{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:53:03Z","timestamp":1790995983635,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Funct Integr Genomics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10142-026-02059-9","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:57:06Z","timestamp":1790992626000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell-resolved testing of network-pharmacology candidates in dilated cardiomyopathy: PI3K\u2013AKT-associated transcriptional differences are distributed across cardiac lineages and are not enriched above a genome-wide background"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1472-1426","authenticated-orcid":false,"given":"Yingying","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshuang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-9053","authenticated-orcid":false,"given":"Runquan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"2059_CR1","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.2174\/138161211796390976","volume":"17","author":"T Aoyagi","year":"2011","unstructured":"Aoyagi T, Matsui T (2011) Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Curr Pharm Des 17:1818\u20131824. https:\/\/doi.org\/10.2174\/138161211796390976","journal-title":"Curr Pharm Des"},{"key":"2059_CR2","doi-asserted-by":"publisher","first-page":"113069","DOI":"10.1016\/j.jep.2020.113069","volume":"261","author":"R Chen","year":"2020","unstructured":"Chen R, Chen T, Wang T, Dai X, Meng K, Zhang S et al (2020) Tongmai Yangxin pill reduces myocardial no-reflow by regulating apoptosis and activating PI3K\/Akt\/eNOS pathway. J Ethnopharmacol 261:113069. https:\/\/doi.org\/10.1016\/j.jep.2020.113069","journal-title":"J Ethnopharmacol"},{"key":"2059_CR3","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.biopha.2017.12.052","volume":"98","author":"Y Cheng","year":"2018","unstructured":"Cheng Y, Tan J, Li H, Kong X, Liu Y, Guo R et al (2018) Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K\/Akt signaling pathway in myocardial ischemia injury. Biomed Pharmacother 98:308\u2013317. https:\/\/doi.org\/10.1016\/j.biopha.2017.12.052","journal-title":"Biomed Pharmacother"},{"key":"2059_CR4","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","volume":"23","author":"G Davey Smith","year":"2014","unstructured":"Davey Smith G, Hemani G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23:R89\u2013R98. https:\/\/doi.org\/10.1093\/hmg\/ddu328","journal-title":"Hum Mol Genet"},{"key":"2059_CR6","doi-asserted-by":"publisher","first-page":"1771707","DOI":"10.3389\/fgene.2026.1771707","volume":"17","author":"J Fan","year":"2026","unstructured":"Fan J, Xu Y (2026b) Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species. Front Genet 17:1771707. https:\/\/doi.org\/10.3389\/fgene.2026.1771707","journal-title":"Front Genet"},{"key":"2059_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41421-019-0112-z","volume":"5","author":"J Fan","year":"2019","unstructured":"Fan J, Gao Y, Lu Y, Wu W, Yuan S, Wu H et al (2019) PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila. Cell Discov 5:44. https:\/\/doi.org\/10.1038\/s41421-019-0112-z","journal-title":"Cell Discov"},{"key":"2059_CR7","doi-asserted-by":"publisher","first-page":"116811","DOI":"10.1016\/j.celrep.2025.116811","volume":"45","author":"J Fan","year":"2026","unstructured":"Fan J, Zhang X, Zhang J, Zhao T, Burley SK, Zheng XFS (2026a) PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to \u03b2 cell function and metabolic disease. Cell Rep 45:116811. https:\/\/doi.org\/10.1016\/j.celrep.2025.116811","journal-title":"Cell Rep"},{"key":"2059_CR8","doi-asserted-by":"publisher","first-page":"e1004383","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C et al (2014) Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet 10:e1004383. https:\/\/doi.org\/10.1371\/journal.pgen.1004383","journal-title":"PLoS Genet"},{"key":"2059_CR9","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","volume":"369","author":"GTEx Consortium","year":"2020","unstructured":"GTEx Consortium (2020) The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science 369:1318\u20131330. https:\/\/doi.org\/10.1126\/science.aaz1776","journal-title":"Science"},{"key":"2059_CR10","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1017\/S1047951124000180","volume":"34","author":"H Hao","year":"2024","unstructured":"Hao H, Ji M, Zhou K, Zhang Y, Zhang