{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T02:27:22Z","timestamp":1786588042371,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-02007-7","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T01:42:24Z","timestamp":1786585344000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated profiling identifies NCOA3 as a prognostic factor in patients with glioma"],"prefix":"10.1007","volume":"26","author":[{"given":"Qian","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinze","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"7286","key":"2007_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nature08782","volume":"464","author":"M Ammirante","year":"2010","unstructured":"Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M (2010) B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302\u20135","journal-title":"Nature"},{"issue":"5328","key":"2007_CR2","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1126\/science.277.5328.965","volume":"277","author":"SL Anzick","year":"1997","unstructured":"Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Sci (New York N Y) 277(5328):965\u2013968","journal-title":"Sci (New York N Y)"},{"issue":"1","key":"2007_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23965-5","volume":"12","author":"CM Bielski","year":"2021","unstructured":"Bielski CM, Taylor BS (2021) Homing in on genomic instability as a therapeutic target in cancer. Nat Commun 12(1):3663","journal-title":"Nat Commun"},{"key":"2007_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2022.101707","volume":"65","author":"JR Conejo-Garcia","year":"2023","unstructured":"Conejo-Garcia JR, Biswas S, Chaurio R, Rodriguez PC (2023) Neglected no more: B cell-mediated anti-tumor immunity. Semin Immunol 65:101707","journal-title":"Semin Immunol"},{"issue":"11","key":"2007_CR6","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1158\/0008-5472.CAN-20-3450","volume":"81","author":"D de Semir","year":"2021","unstructured":"de Semir D, Bezrookove V, Nosrati M, Dar AA, Miller JR 3rd, Leong SP, Kim KB, Liao W, Soroceanu L, McAllister S, Debs RJ, Schadendorf D, Leachman SA, Cleaver JE, Kashani-Sabet M (2021) Nuclear receptor coactivator NCOA3 regulates UV radiation-induced DNA damage and melanoma susceptibility. Cancer Res 81(11):2956\u20132969","journal-title":"Cancer Res"},{"key":"2007_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101266","volume":"82","author":"Z Du","year":"2025","unstructured":"Du Z, Kan H, Sun J, Liu Y, Gu J, Akemujiang S, Zou Y, Jiang L, Wang Q, Li C, Luo L, Zhang Y, Fan H, Luo P, Wang B (2025) Molecular mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. Drug Resist Updat 82:101266","journal-title":"Drug Resist Updat"},{"key":"2007_CR8","doi-asserted-by":"crossref","unstructured":"Fridman WH, Petitprez F, Meylan M, Chen TW, Sun CM, Roumenina LT (2021) C. Saut\u00e8s-Fridman, B cells and cancer: To B or not to B? J Exp Med 218(1)","DOI":"10.1084\/jem.20200851"},{"issue":"1","key":"2007_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41392-021-00855-2","volume":"7","author":"QJ Gai","year":"2022","unstructured":"Gai QJ, Fu Z, He J, Mao M, Yao XX, Qin Y, Lan X, Zhang L, Miao JY, Wang YX, Zhu J, Yang FC, Lu HM, Yan ZX, Chen FL, Shi Y, Ping YF, Cui YH, Zhang X, Liu X, Yao XH, Lv SQ, Bian XW, Wang Y (2022) EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma. Signal Transduct Target Ther 7(1):33","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"2007_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nrclinonc.2009.219","volume":"7","author":"O Gojis","year":"2010","unstructured":"Gojis O, Rudraraju B, Gudi M, Hogben K, Sousha S, Coombes RC, Cleator S, Palmieri C (2010) The role of SRC-3 in human breast cancer. Nat Rev Clin Oncol 7(2):83\u201389","journal-title":"Nat Rev Clin Oncol"},{"issue":"5","key":"2007_CR11","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"1","key":"2007_CR12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s13287-025-04352-z","volume":"16","author":"J He","year":"2025","unstructured":"He J, Yan X, Hu S (2025) Glioma stem cells: drivers of tumor progression and recurrence. Stem Cell Res Ther 16(1):293","journal-title":"Stem Cell Res Ther"},{"key":"2007_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197006","author":"B Kaina","year":"2020","unstructured":"Kaina B, Beltzig L, Piee-Staffa A, Haas B (2020) Cytotoxic and senolytic effects of methadone in combination with temozolomide in glioblastoma cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21197006","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2007_CR14","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/s41419-024-06936-8","volume":"15","author":"B Lan","year":"2024","unstructured":"Lan