{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:55:07Z","timestamp":1782968107950,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s10143-017-0914-0","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T06:43:13Z","timestamp":1507272193000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Primary central nervous system malignant melanoma with leptomeningeal melanomatosis: a case report and review of the literature"],"prefix":"10.1007","volume":"41","author":[{"given":"Kentaro","family":"Fujimori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-8620","authenticated-orcid":false,"given":"Keiichi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusakazu","family":"Oya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Maejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"914_CR1","doi-asserted-by":"publisher","unstructured":"Ahmed KA, Stallworth DG, Kim Y, Johnstone PA, Harrison LB, Caudell JJ, Yu HH, Etame AB, Weber JS, Gibney GT (2016) Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy. Ann Oncol 27:434\u2013441. https:\/\/doi.org\/10.1093\/annonc\/mdv622","DOI":"10.1093\/annonc\/mdv622"},{"key":"914_CR2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1186\/s12885-016-2556-y","volume":"16","author":"G Angelino","year":"2016","unstructured":"Angelino G, De Pasquale MD, De Sio L, Serra A, Massimi L, De Vito R, Marrazzo A, Lancella L, Carai A, Antonelli M, Giangaspero F, Gessi M, Menchini L, Scarciolla L, Longo D, Mastronuzzi A (2016) NRAS(Q61K) mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications. BMC Cancer 16:512. https:\/\/doi.org\/10.1186\/s12885-016-2556-y","journal-title":"BMC Cancer"},{"key":"914_CR3","first-page":"228","volume":"111","author":"M Arias","year":"2011","unstructured":"Arias M, Alberte-Woodward M, Arias S, Dapena D, Prieto A, Su\u00e1rez-Pe\u00f1aranda JM (2011) Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. Acta Neurol Belg 111:228\u2013231","journal-title":"Acta Neurol Belg"},{"key":"914_CR4","doi-asserted-by":"publisher","first-page":"293802","DOI":"10.1155\/2015\/293802","volume":"2015","author":"R Balakrishnan","year":"2015","unstructured":"Balakrishnan R, Porag R, Asif DS, Satter AM, Taufiq M, Gaddam SS (2015) Primary intracranial melanoma with early leptomeningeal spread: a case report and treatment options available. Case Rep Oncol Med 2015:293802. https:\/\/doi.org\/10.1155\/2015\/293802","journal-title":"Case Rep Oncol Med"},{"key":"914_CR5","first-page":"235","volume":"45","author":"P Celli","year":"2001","unstructured":"Celli P, Acqui M, Trill\u00f2 G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L (2001) Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI. J Neurosurg Sci 45:235\u2013240","journal-title":"J Neurosurg Sci"},{"key":"914_CR6","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","volume":"364","author":"PB Chapman","year":"2011","unstructured":"Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA, BRIM-3 Study Group (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507\u20132516. https:\/\/doi.org\/10.1056\/NEJMoa1103782","journal-title":"N Engl J Med"},{"key":"914_CR7","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1148\/radiol.2473050507","volume":"247","author":"MK Demir","year":"2008","unstructured":"Demir MK, Aker FV, Akinci O, Ozg\u00fcltekin A (2008) Case 134: primary leptomeningeal melanomatosis. Radiology 247:905\u2013909. https:\/\/doi.org\/10.1148\/radiol.2473050507","journal-title":"Radiology"},{"key":"914_CR8","first-page":"1323","volume":"45","author":"D Fuster","year":"2004","unstructured":"Fuster D, Chiang S, Johnson G, Schuchter LM, Zhuang H, Alavi A (2004) Is 18F-FDG PET more accurate than standard diagnostic procedures in the detection of suspected recurrent melanoma? J Nucl Med 45:1323\u20131327","journal-title":"J Nucl Med"},{"key":"914_CR9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0090-3019(01)00348-2","volume":"55","author":"S Greco Crasto","year":"2001","unstructured":"Greco Crasto S, Soffietti R, Bradac GB, Boldorini R (2001) Primitive cerebral melanoma: case report and review of the literature. Surg Neurol 55:163\u2013168","journal-title":"Surg Neurol"},{"key":"914_CR10","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1634\/theoncologist.2014-0012","volume":"20","author":"JJ Harding","year":"2015","unstructured":"Harding JJ, Catalanotti F, Munhoz RR, Cheng DT, Yaqubie A, Kelly N, McDermott GC, Kersellius R, Merghoub T, Lacouture ME, Carvajal RD, Panageas KS, Berger MF, Rosen N, Solit DB, Chapman PB (2015) A retrospective evaluation of vemurafenib as treatment for BRAF-mutant melanoma