{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:46:54Z","timestamp":1792090014850,"version":"4.4.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2021YFC2501101"],"award-info":[{"award-number":["2021YFC2501101"]}]},{"name":"National Key Research and Development Program of China","award":["2020YFC2004701"],"award-info":[{"award-number":["2020YFC2004701"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071296"],"award-info":[{"award-number":["82071296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671129"],"award-info":[{"award-number":["81671129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471210"],"award-info":[{"award-number":["81471210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s10143-022-01780-w","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T18:02:22Z","timestamp":1648922542000},"page":"2689-2699","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage"],"prefix":"10.1007","volume":"45","author":[{"given":"Runting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heze","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruinan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-7197","authenticated-orcid":false,"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"1780_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/neuros\/nyx364","volume":"83","author":"SH Ahn","year":"2018","unstructured":"Ahn SH, Savarraj JP, Pervez M, Jones W, Park J, Jeon SB, Kwon SU, Chang TR, Lee K, Kim DH, Day AL, Choi HA (2018) The subarachnoid hemorrhage early brain edema score predicts delayed cerebral ischemia and clinical outcomes. Neurosurgery 83:137\u2013145. https:\/\/doi.org\/10.1093\/neuros\/nyx364","journal-title":"Neurosurgery"},{"key":"1780_CR2","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1161\/strokeaha.117.020260","volume":"49","author":"OGS Ayling","year":"2018","unstructured":"Ayling OGS, Ibrahim GM, Alotaibi NM, Gooderham PA, Macdonald RL (2018) Anemia after aneurysmal subarachnoid hemorrhage is associated with poor outcome and death. Stroke 49:1859\u20131865. https:\/\/doi.org\/10.1161\/strokeaha.117.020260","journal-title":"Stroke"},{"key":"1780_CR3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.niox.2008.02.006","volume":"18","author":"I Azarov","year":"2008","unstructured":"Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR, Levy A, Kim-Shapiro DB (2008) Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide 18:296\u2013302. https:\/\/doi.org\/10.1016\/j.niox.2008.02.006","journal-title":"Nitric Oxide"},{"key":"1780_CR4","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","volume":"43","author":"ES Connolly Jr","year":"2012","unstructured":"Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P, Stroke AHA, C, Council on Cardiovascular R, Intervention, Council on Cardiovascular N, Council on Cardiovascular S, Anesthesia, Council on Clinical C, (2012) Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association\/american Stroke Association. Stroke 43:1711\u20131737. https:\/\/doi.org\/10.1161\/STR.0b013e3182587839","journal-title":"Stroke"},{"key":"1780_CR5","doi-asserted-by":"publisher","first-page":"R23","DOI":"10.1186\/cc8886","volume":"14","author":"JW Dankbaar","year":"2010","unstructured":"Dankbaar JW, Slooter AJ, Rinkel GJ, Schaaf IC (2010) Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic review. Crit Care 14:R23. https:\/\/doi.org\/10.1186\/cc8886","journal-title":"Crit Care"},{"key":"1780_CR6","doi-asserted-by":"publisher","unstructured":"Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, van Gijn J (2007) Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 2007:Cd000277. https:\/\/doi.org\/10.1002\/14651858.CD000277.pub3","DOI":"10.1002\/14651858.CD000277.pub3"},{"key":"1780_CR7","doi-asserted-by":"publisher","unstructured":"Dreier JP, Drenckhahn C, Woitzik J, Major S, Offenhauser N, Weber-Carstens S, Wolf S, Strong AJ, Vajkoczy P, Hartings JA, Group CS (2013) Spreading ischemia after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl 115:125-129.https:\/\/doi.org\/10.1007\/978-3-7091-1192-5_26","DOI":"10.1007\/978-3-7091-1192-5_26"},{"key":"1780_CR8","doi-asserted-by":"crossref","unstructured":"Dreier