B, Zhuang Z, Zhang J, He Y, Wang N, Deng Z, Mei L, Li Y, Gao Y (2024) Triggering of endoplasmic reticulum stress via ATF4-SPHK1 signaling promotes glioblastoma invasion and chemoresistance. Cell Death Dis 15(8):552","journal-title":"Cell Death Dis"},{"issue":"12","key":"2007_CR15","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1101\/gad.261982.115","volume":"29","author":"JD Lathia","year":"2015","unstructured":"Lathia JD, Mack SC, Mulkearns-Hubert EE, Valentim CL, Rich JN (2015) Cancer stem cells in glioblastoma. Genes Dev 29(12):1203\u20131217","journal-title":"Genes Dev"},{"issue":"1","key":"2007_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.5483\/BMBRep.2019.52.1.294","volume":"52","author":"S Lee","year":"2019","unstructured":"Lee S, Lee JS (2019) Cellular senescence: a promising strategy for cancer therapy. BMB Rep 52(1):35\u201341","journal-title":"BMB Rep"},{"key":"2007_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114579","volume":"155","author":"J Liu","year":"2025","unstructured":"Liu J, Su Y, Zhang C, Dong H, Yu R, Yang X, Tian Y, Feng Y, Zhang J, Shi M, Wang C, Li W, Liu J, He L, Yang X, Liu H (2025) NCOA3 impairs the efficacy of anti-PD-L1 therapy via HSP90\u03b1\/EZH2\/CXCL9 axis in colon cancer. Int Immunopharmacol 155:114579","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"2007_CR17","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/s41419-020-03218-x","volume":"11","author":"W Li","year":"2020","unstructured":"Li W, Yan Y, Zheng Z, Zhu Q, Long Q, Sui S, Luo M, Chen M, Li Y, Hua Y, Deng W, Lai R, Li L (2020) Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma. Cell Death Dis 11(11):1011","journal-title":"Cell Death Dis"},{"issue":"3","key":"2007_CR18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/1878-0261.12173","volume":"12","author":"Y Li","year":"2018","unstructured":"Li Y, Li L, Chen M, Yu X, Gu Z, Qiu H, Qin G, Long Q, Fu X, Liu T, Li W, Huang W, Shi D, Kang T, Luo M, Wu X, Deng W (2018) MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation. Mol Oncol 12(3):391\u2013405","journal-title":"Mol Oncol"},{"key":"2007_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2020.108346","volume":"787","author":"M Mognato","year":"2021","unstructured":"Mognato M, Burdak-Rothkamm S, Rothkamm K (2021) Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability. Mutat Res Rev Mutat Res 787:108346","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"20","key":"2007_CR21","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1101\/gad.195545.112","volume":"26","author":"M Percharde","year":"2012","unstructured":"Percharde M, Lavial F, Ng JH, Kumar V, Tomaz RA, Martin N, Yeo JC, Gil J, Prabhakar S, Ng HH, Parker MG, Azuara V (2012) Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev 26(20):2286\u20132298","journal-title":"Genes Dev"},{"issue":"13","key":"2007_CR22","doi-asserted-by":"publisher","first-page":"9153","DOI":"10.1074\/jbc.M112.440354","volume":"288","author":"E Poteet","year":"2013","unstructured":"Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir ST, Yan H, Bigner DD, Simpkins JW, Yang SH (2013) Reversing the Warburg effect as a treatment for glioblastoma. J Biol Chem 288(13):9153\u201364","journal-title":"J Biol Chem"},{"issue":"16","key":"2007_CR23","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1158\/0008-5472.CAN-16-2982","volume":"77","author":"AD Rohira","year":"2017","unstructured":"Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O\u2019Malley BW (2017) Targeting SRC coactivators blocks the tumor-initiating capacity of cancer stem-like cells. Cancer Res 77(16):4293\u20134304","journal-title":"Cancer Res"},{"issue":"17","key":"2007_CR24","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1038\/onc.2016.395","volume":"36","author":"GR Sareddy","year":"2017","unstructured":"Sareddy GR, Viswanadhapalli S, Surapaneni P, Suzuki T, Brenner A, Vadlamudi RK (2017) Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway. Oncogene 36(17):2423\u20132434","journal-title":"Oncogene"},{"issue":"7","key":"2007_CR25","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1001\/jama.2023.0023","volume":"329","author":"LR Schaff","year":"2023","unstructured":"Schaff LR, Mellinghoff IK (2023) Glioblastoma and Other Primary Brain Malignancies in Adults: A Review. JAMA 329(7):574\u2013587","journal-title":"JAMA"},{"issue":"10","key":"2007_CR26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41571-022-00668-4","volume":"19","author":"CA Schmitt","year":"2022","unstructured":"Schmitt CA, Wang B, Demaria M (2022) Senescence and cancer - role and therapeutic opportunities. Nat Rev Clin Oncol 19(10):619\u2013636","journal-title":"Nat Rev Clin