{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:55:44Z","timestamp":1790924144670,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation of Hunan Province China","award":["2025JJ80843"],"award-info":[{"award-number":["2025JJ80843"]}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["20255568"],"award-info":[{"award-number":["20255568"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-02053-1","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:49:24Z","timestamp":1790923764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["METTL14-mediated m6A modification of CXCL9 mRNA regulates macrophage CS polarization to suppress OSCC growth and stemness"],"prefix":"10.1007","volume":"26","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"2053_CR1","doi-asserted-by":"publisher","first-page":"1492282","DOI":"10.3389\/fmolb.2025.1492282","volume":"12","author":"A Lipka","year":"2025","unstructured":"Lipka A, Soland TM, Nieminen AI, Sapkota D, Haug TM, Galtung HK (2025) The effect of extracellular vesicles derived from oral squamous cell carcinoma on the metabolic profile of oral fibroblasts. Front Mol Biosci 12:1492282. https:\/\/doi.org\/10.3389\/fmolb.2025.1492282","journal-title":"Front Mol Biosci"},{"issue":"5","key":"2053_CR2","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s13402-025-01068-3","volume":"48","author":"N Xue","year":"2025","unstructured":"Xue N, Wang Y, Wang Z, Zeng X, Wang J, Zhang X (2025) Trends in immunotherapy for oral squamous cell carcinoma. Cell Oncol (Dordr) 48(5):1159\u20131179. https:\/\/doi.org\/10.1007\/s13402-025-01068-3","journal-title":"Cell Oncol (Dordr)"},{"key":"2053_CR3","doi-asserted-by":"publisher","first-page":"104672","DOI":"10.1016\/j.critrevonc.2025.104672","volume":"209","author":"S Gupta","year":"2025","unstructured":"Gupta S, Singh A, Deorah S, Tomar A (2025) Immunotherapy in OSCC: Current trend and challenges. Crit Rev Oncol Hematol 209:104672. https:\/\/doi.org\/10.1016\/j.critrevonc.2025.104672","journal-title":"Crit Rev Oncol Hematol"},{"issue":"9","key":"2053_CR4","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1007\/s00432-022-04028-8","volume":"148","author":"H Li","year":"2022","unstructured":"Li H, Zhang Y, Xu M, Yang D (2022) Current trends of targeted therapy for oral squamous cell carcinoma. J Cancer Res Clin Oncol 148(9):2169\u20132186. https:\/\/doi.org\/10.1007\/s00432-022-04028-8","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"2053_CR5","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s00018-024-05325-w","volume":"81","author":"J Bai","year":"2024","unstructured":"Bai J, Chen Y, Sun Y, Wang X, Wang Y, Guo S, Shang Z, Shao Z (2024) EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma. Cell Mol Life Sci 81(1):278. https:\/\/doi.org\/10.1007\/s00018-024-05325-w","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"2053_CR6","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.stem.2024.06.003","volume":"31","author":"PE Saw","year":"2024","unstructured":"Saw PE, Liu Q, Wong PP, Song E (2024) Cancer stem cell mimicry for immune evasion and therapeutic resistance. Cell Stem Cell 31(8):1101\u20131112. https:\/\/doi.org\/10.1016\/j.stem.2024.06.003","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2053_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12943-022-01682-x","volume":"21","author":"P Nallasamy","year":"2022","unstructured":"Nallasamy P, Nimmakayala RK, Parte S, Are AC, Batra SK, Ponnusamy MP (2022) Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis. Mol Cancer 21(1):225. https:\/\/doi.org\/10.1186\/s12943-022-01682-x","journal-title":"Mol