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This study revealed the clinical and image predictors of P\/R in lNFPA and gNFPA, with emphasis on <jats:italic>solid<\/jats:italic> tumor size. This retrospective study investigated the preoperative MR imaging features for the prediction of P\/R in lNFPA (&gt;\u20093\u00a0cm) and gNFPA (&gt;\u20094\u00a0cm). Only the patients with a complete preoperative brain MRI and undergone postoperative MRI follow-ups for more than 1\u00a0year were included. From November 2010 to December 2020, a total of 34 patients diagnosed with lNFPA and gNFPA were included (median follow-up time 47.6\u00a0months) in this study. A total of twenty-three (23\/34, 67.6%) patients had P\/R, and the median time to P\/R is 25.2\u00a0months. Solid tumor diameter (STD), solid tumor volume (STV), and extent of resection are associated with P\/R (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Multivariate analysis showed large STV is a risk factor for P\/R (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) with a hazard ratio of 30.79. The cutoff points of STD and STV for prediction of P\/R are 26\u00a0mm and 7.6 cm<jats:sup>3<\/jats:sup>, with AUCs of 0.78 and 0.79 respectively. Kaplan\u2013Meier analysis of tumor P\/R trends showed that patients with larger STD and STV exhibited shorter progression-free survival (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). For lNFPA and gNFPA, preoperative STD and STV are significant predictors of P\/R. The results offer objective and valuable information for treatment planning in this subgroup.<\/jats:p>","DOI":"10.1007\/s10143-021-01662-7","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T05:16:51Z","timestamp":1633411011000},"page":"1401-1411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Solid tumor size for prediction of recurrence in large and giant non-functioning pituitary adenomas"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0721-9606","authenticated-orcid":false,"given":"Ching-Chung","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sher-Wei","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Chang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeon-Hor","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ting","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"1662_CR1","doi-asserted-by":"publisher","first-page":"720","DOI":"10.2214\/ajr.09.4128","volume":"195","author":"JL Boxerman","year":"2010","unstructured":"Boxerman JL, Rogg JM, Donahue JE, Machan JT, Goldman MA, Doberstein CE (2010) Preoperative MRI evaluation of pituitary macroadenoma: imaging features predictive of successful transsphenoidal surgery. 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