JP, Ebert N, Priller J, Megow D, Lindauer U, Klee R, Reuter U, Imai Y, Einh?Upl KM, Victorov I (2000) Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage? J Neurosurg 93:658-666","DOI":"10.3171\/jns.2000.93.4.0658"},{"key":"1780_CR9","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1097\/00004647-199809000-00007","volume":"18","author":"JP Dreier","year":"1998","unstructured":"Dreier JP, K\u00f6rner K, Ebert N, G\u00f6rner A, Rubin I, Back T, Lindauer U, Wolf T, Villringer A, Einh\u00e4upl KM, Lauritzen M, Dirnagl U (1998) Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces cortical spreading ischemia when K+ is increased in the subarachnoid space. J Cereb Blood Flow Metab 18:978\u2013990. https:\/\/doi.org\/10.1097\/00004647-199809000-00007","journal-title":"J Cereb Blood Flow Metab"},{"key":"1780_CR10","first-page":"157","volume":"18","author":"R Durmaz","year":"2008","unstructured":"Durmaz R, Ozkara E, Kanbak G, Arslan OC, Atasoy MA (2008) Nitric oxide level and adenosine deaminase activity in cerebrospinal fluid of patients with subarachnoid hemorrhage. Turk Neurosurg 18:157","journal-title":"Turk Neurosurg"},{"key":"1780_CR11","doi-asserted-by":"publisher","first-page":"H1216","DOI":"10.1152\/ajpheart.1990.259.4.H1216","volume":"259","author":"FM Faraci","year":"1990","unstructured":"Faraci FM (1990) Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol 259:H1216-1221. https:\/\/doi.org\/10.1152\/ajpheart.1990.259.4.H1216","journal-title":"Am J Physiol"},{"key":"1780_CR12","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.clineuro.2015.09.005","volume":"139","author":"PM Foreman","year":"2015","unstructured":"Foreman PM, Chua M, Harrigan MR, Fisher WS 3rd, Tubbs RS, Shoja MM, Griessenauer CJ (2015) Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: a case-control study. Clin Neurol Neurosurg 139:66\u201369. https:\/\/doi.org\/10.1016\/j.clineuro.2015.09.005","journal-title":"Clin Neurol Neurosurg"},{"key":"1780_CR13","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12975-013-0257-2","volume":"4","author":"M Fujii","year":"2013","unstructured":"Fujii M, Yan J, Rolland WB, Soejima Y, Caner B, Zhang JH (2013) Early brain injury, an evolving frontier in subarachnoid hemorrhage research. Transl Stroke Res 4:432\u2013446. https:\/\/doi.org\/10.1007\/s12975-013-0257-2","journal-title":"Transl Stroke Res"},{"key":"1780_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0014-2999(95)00070-2","volume":"277","author":"H Hirose","year":"1995","unstructured":"Hirose H, Ide K, Sasaki T, Takahashi R, Kobayashi M, Ikemoto F, Yano M, Nishikibe M (1995) The role of endothelin and nitric oxide in modulation of normal and spastic cerebral vascular tone in the dog. Eur J Pharmacol 277:77\u201387","journal-title":"Eur J Pharmacol"},{"key":"1780_CR15","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1161\/01.RES.0000250821.32324.e1","volume":"99","author":"M Ishiguro","year":"2006","unstructured":"Ishiguro M, Morielli AD, Zvarova K, Tranmer BI, Penar PL, Wellman GC (2006) Oxyhemoglobin-induced suppression of voltage-dependent K+ channels in cerebral arteries by enhanced tyrosine kinase activity. Circ Res 99:1252\u20131260. https:\/\/doi.org\/10.1161\/01.RES.0000250821.32324.e1","journal-title":"Circ Res"},{"key":"1780_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-3-211-75718-5_19","volume":"104","author":"M Ishiguro","year":"2008","unstructured":"Ishiguro M, Murakami K, Link T, Zvarova K, Tranmer BI, Morielli AD, Wellman GC (2008) Acute and chronic effects of oxyhemoglobin on voltage-dependent ion channels in cerebral arteries. Acta Neurochir Suppl 104:99\u2013102. https:\/\/doi.org\/10.1007\/978-3-211-75718-5_19","journal-title":"Acta Neurochir Suppl"},{"key":"1780_CR17","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3171\/JNS-07\/11\/0945","volume":"107","author":"CS Jung","year":"2007","unstructured":"Jung CS, Oldfield EH, Harvey-White J, Espey MG, Zimmermann M, Seifert V, Pluta RM (2007) Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 107:945\u2013950. https:\/\/doi.org\/10.3171\/JNS-07\/11\/0945","journal-title":"J