{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:53:45Z","timestamp":1790927625901,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["9456 and 12369"],"award-info":[{"award-number":["9456 and 12369"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-02058-w","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:08:22Z","timestamp":1790924902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic insights into gallic acid\u2013induced autophagy in triple negative breast cancer through network pharmacology, molecular docking, and in vitro validation"],"prefix":"10.1007","volume":"26","author":[{"given":"Essha","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankush","family":"Bansode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Basak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-1836","authenticated-orcid":false,"given":"Santosh Kumar","family":"Guru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"2058_CR1","doi-asserted-by":"publisher","unstructured":"Lyons TG (2019) Targeted Therapies for Triple-Negative Breast Cancer, Curr. Treat. Options Oncol 20. https:\/\/doi.org\/10.1007\/s11864-019-0682-x","DOI":"10.1007\/s11864-019-0682-x"},{"key":"2058_CR2","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1200\/jco.20.03399","volume":"39","author":"LA Korde","year":"2021","unstructured":"Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, Khan SA, Loibl S, Morris EA, Perez A, Regan MM, Spears PA, Sudheendra PK, Symmans WF, Yung RL, Harvey BE, Hershman DL (2021) Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline J Clin Oncol 39:1485\u20131505. https:\/\/doi.org\/10.1200\/jco.20.03399","journal-title":"J Clin Oncol"},{"key":"2058_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2020.00606","volume":"11","author":"X Chen","year":"2020","unstructured":"Chen X, Li S, Li D, Li M, Su Z, Lai X, Zhou C, Chen S, Li S, Yang X, Su J, Zhang Y (2020) Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K\/Akt\/mTOR Pathway. Front Pharmacol 11:1\u201310. https:\/\/doi.org\/10.3389\/fphar.2020.00606","journal-title":"Front Pharmacol"},{"key":"2058_CR4","doi-asserted-by":"publisher","first-page":"112969","DOI":"10.1016\/j.jep.2020.112969","volume":"260","author":"J Li","year":"2020","unstructured":"Li J, Cai H, Sun H, Qu J, Zhao B, Hu X, Li W, Qian Z, Yu X, Kang F, Wang W, Zou Z, Gu B, Xu K (2020) Extracts of Cordyceps sinensis inhibit breast cancer growth through promoting M1 macrophage polarization via NF-\u03baB pathway activation. J Ethnopharmacol 260:112969. https:\/\/doi.org\/10.1016\/j.jep.2020.112969","journal-title":"J Ethnopharmacol"},{"key":"2058_CR5","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.phytochem.2005.01.009","volume":"66","author":"R Niemetz","year":"2005","unstructured":"Niemetz R, Gross GG (2005) Enzymology of gallotannin and ellagitannin biosynthesis. Phytochemistry 66:2001\u20132011. https:\/\/doi.org\/10.1016\/j.phytochem.2005.01.009","journal-title":"Phytochemistry"},{"key":"2058_CR6","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3390\/antiox13081001","volume":"13","author":"M Hadidi","year":"2024","unstructured":"Hadidi M, Li\u00f1\u00e1n-Atero R, Tarahi M, Christodoulou MC (2024) The Potential Health Benefits of Gallic Acid: Therapeutic and Food Applications. Antioxidants (Basel) 13:1001. https:\/\/doi.org\/10.3390\/antiox13081001","journal-title":"Antioxidants (Basel)"},{"key":"2058_CR7","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s12275-008-0235-7","volume":"46","author":"M-S Kang","year":"2008","unstructured":"Kang M-S, Oh J-S, Kang I-C, Hong S-J, Choi C-H (2008) Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol 46:744\u2013750. https:\/\/doi.org\/10.1007\/s12275-008-0235-7","journal-title":"J Microbiol"},{"key":"2058_CR8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0168-1605(02)00108-3","volume":"79","author":"KI Fujita","year":"2002","unstructured":"Fujita KI, Kubo I (2002) Antifungal activity of octyl gallate. Int J Food Microbiol 79:193\u2013201. https:\/\/doi.org\/10.1016\/S0168-1605(02)00108-3","journal-title":"Int J Food Microbiol"},{"key":"2058_CR9","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1055\/s-2006-961535","volume":"58","author":"BH Kroes","year":"1992","unstructured":"Kroes BH, van den Berg AJ, Quarles HC, Dijk H Van, Labadie RP (1992) Anti-inflammatory activity of gallic acid. Planta