{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:19:39Z","timestamp":1788412779910,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science and Technology Plan Project of Jiangxi Provincial Administration of Traditional Chinese Medicine","award":["2023A0060"],"award-info":[{"award-number":["2023A0060"]}]},{"name":"Guangdong Basic and Applied Basic Research Fundation","award":["2024A1515013292"],"award-info":[{"award-number":["2024A1515013292"]}]},{"name":"Guangdong Basic and Applied Basic Research Fundation","award":["2025A1515010567"],"award-info":[{"award-number":["2025A1515010567"]}]},{"name":"Guangdong Basic and Applied Basic Research Fundation","award":["2026A1515012094"],"award-info":[{"award-number":["2026A1515012094"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300085"],"award-info":[{"award-number":["32300085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504340"],"award-info":[{"award-number":["82504340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473567"],"award-info":[{"award-number":["82473567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-02025-5","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:08:41Z","timestamp":1788412121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral and gut microbiota profiles in patients with locally advanced rectal cancer with varying responses to neoadjuvant chemoradiotherapy"],"prefix":"10.1007","volume":"26","author":[{"given":"Yajing","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhemin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-533X","authenticated-orcid":false,"given":"Zhenhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-3842","authenticated-orcid":false,"given":"Lu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-9255","authenticated-orcid":false,"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2025_CR18","doi-asserted-by":"publisher","unstructured":"Atreya MR, Banerjee S, Lautz AJ, Alder MN, Varisco BM, Sanchez-Pinto LN et al (2024) Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness. EBioMedicine 99:104938. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104938","DOI":"10.1016\/j.ebiom.2023.104938"},{"key":"2025_CR4","doi-asserted-by":"publisher","first-page":"3724","DOI":"10.1200\/JCO.23.00903","volume":"41","author":"E Basch","year":"2023","unstructured":"Basch E, Dueck AC, Mitchell SA, Mamon H, Weiser M, Saltz L et al (2023) Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048). J Clin Oncol 41:3724\u20133734. https:\/\/doi.org\/10.1200\/JCO.23.00903","journal-title":"J Clin Oncol"},{"key":"2025_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.6004\/jnccn.2024.0041","volume":"22","author":"AB Benson","year":"2024","unstructured":"Benson AB, Venook AP, Adam M, Chang G, Chen YJ, Ciombor KK et al (2024) NCCN Guidelines\u00ae Insights: Rectal Cancer, Version 3.2024. J Natl Compr Cancer Network: JNCCN 22:366\u2013375. https:\/\/doi.org\/10.6004\/jnccn.2024.0041","journal-title":"J Natl Compr Cancer Network: JNCCN"},{"key":"2025_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung HYA, Ferlay J, Siegel RL, Soerjomataram I et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca-Cancer J Clin 74:229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"Ca-Cancer J Clin"},{"key":"2025_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nmeth.3176","volume":"12","author":"B Buchfink","year":"2015","unstructured":"Buchfink B, Xie C, Huson DH (2015) Fast and sensitive protein alignment using DIAMOND. Nat Methods 12:59\u201360. https:\/\/doi.org\/10.1038\/nmeth.3176","journal-title":"Nat Methods"},{"key":"2025_CR27","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00284-020-02299-3","volume":"78","author":"H Chang","year":"2021","unstructured":"Chang H, Mishra R, Cen C, Tang Y, Ma C, Wasti S et al (2021) Metagenomic Analyses Expand Bacterial and Functional Profiling