Neurosurg"},{"key":"1780_CR18","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1097\/CCM.0b013e31817c1095","volume":"36","author":"AH Kramer","year":"2008","unstructured":"Kramer AH, Gurka MJ, Nathan B, Dumont AS, Kassell NF, Bleck TP (2008) Complications associated with anemia and blood transfusion in patients with aneurysmal subarachnoid hemorrhage. Crit Care Med 36:2070\u20132075. https:\/\/doi.org\/10.1097\/CCM.0b013e31817c1095","journal-title":"Crit Care Med"},{"key":"1780_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12028-008-9171-y","volume":"10","author":"AH Kramer","year":"2009","unstructured":"Kramer AH, Zygun DA, Bleck TP, Dumont AS, Kassell NF, Nathan B (2009) Relationship between hemoglobin concentrations and outcomes across subgroups of patients with aneurysmal subarachnoid hemorrhage. Neurocrit Care 10:157\u2013165","journal-title":"Neurocrit Care"},{"key":"1780_CR20","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1097\/01.WCB.0000125886.48838.7E","volume":"24","author":"G Kusaka","year":"2004","unstructured":"Kusaka G, Ishikawa M, Nanda A, Granger DN, Zhang JH (2004) Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 24:916\u2013925. https:\/\/doi.org\/10.1097\/01.WCB.0000125886.48838.7E","journal-title":"J Cereb Blood Flow Metab"},{"key":"1780_CR21","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3171\/2014.12.JNS141288","volume":"123","author":"CW Liang","year":"2015","unstructured":"Liang CW, Su K, Liu JJ, Dogan A, Hinson HE (2015) Timing of deep vein thrombosis formation after aneurysmal subarachnoid hemorrhage. J Neurosurg 123:891\u2013896. https:\/\/doi.org\/10.3171\/2014.12.JNS141288","journal-title":"J Neurosurg"},{"key":"1780_CR22","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1006\/bbrc.2000.4167","volume":"280","author":"G Lin","year":"2001","unstructured":"Lin G, Macdonald RL, Marton LS, Kowalczuk A, Solenski NJ, Weir BK (2001) Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric oxide. Biochem Biophys Res Commun 280:824\u2013830. https:\/\/doi.org\/10.1006\/bbrc.2000.4167","journal-title":"Biochem Biophys Res Commun"},{"key":"1780_CR23","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1212\/WNL.0b013e3181dd42b3","volume":"74","author":"CE Lovelock","year":"2010","unstructured":"Lovelock CE, Rinkel GJ, Rothwell PM (2010) Time trends in outcome of subarachnoid hemorrhage: population-based study and systematic review. Neurology 74:1494\u20131501. https:\/\/doi.org\/10.1212\/WNL.0b013e3181dd42b3","journal-title":"Neurology"},{"key":"1780_CR24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10628-005-0141-4","volume":"405","author":"OG Luneva","year":"2005","unstructured":"Luneva OG, Brazhe NA, Fadyukova OE, Akhalaya MY, Baizhumanov AA, Parshina EY, Demidova AE, Koshelev VB, Maksimov GV (2005) Changes in plasma membrane viscosity and hemoporphyrin conformation in erythrocyte hemoglobin under the conditions of ischemia and reperfusion of rat brain. Dokl Biochem Biophys 405:465\u2013467. https:\/\/doi.org\/10.1007\/s10628-005-0141-4","journal-title":"Dokl Biochem Biophys"},{"key":"1780_CR25","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/01.str.22.8.971","volume":"22","author":"RL Macdonald","year":"1991","unstructured":"Macdonald RL, Weir BK (1991) A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 22:971\u2013982. https:\/\/doi.org\/10.1161\/01.str.22.8.971","journal-title":"Stroke"},{"key":"1780_CR26","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3171\/2015.5.Jns142115","volume":"125","author":"TK Mukhtar","year":"2016","unstructured":"Mukhtar TK, Molyneux AJ, Hall N, Yeates DR, Goldacre R, Sneade M, Clarke A, Goldacre MJ (2016) The falling rates of hospital admission, case fatality, and population-based mortality for subarachnoid hemorrhage in England, 1999\u20132010. J Neurosurg 125:698\u2013704. https:\/\/doi.org\/10.3171\/2015.5.Jns142115","journal-title":"J Neurosurg"},{"key":"1780_CR27","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1227\/01.NEU.0000232662.86771.A9","volume":"59","author":"AM Naidech","year":"2006","unstructured":"Naidech