Med 58:499\u2013504. https:\/\/doi.org\/10.1055\/s-2006-961535","journal-title":"Planta Med"},{"key":"2058_CR10","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1097\/CAD.0000000000000565","volume":"28","author":"HL Lee","year":"2017","unstructured":"Lee HL, Lin CS, Kao SH, Chou MC (2017) Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase\/p21\/p27 axis. Anticancer Drugs 28:1150\u20131156. https:\/\/doi.org\/10.1097\/CAD.0000000000000565","journal-title":"Anticancer Drugs"},{"key":"2058_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3892\/ijo.30.3.605","volume":"30","author":"A Faried","year":"2007","unstructured":"Faried A, Kurnia D, Faried LS, Usman N, Miyazaki T, Kato H, Kuwano H (2007) Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff). Boerl, on human cancer cell lines. Int J Oncol 30:605\u2013613. https:\/\/doi.org\/10.3892\/ijo.30.3.605","journal-title":"Int J Oncol"},{"key":"2058_CR12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.15171\/bi.2018.21","volume":"8","author":"H Moghtaderi","year":"2018","unstructured":"Moghtaderi H, Sepehri H, Delphi L, Attari F (2018) Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231. Bioimpacts 8:185\u2013194. https:\/\/doi.org\/10.15171\/bi.2018.21","journal-title":"Bioimpacts"},{"key":"2058_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.1049117","volume":"13","author":"S Lin","year":"2022","unstructured":"Lin S, Qin HZ, Li ZY, Zhu H, Long L, Xu LB (2022) Gallic acid suppresses the progression of triple-negative breast cancer HCC1806 cells via modulating PI3K\/AKT\/EGFR and MAPK signaling pathways. Front Pharmacol 13:1\u201314. https:\/\/doi.org\/10.3389\/fphar.2022.1049117","journal-title":"Front Pharmacol"},{"key":"2058_CR14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1089\/ars.2018.7518","volume":"30","author":"SW Ryter","year":"2019","unstructured":"Ryter SW, Bhatia D, Choi ME (2019) Autophagy: A lysosome-dependent process with implications in cellular redox homeostasis and human disease. Antioxid Redox Signal 30:138\u2013159. https:\/\/doi.org\/10.1089\/ars.2018.7518","journal-title":"Antioxid Redox Signal"},{"key":"2058_CR15","first-page":"251","volume":"3","author":"K Jain","year":"2013","unstructured":"Jain K, Paranandi KS, Sridharan S, Basu A (2013) Autophagy in breast cancer and its implications for therapy. Am J Cancer Res 3:251\u2013265","journal-title":"Am J Cancer Res"},{"key":"2058_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4161\/cbt.11.2.14663","volume":"11","author":"ZJ Yang","year":"2011","unstructured":"Yang ZJ, Chee CE, Huang S, Sinicrope FA (2011) Autophagy modulation for cancer therapy. Cancer Biol Ther 11:169\u2013176. https:\/\/doi.org\/10.4161\/cbt.11.2.14663","journal-title":"Cancer Biol Ther"},{"key":"2058_CR17","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gku293","volume":"42","author":"D Gfeller","year":"2014","unstructured":"Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V (2014) SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res 42:W32\u2013W38. https:\/\/doi.org\/10.1093\/nar\/gku293","journal-title":"Nucleic Acids Res"},{"key":"2058_CR18","doi-asserted-by":"publisher","first-page":"W609","DOI":"10.1093\/nar\/gkq300","volume":"38","author":"X Liu","year":"2010","unstructured":"Liu X, Ouyang S, Yu B, Liu Y, Huang K, Gong J, Zheng S, Li Z, Li H, Jiang H (2010) PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res 38:W609\u2013W614. https:\/\/doi.org\/10.1093\/nar\/gkq300","journal-title":"Nucleic Acids Res"},{"key":"2058_CR19","doi-asserted-by":"publisher","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Iny Stein T, Nudel R, Lieder I, Mazor Y, Kaplan S, Dahary D, Warshawsky D, Guan-Golan Y, Kohn A, Rappaport N, Safran M, Lancet D (2016) The GeneCards suite: From gene data mining to disease genome sequence analyses. Curr Protoc Bioinforma 54:1.30.1\u20131.30.33. https:\/\/doi.org\/10.1002\/cpbi.5","journal-title":"Curr Protoc Bioinforma"},{"key":"2058_CR20","doi-asserted-by":"publisher","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","volume":"53","author":"Uniprot Consortium","year":"2025","unstructured":"UniprotConsortium (2025) UniProt: the Universal Protein Knowledgebase in 2025. Nucleic Acids Res 53:D609\u2013617. https:\/\/doi.org\/10.1093\/nar\/gkae1010","journal-title":"Nucleic Acids