Biomarkers for Colorectal Cancer in a Hainan Cohort, China. Curr Microbiol 78:705\u2013712. https:\/\/doi.org\/10.1007\/s00284-020-02299-3","journal-title":"Curr Microbiol"},{"key":"2025_CR17","doi-asserted-by":"publisher","first-page":"109886","DOI":"10.1016\/j.celrep.2021.109886","volume":"37","author":"J Dong","year":"2021","unstructured":"Dong J, Li Y, Xiao H, Zhang S, Wang B, Wang H et al (2021) Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models. Cell Rep 37:109886. https:\/\/doi.org\/10.1016\/j.celrep.2021.109886","journal-title":"Cell Rep"},{"key":"2025_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/0471250953.bi1111s44","volume":"44","author":"S Gu","year":"2013","unstructured":"Gu S, Fang L, Xu X (2013) Using SOAPaligner for Short Reads Alignment. Curr Protoc Bioinf 44:111\u2013117. https:\/\/doi.org\/10.1002\/0471250953.bi1111s44","journal-title":"Curr protocols Bioinf"},{"key":"2025_CR28","doi-asserted-by":"publisher","first-page":"110708","DOI":"10.1016\/j.foodres.2021.110708","volume":"152","author":"Guiomar de Almeida Brasiel","year":"2022","unstructured":"Guiomar de Almeida Brasiel, Cristina Potente Dutra Luquetti S, Dutra Medeiros J, Otavio do Amaral Corr\u00eaa J, Barbosa Ferreira Machado A, Paula Boroni Moreira A et al (2022) Kefir modulates gut microbiota and reduces DMH-associated colorectal cancer via regulation of intestinal inflammation in adulthood offsprings programmed by neonatal overfeeding. Food Res Int (Ottawa Ont) 152:110708. https:\/\/doi.org\/10.1016\/j.foodres.2021.110708","journal-title":"Food Res Int (Ottawa Ont)"},{"key":"2025_CR38","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/s41564-023-01363-5","volume":"8","author":"JX Han","year":"2023","unstructured":"Han JX, Tao ZH, Wang JL, Zhang L, Yu CY, Kang ZR et al (2023) Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer. Nat Microbiol 8:919\u2013933. https:\/\/doi.org\/10.1038\/s41564-023-01363-5","journal-title":"Nat Microbiol"},{"key":"2025_CR20","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1002\/imt2.217","volume":"3","author":"C Han","year":"2024","unstructured":"Han C, Shi C, Liu L, Han J, Yang Q, Wang Y et al (2024) Majorbio Cloud 2024: Update single-cell and multiomics workflows. iMeta 3:e217. https:\/\/doi.org\/10.1002\/imt2.217","journal-title":"iMeta"},{"key":"2025_CR41","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/gutjnl-2018-317200","volume":"68","author":"Z He","year":"2019","unstructured":"He Z, Gharaibeh RZ, Newsome RC, Pope JL, Dougherty MW, Tomkovich S et al (2019) Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin. Gut 68:289\u2013300. https:\/\/doi.org\/10.1136\/gutjnl-2018-317200","journal-title":"Gut"},{"key":"2025_CR7","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1200\/JCO.23.01889","volume":"42","author":"H Hu","year":"2024","unstructured":"Hu H, Zhang J, Li Y, Wang X, Wang Z, Wang H et al (2024) Neoadjuvant Chemotherapy With Oxaliplatin and Fluoropyrimidine Versus Upfront Surgery for Locally Advanced Colon Cancer: The Randomized, Phase III OPTICAL Trial. J Clin Oncol 42:2978\u20132988. https:\/\/doi.org\/10.1200\/JCO.23.01889","journal-title":"J Clin Oncol"},{"key":"2025_CR34","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s40168-022-01388-8","volume":"10","author":"JW Huh","year":"2022","unstructured":"Huh JW, Kim MJ, Kim J, Lee HG, Ryoo SB, Ku JL et al (2022) Enterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer. Microbiome 10:203. https:\/\/doi.org\/10.1186\/s40168-022-01388-8","journal-title":"Microbiome"},{"key":"2025_CR43","doi-asserted-by":"publisher","unstructured":"Jiang SS, Xie YL, Xiao XY, Kang ZR, Lin XL, Zhang L et al (2023) Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer. Cell Host Microbe 31:781\u2013797. https:\/\/doi.org\/10.1016\/j.chom.2023.04.010","DOI":"10.1016\/j.chom.2023.04.010"},{"key":"2025_CR5","doi-asserted-by":"publisher","unstructured":"Judge