{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:38:56Z","timestamp":1768891136170,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003484","name":"Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebellar mutism syndrome (CMS) occurs in one out of four children after posterior fossa tumor surgery, with open questions regarding risk factors, pathophysiology, and prevention strategies. Because of similarities between several cerebellar syndromes, a common pathophysiology with damage to the dentato-thalamo-cortical and dentato-rubro-olivary pathways has been proposed. Hypertrophic olivary degeneration (HOD) is an imaging correlate of cerebellar injury observed for instance in stroke patients. Aim of this study was to investigate whether the occurrence and severity of CMS correlates with the extent of damage to the relevant anatomical structures and whether HOD is a time-dependent postoperative neuroimaging correlate of CMS. We performed a retrospective single center study of CMS patients compared with matched non-CMS controls. CMS occurred in 10 children (13% of the overall cohort) with a median age of 8\u00a0years. Dentate nucleus (DN) injury significantly correlated with CMS, and superior cerebellar peduncle (SCP) injury was associated by tendency. HOD was observed as a dynamic neuroimaging phenomenon in the postoperative course and its presence significantly correlated with CMS and DN injury. Children who later developed HOD had an earlier onset and tended to have longer persistence of CMS. These findings can guide surgical measures to protect the DN and SCP during posterior fossa tumor resections and to avoid a high damage burden (i.e., bilateral damage). Development of intraoperative neuromonitoring of the cerebellar efferent pathways as well as improved preoperative risk stratification could help to establish a patient-specific strategy with optimal balance between degree of resection and functional integrity.<\/jats:p>","DOI":"10.1007\/s10143-022-01791-7","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T05:04:36Z","timestamp":1650431076000},"page":"2757-2765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structural damage burden and hypertrophic olivary degeneration in pediatric postoperative cerebellar mutism syndrome"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8715-5237","authenticated-orcid":false,"given":"Thomas","family":"Beez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Munoz-Bendix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik-Jan","family":"Mijderwijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Remke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"H\u00e4nggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"issue":"9","key":"1791_CR1","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1007\/s00381-021-05225-5","volume":"37","author":"N Ahmadian","year":"2021","unstructured":"Ahmadian N, van Baarsen KM, Robe PAJT, Hoving EW (2021) Association between cerebral perfusion and paediatric postoperative cerebellar mutism syndrome after posterior fossa surgery\u2014a systematic review. Child\u2019s Nerv Syst 37(9):2743\u20132751","journal-title":"Child\u2019s Nerv Syst"},{"issue":"1","key":"1791_CR2","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3171\/2018.8.JNS181207","volume":"132","author":"CM Alfaro","year":"2019","unstructured":"Alfaro CM, Pirro V, Keating MF, Hattab EM, Cooks RG, Cohen-Gadol AA (2019) Intraoperative assessment of isocitrate dehydrogenase mutation status in human gliomas using desorption electrospray ionization-mass spectrometry. J Neurosurg 132(1):180\u2013187","journal-title":"J Neurosurg"},{"issue":"5","key":"1791_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.21037\/qims.2016.10.11","volume":"6","author":"S Avula","year":"2016","unstructured":"Avula S, Spiteri M, Kumar R, Lewis E, Harave S, Windridge D, Ong C, Pizer B (2016) Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. Quant Imaging Med Surg 6(5):535\u2013544","journal-title":"Quant Imaging Med Surg"},{"issue":"1","key":"1791_CR4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10143-020-01242-1","volume":"44","author":"T