{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:18:32Z","timestamp":1787732312241,"version":"build-2784847793"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-02017-5","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:27:59Z","timestamp":1787729279000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive study of the tumor immune microenvironment and the prognostic significance of reticulocalbin-1: a pan-cancer analysis"],"prefix":"10.1007","volume":"26","author":[{"given":"JiangLi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XuChen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QingYuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuJie","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiWei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunZhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiWei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"1","key":"2017_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G, The Gene Ontology Consortium (2000) Gene ontology: tool for the unification of biology. Nat Genet 25(1):25\u201329. https:\/\/doi.org\/10.1038\/75556","journal-title":"Nat Genet"},{"issue":"1","key":"2017_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/cdd.2017.169","volume":"25","author":"BJ Aubrey","year":"2018","unstructured":"Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A (2018) How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 25(1):104\u2013113. https:\/\/doi.org\/10.1038\/cdd.2017.169","journal-title":"Cell Death Differ"},{"issue":"7","key":"2017_CR3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","volume":"21","author":"E Boada-Romero","year":"2020","unstructured":"Boada-Romero E, Martinez J, Heckmann BL, Green DR (2020) The clearance of dead cells by efferocytosis. Nat Rev Mol Cell Biol 21(7):398\u2013414. https:\/\/doi.org\/10.1038\/s41580-020-0232-1","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"2017_CR4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molcel.2019.09.030","volume":"76","author":"JH Cha","year":"2019","unstructured":"Cha JH, Chan LC, Li CW, Hsu JL, Hung MC (2019) Mechanisms controlling PD-L1 expression in cancer. Mol Cell 76(3):359\u2013370. https:\/\/doi.org\/10.1016\/j.molcel.2019.09.030","journal-title":"Mol Cell"},{"issue":"2","key":"2017_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","volume":"21","author":"X Chen","year":"2021","unstructured":"Chen X, Cubillos-Ruiz JR (2021) Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer 21(2):71\u201388. https:\/\/doi.org\/10.1038\/s41568-020-00312-2","journal-title":"Nat Rev Cancer"},{"issue":"7637","key":"2017_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature21349","volume":"541","author":"DS Chen","year":"2017","unstructured":"Chen DS, Mellman I (2017) Elements of cancer immunity and the cancer-immune set point. Nature 541(7637):321\u2013330. https:\/\/doi.org\/10.1038\/nature21349","journal-title":"Nature"},{"key":"2017_CR38","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","volume":"1711","author":"B Chen","year":"2018","unstructured":"Chen B, Khodadoust MS, Liu CL, Newman AM, Alizadeh AA (2018) Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol 1711:243\u2013259. https:\/\/doi.org\/10.1007\/978-1-4939-7493-1_12","journal-title":"Methods Mol Biol"},{"key":"2017_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.humpath.2018.08.014","volume":"83","author":"X Chen","year":"2019","unstructured":"Chen X, Shao W, Huang H, Feng X, Yao S, Ke H (2019) Overexpression of RCN1 correlates with poor prognosis and progression in non-small cell lung cancer. Hum Pathol 83:140\u2013148. https:\/\/doi.org\/10.1016\/j.humpath.2018.08.014","journal-title":"Hum Pathol"},{"key":"2017_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-1661-0_1","volume":"1219","author":"GS Choudhary","year":"2015","unstructured":"Choudhary GS, Al-Harbi S, Almasan A (2015) Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods Mol Biol 1219:1\u20139. https:\/\/doi.org\/10.1007\/978-1-4939-1661-0_1","journal-title":"Methods Mol Biol"},{"issue":"7","key":"2017_CR9","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.cell.2015.05.025","volume":"161","author":"JR Cubillos-Ruiz","year":"2015","unstructured":"Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M et al (2015) ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161(7):1527\u20131538. https:\/\/doi.org\/10.1016\/j.cell.2015.05.025","journal-title":"Cell"},{"key":"2017_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030695","author":"G Di Conza","year":"2020","unstructured":"Di Conza G, Ho PC (2020) ER stress responses: an emerging modulator for innate immunity. Cells. https:\/\/doi.org\/10.3390\/cells9030695","journal-title":"Cells"},{"issue":"5","key":"2017_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126993","volume":"10","author":"Y Ding","year":"2015","unstructured":"Ding Y, Caberoy NB, Guo F, LeBlanc ME, Zhang C, Wang W et al (2015) Reticulocalbin-1 facilitates microglial phagocytosis. PLoS ONE 10(5):e0126993. https:\/\/doi.org\/10.1371\/journal.pone.0126993","journal-title":"PLoS