SJ, Malekzadeh P, Corines MJ, Gollub MJ, Horvat N, Gonen M et al (2024) Watch and wait in rectal cancer patients with residual mucin on MRI following neoadjuvant therapy. J Natl Cancer Inst 116:1761\u20131766. https:\/\/doi.org\/10.1093\/jnci\/djae152","DOI":"10.1093\/jnci\/djae152"},{"key":"2025_CR21","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25:1754\u20131760. https:\/\/doi.org\/10.1093\/bioinformatics\/btp324","journal-title":"Bioinformatics"},{"key":"2025_CR23","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","volume":"22","author":"W Li","year":"2006","unstructured":"Li W, Godzik A (2006) Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics 22:1658\u20131659. https:\/\/doi.org\/10.1093\/bioinformatics\/btl158","journal-title":"Bioinformatics"},{"key":"2025_CR22","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","volume":"31","author":"D Li","year":"2015","unstructured":"Li D, Liu CM, Luo R, Sadakane K, Lam TW (2015) MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. Bioinformatics 31:1674\u20131676. https:\/\/doi.org\/10.1093\/bioinformatics\/btv033","journal-title":"Bioinformatics"},{"key":"2025_CR33","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.21037\/tcr.2020.03.33","volume":"9","author":"J Li","year":"2020","unstructured":"Li J, Chu R, Wang C, Li Y, Wu B, Wan J (2020) Microbiome characteristics and Bifidobacterium longum in colorectal cancer patients pre- and post-chemotherapy. Translational cancer Res 9:2178\u20132190. https:\/\/doi.org\/10.21037\/tcr.2020.03.33","journal-title":"Translational cancer Res"},{"key":"2025_CR39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12951-024-02506-4","volume":"22","author":"N Li","year":"2024","unstructured":"Li N, Niu L, Liu Y, Wang Y, Su X, Xu C et al (2024) Taking SCFAs produced by Lactobacillus reuteri orally reshapes gut microbiota and elicits antitumor responses. J Nanobiotechnol 22:241. https:\/\/doi.org\/10.1186\/s12951-024-02506-4","journal-title":"J Nanobiotechnol"},{"key":"2025_CR10","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1001\/jamaoncol.2022.0494","volume":"8","author":"LS Liu","year":"2022","unstructured":"Liu L, Shah K (2022) The Potential of the Gut Microbiome to Reshape the Cancer Therapy Paradigm. Jama Oncol 8:1059\u20131067. https:\/\/doi.org\/10.1001\/jamaoncol.2022.0494","journal-title":"Jama Oncol"},{"key":"2025_CR35","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12929-022-00869-0","volume":"29","author":"CH Lo","year":"2022","unstructured":"Lo CH, Wu DC, Jao SW, Wu CC, Lin CY, Chuang CH et al (2022) Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas. J Biomed Sci 29:88. https:\/\/doi.org\/10.1186\/s12929-022-00869-0","journal-title":"J Biomed Sci"},{"key":"2025_CR11","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.annonc.2020.06.019","volume":"31","author":"EH Mann","year":"2020","unstructured":"Mann EH, Maughan TS (2020) Fusobacterium nucleatum, rectal cancer and radiotherapy. Annals oncology: official J Eur Soc Med Oncol 31:1277\u20131278. https:\/\/doi.org\/10.1016\/j.annonc.2020.06.019","journal-title":"Annals oncology: official J Eur Soc Med Oncol"},{"key":"2025_CR31","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.jcmgh.2024.01.010","volume":"17","author":"Y Miyakawa","year":"2024","unstructured":"Miyakawa Y, Otsuka M, Shibata C, Seimiya T, Yamamoto K, Ishibashi R et al (2024) Gut Bacteria-derived Membrane Vesicles Induce Colonic Dysplasia by Inducing DNA Damage in Colon Epithelial Cells. Cell Mol Gastroenterol Hepatol 17:745\u2013767. https:\/\/doi.org\/10.1016\/j.jcmgh.2024.01.010","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2025_CR36","doi-asserted-by":"publisher","first-page":"573158","DOI":"10.3389\/fimmu.2020.573158","volume":"11","author":"E Niccolai","year":"2020","unstructured":"Niccolai