Beez","year":"2021","unstructured":"Beez T, Munoz-Bendix C, Steiger H-J, H\u00e4nggi D (2021) Functional tracts of the cerebellum-essentials for the neurosurgeon. Neurosurg Rev 44(1):273\u2013278","journal-title":"Neurosurg Rev"},{"key":"1791_CR5","doi-asserted-by":"crossref","unstructured":"Boisgontier J, Fillon L, Rutten C, Saitovitch A, Dufour C, Lema\u00eetre H, Beccaria K, Blauwblomme T, Levy R, Dangouloff-Ros V, Gr\u00e9vent D, Roux C-J, Grill J, Vin\u00e7on-Leite A, Saidoun L, Bourdeaut F, Zilbovicius M, Boddaert N, Puget S (2021) A CBF decrease in the left supplementary motor areas: new insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI. J Cereb Blood Flow Metab 0271678X2110313","DOI":"10.1177\/0271678X211031321"},{"issue":"2","key":"1791_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/WCO.0000000000000426","volume":"30","author":"CE Catsman-Berrevoets","year":"2017","unstructured":"Catsman-Berrevoets CE (2017) Cerebellar mutism syndrome: cause and rehabilitation. Curr Opin Neurol 30(2):133\u2013139","journal-title":"Curr Opin Neurol"},{"issue":"3","key":"1791_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3171\/jns.1995.83.3.0467","volume":"83","author":"AT Dailey","year":"1995","unstructured":"Dailey AT, McKhann GM, Berger MS (1995) The pathophysiology of oral pharyngeal apraxia and mutism following posterior fossa tumor resection in children. J Neurosurg 83(3):467\u2013475","journal-title":"J Neurosurg"},{"key":"1791_CR8","doi-asserted-by":"crossref","unstructured":"Dhaenens BAE, van Veelen MLC, Catsman-Berrevoets CE (2020) Preoperative prediction of postoperative cerebellar mutism syndrome. Validation of existing MRI models and proposal of the new Rotterdam pCMS prediction model. Child\u2019s Nerv Syst 36(7):1471\u20131480","DOI":"10.1007\/s00381-020-04535-4"},{"key":"1791_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-13147-3","volume-title":"The cerebellum as a neuronal machine","author":"JC Eccles","year":"1967","unstructured":"Eccles JC, Ito M, Szent\u00e1gothai J (1967) The cerebellum as a neuronal machine. Springer, Berlin Heidelberg, Berlin, Heidelberg"},{"issue":"5","key":"1791_CR10","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s00381-021-05126-7","volume":"37","author":"D Giampiccolo","year":"2021","unstructured":"Giampiccolo D, Basaldella F, Badari A, Squintani GM, Cattaneo L, Sala F (2021) Feasibility of cerebello-cortical stimulation for intraoperative neurophysiological monitoring of cerebellar mutism. Childs Nerv Syst 37(5):1505\u20131514","journal-title":"Childs Nerv Syst"},{"issue":"6","key":"1791_CR11","first-page":"1073","volume":"21","author":"M Goyal","year":"2000","unstructured":"Goyal M, Versnick E, Tuite P, Saint Cyr J, Kucharczyk W, Montanera W, Willinsky R, Mikulis D (2000) Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings. Am J Neuroradiol 21(6):1073\u20131077","journal-title":"Am J Neuroradiol"},{"issue":"6","key":"1791_CR12","first-page":"1073","volume":"21","author":"M Goyal","year":"2000","unstructured":"Goyal M, Versnick E, Tuite P, Cyr JS, Kucharczyk W, Montanera W, Willinsky R, Mikulis D (2000) Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings. AJNR Am J Neuroradiol 21(6):1073\u20131077","journal-title":"AJNR Am J Neuroradiol"},{"key":"1791_CR13","doi-asserted-by":"crossref","unstructured":"Gr\u00f8nb\u00e6k JK, Wibroe M, Toescu S,\u00a0Fri\u010d R, Thomsen BL, M\u00f8ller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R; CMS study group (2021) Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study. Lancet Child Adolesc Heal 5(11):814\u2013824","DOI":"10.2139\/ssrn.3788120"},{"key":"1791_CR14","doi-asserted-by":"publisher","unstructured":"Gudrunardottir T, Morgan AT, Lux AL, Walker DA, Walsh KS, Wells EM, Wisoff JH, Juhler M, Schmahmann JD, Keating RF, Catsman-Berrevoets CE (2016) Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results. https:\/\/doi.org\/10.1007\/s00381-016-3093-3","DOI":"10.1007\/s00381-016-3093-3"},{"issue":"9","key":"1791_CR15","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s00381-011-1509-7","volume":"27","author":"T