ONE"},{"issue":"24","key":"2017_CR12","doi-asserted-by":"publisher","first-page":"11198","DOI":"10.1111\/jcmm.17040","volume":"25","author":"H Fu","year":"2021","unstructured":"Fu H, Chen R, Wang Y, Xu Y, Xia C, Zhang B (2021) Reticulocalbin 1 is required for proliferation and migration of non-small cell lung cancer cells regulated by osteoblast-conditioned medium. J Cell Mol Med 25(24):11198\u201311211. https:\/\/doi.org\/10.1111\/jcmm.17040","journal-title":"J Cell Mol Med"},{"issue":"4","key":"2017_CR13","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1369\/jhc.6A6943.2006","volume":"55","author":"T Fukuda","year":"2007","unstructured":"Fukuda T, Oyamada H, Isshiki T, Maeda M, Kusakabe T, Hozumi A et al (2007) Distribution and variable expression of secretory pathway protein reticulocalbin in normal human organs and non-neoplastic pathological conditions. J Histochem Cytochem 55(4):335\u2013345. https:\/\/doi.org\/10.1369\/jhc.6A6943.2006","journal-title":"J Histochem Cytochem"},{"key":"2017_CR14","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.jprot.2013.07.018","volume":"91","author":"G Giribaldi","year":"2013","unstructured":"Giribaldi G, Barbero G, Mandili G, Daniele L, Khadjavi A, Notarpietro A et al (2013) Proteomic identification of Reticulocalbin 1 as potential tumor marker in renal cell carcinoma. J Proteomics 91:385\u2013392. https:\/\/doi.org\/10.1016\/j.jprot.2013.07.018","journal-title":"J Proteomics"},{"key":"2017_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061198","author":"J Gomez","year":"2021","unstructured":"Gomez J, Areeb Z, Stuart SF, Nguyen HPT, Paradiso L, Zulkifli A et al (2021) EGFRvIII promotes cell survival during endoplasmic reticulum stress through a reticulocalbin 1-dependent mechanism. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13061198","journal-title":"Cancers (Basel)"},{"key":"2017_CR39","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7. https:\/\/doi.org\/10.1186\/1471-2105-14-7","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"2017_CR16","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/bies.200800186","volume":"31","author":"B Honor\u00e9","year":"2009","unstructured":"Honor\u00e9 B (2009) The rapidly expanding CREC protein family: members, localization, function, and role in disease. BioEssays 31(3):262\u2013277. https:\/\/doi.org\/10.1002\/bies.200800186","journal-title":"BioEssays"},{"issue":"1","key":"2017_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27","journal-title":"Nucleic Acids Res"},{"key":"2017_CR18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.yexmp.2019.02.001","volume":"107","author":"A Kurpi\u0144ska","year":"2019","unstructured":"Kurpi\u0144ska A, Suraj J, Bonar E, Zakrzewska A, Stojak M, Sternak M et al (2019) Proteomic characterization of early lung response to breast cancer metastasis in mice. Exp Mol Pathol 107:129\u2013140. https:\/\/doi.org\/10.1016\/j.yexmp.2019.02.001","journal-title":"Exp Mol Pathol"},{"key":"2017_CR40","doi-asserted-by":"publisher","unstructured":"Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, (2020) TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res 48(W1):W509\u2013w514. https:\/\/doi.org\/10.1093\/nar\/gkaa407","DOI":"10.1093\/nar\/gkaa407"},{"key":"2017_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109249","volume":"118","author":"Y Lin","year":"2019","unstructured":"Lin Y, Jiang M, Chen W, Zhao T, Wei Y (2019) Cancer and ER stress: mutual crosstalk between autophagy, oxidative stress and inflammatory response. Biomed Pharmacother 118:109249. https:\/\/doi.org\/10.1016\/j.biopha.2019.109249","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"2017_CR20","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/cas.13541","volume":"109","author":"X Liu","year":"2018","unstructured":"Liu X, Zhang N, Wang D, Zhu D, Yuan Q, Zhang X et al (2018) Downregulation of reticulocalbin-1 differentially facilitates apoptosis and necroptosis in human prostate cancer cells. Cancer Sci 109(4):1147\u20131157. https:\/\/doi.org\/10.1111\/cas.13541","journal-title":"Cancer Sci"},{"key":"2017_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1790936","volume":"17","author":"Z Liu","year":"2026","unstructured":"Liu Z, Liu J, Chu H, Lu Z, Xu S, Qin Y et al (2026) JAK inhibition in PD-1 immunotherapy and tumor microenvironment. Front Immunol 17:1790936. https:\/\/doi.org\/10.3389\/fimmu.2026.1790936","journal-title":"Front Immunol"},{"key":"2017_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.164202","volume":"516","author":"W Luo","year":"2025","unstructured":"Luo W, Pan X, Ren C, Wang T, Li G, Jin L et al (2025) Anti-swelling and ROS-scavenging nanofiber hydrogel to prevent postoperative abdominal adhesion. Chem Eng J 516:164202. https:\/\/doi.org\/10.1016\/j.cej.2025.164202","journal-title":"Chem Eng J"},{"key":"2017_CR23","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2741\/2692","volume":"13","author":"FO Martinez","year":"2008","unstructured":"Martinez FO, Sica A, Mantovani A, Locati M (2008) Macrophage activation and polarization. Front Biosci 13:453\u2013461. https:\/\/doi.org\/10.2741\/2692","journal-title":"Front