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This study was approved by the Ethics Committee of Beijing Huairou Hospital Affiliated to Capital Medical University, and written informed consent was obtained from all participants.All protocols were approved by the Animal Ethics Committee of Beijing Huairou Hospital Affiliated to Capital Medical University. All animal experiments in this study were in strict accordance with the protocols stated in the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health. The study was conducted in agreement with the ARRIVE guidelines. Appropriate measures were taken to minimize the number and suffering of animals.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"297"}}