G, Ruan L et al (2024) Effect of Yangxin Huoxue Jiedu recipe on inflammatory factors and oxidative stress on viral myocarditis in children. Cardiol Young 34:1521\u20131528. https:\/\/doi.org\/10.1017\/S1047951124000180","journal-title":"Cardiol Young"},{"key":"2059_CR11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins AL (2008) Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4:682\u2013690. https:\/\/doi.org\/10.1038\/nchembio.118","journal-title":"Nat Chem Biol"},{"key":"2059_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/pin.12868","volume":"70","author":"K Imanaka-Yoshida","year":"2020","unstructured":"Imanaka-Yoshida K (2020) Inflammation in myocardial disease: from myocarditis to dilated cardiomyopathy. Pathol Int 70:1\u201311. https:\/\/doi.org\/10.1111\/pin.12868","journal-title":"Pathol Int"},{"key":"2059_CR13","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1016\/j.jacc.2016.03.590","volume":"67","author":"AG Japp","year":"2016","unstructured":"Japp AG, Gulati A, Cook SA, Cowie MR, Prasad SK (2016) The diagnosis and evaluation of dilated cardiomyopathy. J Am Coll Cardiol 67:2996\u20133010. https:\/\/doi.org\/10.1016\/j.jacc.2016.03.590","journal-title":"J Am Coll Cardiol"},{"key":"2059_CR14","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/01.CIR.99.8.1091","volume":"99","author":"C Kawai","year":"1999","unstructured":"Kawai C (1999) From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death. Circulation 99:1091\u20131100. https:\/\/doi.org\/10.1161\/01.CIR.99.8.1091","journal-title":"Circulation"},{"key":"2059_CR15","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s41588-021-00924-w","volume":"53","author":"N Kerimov","year":"2021","unstructured":"Kerimov N, Hayhurst JD, Peikova K, Manning JR, Walter P, Kolberg L et al (2021) A compendium of uniformly processed human gene expression and splicing quantitative trait loci. Nat Genet 53:1290\u20131299. https:\/\/doi.org\/10.1038\/s41588-021-00924-w","journal-title":"Nat Genet"},{"key":"2059_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s44161-022-00028-6","volume":"1","author":"AL Koenig","year":"2022","unstructured":"Koenig AL, Shchukina I, Amrute J, Andhey PS, Zaitsev K, Lai L et al (2022) Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure. Nat Cardiovasc Res 1:263\u2013280. https:\/\/doi.org\/10.1038\/s44161-022-00028-6","journal-title":"Nat Cardiovasc Res"},{"key":"2059_CR17","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, Sipil\u00e4 TP, Kristiansson K, Donner KM et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613:508\u2013518. https:\/\/doi.org\/10.1038\/s41586-022-05473-8","journal-title":"Nature"},{"key":"2059_CR18","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S1875-5364(13)60037-0","volume":"11","author":"S Li","year":"2013","unstructured":"Li S, Zhang B (2013) Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med 11:110\u2013120. https:\/\/doi.org\/10.1016\/S1875-5364(13)60037-0","journal-title":"Chin J Nat Med"},{"key":"2059_CR19","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","volume":"588","author":"M Litvi\u0148ukov\u00e1","year":"2020","unstructured":"Litvi\u0148ukov\u00e1 M, Talavera-L\u00f3pez C, Maatz H, Reichart D, Worth CL, Lindberg EL et al (2020) Cells of the adult human heart. Nature 588:466\u2013472. https:\/\/doi.org\/10.1038\/s41586-020-2797-4","journal-title":"Nature"},{"key":"2059_CR20","doi-asserted-by":"publisher","first-page":"910","DOI":"10.4161\/cc.6.8.4124","volume":"6","author":"JR McMullen","year":"2007","unstructured":"McMullen JR, Jay PY (2007) PI3K(p110alpha) inhibitors as anti-cancer agents: minding the heart. Cell Cycle 6:910\u2013913. https:\/\/doi.org\/10.4161\/cc.6.8.4124","journal-title":"Cell Cycle"},{"key":"2059_CR21","doi-asserted-by":"publisher","first-page":"btad547","DOI":"10.1093\/bioinformatics\/btad547","volume":"39","author":"B Muzellec","year":"2023","unstructured":"Muzellec B, Tele\u0144czuk M, Cabeli V, Andreux M (2023) PyDESeq2: a Python package for bulk RNA-seq differential expression analysis. Bioinformatics 39:btad547. https:\/\/doi.org\/10.1093\/bioinformatics\/btad547","journal-title":"Bioinformatics"},{"key":"2059_CR22","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","volume":"43","author":"C Nogales","year":"2022","unstructured":"Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, Schmidt HHHW (2022) Network pharmacology: curing causal