Cancer"},{"issue":"3","key":"2053_CR8","doi-asserted-by":"publisher","first-page":"e70272","DOI":"10.1002\/ctm2.70272","volume":"15","author":"Z Wang","year":"2025","unstructured":"Wang Z, Wu H, Li Z, Chen Z, Feng A, Chu Y, Fang K, Zhang Z, Zhao Z, Leng Z et al (2025) PADI4 facilitates stem-like properties and cisplatin resistance through upregulating PRMT2\/IDs family in oesophageal squamous cell carcinoma. Clin Transl Med 15(3):e70272. https:\/\/doi.org\/10.1002\/ctm2.70272","journal-title":"Clin Transl Med"},{"issue":"3","key":"2053_CR9","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1080\/15548627.2022.2103961","volume":"19","author":"S Chouhan","year":"2023","unstructured":"Chouhan S, Sawant M, Weimholt C, Luo J, Sprung RW, Terrado M, Mueller DM, Earp HS, Mahajan NP (2023) TNK2\/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability. Autophagy 19(3):1000\u20131025. https:\/\/doi.org\/10.1080\/15548627.2022.2103961 From NLM Medline","journal-title":"Autophagy"},{"key":"2053_CR10","doi-asserted-by":"publisher","first-page":"27558","DOI":"10.1038\/srep27558","volume":"6","author":"S Chouhan","year":"2016","unstructured":"Chouhan S, Singh S, Athavale D, Ramteke P, Pandey V, Joseph J, Mohan R, Shetty PK, Bhat MK (2016) Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4. Sci Rep 6:27558. https:\/\/doi.org\/10.1038\/srep27558 From NLM Medline","journal-title":"Sci Rep"},{"key":"2053_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40170-018-0176-5","volume":"6","author":"P Malvi","year":"2018","unstructured":"Malvi P, Chaube B, Singh SV, Mohammad N, Vijayakumar MV, Singh S, Chouhan S, Bhat MK (2018) Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state. Cancer Metab 6:2. https:\/\/doi.org\/10.1186\/s40170-018-0176-5 From NLM PubMed-not-MEDLINE","journal-title":"Cancer Metab"},{"key":"2053_CR12","doi-asserted-by":"crossref","unstructured":"Chouhan S, Singh S, Athavale D, Ramteke P, Vanuopadath M, Nair BG, Nair SS, Bhat MK (2020) Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4. J Biosci 45. From NLM Medline","DOI":"10.1007\/s12038-020-00065-y"},{"key":"2053_CR13","doi-asserted-by":"publisher","unstructured":"Cabral LGS, Martins IM, Paulo EPA, Pomini KT, Poyet JL, Maria DA (2025) Molecular Mechanisms in the Carcinogenesis of Oral Squamous Cell Carcinoma: A Literature Review. Biomolecules 15(5). https:\/\/doi.org\/10.3390\/biom15050621","DOI":"10.3390\/biom15050621"},{"issue":"7","key":"2053_CR14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.it.2022.04.008","volume":"43","author":"RY Ma","year":"2022","unstructured":"Ma RY, Black A, Qian BZ (2022) Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol 43(7):546\u2013563. https:\/\/doi.org\/10.1016\/j.it.2022.04.008 From NLM Medline","journal-title":"Trends Immunol"},{"issue":"6657","key":"2053_CR15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1126\/science.ade2292","volume":"381","author":"R Bill","year":"2023","unstructured":"Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J et al (2023) CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science 381(6657):515\u2013524. https:\/\/doi.org\/10.1126\/science.ade2292","journal-title":"Science"},{"key":"2053_CR16","doi-asserted-by":"publisher","first-page":"1547529","DOI":"10.3389\/fonc.2025.1547529","volume":"15","author":"P Shi","year":"2025","unstructured":"Shi P, Zhang W, Yao Q, Yuan Z, Wang J, Yang Z, Qu P (2025) CS Ratio is an immune-related prognostic biomarker for cervical cancer. Front Oncol 15:1547529. https:\/\/doi.org\/10.3389\/fonc.2025.1547529","journal-title":"Front Oncol"},{"key":"2053_CR17","doi-asserted-by":"publisher","first-page":"1528103","DOI":"10.3389\/fimmu.2025.1528103","volume":"16","author":"Y Gu","year":"2025","unstructured":"Gu