AM, Drescher J, Ault ML, Shaibani A, Batjer HH, Alberts MJ (2006) Higher hemoglobin is associated with less cerebral infarction, poor outcome, and death after subarachnoid hemorrhage. Neurosurgery 59:775\u2013779","journal-title":"Neurosurgery"},{"key":"1780_CR28","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1097\/01.Ccm.0000284516.17580.2c","volume":"35","author":"AM Naidech","year":"2007","unstructured":"Naidech AM, Jovanovic B, Wartenberg KE, Parra A, Ostapkovich N, Connolly ES, Mayer SA, Commichau C (2007) Higher hemoglobin is associated with improved outcome after subarachnoid hemorrhage. Crit Care Med 35:2383\u20132389. https:\/\/doi.org\/10.1097\/01.Ccm.0000284516.17580.2c","journal-title":"Crit Care Med"},{"key":"1780_CR29","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s12028-010-9424-4","volume":"13","author":"AM Naidech","year":"2010","unstructured":"Naidech AM, Shaibani A, Garg RK, Duran IM, Liebling SM, Bassin SL, Bendok BR, Bernstein RA, Batjer HH, Alberts MJ (2010) Prospective, randomized trial of higher goal hemoglobin after subarachnoid hemorrhage. Neurocrit Care 13:313\u2013320. https:\/\/doi.org\/10.1007\/s12028-010-9424-4","journal-title":"Neurocrit Care"},{"key":"1780_CR30","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1161\/STROKEAHA.108.527911","volume":"40","author":"M Oddo","year":"2009","unstructured":"Oddo M, Milby A, Chen I, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel M, Kofke WA, Levine JM, Le Roux PD (2009) Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage. Stroke 40:1275\u20131281. https:\/\/doi.org\/10.1161\/STROKEAHA.108.527911","journal-title":"Stroke"},{"key":"1780_CR31","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3171\/jns.1992.77.2.0274","volume":"77","author":"EH Ohlstein","year":"1992","unstructured":"Ohlstein EH, Storer BL (1992) Oxyhemoglobin stimulation of endothelin production in cultured endothelial cells. J Neurosurg 77:274\u2013278. https:\/\/doi.org\/10.3171\/jns.1992.77.2.0274","journal-title":"J Neurosurg"},{"key":"1780_CR32","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11910-019-0990-3","volume":"19","author":"V Rass","year":"2019","unstructured":"Rass V, Helbok R (2019) Early brain injury after poor-grade subarachnoid hemorrhage. Curr Neurol Neurosci Rep 19:78. https:\/\/doi.org\/10.1007\/s11910-019-0990-3","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1780_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-3-319-04981-6_4","volume":"120","author":"FA Sehba","year":"2015","unstructured":"Sehba FA, Friedrich V (2015) Early events after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl 120:23\u201328. https:\/\/doi.org\/10.1007\/978-3-319-04981-6_4","journal-title":"Acta Neurochir Suppl"},{"key":"1780_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12035-010-8155-z","volume":"43","author":"FA Sehba","year":"2011","unstructured":"Sehba FA, Pluta RM, Zhang JH (2011) Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol 43:27\u201340. https:\/\/doi.org\/10.1007\/s12035-010-8155-z","journal-title":"Mol Neurobiol"},{"key":"1780_CR35","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1097\/00004647-200003000-00018","volume":"20","author":"FA Sehba","year":"2000","unstructured":"Sehba FA, Schwartz AY, Chereshnev I, Bederson JB (2000) Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage. J Cereb Blood Flow Metab 20:604\u2013611. https:\/\/doi.org\/10.1097\/00004647-200003000-00018","journal-title":"J Cereb Blood Flow Metab"},{"key":"1780_CR36","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/s1474-4422(03)00531-3","volume":"2","author":"J Sen","year":"2003","unstructured":"Sen J, Belli A, Albon H, Morgan L, Petzold A, Kitchen N (2003) Triple-H therapy in the management of aneurysmal subarachnoid haemorrhage. Lancet Neurol 2:614\u2013621. https:\/\/doi.org\/10.1016\/s1474-4422(03)00531-3","journal-title":"Lancet Neurol"},{"key":"1780_CR37","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.jocn.2014.08.026","volume":"22","author":"M Stein","year":"2015","unstructured":"Stein M, Brokmeier L, Herrmann J, Scharbrodt