Biosci"},{"key":"2017_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2014.08.007","volume":"90","author":"EW May","year":"2014","unstructured":"May EW, Lin ST, Lin CC, Chang JF, Hung E, Lo YW et al (2014) Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance. Pharmacol Res 90:1\u201317. https:\/\/doi.org\/10.1016\/j.phrs.2014.08.007","journal-title":"Pharmacol Res"},{"issue":"6 Suppl","key":"2017_CR25","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1586\/14737175.5.6.S41","volume":"5","author":"MK Nicholas","year":"2005","unstructured":"Nicholas MK, Lukas R, Bangalore S (2005) Chemotherapy for malignant glioma. Expert Rev Neurother 5(6 Suppl):S41-49. https:\/\/doi.org\/10.1586\/14737175.5.6.S41","journal-title":"Expert Rev Neurother"},{"key":"2017_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.167519","volume":"522","author":"X Pan","year":"2025","unstructured":"Pan X, Zhu P, Ding Y, Di C, Yang Z, Zhou H et al (2025) Engineered honeysuckle extracellular vesicles loaded in ROS response hydrogel for inhibition of postoperative abdominal adhesion. Chem Eng J 522:167519. https:\/\/doi.org\/10.1016\/j.cej.2025.167519","journal-title":"Chem Eng J"},{"issue":"7","key":"2017_CR41","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43(7):e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2017_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","volume":"73","author":"DS Schwarz","year":"2016","unstructured":"Schwarz DS, Blower MD (2016) The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci 73(1):79\u201394. https:\/\/doi.org\/10.1007\/s00018-015-2052-6","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"2017_CR28","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"issue":"9","key":"2017_CR29","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","unstructured":"Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F et al (2018) Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol 233(9):6425\u20136440. https:\/\/doi.org\/10.1002\/jcp.26429","journal-title":"J Cell Physiol"},{"issue":"1","key":"2017_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07582-4","volume":"16","author":"H Shen","year":"2025","unstructured":"Shen H, Jin J, Yu N, Liu T, Nie Y, Wan Z et al (2025) PRKCSH enhances colorectal cancer radioresistance via IRE1\u03b1\/XBP1s-mediated DNA repair. Cell Death Dis 16(1):258. https:\/\/doi.org\/10.1038\/s41419-025-07582-4","journal-title":"Cell Death Dis"},{"issue":"43","key":"2017_CR31","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2017_CR32","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.21873\/invivo.12048","volume":"34","author":"S Ueda","year":"2020","unstructured":"Ueda S, Hashimoto K, Miyabe S, Hasegawa S, Goto M, Shimizu D et al (2020) Salivary NUS1 and RCN1 levels as biomarkers for oral squamous cell carcinoma diagnosis. In Vivo 34(5):2353\u20132361. https:\/\/doi.org\/10.21873\/invivo.12048","journal-title":"In Vivo"},{"issue":"1","key":"2017_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00696-6","volume":"7","author":"JW Wang","year":"2021","unstructured":"Wang JW, Ma L, Liang Y, Yang XJ, Wei S, Peng H et al (2021) RCN1 induces sorafenib resistance and malignancy in hepatocellular carcinoma by activating c-MYC signaling via the IRE1\u03b1-XBP1s pathway. Cell Death Discov 7(1):298. https:\/\/doi.org\/10.1038\/s41420-021-00696-6","journal-title":"Cell Death Discov"},{"key":"2017_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1678907","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang Y, Lu K, Xu Y, Xu S, Chu H, Fang X (2025) Antibody-drug conjugates as immuno-oncology agents in colorectal cancer: targets, payloads, and therapeutic synergies. Front Immunol 16:1678907. https:\/\/doi.org\/10.3389\/fimmu.2025.1678907","journal-title":"Front Immunol"},{"issue":"5","key":"2017_CR35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"OMICS"},{"key":"2017_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.683915","volume":"11","author":"H Zhang","year":"2021","unstructured":"Zhang H, Zhao X, Wang J, Ji W (2021) Development and validation of an immune-related signature for the prediction of recurrence risk of patients with laryngeal cancer. Front Oncol 11:683915. https:\/\/doi.org\/10.3389\/fonc.2021.683915","journal-title":"Front Oncol"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02017-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-02017-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02017-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:28:01Z","timestamp":1787729281000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-02017-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2017"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-02017-5","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"31 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee of the Qilu Hospital (Jinan, China) reviewed and approved for all experiments conducted in this research (Approval Number: KYLL-2023(ZM)626). Patients-related information was all obtained from publicly available datasets.","order":1,"name":"Ethics","label":"Ethical statements","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"234"}}