Y, Zhang Z, Huang H, Zhu W, Liu H, Zhang R, Weng N, Sun X (2025) The dual role of CXCL9\/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma. Front Immunol 16:1528103. https:\/\/doi.org\/10.3389\/fimmu.2025.1528103","journal-title":"Front Immunol"},{"issue":"7","key":"2053_CR18","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1016\/j.immuni.2025.06.008","volume":"58","author":"M Kiss","year":"2025","unstructured":"Kiss M, Pittet MJ (2025) Mitochondrial control of macrophage polarity in tumors. Immunity 58(7):1618\u20131620. https:\/\/doi.org\/10.1016\/j.immuni.2025.06.008","journal-title":"Immunity"},{"key":"2053_CR19","doi-asserted-by":"publisher","first-page":"110884","DOI":"10.1016\/j.cellsig.2023.110884","volume":"111","author":"X Shi","year":"2023","unstructured":"Shi X, Wei K, Wu Y, Mao L, Pei W, Zhu H, Shi Y, Zhang S, Tao S, Wang J et al (2023) Exosome-derived miR-372-5p promotes stemness and metastatic ability of CRC cells by inducing macrophage polarization. Cell Signal 111:110884. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110884","journal-title":"Cell Signal"},{"issue":"8","key":"2053_CR20","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1007\/s12033-023-00843-7","volume":"66","author":"D Xu","year":"2024","unstructured":"Xu D, Han S, Yue X, Xu X, Huang T (2024) METTL14 Suppresses Tumor Stemness and Metastasis of Colon Cancer Cells by Modulating m6A-Modified SCD1. Mol Biotechnol 66(8):2095\u20132105. https:\/\/doi.org\/10.1007\/s12033-023-00843-7","journal-title":"Mol Biotechnol"},{"issue":"2","key":"2053_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41590-022-01398-6","volume":"24","author":"S Ma","year":"2023","unstructured":"Ma S, Sun B, Duan S, Han J, Barr T, Zhang J, Bissonnette MB, Kortylewski M, He C, Chen J et al (2023) YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells. Nat Immunol 24(2):255\u2013266. https:\/\/doi.org\/10.1038\/s41590-022-01398-6","journal-title":"Nat Immunol"},{"key":"2053_CR22","doi-asserted-by":"publisher","first-page":"798583","DOI":"10.3389\/fimmu.2022.798583","volume":"13","author":"F Yuan","year":"2022","unstructured":"Yuan F, Cai X, Cong Z, Wang Y, Geng Y, Aili Y, Du C, Zhu J, Yang J, Tang C et al (2022) Roles of the m(6)A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses. Front Immunol 13:798583. https:\/\/doi.org\/10.3389\/fimmu.2022.798583","journal-title":"Front Immunol"},{"issue":"1","key":"2053_CR23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12885-025-13532-2","volume":"25","author":"L Li","year":"2025","unstructured":"Li L, Zhang R, Li Y (2025) Up-regulation of m(6)A writer METTL14 inhibits tumorigenesis by suppressing glycolysis in colorectal cancer. BMC Cancer 25(1):305. https:\/\/doi.org\/10.1186\/s12885-025-13532-2","journal-title":"BMC Cancer"},{"issue":"7","key":"2053_CR24","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.ccell.2021.04.016","volume":"39","author":"L Dong","year":"2021","unstructured":"Dong L, Chen C, Zhang Y, Guo P, Wang Z, Li J, Liu Y, Liu J, Chang R, Li Y et al (2021) The loss of RNA N(6)-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8(+) T cell dysfunction and tumor growth. Cancer Cell 39(7):945\u2013957e910. https:\/\/doi.org\/10.1016\/j.ccell.2021.04.016","journal-title":"Cancer Cell"},{"issue":"1","key":"2053_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, Yang C, Chen Y (2021) The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther 6(1):74. https:\/\/doi.org\/10.1038\/s41392-020-00450-x From NLM Medline","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"2053_CR26","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41588-020-0636-z","volume":"52","author":"HO