Res"},{"key":"2058_CR21","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.3390\/cimb44120398","volume":"44","author":"H-J Kim","year":"2022","unstructured":"Kim H-J, Seo B-G, Seo E-C, Lee K-M, Hwangbo C (2022) Checkpoint Kinase 1 (CHK1) Functions as Both a Diagnostic Marker and a Regulator of Epithelial-to-Mesenchymal Transition (EMT) in Triple-Negative Breast Cancer, Curr. Issues Mol Biol 44:5848\u20135865. https:\/\/doi.org\/10.3390\/cimb44120398","journal-title":"Issues Mol Biol"},{"key":"2058_CR22","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci USA"},{"key":"2058_CR23","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, Bork P, Jensen LJ, von Mering C (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51:D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000","journal-title":"Nucleic Acids Res"},{"key":"2058_CR24","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"key":"2058_CR25","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T, Chang W (2022) DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res 50:W216\u2013W221. https:\/\/doi.org\/10.1093\/nar\/gkac194","journal-title":"Nucleic Acids Res"},{"key":"2058_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2025.1544666","volume":"16","author":"E Chatterjee","year":"2025","unstructured":"Chatterjee E, Sharma R, Dey B, Singh H, Naik A, Khan A, Basak S, Bansode A, Sachdeva R, Sharma A, Kumar R, Naik P, Singh PK, Nepali K, Guru SK (2025) Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo. Front Pharmacol 16:1\u201319. https:\/\/doi.org\/10.3389\/fphar.2025.1544666","journal-title":"Front Pharmacol"},{"key":"2058_CR27","doi-asserted-by":"publisher","unstructured":"Crowley LC, Scott AP, Marfell BJ, Boughaba JA, Chojnowski G, Waterhouse NJ (2016) Measuring cell death by propidium iodide uptake and flow cytometry. Cold Spring Harb Protoc 2016. https:\/\/doi.org\/10.1101\/pdb.prot087163","DOI":"10.1101\/pdb.prot087163"},{"key":"2058_CR28","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1158\/0008-5472.CAN-14-2312","volume":"75","author":"SK Guru","year":"2015","unstructured":"Guru SK, Pathania AS, Kumar S, Ramesh D, Kumar M, Rana S, Kumar A, Malik F, Sharma PR, Chandan BK, Jaglan S, Sharma JP, Shah BA, Tasduq SA, Lattoo SK, Faruk A, Saxena AK, Vishwakarma RA, Bhushan S (2015) Secalonic Acid-D Represses HIF1\u03b1\/VEGF-Mediated Angiogenesis by Regulating the Akt\/mTOR\/p70S6K Signaling Cascade. Cancer Res 75:2886\u20132896. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-2312","journal-title":"Cancer Res"},{"key":"2058_CR29","doi-asserted-by":"publisher","first-page":"114602","DOI":"10.1016\/j.ejmech.2022.114602","volume":"240","author":"R Sharma","year":"2022","unstructured":"Sharma R, Chatterjee E, Mathew J, Sharma S, Rao NV, Pan CH, Lee SB, Dhingra A, Grewal AS, Liou JP, Guru SK, Nepali K (2022) Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier. Eur J Med Chem 240:114602. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114602","journal-title":"Eur J Med Chem"},{"key":"2058_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.1027112","volume":"13","author":"Y Liao","year":"2022","unstructured":"Liao Y, Ding Y, Yu L, Xiang C, Yang M (2022) Exploring the mechanism of Alisma orientale for the treatment of pregnancy induced hypertension and potential hepato-nephrotoxicity by using network pharmacology, network toxicology, molecular docking and molecular dynamics simulation. Front Pharmacol 13:1\u201318. https:\/\/doi.org\/10.3389\/fphar.2022.1027112","journal-title":"Front Pharmacol"},{"key":"2058_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-020-1100-y","volume":"20","author":"K Khorsandi","year":"2020","unstructured":"Khorsandi K, Kianmehr Z, Hosseinmardi Z, Hosseinzadeh R (2020) Anti \u2013 cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis. Cancer Cell Int 20:1\u201314. https:\/\/doi.org\/10.1186\/s12935-020-1100-y","journal-title":"Cancer Cell Int"},{"key":"2058_CR32","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1158\/1535-7163.MCT-10-0994","volume":"10","author":"F Janku","year":"2011","unstructured":"Janku F, Tsimberidou AM, Garrido-Laguna I, Wang X, Luthra R, Hong DS, Naing A, Falchook GS, Moroney JW, Piha-Paul SA, Wheler JJ, Moulder SL, Fu S, Kurzrock R (2011) PIK3CA mutations in patients with advanced cancers treated with PI3K\/AKT\/mTOR axis inhibitors. Mol Cancer Ther 10:558\u2013565. https:\/\/doi.org\/10.1158\/1535-7163.MCT-10-0994","journal-title":"Mol