W, Schreiber V, Bender M, Oertel MF (2015) Mean hemoglobin concentration after acute subarachnoid hemorrhage and the relation to outcome, mortality, vasospasm, and brain infarction. J Clin Neurosci 22:530\u2013534. https:\/\/doi.org\/10.1016\/j.jocn.2014.08.026","journal-title":"J Clin Neurosci"},{"key":"1780_CR38","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/WNR.0000000000000340","volume":"26","author":"J Sun","year":"2015","unstructured":"Sun J, Tan G, Xing W, He Z (2015) Optimal hemoglobin concentration in patients with aneurysmal subarachnoid hemorrhage after surgical treatment to prevent symptomatic cerebral vasospasm. NeuroReport 26:263\u2013266. https:\/\/doi.org\/10.1097\/WNR.0000000000000340","journal-title":"NeuroReport"},{"key":"1780_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/MCC.0b013e32832922d1","volume":"15","author":"MM Treggiari","year":"2009","unstructured":"Treggiari MM, Deem S (2009) Which H is the most important in triple-H therapy for cerebral vasospasm? Curr Opin Crit Care 15:83\u201386","journal-title":"Curr Opin Crit Care"},{"key":"1780_CR40","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3171\/jns.2003.98.5.0978","volume":"98","author":"MM Treggiari","year":"2003","unstructured":"Treggiari MM, Walder B, Suter PM, Romand J-A (2003) Systematic review of the prevention of delayed ischemic neurological deficits with hypertension, hypervolemia, and hemodilution therapy following subarachnoid hemorrhage. J Neurosurg 98:978\u2013984","journal-title":"J Neurosurg"},{"key":"1780_CR41","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1136\/heart.85.3.342","volume":"85","author":"P Vallance","year":"2001","unstructured":"Vallance P, Chan N (2001) Endothelial function and nitric oxide: clinical relevance. Heart 85:342\u2013350. https:\/\/doi.org\/10.1136\/heart.85.3.342","journal-title":"Heart"},{"key":"1780_CR42","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.wneu.2011.02.030","volume":"76","author":"GJ Velat","year":"2011","unstructured":"Velat GJ, Kimball MM, Mocco JD, Hoh BL (2011) Vasospasm after aneurysmal subarachnoid hemorrhage: review of randomized controlled trials and meta-analyses in the literature. World Neurosurg 76:446\u2013454. https:\/\/doi.org\/10.1016\/j.wneu.2011.02.030","journal-title":"World Neurosurg"},{"key":"1780_CR43","doi-asserted-by":"publisher","unstructured":"Wartenberg KE, Schmidt JM, Claassen J, Temes RE, Frontera JA, Ostapkovich N, Parra A, Connolly ES, Mayer SA (2006) Impact of medical complications on outcome after subarachnoid hemorrhage. Crit Care Med 34:617\u2013623; quiz 624. https:\/\/doi.org\/10.1097\/01.ccm.0000201903.46435.35","DOI":"10.1097\/01.ccm.0000201903.46435.35"},{"key":"1780_CR44","doi-asserted-by":"crossref","unstructured":"Xiao A, Chen R, Ren Y, You C (2019) Elevated hemoglobin is associated with poor prognosis in Tibetans with poor-grade aneurysmal subarachnoid hemorrhage after clipping: A Retrospective Case-Control Study. Neurochirurgie 65","DOI":"10.1016\/j.neuchi.2019.06.005"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-022-01780-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-022-01780-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-022-01780-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T09:04:50Z","timestamp":1659517490000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-022-01780-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,2]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1780"],"URL":"https:\/\/doi.org\/10.1007\/s10143-022-01780-w","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,2]]},"assertion":[{"value":"12 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of Beijing Tiantan Hospital (KY 2021\u2013008-01). All the analyses were performed according to the Declaration of Helsinki and the local ethics policies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent for clinical analysis was obtained from all individual participants or their authorized representatives.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and approved the final manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}