brain metastases. Oncologist 20:789\u2013797. https:\/\/doi.org\/10.1634\/theoncologist.2014-0012","journal-title":"Oncologist"},{"key":"914_CR11","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1215\/15228517-2008-062","volume":"10","author":"L Harstad","year":"2008","unstructured":"Harstad L, Hess KR, Groves MD (2008) Prognostic factors and outcomes in patients with leptomeningeal melanomatosis. Neuro-Oncology 10:1010\u20131018. https:\/\/doi.org\/10.1215\/15228517-2008-062","journal-title":"Neuro-Oncology"},{"key":"914_CR12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/jnnp.39.6.526","volume":"39","author":"RD Hayward","year":"1976","unstructured":"Hayward RD (1976) Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings. J Neurol Neurosurg Psychiatry 39:526\u2013530","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"914_CR13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/02841868909111189","volume":"28","author":"A Helseth","year":"1989","unstructured":"Helseth A, Helseth E, Unsgaard G (1989) Primary meningeal melanoma. Acta Oncol 28:103\u2013104","journal-title":"Acta Oncol"},{"key":"914_CR14","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3340\/jkns.2015.58.6.554","volume":"58","author":"DH Kim","year":"2015","unstructured":"Kim DH, Choi CY, Lee CH, Joo M (2015) Primary intracranial leptomeningeal melanomatosis. J Korean Neurosurg Soc 58:554\u2013556. https:\/\/doi.org\/10.3340\/jkns.2015.58.6.554","journal-title":"J Korean Neurosurg Soc"},{"key":"914_CR15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3348\/kjr.2013.14.2.343","volume":"14","author":"HJ Lee","year":"2013","unstructured":"Lee HJ, Ahn BC, Hwang SW, Cho SK, Kim HW, Lee SW, Hwang JH, Lee J (2013) F-18 fluorodeoxyglucose PET\/CT and post hoc PET\/MRI in a case of primary meningeal melanomatosis. Korean J Radiol 14:343\u2013349. https:\/\/doi.org\/10.3348\/kjr.2013.14.2.343","journal-title":"Korean J Radiol"},{"key":"914_CR16","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.jocn.2010.01.017","volume":"17","author":"SV Liubinas","year":"2010","unstructured":"Liubinas SV, Maartens N, Drummond KJ (2010) Primary melanocytic neoplasms of the central nervous system. J Clin Neurosci 17:1227\u20131232. https:\/\/doi.org\/10.1016\/j.jocn.2010.01.017","journal-title":"J Clin Neurosci"},{"key":"914_CR17","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3892\/ol.2015.3537","volume":"10","author":"Y Ma","year":"2015","unstructured":"Ma Y, Gui Q, Lang S (2015) Intracranial malignant melanoma: a report of 7 cases. Oncol Lett 10:2171\u20132175","journal-title":"Oncol Lett"},{"key":"914_CR18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/(SICI)1097-0142(19990901)86:5<878::AID-CNCR26>3.0.CO;2-Y","volume":"86","author":"GW Makin","year":"1999","unstructured":"Makin GW, Eden OB, Lashford LS, Moppett J, Gerrard MP, Davies HA, Powell CV, Campbell AN, Frances H (1999) Leptomeningeal melanoma in childhood. Cancer 86:878\u2013886","journal-title":"Cancer"},{"key":"914_CR19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF01410075","volume":"101","author":"H Nakagawa","year":"1989","unstructured":"Nakagawa H, Hayakawa T, Niiyama K, Nii Y, Yoshimine T, Mori S (1989) Long-term survival after removal of primary intracranial malignant melanoma: case report. Acta Neurochir 101:84\u201388","journal-title":"Acta Neurochir"},{"key":"914_CR20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0887-8994(94)00155-U","volume":"12","author":"P Nicolaides","year":"1995","unstructured":"Nicolaides P, Newton RW, Kelsey A (1995) Primary malignant melanoma of meninges: atypical presentation of subacute meningitis. Pediatr Neurol 12:172\u2013174","journal-title":"Pediatr Neurol"},{"key":"914_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/1477-7819-12-265","volume":"12","author":"Z Pan","year":"2014","unstructured":"Pan Z, Yang G, Wang Y, Yuan T, Gao Y, Dong L (2014) Leptomeningeal metastases from a primary central nervous system melanoma: a case report and literature review. World J Surg Oncol 12:265. https:\/\/doi.org\/10.1186\/1477-7819-12-265","journal-title":"World J Surg Oncol"},{"key":"914_CR22","first-page":"115","volume":"24","author":"MG Pirini","year":"2003","unstructured":"Pirini MG, Mascalchi M, Salvi F, Tassinari CA, Zanella L, Bacchini P, Bertoni F, D'Errico A, Corti B, Grigioni WF (2003) Primary diffuse meningeal melanomatosis: radiologic-pathologic correlation. AJNR Am J Neuroradiol 24:115\u2013118","journal-title":"AJNR Am J Neuroradiol"},{"key":"914_CR23","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1056\/NEJMoa1412082","volume":"372","author":"C