Lee","year":"2020","unstructured":"Lee HO, Hong Y, Etlioglu HE, Cho YB, Pomella V, Van den Bosch B, Vanhecke J, Verbandt S, Hong H, Min JW et al (2020) Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat Genet 52(6):594\u2013603. https:\/\/doi.org\/10.1038\/s41588-020-0636-z","journal-title":"Nat Genet"},{"key":"2053_CR27","doi-asserted-by":"publisher","unstructured":"Dalaka E, Stefos GC, Politis I, Theodorou G (2025) Immunomodulatory Properties of Sweet Whey-Derived Peptides in THP-1 Macrophages. Molecules 30(6). https:\/\/doi.org\/10.3390\/molecules30061261","DOI":"10.3390\/molecules30061261"},{"issue":"3","key":"2053_CR28","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3233\/CBM-201463","volume":"28","author":"RP Nagare","year":"2020","unstructured":"Nagare RP, Sneha S, Sidhanth C, Roopa S, Murhekar K, Shirley S, Swaminathan R, Sridevi V, Ganesan TS (2020) Expression of cancer stem cell markers CD24, EPHA1 and CD9 and their correlation with clinical outcome in epithelial ovarian tumours. Cancer Biomark 28(3):397\u2013408. https:\/\/doi.org\/10.3233\/CBM-201463","journal-title":"Cancer Biomark"},{"issue":"3","key":"2053_CR29","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1097\/HEP.0000000000000875","volume":"81","author":"S Han","year":"2025","unstructured":"Han S, Fan H, Zhong G, Ni L, Shi W, Fang Y, Wang C, Wang L, Song L, Zhao J et al (2025) Nuclear KRT19 is a transcriptional corepressor promoting histone deacetylation and liver tumorigenesis. Hepatology 81(3):808\u2013822. https:\/\/doi.org\/10.1097\/HEP.0000000000000875","journal-title":"Hepatology"},{"issue":"6","key":"2053_CR30","doi-asserted-by":"publisher","first-page":"5581","DOI":"10.18632\/aging.205665","volume":"16","author":"Y Li","year":"2024","unstructured":"Li Y, Yang X, Jin T, Li Q, Li X, Ma L (2024) Correlation between S100A7 and immune characteristics, methylation, tumor stemness and tumor heterogeneity in pan-cancer and its role in chemotherapy resistance in breast cancer. Aging 16(6):5581\u20135600. https:\/\/doi.org\/10.18632\/aging.205665","journal-title":"Aging"},{"key":"2053_CR31","doi-asserted-by":"publisher","first-page":"1077780","DOI":"10.3389\/fonc.2023.1077780","volume":"13","author":"S Xue","year":"2023","unstructured":"Xue S, Su XM, Ke LN, Huang YG (2023) CXCL9 correlates with antitumor immunity and is predictive of a favorable prognosis in uterine corpus endometrial carcinoma. Front Oncol 13:1077780. https:\/\/doi.org\/10.3389\/fonc.2023.1077780","journal-title":"Front Oncol"},{"issue":"1","key":"2053_CR32","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40246-023-00558-5","volume":"17","author":"Y Zou","year":"2023","unstructured":"Zou Y, Tan X, Yuan G, Tang Y, Wang Y, Yang C, Luo S, Wu Z, Yao K (2023) SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer. Hum Genomics 17(1):116. https:\/\/doi.org\/10.1186\/s40246-023-00558-5","journal-title":"Hum Genomics"},{"issue":"1","key":"2053_CR33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12943-023-01931-7","volume":"23","author":"X Su","year":"2024","unstructured":"Su X, Liang C, Chen R, Duan S (2024) Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators. Mol Cancer 23(1):13. https:\/\/doi.org\/10.1186\/s12943-023-01931-7","journal-title":"Mol Cancer"},{"issue":"8","key":"2053_CR34","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1158\/2159-8290.CD-23-1300","volume":"14","author":"M Matusiak","year":"2024","unstructured":"Matusiak M, Hickey JW, van IDGP, Lu G, Kidzinski L, Zhu S, Colburg DRC, Luca B, Phillips DJ, Brubaker SW et al (2024) Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer. Cancer Discov 