mechanisms instead of treating symptoms. Trends Pharmacol Sci 43:136\u2013150. https:\/\/doi.org\/10.1016\/j.tips.2021.11.004","journal-title":"Trends Pharmacol Sci"},{"key":"2059_CR24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/joim.12944","volume":"286","author":"D Reichart","year":"2019","unstructured":"Reichart D, Magnussen C, Zeller T, Blankenberg S (2019) Dilated cardiomyopathy: from epidemiologic to genetic phenotypes. J Intern Med 286:362\u2013372. https:\/\/doi.org\/10.1111\/joim.12944","journal-title":"J Intern Med"},{"key":"2059_CR23","doi-asserted-by":"publisher","first-page":"eabo1984","DOI":"10.1126\/science.abo1984","volume":"377","author":"D Reichart","year":"2022","unstructured":"Reichart D, Lindberg EL, Maatz H, Miranda AMA, Viveiros A, Shvetsov N et al (2022) Pathogenic variants damage cell composition and single-cell transcription in cardiomyopathies. Science 377:eabo1984. https:\/\/doi.org\/10.1126\/science.abo1984","journal-title":"Science"},{"key":"2059_CR25","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W et al (2015) limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"key":"2059_CR28","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","volume":"114","author":"S Sciarretta","year":"2014","unstructured":"Sciarretta S, Volpe M, Sadoshima J (2014) Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res 114:549\u2013564. https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.302022","journal-title":"Circ Res"},{"key":"2059_CR26","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","volume":"122","author":"S Sciarretta","year":"2018","unstructured":"Sciarretta S, Forte M, Frati G, Sadoshima J (2018a) New insights into the role of mTOR signaling in the cardiovascular system. Circ Res 122:489\u2013505. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311147","journal-title":"Circ Res"},{"key":"2059_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121427","volume":"80","author":"S Sciarretta","year":"2018","unstructured":"Sciarretta S, Maejima Y, Zablocki D, Sadoshima J (2018b) The role of autophagy in the heart. Annu Rev Physiol 80:1\u201326. https:\/\/doi.org\/10.1146\/annurev-physiol-021317-121427","journal-title":"Annu Rev Physiol"},{"key":"2059_CR29","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/S0254-6272(18)30985-3","volume":"38","author":"L Shen","year":"2018","unstructured":"Shen L, Xing Q, Lu S, Zhou Y, Zhou C, Li L et al (2018) Effect of Shenqi Yangxin decoction on high mobility group box 1 and inflammatory signal pathway in a rat model of dilated cardiomyopathy. J Tradit Chin Med 38:862\u2013871","journal-title":"J Tradit Chin Med"},{"key":"2059_CR30","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1161\/CIRCULATIONAHA.110.977066","volume":"123","author":"P Shende","year":"2011","unstructured":"Shende P, Plaisance I, Morandi C, Pellieux C, Berthonneche C, Zorzato F et al (2011) Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation 123:1073\u20131082. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.977066","journal-title":"Circulation"},{"key":"2059_CR31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13643-025-02802-6","volume":"14","author":"S Tao","year":"2025","unstructured":"Tao S, Yu L, Li J, Wu J, Xia X, Li Y et al (2025) Efficacy and safety of Chinese classical prescriptions for dilated cardiomyopathy: a systematic review and Bayesian network meta-analysis. Syst Rev 14:59. https:\/\/doi.org\/10.1186\/s13643-025-02802-6","journal-title":"Syst Rev"},{"key":"2059_CR32","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. J Comput Chem 31:455\u2013461. https:\/\/doi.org\/10.1002\/jcc.21334","journal-title":"J Comput Chem"},{"key":"2059_CR33","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z et al (2021) clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innov (Camb) 2:100141. https:\/\/doi.org\/10.1016\/j.xinn.2021.100141","journal-title":"Innov (Camb)"},{"key":"2059_CR35","unstructured":"Yang SY (1264) Renzhai zhizhi fanglun [Renzhai\u2019s direct guidance on formulas], vol 11. Siku Quanshu recension, Chinese Wikisource digital edition. https:\/\/zh.wikisource.org\/wiki\/%E4%BB%81%E9%BD%8B%E7%9B%B4%E6%8C%87_(%E5%9B%9B%E5%BA%AB%E5%85%A8%E6%9B%B8%E6%9C%AC)\/%E5%8D%B711. Accessed 2 Aug 2026"},{"key":"2059_CR34","first-page":"2059","volume":"34","author":"Q Yang","year":"2021","unstructured":"Yang Q, Qian Z (2021) Impacts of Yangxin decoction on the