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The original study obtained its own ethics approvals and participant consent as reported in that publication. No new human or animal subject research was performed; therefore, additional Institutional Review Board\/Ethics Committee approval and informed consent were not applicable, and no animal experiments were performed.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This study analysed only publicly available, de-identified single-cell RNA-sequencing data from previously published studies; no new human participants were involved, so consent to participate and consent to publish are not applicable.","order":2,"name":"Ethics","label":"Consent to participate and consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declares the following potential competing interest: the author is a co-author of Yokoyama et al. (2024), the prior murine study whose\n                      KCNQ1OT1\n                      finding is examined here at human single-cell resolution. No other competing interests are declared.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work the author used Anthropic Claude (Claude Code) to write and test the analysis code, including the code that computes every reported statistic and renders the figures from the computed results, and to produce drafts of the manuscript text, including the English of this revised version; and used OpenAI ChatGPT, OpenAI Codex and Google Gemini to generate adversarial critiques of earlier drafts. After using these tools the author reviewed and edited the content as needed and takes full responsibility for the content of the published article. No generative AI tool was used to create or to manipulate any image, figure or research datum: all primary data are the public datasets cited in the Methods, and every figure is a deterministic rendering of the computed results by the analysis code. The author conceived the study, specified every analysis, verified every reported number against the primary output files of the analysis, and checked every cited reference against the primary bibliographic record. No AI tool is listed or cited as an author. A fuller account of what each tool was used for is given in the Methods.","order":4,"name":"Ethics","label":"Declaration of generative AI and AI-assisted technologies in the manuscript preparation process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"268"}}