E, Russo E, Baldi S, Ricci F, Nannini G, Pedone M et al (2020) Significant and Conflicting Correlation of IL-9 With Prevotella and Bacteroides in Human Colorectal Cancer. Front Immunol 11:573158. https:\/\/doi.org\/10.3389\/fimmu.2020.573158","journal-title":"Front Immunol"},{"key":"2025_CR8","doi-asserted-by":"publisher","unstructured":"Qin QY, Huang BJ, Wu AW, Gao JL, Liu XZ, Cao WT et al (2023) Development and validation of a post-radiotherapy prediction model for bowel dysfunction after rectal cancer resection. Gastroenterology 165:1430-1442 e14. https:\/\/doi.org\/10.1053\/j.gastro.2023.08.022","DOI":"10.1053\/j.gastro.2023.08.022"},{"key":"2025_CR9","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1126\/science.abc4552","volume":"371","author":"GD Sepich-Poore","year":"2021","unstructured":"Sepich-Poore GD, Zitvogel L, Straussman R, Hasty J, Wargo JA, Knight R (2021) The microbiome and human cancer. Science 371(6536):eabc4552. https:\/\/doi.org\/10.1126\/science.abc4552","journal-title":"Science"},{"key":"2025_CR16","doi-asserted-by":"publisher","unstructured":"Shi W, Shen LJ, Zou W, Wang JW, Yang JN, Wang YZ et al (2020) The gut microbiome is associated with therapeutic responses and toxicities of neoadjuvant chemoradiotherapy in rectal cancer patients-a pilot study. Front Cell Infect Microbiol 10:562463. https:\/\/doi.org\/10.3389\/fcimb.2020.562463","DOI":"10.3389\/fcimb.2020.562463"},{"key":"2025_CR2","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1200\/JCO.2014.60.1054","volume":"33","author":"JJ Smith","year":"2015","unstructured":"Smith JJ, Garcia-Aguilar J (2015) Advances and Challenges in Treatment of Locally Advanced Rectal Cancer. J Clin Oncol 33:1797\u2013808. https:\/\/doi.org\/10.1200\/JCO.2014.60.1054","journal-title":"J Clin Oncol"},{"key":"2025_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ccell.2022.11.013","volume":"41","author":"HJ Teng","year":"2023","unstructured":"Teng HJ, Wang Y, Sui X, Fan JW, Li S, Lei X et al (2023) Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer. Cancer Cell 41:124\u2013138.e6. https:\/\/doi.org\/10.1016\/j.ccell.2022.11.013","journal-title":"Cancer Cell"},{"key":"2025_CR40","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.tim.2022.08.010","volume":"31","author":"N Wang","year":"2023","unstructured":"Wang N, Fang JY (2023) Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer. Trends Microbiol 31:159\u2013172. https:\/\/doi.org\/10.1016\/j.tim.2022.08.010","journal-title":"Trends Microbiol"},{"key":"2025_CR29","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12866-019-1610-8","volume":"19","author":"C Wang","year":"2019","unstructured":"Wang C, Li W, Wang H, Ma Y, Zhao X, Zhang X et al (2019) Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-\u03b1 and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol 19:246. https:\/\/doi.org\/10.1186\/s12866-019-1610-8","journal-title":"BMC Microbiol"},{"key":"2025_CR26","doi-asserted-by":"publisher","first-page":"1288666","DOI":"10.3389\/fcimb.2023.1288666","volume":"13","author":"K Wang","year":"2023","unstructured":"Wang K, Zhang J, Zhang Y, Xue J, Wang H, Tan X et al (2023) The recovery of intestinal barrier function and changes in oral microbiota after radiation therapy injury. Front Cell Infect Microbiol 13:1288666. https:\/\/doi.org\/10.3389\/fcimb.2023.1288666","journal-title":"Front Cell Infect Microbiol"},{"key":"2025_CR12","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/s41579-023-00973-4","volume":"22","author":"MT White","year":"2024","unstructured":"White MT, Sears CL (2024) The microbial landscape of colorectal cancer. Nat Rev Microbiol 22:240\u2013254. https:\/\/doi.org\/10.1038\/s41579-023-00973-4","journal-title":"Nat Rev Microbiol"},{"key":"2025_CR6","doi-asserted-by":"publisher","first-page":"e232748","DOI":"10.1148\/radiol.232748","volume":"312","author":"H