Gudrunardottir","year":"2011","unstructured":"Gudrunardottir T, Sehested A, Juhler M, Grill J, Schmiegelow K (2011) Cerebellar mutism: definitions, classification and grading of symptoms. Child\u2019s Nerv Syst 27(9):1361\u20131363","journal-title":"Child\u2019s Nerv Syst"},{"issue":"9","key":"1791_CR16","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/neuonc\/noab030","volume":"23","author":"RB Khan","year":"2021","unstructured":"Khan RB, Patay Z, Klimo P, Huang J, Kumar R, Boop FA, Raches D, Conklin HM, Sharma R, Simmons A, Sadighi ZS, Onar-Thomas A, Gajjar A, Robinson GW (2021) Clinical features, neurologic recovery, and risk factors of postoperative posterior fossa syndrome and delayed recovery: a prospective study. Neuro Oncol 23(9):1586\u20131596","journal-title":"Neuro Oncol"},{"issue":"Pt 12","key":"1791_CR17","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1093\/brain\/123.12.2512","volume":"123","author":"S Knecht","year":"2000","unstructured":"Knecht S, Dr\u00e4ger B, Deppe M, Bobe L, Lohmann H, Fl\u00f6el A, Ringelstein EB, Henningsen H (2000) Handedness and hemispheric language dominance in healthy humans. Brain 123(Pt 12):2512\u20132518","journal-title":"Brain"},{"issue":"1","key":"1791_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/02688697.2018.1431204","volume":"32","author":"J-F Liu","year":"2018","unstructured":"Liu J-F, Dineen RA, Avula S, Chambers T, Dutta M, Jaspan T, MacArthur DC, Howarth S, Soria D, Quinlan P, Harave S, Ong CC, Mallucci CL, Kumar R, Pizer B, Walker DA (2018) Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome. Br J Neurosurg 32(1):18\u201327","journal-title":"Br J Neurosurg"},{"issue":"3","key":"1791_CR19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00062-009-9001-4","volume":"19","author":"S Macht","year":"2009","unstructured":"Macht S, H\u00e4nggi D, Turowski B (2009) Hypertrophic olivary degeneration following pontine cavernoma hemorrhage: a typical change accompanying lesions in the Guillain-Mollaret triangle. Klin Neuroradiol 19(3):235\u2013237","journal-title":"Klin Neuroradiol"},{"issue":"1","key":"1791_CR20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.schres.2014.09.007","volume":"161","author":"LJ O\u2019Donnell","year":"2015","unstructured":"O\u2019Donnell LJ, Pasternak O (2015) Does diffusion MRI tell us anything about the white matter? An overview of methods and pitfalls. Schizophr Res 161(1):133\u2013141","journal-title":"Schizophr Res"},{"key":"1791_CR21","doi-asserted-by":"publisher","first-page":"e763","DOI":"10.1016\/j.wneu.2018.01.150","volume":"112","author":"MR Onen","year":"2018","unstructured":"Onen MR, Moore K, Cikla U, Ucer M, Schmidt B, Field AS, Baskaya MK (2018) Hypertrophic olivary degeneration: neurosurgical perspective and literature review. World Neurosurg 112:e763\u2013e771","journal-title":"World Neurosurg"},{"issue":"1","key":"1791_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-016-1643-0","volume":"133","author":"KW Pajtler","year":"2017","unstructured":"Pajtler KW, Mack SC, Ramaswamy V, Smith CA, Witt H, Smith A, Hansford JR, von Hoff K, Wright KD, Hwang E, Frappaz D, Kanemura Y, Massimino M, Faure-Conter C, Modena P, Tabori U, Warren KE, Holland EC, Ichimura K, Giangaspero F, Castel D, von Deimling A, Kool M, Dirks PB, Grundy RG, Foreman NK, Gajjar A, Korshunov A, Finlay J, Gilbertson RJ, Ellison DW, Aldape KD, Merchant TE, Bouffet E, Pfister SM, Taylor MD (2017) The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants. Acta Neuropathol 133(1):5\u201312","journal-title":"Acta Neuropathol"},{"issue":"4","key":"1791_CR23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3174\/ajnr.A3762","volume":"35","author":"Z Patay","year":"2014","unstructured":"Patay Z, Enterkin J, Harreld JH, Yuan Y, L\u00f6bel U, Rumboldt Z, Khan R, Boop F (2014) MR imaging evaluation of inferior olivary nuclei: comparison of postoperative subjects with and without posterior fossa syndrome. AJNR Am J Neuroradiol 35(4):797\u2013802","journal-title":"AJNR Am J