expressions of MMP-9, CaN, NFAT3 and GATA4 in myocardial tissue of rats with chronic heart failure. Pak J Pharm Sci 34:2059\u20132064","journal-title":"Pak J Pharm Sci"},{"key":"2059_CR36","doi-asserted-by":"publisher","first-page":"e30394","DOI":"10.1097\/MD.0000000000030394","volume":"101","author":"XH Yu","year":"2022","unstructured":"Yu XH, Yu XW, Xu ZM, Li HX (2022) Yangxin decoction for the treatment of angina pectoris of coronary heart disease: a systematic review of randomized controlled trials. Med (Baltim) 101:e30394. https:\/\/doi.org\/10.1097\/MD.0000000000030394","journal-title":"Med (Baltim)"},{"key":"2059_CR37","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3389\/fphar.2020.00946","volume":"11","author":"X Zhai","year":"2020","unstructured":"Zhai X, Wang X, Wang L, Xiu L, Wang W, Pang X (2020) Treating different diseases with the same method\u2014a traditional Chinese medicine concept analyzed for its biological basis. Front Pharmacol 11:946. https:\/\/doi.org\/10.3389\/fphar.2020.00946","journal-title":"Front Pharmacol"},{"key":"2059_CR38","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1172\/JCI43008","volume":"120","author":"D Zhang","year":"2010","unstructured":"Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D et al (2010) MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest 120:2805\u20132816. https:\/\/doi.org\/10.1172\/JCI43008","journal-title":"J Clin Invest"},{"key":"2059_CR39","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O et al (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10:1523. https:\/\/doi.org\/10.1038\/s41467-019-09234-6","journal-title":"Nat Commun"}],"container-title":["Functional & Integrative Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02059-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10142-026-02059-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10142-026-02059-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:57:13Z","timestamp":1790992633000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10142-026-02059-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2059"],"URL":"https:\/\/doi.org\/10.1007\/s10142-026-02059-9","relation":{},"ISSN":["1438-793X","1438-7948"],"issn-type":[{"value":"1438-793X","type":"print"},{"value":"1438-7948","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"4 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study is a computational secondary analysis of publicly available, de-identified datasets and summary statistics. No participants were recruited and no new human or animal material was collected. The work therefore qualified for exemption from ethics committee review under the institutional policy covering research that uses only already-published, publicly accessible de-identified data, and no separate ethics approval was sought or required for the present analysis. Each primary study from which the analyzed data originate was approved by its own institutional ethics committee and was conducted in accordance with the 1964 Declaration of Helsinki and its later amendments; the corresponding approval details are reported in those publications.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. The study did not recruit participants and used only publicly available, de-identified data and summary statistics, so no consent to participate was sought by the authors.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. The manuscript contains no individually identifiable data, images or other personal details for which consent to publish would be required.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Clinical trial number: not applicable. This study is a computational secondary analysis of previously published, publicly available datasets and summary statistics; it is not a clinical trial, no participants were prospectively enrolled or assigned to an intervention, and no trial registration was therefore required or obtained.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The analyses reported in this study were performed in China and comply with the current laws of that country. The study is entirely computational and used only publicly available data; no laboratory experiments involving human participants, animals or regulated biological material were carried out.","order":5,"name":"Ethics","label":"Compliance with national legislation","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"280"}}