14(8):1418\u20131439. https:\/\/doi.org\/10.1158\/2159-8290.CD-23-1300","journal-title":"Cancer Discov"},{"issue":"1","key":"2053_CR35","doi-asserted-by":"publisher","first-page":"35138","DOI":"10.1038\/s41598-025-19003-9","volume":"15","author":"Y Yang","year":"2025","unstructured":"Yang Y, Sun D, Ma X, Wang T, Wu J (2025) CD68- and CD163-positive tumor-associated macrophages in renal clear cell carcinoma. Sci Rep 15(1):35138. https:\/\/doi.org\/10.1038\/s41598-025-19003-9","journal-title":"Sci Rep"},{"issue":"9","key":"2053_CR36","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1002\/ijc.70018","volume":"157","author":"X Li","year":"2025","unstructured":"Li X, Lian J, Lu H (2025) The role of SPP1(+)TAMs in cancer: Impact on patient prognosis and future therapeutic targets. Int J Cancer 157(9):1763\u20131771. https:\/\/doi.org\/10.1002\/ijc.70018","journal-title":"Int J Cancer"},{"issue":"15","key":"2053_CR37","doi-asserted-by":"publisher","first-page":"e2309026","DOI":"10.1002\/advs.202309026","volume":"11","author":"N Enbergs","year":"2024","unstructured":"Enbergs N, Halabi EA, Goubet AG, Schleyer K, Fredrich IR, Kohler RH, Garris CS, Pittet MJ, Weissleder R (2024) Pharmacological Polarization of Tumor-Associated Macrophages Toward a CXCL9 Antitumor Phenotype. Adv Sci (Weinh) 11(15):e2309026. https:\/\/doi.org\/10.1002\/advs.202309026","journal-title":"Adv Sci (Weinh)"},{"issue":"6","key":"2053_CR38","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41571-022-00620-6","volume":"19","author":"MJ Pittet","year":"2022","unstructured":"Pittet MJ, Michielin O, Migliorini D (2022) Clinical relevance of tumour-associated macrophages. Nat Rev Clin Oncol 19(6):402\u2013421. https:\/\/doi.org\/10.1038\/s41571-022-00620-6","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"2053_CR39","doi-asserted-by":"publisher","first-page":"188609","DOI":"10.1016\/j.bbcan.2021.188609","volume":"1876","author":"H Zhou","year":"2021","unstructured":"Zhou H, Yin K, Zhang Y, Tian J, Wang S (2021) The RNA m6A writer METTL14 in cancers: Roles, structures, and applications. Biochim Biophys Acta Rev Cancer 1876(2):188609. https:\/\/doi.org\/10.1016\/j.bbcan.2021.188609","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"2053_CR40","doi-asserted-by":"publisher","unstructured":"Zhang TH, Jo S, Zhang M, Wang K, Gao SJ, Huang Y (2024) Understanding YTHDF2-mediated mRNA degradation by m6A-BERT-Deg. Brief Bioinform 25(3). https:\/\/doi.org\/10.1093\/bib\/bbae170 From NLM Medline","DOI":"10.1093\/bib\/bbae170"},{"issue":"1","key":"2053_CR41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s11658-024-00611-8","volume":"29","author":"W Jin","year":"2024","unstructured":"Jin W, Yao Y, Fu Y, Lei X, Fu W, Lu Q, Tong X, Xu Q, Su W, Hu X (2024) WTAP\/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc. Cell Mol Biol Lett 29(1):97. https:\/\/doi.org\/10.1186\/s11658-024-00611-8 From NLM Medline","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"2053_CR42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41419-023-06407-6","volume":"15","author":"F Cao","year":"2024","unstructured":"Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, Song X, Yang X, Zeng W, Xie J (2024) METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner. Cell Death Dis 15(1):43. https:\/\/doi.org\/10.1038\/s41419-023-06407-6 From NLM Medline","journal-title":"Cell Death Dis"},{"issue":"7481","key":"2053_CR43","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G et al (2014) N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505(7481):117\u2013120. https:\/\/doi.org\/10.1038\/nature12730 From NLM Medline","journal-title":"Nature"},{"issue":"1","key":"2053_CR44","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s11658-022-00406-9","volume":"27","author":"L