Cancer Ther"},{"key":"2058_CR33","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","volume":"122","author":"S Pattingre","year":"2005","unstructured":"Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122:927\u2013939. https:\/\/doi.org\/10.1016\/j.cell.2005.07.002","journal-title":"Cell"},{"key":"2058_CR34","doi-asserted-by":"publisher","first-page":"415","DOI":"10.4161\/auto.22910","volume":"9","author":"M Niso-Santano","year":"2013","unstructured":"Niso-Santano M, Shen S, Adjemian S, Malik SA, Mari\u00f1o G, Lachkar S, Senovilla L, Kepp O, Galluzzi L, Maiuri MC, Kroemer G (2013) Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy. Autophagy 9:415\u2013417. https:\/\/doi.org\/10.4161\/auto.22910","journal-title":"Autophagy"},{"key":"2058_CR35","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.4161\/cc.7.19.6751","volume":"7","author":"E Morselli","year":"2008","unstructured":"Morselli E, Tasdemir E, Maiuri MC, Galluzzi L, Kepp O, Criollo A, Vicencio JM, Soussi T, Kroemer G (2008) Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 7:3056\u20133061. https:\/\/doi.org\/10.4161\/cc.7.19.6751","journal-title":"Cell Cycle"},{"key":"2058_CR36","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s13167-025-00407-6","volume":"16","author":"P Kubatka","year":"2025","unstructured":"Kubatka P, Bojkova B, Nosalova N, Huniadi M, Samuel SM, Sreenesh B, Hrklova G, Kajo K, Hornk S, Cizkova D, Bubnov R, Smoksovski I, B\u00fcsselberg D, Golubnitschaja O (2025) Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients. EPMA J 16:437\u2013463. https:\/\/doi.org\/10.1007\/s13167-025-00407-6","journal-title":"EPMA J"},{"key":"2058_CR37","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.3892\/ol.2020.11274","volume":"19","author":"W Jiang","year":"2020","unstructured":"Jiang W, Wang X, Zhang C, Xue L, Yang L (2020) Expression and clinical significance of MAPK and EGFR in triple-negative breast cancer. Oncol Lett 19:1842\u20131848. https:\/\/doi.org\/10.3892\/ol.2020.11274","journal-title":"Oncol Lett"},{"key":"2058_CR38","doi-asserted-by":"publisher","unstructured":"Gagliardi M, Pitner MK, Park J, Xie X, Saso H, Larson RA, Sammons RM, Chen H, Wei C, Masuda H, Chauhan G, Kondo K, Tripathy D, Ueno NT, Dalby KN, Debeb BG, Bartholomeusz C (2020) Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer. Sci Rep 10. https:\/\/doi.org\/10.1038\/s41598-020-65250-3","DOI":"10.1038\/s41598-020-65250-3"},{"key":"2058_CR39","doi-asserted-by":"publisher","first-page":"101046","DOI":"10.1016\/j.tranon.2021.101046","volume":"14","author":"AB Bhatt","year":"2021","unstructured":"Bhatt AB, Wright TD, Barnes V, Chakrabarty S, Matossian MD, Lexner E, Ucar DA, Miele L, Flaherty PT, Burow ME, Cavanaugh JE (2021) Translational Oncology Diverse and converging roles of ERK1 \/ 2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer. Transl Oncol 14:101046. https:\/\/doi.org\/10.1016\/j.tranon.2021.101046","journal-title":"Transl Oncol"},{"key":"2058_CR40","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1080\/15548627.2020.1850609","volume":"17","author":"R Deng","year":"2021","unstructured":"Deng R, Zhang H, Huang JH, Cai RZ, Wang Y, Chen YH, Hu BX, Ye ZP, Li ZL, Mai J, Huang Y, Li X, Peng XD, Feng GK, Li JD, Tang J, Zhu XF (2021) MAPK1\/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy 17:3011\u20133029. https:\/\/doi.org\/10.1080\/15548627.2020.1850609","journal-title":"Autophagy"},{"key":"2058_CR41","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/s12276-025-01470-9","volume":"57","author":"SH Dho","year":"2025","unstructured":"Dho SH, Cho M, Woo W, Jeong S, Kim LK (2025) Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond. Exp Mol Med 57:1121\u20131132. https:\/\/doi.org\/10.1038\/s12276-025-01470-9","journal-title":"Exp Mol Med"}],"container-title":["Functional &amp; Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02058-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-02058-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02058-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:08:24Z","timestamp":1790924904000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-02058-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2058"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-02058-w","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"278"}}