Neuroradiol"},{"issue":"7","key":"1791_CR24","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3174\/ajnr.A3990","volume":"35","author":"S Perreault","year":"2014","unstructured":"Perreault S, Ramaswamy V, Achrol AS, Chao K, Liu TT, Shih D, Remke M, Schubert S, Bouffet E, Fisher PG, Partap S, Vogel H, Taylor MD, Cho YJ, Yeom KW (2014) MRI surrogates for molecular subgroups of medulloblastoma. Am J Neuroradiol 35(7):1263\u20131269","journal-title":"Am J Neuroradiol"},{"key":"1791_CR25","unstructured":"Pettersson SD, Kitlinski M, Mi\u0119kisiak G, Ali S, Krakowiak M, Szmuda T (2021) Risk factors for postoperative cerebellar mutism syndrome in pediatric patients: a systematic review and meta-analysis. J Neurosurg Pediatr 1\u20139"},{"issue":"3","key":"1791_CR26","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00381-014-2356-0","volume":"30","author":"R Reed-Berendt","year":"2014","unstructured":"Reed-Berendt R, Phillips B, Picton S, Chumas P, Warren D, Livingston JH, Hughes E, Morrall MCHJ (2014) Cause and outcome of cerebellar mutism: evidence from a systematic review. Child\u2019s Nerv Syst 30(3):375\u2013385","journal-title":"Child\u2019s Nerv Syst"},{"key":"1791_CR27","doi-asserted-by":"crossref","unstructured":"Robertson PL, Muraszko KM, Holmes EJ, Sposto R, Packer RJ, Gajjar A, Dias MS, Allen JC (2006) Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children\u2019s Oncology Group. J Neurosurg 105 Pediat(Suppl 6):444\u2013451","DOI":"10.3171\/ped.2006.105.6.444"},{"issue":"3","key":"1791_CR28","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s12311-011-0273-2","volume":"10","author":"C Di Rocco","year":"2011","unstructured":"Di Rocco C, Chieffo D, Frassanito P, Caldarelli M, Massimi L, Tamburrini G (2011) Heralding cerebellar mutism: evidence for pre-surgical language impairment as primary risk factor in posterior fossa surgery. The Cerebellum 10(3):551\u2013562","journal-title":"The Cerebellum"},{"issue":"6","key":"1791_CR29","first-page":"1362","volume":"27","author":"Z Rumboldt","year":"2006","unstructured":"Rumboldt Z, Camacho DLA, Lake D, Welsh CT, Castillo M (2006) Apparent diffusion coefficients for differentiation of cerebellar tumors in children. Am J Neuroradiol 27(6):1362\u20131369","journal-title":"Am J Neuroradiol"},{"key":"1791_CR30","doi-asserted-by":"crossref","unstructured":"Sanai N, Berger MS (2010) Intraoperative stimulation techniques for functional pathway preservation and glioma resection. Neurosurg Focus 28(2):E1","DOI":"10.3171\/2009.12.FOCUS09266"},{"key":"1791_CR31","doi-asserted-by":"crossref","unstructured":"Schmahmann JD (2019) Pediatric post-operative cerebellar mutism syndrome, cerebellar cognitive affective syndrome, and posterior fossa syndrome: historical review and proposed resolution to guide future study. Child\u2019s Nerv Syst l","DOI":"10.1007\/s00381-019-04253-6"},{"issue":"4","key":"1791_CR32","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00381-012-1973-8","volume":"29","author":"V Soelva","year":"2013","unstructured":"Soelva V, Hern\u00e1iz Driever P, Abbushi A, Rueckriegel S, Bruhn H, Eisner W, Thomale U-W (2013) Fronto-cerebellar fiber tractography in pediatric patients following posterior fossa tumor surgery. Child\u2019s Nerv Syst 29(4):597\u2013607","journal-title":"Child\u2019s Nerv Syst"},{"issue":"4","key":"1791_CR33","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s12311-008-0078-0","volume":"7","author":"C Sotelo","year":"2008","unstructured":"Sotelo C (2008) Viewing the cerebellum through the eyes of Ram\u00f3n Y Cajal. The Cerebellum 7(4):517\u2013522","journal-title":"The Cerebellum"},{"key":"1791_CR34","doi-asserted-by":"crossref","unstructured":"Stoodley CJ, MacMore JP, Makris N, Sherman JC, Schmahmann JD (2016) Location of lesion determines motor vs. cognitive consequences in patients with cerebellar stroke. NeuroImage Clin 12:765\u2013775","DOI":"10.1016\/j.nicl.2016.10.013"},{"issue":"2","key":"1791_CR35","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","volume":"44","author":"CJ Stoodley","year":"2009","unstructured":"Stoodley CJ, Schmahmann JD (2009) Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44(2):489\u2013501","journal-title":"Neuroimage"},{"issue":"1\u20132","key":"1791_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1155\/2010\/840942","volume":"23","author":"CJ Stoodley","year":"2010","unstructured":"Stoodley CJ, Valera EM, Schmahmann JD (2010) An fMRI study of intra-individual functional topography in the human cerebellum. Behav Neurol 23(1\u20132):65\u201379","journal-title":"Behav Neurol"},{"issue":"3","key":"1791_CR37","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3171\/jns.2004.101.3.0484","volume":"101","author":"N Tanriover","year":"2004","unstructured":"Tanriover N, Ulm AJ, Rhoton AL, Yasuda A (2004) Comparison of the transvermian and telovelar approaches to the fourth ventricle. J Neurosurg 101(3):484\u2013498","journal-title":"J Neurosurg"},{"key":"1791_CR38","doi-asserted-by":"crossref","unstructured":"Taylor MD, Northcott PA, Korshunov A, Remke M, Cho Y-J, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123(4):465\u2013472","DOI":"10.1007\/s00401-011-0922-z"},{"key":"1791_CR39","doi-asserted-by":"crossref","unstructured":"Thompson EM, Hielscher T, Bouffet E, Remke M, \u2026, Taylor MD (2016) Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol 17(4):484\u2013495","DOI":"10.1016\/S1470-2045(15)00581-1"},{"issue":"September","key":"1791_CR40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ejrad.2018.09.007","volume":"108","author":"SM Toescu","year":"2018","unstructured":"Toescu SM, Hales PW, Aquilina K, Clark CA (2018) Quantitative MRI in post-operative paediatric cerebellar mutism syndrome. Eur J Radiol 108(September):43\u201351","journal-title":"Eur J Radiol"},{"key":"1791_CR41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.brainres.2019.04.024","volume":"1718","author":"H Wang","year":"2019","unstructured":"Wang H, Wang Y, Wang R, Li Y, Wang P, Li J, Du J (2019) Hypertrophic olivary degeneration: a comprehensive review focusing on etiology. Brain Res 1718:53\u201363","journal-title":"Brain Res"},{"key":"1791_CR42","doi-asserted-by":"crossref","unstructured":"Wibroe M, Cappelen J, Castor C, Clausen N, Grillner P, Gudrunardottir T, Gupta R, Gustavsson B, Heyman M, Holm S, Karppinen A, Klausen C, L\u00f6nnqvist T, Mathiasen R, Nilsson P, Nysom K, Persson K, Rask O, Schmiegelow K, Sehested A, Thomassen H, Tonning-Olsson I, Zetterqvist B, Juhler M (2017) Cerebellar mutism syndrome in children with brain tumours of the posterior fossa. BMC Cancer 17(1):439","DOI":"10.1186\/s12885-017-3416-0"},{"issue":"5","key":"1791_CR43","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00381-019-04075-6","volume":"35","author":"H Zhang","year":"2019","unstructured":"Zhang H, Liao Z, Hao X, Han Z, Li C, Gong J, Liu W, Tian Y (2019) Establishing reproducible predictors of cerebellar mutism syndrome based on pre-operative imaging. Childs Nerv Syst 35(5):795\u2013800","journal-title":"Childs Nerv Syst"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-022-01791-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-022-01791-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-022-01791-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T09:05:37Z","timestamp":1659517537000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-022-01791-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["1791"],"URL":"https:\/\/doi.org\/10.1007\/s10143-022-01791-7","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"assertion":[{"value":"20 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study involving human participants was in accordance with the institutional and national research standards and with the 1964 Helsinki Declaration and its later amendments. The ethical review board of the Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, Germany, approved the study (study no. 2019\u2013417-RetroDEuA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable for this retrospective anonymized study according to ethical review board regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable for this retrospective anonymized study according to ethical review board regulations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}