Williams","year":"2024","unstructured":"Williams H, Omer DM, Thompson HM, Lin ST, Verheij FS, Miranda J et al (2024) MRI Predicts Residual Disease and Outcomes in Watch-and-Wait Patients with Rectal Cancer. Radiology 312:e232748. https:\/\/doi.org\/10.1148\/radiol.232748","journal-title":"Radiology"},{"key":"2025_CR42","doi-asserted-by":"publisher","first-page":"e0236595","DOI":"10.1371\/journal.pone.0236595","volume":"15","author":"AE Wolfe","year":"2020","unstructured":"Wolfe AE, Moskowitz JE, Franklin CL, Wiemken TL, Ericsson AC (2020) Interactions of Segmented Filamentous Bacteria (Candidatus Savagella) and bacterial drivers in colitis-associated colorectal cancer development. PLoS ONE 15:e0236595. https:\/\/doi.org\/10.1371\/journal.pone.0236595","journal-title":"PLoS ONE"},{"key":"2025_CR13","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","volume":"20","author":"CC Wong","year":"2023","unstructured":"Wong CC, Yu J (2023) Gut microbiota in colorectal cancer development and therapy. Nat Rev Clin Oncol 20:429\u2013452. https:\/\/doi.org\/10.1038\/s41571-023-00766-x","journal-title":"Nat reviews Clin Oncol"},{"key":"2025_CR32","doi-asserted-by":"publisher","first-page":"1008975","DOI":"10.3389\/fimmu.2022.1008975","volume":"13","author":"Z Xu","year":"2022","unstructured":"Xu Z, Lv Z, Chen F, Zhang Y, Xu Z, Huo J et al (2022) Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer. Front Immunol 13:1008975. https:\/\/doi.org\/10.3389\/fimmu.2022.1008975","journal-title":"Front Immunol"},{"key":"2025_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2024.07.002","volume-title":"Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer","author":"Z Yang","year":"2024","unstructured":"Yang Z, Ma J, Han J, Li A, Liu G, Sun Y et al (2024) Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer. Med, New York, NY)5:1293-1306 e4. https:\/\/doi.org\/10.1016\/j.medj.2024.07.002"},{"key":"2025_CR14","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1158\/1078-0432.CCR-20-3445","volume":"27","author":"YX Yi","year":"2021","unstructured":"Yi YX, Shen LJ, Shi W, Xia F, Zhang H, Wang Y et al (2021) Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study. Clin Cancer Res 27:1329\u20131340. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-3445","journal-title":"Clin Cancer Res"},{"key":"2025_CR44","doi-asserted-by":"publisher","unstructured":"Yu T, Guo F, Yu Y, Sun T, Ma D, Han J et al (2017) Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell 170:548\u2009\u2013\u2009563.e16 https:\/\/doi.org\/10.1016\/j.cell.2017.07.008","DOI":"10.1016\/j.cell.2017.07.008"},{"key":"2025_CR30","doi-asserted-by":"publisher","first-page":"562189","DOI":"10.3389\/fonc.2020.562189","volume":"10","author":"W Yu","year":"2020","unstructured":"Yu W, Zhang J, Chen Z, Wang S, Ruan C, Zhou W et al (2020) Inhibitory Effect of a Microecological Preparation on Azoxymethane\/Dextran Sodium Sulfate-Induced Inflammatory Colorectal Cancer in Mice. Front Oncol 10:562189. https:\/\/doi.org\/10.3389\/fonc.2020.562189","journal-title":"Front Oncol"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02025-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-02025-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02025-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:08:42Z","timestamp":1788412122000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-02025-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2025"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-02025-5","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study conformed to the ethical guidelines of the Declaration of Helsinki and was approved by the Ethics Committee of Nanfang Hospital, Southern Medical University (NFEC-202305-K22). All patients have signed a written informed consent.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"245"}}