Robert","year":"2015","unstructured":"Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebb\u00e9 C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H, Schadendorf D, Gogas H, Lundgren-Eriksson L, Horak C, Sharkey B, Waxman IM, Atkinson V, Ascierto PA (2015) Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 372:320\u2013330. https:\/\/doi.org\/10.1056\/NEJMoa1412082","journal-title":"N Engl J Med"},{"key":"914_CR24","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.mayocp.2012.07.006","volume":"87","author":"NM Rochet","year":"2012","unstructured":"Rochet NM, Dronca RS, Kottschade LA, Chavan RN, Gorman B, Gilbertson JR, Markovic SN (2012) Melanoma brain metastases and vemurafenib: need for further investigation. Mayo Clinic Proc 87:976\u2013981. https:\/\/doi.org\/10.1016\/j.mayocp.2012.07.006","journal-title":"Mayo Clinic Proc"},{"key":"914_CR25","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1148\/rg.295095109","volume":"29","author":"AB Smith","year":"2009","unstructured":"Smith AB, Rushing EJ, Smirniotopoulos JG (2009) Pigmented lesions of the central nervous system: radiologic-pathologic correlation. Radiographics 29:1503\u20131524. https:\/\/doi.org\/10.1148\/rg.295095109","journal-title":"Radiographics"},{"key":"914_CR26","doi-asserted-by":"publisher","first-page":"581.e15","DOI":"10.1016\/j.wneu.2016.06.039","volume":"92","author":"A Szathmari","year":"2016","unstructured":"Szathmari A, Perbet R, Hermier M, Di Rocco F, Frappaz D, Mottolese C (2016) Primary amelanotic leptomeningeal melanomatosis in a child: a rare but severe disease. World Neurosurg 92:581.e15\u2013581.e20. https:\/\/doi.org\/10.1016\/j.wneu.2016.06.039","journal-title":"World Neurosurg"},{"issue":"suppl 1","key":"914_CR27","first-page":"14","volume":"57","author":"The Committee of the Brain Tumor Registry of Japan","year":"2017","unstructured":"The Committee of the Brain Tumor Registry of Japan (2017) Report of Brain Tumor Registry of Japan (2005-2008), 14th edn. General features of WHO2007 primary brain tumors (2005\u20132008). Neurol Med Chir (Tokyo) 57(suppl 1):14\u201332","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"914_CR28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3171\/jns.2001.94.3.0528","volume":"94","author":"M Tosaka","year":"2001","unstructured":"Tosaka M, Tamura M, Oriuchi N, Horikoshi M, Joshita T, Sugawara K, Kobayashi S, Kohga H, Yoshida T, Sasaki T (2001) Cerebrospinal fluid immunocytochemical analysis and neuroimaging in the diagnosis of primary leptomeningeal melanoma: case report. J Neurosurg 94:528\u2013532","journal-title":"J Neurosurg"},{"key":"914_CR29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4103\/2152-7806.142795","volume":"5","author":"V Trinh","year":"2014","unstructured":"Trinh V, Medina-Flores R, Taylor CL, Yonas H, Chohan MO (2014) Primary melanocytic tumors of the central nervous system: report of two cases and review of literature. Surg Neurol Int 5:147. https:\/\/doi.org\/10.4103\/2152-7806.142795","journal-title":"Surg Neurol Int"},{"key":"914_CR30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12957-016-0965-7","volume":"14","author":"M Troya-Castilla","year":"2016","unstructured":"Troya-Castilla M, Rocha-Romero S, Chocr\u00f3n-Gonz\u00e1lez Y, M\u00e1rquez-Rivas FJ (2016) Primary cerebral malignant melanoma in insular region with extracranial metastasis: case report and review literature. World J Surg Oncol 14:235. https:\/\/doi.org\/10.1186\/s12957-016-0965-7","journal-title":"World J Surg Oncol"},{"key":"914_CR31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1097\/NRL.0b013e3181c29ef8","volume":"16","author":"I Zadro","year":"2010","unstructured":"Zadro I, Brinar VV, Barun B, Ozreti\u0107 D, Pazanin L, Grahovac G, Habek M (2010) Primary diffuse meningeal melanomatosis. Neurologist 16:117\u2013119. https:\/\/doi.org\/10.1097\/NRL.0b013e3181c29ef8","journal-title":"Neurologist"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10143-017-0914-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-017-0914-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-017-0914-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T05:40:25Z","timestamp":1570167625000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10143-017-0914-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,6]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["914"],"URL":"https:\/\/doi.org\/10.1007\/s10143-017-0914-0","relation":{},"ISSN":["0344-5607","1437-2320"],"issn-type":[{"value":"0344-5607","type":"print"},{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,6]]}}}