Oncol"},{"issue":"7550","key":"2007_CR27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature14395","volume":"521","author":"S Shalapour","year":"2015","unstructured":"Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M (2015) Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature 521(7550):94\u20138","journal-title":"Nature"},{"issue":"1","key":"2007_CR28","first-page":"17","volume":"4","author":"N Singh","year":"2021","unstructured":"Singh N, Miner A, Hennis L, Mittal S (2021) Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review, Cancer drug resistance (Alhambra. Calif) 4(1):17\u201343","journal-title":"Calif)"},{"key":"2007_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.914249","volume":"10","author":"K Sundararajan","year":"2022","unstructured":"Sundararajan K, Straight AF (2022) Centromere identity and the regulation of chromosome segregation. Front Cell Dev Biol 10:914249","journal-title":"Front Cell Dev Biol"},{"issue":"8061","key":"2007_CR29","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41586-025-08634-7","volume":"641","author":"Y Sun","year":"2025","unstructured":"Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gon\u00e7alves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O\u2019Rourke DM, Ma M, Ming GL, Song H (2025) Brain-wide neuronal circuit connectome of human glioblastoma. Nature 641(8061):222\u2013231","journal-title":"Nature"},{"issue":"1","key":"2007_CR32","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41392-024-01979-x","volume":"9","author":"B Wu","year":"2024","unstructured":"Wu B, Zhang B, Li B, Wu H, Jiang M (2024) Cold and hot tumors: from molecular mechanisms to targeted therapy. Signal Transduct Target therapy 9(1):274","journal-title":"Signal Transduct Target therapy"},{"issue":"1","key":"2007_CR33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12967-025-06202-1","volume":"23","author":"Y Xi","year":"2025","unstructured":"Xi Y, Yang Q, Wang Y, An W, Huang X, Sun C, Luo W, Shi C, Wang Q, Pan H, Chen Q, Li X, Hua D, Yu S, Zhou X (2025) ZNRF2 is essential for gliomagenesis through orchestrating glycolysis and acts as a promising therapeutic target in glioma. J translational Med 23(1):185","journal-title":"J translational Med"},{"issue":"1","key":"2007_CR34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12943-022-01513-z","volume":"21","author":"K Yang","year":"2022","unstructured":"Yang K, Wu Z, Zhang H, Zhang N, Wu W, Wang Z, Dai Z, Zhang X, Zhang L, Peng Y, Ye W, Zeng W, Liu Z, Cheng Q (2022) Glioma targeted therapy: insight into future of molecular approaches. Mol Cancer 21(1):39","journal-title":"Mol Cancer"},{"key":"2007_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1255611","volume":"14","author":"F Yasinjan","year":"2023","unstructured":"Yasinjan F, Xing Y, Geng H, Guo R, Yang L, Liu Z, Wang H (2023) Immunotherapy: a promising approach for glioma treatment. Front Immunol 14:1255611","journal-title":"Front Immunol"},{"issue":"7216","key":"2007_CR36","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/nature07443","volume":"455","author":"H Zheng","year":"2008","unstructured":"Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA (2008) p53 and Pten control neural and glioma stem\/progenitor cell renewal and differentiation. Nature 455(7216):1129\u201333","journal-title":"Nature"},{"issue":"3","key":"2007_CR37","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/neuonc\/noae224","volume":"27","author":"H Zhu","year":"2025","unstructured":"Zhu H, Cheng L, Liu D, Ma X, Chen Z, Fan H, Li R, Zhang Y, Mi H, Li J, Zhang S, Yu X, Shu K (2025) ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells. Neuro Oncol 27(3):695\u2013710","journal-title":"Neuro Oncol"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02007-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-02007-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02007-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T01:42:26Z","timestamp":1786585346000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-02007-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2007"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-02007-7","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"1 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal experiments were approved by the Ethics Committee of the Basic Medical College of Jilin University [Approval No.: 2025; (543)], and were carried out in accordance with the relevant regulations on the welfare and ethics of experimental animals in China, conforming to the values of animal protection, welfare and ethics.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Clinical trial number: not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"224"}}