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All animal experiments were performed in strict compliance with the Guide for the Care and Use of Laboratory Animals (NIH Publication No. 85\u2009\u2212\u200923, revised 1996) and the 3R principles (Replacement, Reduction, Refinement) to minimize animal suffering. The animal facility meets standard requirements for laboratory animal care and management.","order":1,"name":"Ethics","label":"Ethics declarations","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"267"}}