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The specific implications on therapy and outcome of a simultaneous presence of both diseases are not yet fully evaluated. Therefore, the aim of this study was to investigate the influence of a simultaneously present endocarditis on the course of therapy and outcome of spondylodiscitis. A prospective database analysis of 328 patients diagnosed with spontaneous spondylodiscitis (S) using statistical analysis with propensity score matching was conducted. Thirty-six patients (11.0%) were diagnosed with concurrent endocarditis (SIE) by means of transoesophageal echocardiography. In our cohort, the average age was 65.82\u2009\u00b1\u20094.12\u00a0years and 64.9% of patients were male. The incidence of prior cardiac or renal disease was significantly higher in the SIE group (coronary heart disease SIE <jats:italic>n<\/jats:italic>\u2009=\u200913\/36 vs. S <jats:italic>n<\/jats:italic>\u2009=\u200957\/292, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 and chronic heart failure <jats:italic>n<\/jats:italic>\u2009=\u200911\/36 vs. S <jats:italic>n<\/jats:italic>\u2009=\u200941\/292, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, chronic renal failure SIE <jats:italic>n<\/jats:italic>\u2009=\u200914\/36 vs. S <jats:italic>n<\/jats:italic>\u2009=\u200955\/292, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Complex interdisciplinary coordination and diagnostics lead to a significant delay in surgical intervention (S\u2009=\u20094.5\u2009\u00b1\u20094.5\u00a0days vs. SIE\u2009=\u20098.9\u2009\u00b1\u20099.5\u00a0days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Mortality did not show statistically significant differences: S (13.4%) and SIE (19.1%). Time to diagnosis and treatment is a key to efficient treatment and patient safety. In order to counteract delayed therapy, we developed a novel therapy algorithm based on the analysis of treatment processes of the SIE group. We propose a clear therapy pathway to avoid frequently observed pitfalls and delays in diagnosis to improve patient care and outcome.<\/jats:p>","DOI":"10.1007\/s10143-021-01640-z","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T12:04:13Z","timestamp":1631448253000},"page":"1335-1342","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Spontaneous spondylodiscitis and endocarditis: interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-667X","authenticated-orcid":false,"given":"Lennart","family":"Viezens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dreimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Strahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Heuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon-Gordian","family":"Koepke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Waldeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stangenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"1640_CR1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.jinf.2015.08.002","volume":"71","author":"M Al-Mayahi","year":"2015","unstructured":"Al-Mayahi M, Cian A, Lipsky BA, Suv\u00e0 D, M\u00fcller C, Landelle C, Miozzari HH, U\u00e7kay I (2015) Administration of antibiotic agents before intraoperative sampling in orthopedic infections alters culture results. 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The other authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}