179","author":"A Moeller","year":"2009","unstructured":"Moeller A, Gilpin SE, Ask K et al (2009) Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179(7):588\u2013594","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"1996_CR22","doi-asserted-by":"publisher","first-page":"1802441","DOI":"10.1183\/13993003.02441-2018","volume":"54","author":"C Morse","year":"2019","unstructured":"Morse C, Tabib T, Sembrat J et al (2019) Proliferating SPP1\/MERTK-expressing macrophages in idiopathic pulmonary fibrosis. Eur Respir J 54(2):1802441","journal-title":"Eur Respir J"},{"key":"1996_CR50","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.biopha.2017.09.023","volume":"95","author":"Y Nie","year":"2017","unstructured":"Nie Y, Yang Y, Zhang J et al (2017) Shikonin suppresses pulmonary fibroblasts proliferation and activation by regulating Akt and p38 MAPK signaling pathways. Biomed Pharmacother 95:1119\u20131128","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"1996_CR15","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3390\/ijms20092195","volume":"20","author":"N Ozawa","year":"2019","unstructured":"Ozawa N, Sato Y, Mori Y et al (2019) Legumain Promotes Atherosclerotic Vascular Remodeling. Int J Mol Sci 20(9):2195","journal-title":"Int J Mol Sci"},{"issue":"9","key":"1996_CR46","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3390\/ijms20092195","volume":"20","author":"N Ozawa","year":"2019","unstructured":"Ozawa N, Sato Y, Mori Y et al (2019) Legumain Promotes Atherosclerotic Vascular Remodeling. Int J Mol Sci 20(9):2195","journal-title":"Int J Mol Sci"},{"key":"1996_CR8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cytogfr.2016.09.002","volume":"33","author":"L P\u00e9rez","year":"2017","unstructured":"P\u00e9rez L, Mu\u00f1oz-Durango N, Riedel CA et al (2017) Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Cytokine Growth Factor Rev 33:41\u201354","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"1996_CR27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1172\/JCI200420997","volume":"114","author":"RJ Phillips","year":"2004","unstructured":"Phillips RJ, Burdick MD, Hong K et al (2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 114(3):438\u2013446","journal-title":"J Clin Invest"},{"issue":"1","key":"1996_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s10020-025-01128-2","volume":"31","author":"V Pulito-Cueto","year":"2025","unstructured":"Pulito-Cueto V, Atienza-Mateo B, Batista-Liz JC et al (2025) Matrix metalloproteinases and their tissue inhibitors as upcoming biomarker signatures of connective tissue diseases-related interstitial lung disease: towards an earlier and accurate diagnosis. Mol Med 31(1):70","journal-title":"Mol Med"},{"issue":"6","key":"1996_CR20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00109-020-01911-0","volume":"98","author":"Y-C Ren","year":"2020","unstructured":"Ren Y-C, Zhao Q, He Y et al (2020) Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor \u03b21. J Mol Med (Berl) 98(6):863\u2013874","journal-title":"J Mol Med (Berl)"},{"issue":"6","key":"1996_CR44","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00109-020-01911-0","volume":"98","author":"Y-C Ren","year":"2020","unstructured":"Ren Y-C, Zhao Q, He Y et al (2020) Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor \u03b21. J Mol Med (Berl) 98(6):863\u2013874","journal-title":"J Mol Med (Berl)"},{"issue":"10082","key":"1996_CR2","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1016\/S0140-6736(17)30866-8","volume":"389","author":"L Richeldi","year":"2017","unstructured":"Richeldi L, Collard HR, Jones MG (2017) Idiopathic pulmonary fibrosis. Lancet 389(10082):1941\u20131952","journal-title":"Lancet"},{"issue":"445","key":"1996_CR29","doi-asserted-by":"publisher","first-page":"eaap7294","DOI":"10.1126\/scitranslmed.aap7294","volume":"10","author":"AO Samokhin","year":"2018","unstructured":"Samokhin AO, Stephens T, Wertheim BM et al (2018) NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med 10(445):eaap7294","journal-title":"Sci Transl Med"},{"key":"1996_CR36","doi-asserted-by":"publisher","first-page":"111148","DOI":"10.1016\/j.intimp.2023.111148","volume":"126","author":"C Song","year":"2024","unstructured":"Song C, Xu Z, Liang Q et al (2024) OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1. Int Immunopharmacol 126:111148","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1996_CR24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/s41420-023-01702-9","volume":"9","author":"R Wan","year":"2023","unstructured":"Wan R, Wang L, Duan Y et al (2023) ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGF\u03b2\/SMAD signaling in lung fibroblasts. Cell Death Discov 9(1):407","journal-title":"Cell Death Discov"},{"issue":"1","key":"1996_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.kint.2017.12.025","volume":"94","author":"D Wang","year":"2018","unstructured":"Wang D, Xiong M, Chen C et al (2018) Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy. Kidney Int 94(1):91\u2013101","journal-title":"Kidney Int"},{"issue":"10","key":"1996_CR45","doi-asserted-by":"publisher","first-page":"e185128","DOI":"10.1172\/JCI185128","volume":"135","author":"M Wang","year":"2025","unstructured":"Wang M, Li B, Nie S et al (2025) Asparagine endopeptidase cleaves apolipoprotein A1 and accelerates pathogenesis of atherosclerosis. J Clin Invest 135(10):e185128","journal-title":"J Clin Invest"},{"key":"1996_CR37","unstructured":"Wogonoside inhibits fibroblast activation and pulmonary fibrosis by dual regulation of Snail1 lactylation and PGC1\u03b1\/PINK1-mediated mitophagy - PubMed [Internet]. [cited 2025 Oct 26];Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/40939548\/"},{"issue":"39","key":"1996_CR6","doi-asserted-by":"publisher","first-page":"26704","DOI":"10.1021\/acsnano.4c06598","volume":"18","author":"Y Xie","year":"2024","unstructured":"Xie Y, Shi S, Lv W et al (2024) Tetrahedral Framework Nucleic Acids Delivery of Pirfenidone for Anti-Inflammatory and Antioxidative Effects to Treat Idiopathic Pulmonary Fibrosis. ACS Nano 18(39):26704\u201326721","journal-title":"ACS Nano"},{"issue":"1","key":"1996_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nm.4447","volume":"24","author":"G Yu","year":"2018","unstructured":"Yu G, Tzouvelekis A, Wang R et al (2018) Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med 24(1):39\u201349","journal-title":"Nat Med"},{"issue":"5","key":"1996_CR12","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.3390\/cells10051153","volume":"10","author":"W Zhang","year":"2021","unstructured":"Zhang W, Lin Y (2021) The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review. Cells 10(5):1153","journal-title":"Cells"},{"key":"1996_CR35","doi-asserted-by":"publisher","first-page":"155715","DOI":"10.1016\/j.phymed.2024.155715","volume":"130","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Zhang B, Yang F et al (2024) Forsythoside A regulates pulmonary fibrosis by inhibiting endothelial-to-mesenchymal transition and lung fibroblast proliferation via the PTPRB signaling. Phytomedicine 130:155715","journal-title":"Phytomedicine"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01996-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-01996-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-01996-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:20:37Z","timestamp":1785522037000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-01996-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["1996"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-01996-9","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"22 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments were conducted following approval from the Animal Care and Use Committee of Southern Medical University Nanfang Hospital (IACUC-LAC-20240413-001). Written informed consent was obtained from all participants or their legal guardians. Clinical trial number: not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"211"}}