Wang","year":"2022","unstructured":"Wang L, Yi X, Xiao X, Zheng Q, Ma L, Li B, Exosomal (2022) miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression. Cell Mol Biol Lett 27(1):106. https:\/\/doi.org\/10.1186\/s11658-022-00406-9","journal-title":"Cell Mol Biol Lett"},{"key":"2053_CR45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bioactmat.2022.09.027","volume":"23","author":"X Huang","year":"2023","unstructured":"Huang X, Wang L, Guo H, Zhang W (2023) Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization. Bioact Mater 23:69\u201379. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.09.027","journal-title":"Bioact Mater"},{"issue":"1","key":"2053_CR46","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41416-021-01596-3","volume":"126","author":"J Hu","year":"2022","unstructured":"Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VWS, Cheuk W, So GYK, He Q, Geoffrey Lau C et al (2022) TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. Br J Cancer 126(1):57\u201371. https:\/\/doi.org\/10.1038\/s41416-021-01596-3","journal-title":"Br J Cancer"},{"key":"2053_CR47","doi-asserted-by":"publisher","first-page":"217199","DOI":"10.1016\/j.canlet.2024.217199","volume":"604","author":"Y Wang","year":"2024","unstructured":"Wang Y, Wang Q, Tao S, Li H, Zhang X, Xia Y, Wang Y, Yang C, Sui C (2024) Identification of SPP1(+) macrophages in promoting cancer stemness via vitronectin and CCL15 signals crosstalk in liver cancer. Cancer Lett 604:217199. https:\/\/doi.org\/10.1016\/j.canlet.2024.217199","journal-title":"Cancer Lett"},{"issue":"19","key":"2053_CR48","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1158\/0008-5472.CAN-20-1079","volume":"80","author":"KE Gomez","year":"2020","unstructured":"Gomez KE, Wu F, Keysar SB, Morton JJ, Miller B, Chimed TS, Le PN, Nieto C, Chowdhury FN, Tyagi A et al (2020) Cancer Cell CD44 Mediates Macrophage\/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells. Cancer Res 80(19):4185\u20134198. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1079 From NLM Medline","journal-title":"Cancer Res"},{"key":"2053_CR49","doi-asserted-by":"publisher","unstructured":"Jaksic Karisik M, Lazarevic M, Mitic D, Milosevic Markovic M, Riberti N, Jelovac D, Milasin J (2025) MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer. Cells 14(2). https:\/\/doi.org\/10.3390\/cells14020091","DOI":"10.3390\/cells14020091"},{"issue":"1","key":"2053_CR50","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1111\/jcmm.13987","volume":"23","author":"J Wu","year":"2019","unstructured":"Wu J, Zhao W, Wang Z, Xiang X, Zhang S, Liu L (2019) Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197\/LIN28 axis. J Cell Mol Med 23(1):680\u2013688. https:\/\/doi.org\/10.1111\/jcmm.13987","journal-title":"J Cell Mol Med"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02053-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-02053-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02053-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:49:26Z","timestamp":1790923766000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-02053-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2053"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-02053-1","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"27 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal experiment was finished under the approval conferred by the Ethics Committee of the Hunan Cancer Hospital (Approval No. 2024\u2009\u2212\u2009149).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to Publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"279"}}