{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:14:21Z","timestamp":1781939661733,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore might be considered in clinical decision making and patient counseling. In the present study, the authors analyzed infra- and supratentorial BM location for a potential prognostic difference. Between 2013 and 2019, 245 patients with solitary BM received BM resection at the authors\u2019 neuro-oncological center. In order to produce a covariate balance for commonly-known prognostic variables (tumor entity, age, preoperative Karnofsky Performance Score, and preoperative Charlson Comorbidity Index), a propensity score matching at a ratio of 1:1 between the cohort of patients with infra- and supratentorial BM location was performed using R. Overall survival (OS) rates were assessed for both matched cohorts of patients with BM. Sixty-one of 245 patients (25%) with solitary BM exhibited an infratentorial tumor location; 184 patients (75%) suffered from supratentorial solitary BM. Patients with infratentorial BM revealed a median OS of 11 months (95% confidence interval (CI) 7.4\u201314.6 months). Compared with this, median OS for the group of 61 individually matched patients with solitary supratentorial solitary BM was 13 months (95% CI 10.9-15.1 months) (<jats:italic>p<\/jats:italic> = 0.32). The present study suggests that the prognostic value of infra- and supratentorial BMs does not significantly differ in patients that undergo surgery for solitary BM. These results might encourage physicians to induce surgical therapy of supra- and infratentorial BM in a similar manner.<\/jats:p>","DOI":"10.1007\/s10143-023-01986-6","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T11:52:19Z","timestamp":1680609139000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Survival in patients with surgically treated brain metastases: does infratentorial location matter?"],"prefix":"10.1007","volume":"46","author":[{"given":"Motaz","family":"Hamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Laura","family":"Potthoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Borger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Radbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Herrlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Vatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"1986_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41568-019-0220-y","volume":"20","author":"A Boire","year":"2020","unstructured":"Boire A, Brastianos PK, Garzia L, Valiente M (2020) Brain metastasis. Nature reviews. Cancer 20:4\u201311. https:\/\/doi.org\/10.1038\/s41568-019-0220-y","journal-title":"Cancer"},{"key":"1986_CR2","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","volume":"22","author":"JS Barnholtz-Sloan","year":"2004","unstructured":"Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE (2004) Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol 22:2865\u20132872. https:\/\/doi.org\/10.1200\/JCO.2004.12.149","journal-title":"J Clin Oncol"},{"key":"1986_CR3","doi-asserted-by":"publisher","unstructured":"Schneider M, Heimann M, Schaub C, Eichhorn L, Potthoff AL, Giordano FA, Guresir E, Ko YD, Landsberg J, Lehmann F, Radbruch A, Schwab KS, Weinhold L, Weller J, Wispel C, Herrlinger U, Vatter H, Schafer N, Schuss P (2020) Comorbidity burden and presence of multiple intracranial lesions are associated with adverse events after surgical treatment of patients with brain metastases. Cancers 12. https:\/\/doi.org\/10.3390\/cancers12113209","DOI":"10.3390\/cancers12113209"},{"key":"1986_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41572-018-0055-y","volume":"5","author":"AS Achrol","year":"2019","unstructured":"Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, Peters S, Arvold ND, Harsh GR, Steeg PS, Chang SD (2019) Brain metastases. Nat rev Dis prim 5:5. https:\/\/doi.org\/10.1038\/s41572-018-0055-y","journal-title":"Nat rev Dis prim"},{"key":"1986_CR5","doi-asserted-by":"publisher","unstructured":"Proescholdt MA, Schodel P, Doenitz C, Pukrop T, Hohne J, Schmidt NO, Schebesch KM (2021) The management of brain metastases-systematic review of neurosurgical aspects. Cancers 13. https:\/\/doi.org\/10.3390\/cancers13071616","DOI":"10.3390\/cancers13071616"},{"key":"1986_CR6","doi-asserted-by":"publisher","unstructured":"Kancharla P, Ivanov A, Chan S, Ashamalla H, Huang RY, Yanagihara TK (2019) The effect of brain metastasis location on clinical outcomes: a review of the literature. Neuro-Oncol Adv 1:vdz017. https:\/\/doi.org\/10.1093\/noajnl\/vdz017","DOI":"10.1093\/noajnl\/vdz017"},{"key":"1986_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.surneu.2007.10.010","volume":"71","author":"S Yoshida","year":"2009","unstructured":"Yoshida S, Takahashi H (2009) Cerebellar metastases in patients with cancer. Surg Neurol 71:184\u2013187; discussion 187. https:\/\/doi.org\/10.1016\/j.surneu.2007.10.010","journal-title":"Surg Neurol"},{"key":"1986_CR8","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/0959-8049(92)90510-9","volume":"28A","author":"E Verger","year":"1992","unstructured":"Verger E, Salamero M, Conill C (1992) Can Karnofsky performance status be transformed to the Eastern Cooperative Oncology Group scoring scale and vice versa? Eur J Cancer 28A:1328\u20131330. https:\/\/doi.org\/10.1016\/0959-8049(92)90510-9","journal-title":"Eur J Cancer"},{"key":"1986_CR9","doi-asserted-by":"publisher","first-page":"772789","DOI":"10.3389\/fonc.2021.772789","volume":"11","author":"C Mantovani","year":"2021","unstructured":"Mantovani C, Gastino A, Cerrato M, Badellino S, Ricardi U, Levis M (2021) Modern radiation therapy for the management of brain metastases from non-small cell lung cancer: current approaches and future directions. Front Oncol 11:772789. https:\/\/doi.org\/10.3389\/fonc.2021.772789","journal-title":"Front Oncol"},{"key":"1986_CR10","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s11060-021-03784-w","volume":"153","author":"N Schafer","year":"2021","unstructured":"Schafer N, Bumes E, Eberle F, Fox V, Gessler F, Giordano FA, Konczalla J, Onken J, Ottenhausen M, Scherer M, Schneider M, Vatter H, Herrlinger U, Schuss P (2021) Implementation, relevance, and virtual adaptation of neuro-oncological tumor boards during the COVID-19 pandemic: a nationwide provider survey. J Neuro-Oncol 153:479\u2013485. https:\/\/doi.org\/10.1007\/s11060-021-03784-w","journal-title":"J Neuro-Oncol"},{"key":"1986_CR11","doi-asserted-by":"publisher","unstructured":"Hamed M, Potthoff AL, Layer JP, Koch D, Borger V, Heimann M, Scafa D, Sarria GR, Holz JA, Schmeel FC, Radbruch A, Guresir E, Schafer N, Schuss P, Garbe S, Giordano FA, Herrlinger U, Vatter H, Schmeel LC, Schneider M (2022) Benchmarking safety indicators of surgical treatment of brain metastases combined with intraoperative radiotherapy: results of prospective observational study with comparative matched-pair analysis. Cancers 14. https:\/\/doi.org\/10.3390\/cancers14061515","DOI":"10.3390\/cancers14061515"},{"key":"1986_CR12","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s11060-020-03629-y","volume":"149","author":"M Schneider","year":"2020","unstructured":"Schneider M, Ilic I, Potthoff AL, Hamed M, Schafer N, Velten M, Guresir E, Herrlinger U, Borger V, Vatter H, Schuss P (2020) Safety metric profiling in surgery for temporal glioblastoma: lobectomy as a supra-total resection regime preserves perioperative standard quality rates. J Neuro-Oncol 149:455\u2013461. https:\/\/doi.org\/10.1007\/s11060-020-03629-y","journal-title":"J Neuro-Oncol"},{"key":"1986_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1179\/1743132813Y.0000000260","volume":"36","author":"KL Chaichana","year":"2014","unstructured":"Chaichana KL, Rao K, Gadkaree S, Dangelmajer S, Bettegowda C, Rigamonti D, Weingart J, Olivi A, Gallia GL, Brem H, Lim M, Quinones-Hinojosa A (2014) Factors associated with survival and recurrence for patients undergoing surgery of cerebellar metastases. Neurol Res 36:13\u201325. https:\/\/doi.org\/10.1179\/1743132813Y.0000000260","journal-title":"Neurol Res"},{"key":"1986_CR14","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1200\/JCO.20.01255","volume":"38","author":"PW Sperduto","year":"2020","unstructured":"Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R et al (2020) Survival in patients with brain metastases: summary report on the updated diagnosis-specific graded prognostic assessment and definition of the eligibility quotient. J Clin Oncol 38:3773\u20133784. https:\/\/doi.org\/10.1200\/JCO.20.01255","journal-title":"J Clin Oncol"},{"key":"1986_CR15","doi-asserted-by":"publisher","unstructured":"Dou Z, Wu J, Wu H, Yu Q, Yan F, Jiang B, Li B, Xu J, Xie Q, Li C, Sun C, Chen G (2021) The infratentorial localization of brain metastases may correlate with specific clinical characteristics and portend worse outcomes based on voxel-wise mapping. Cancers 13. https:\/\/doi.org\/10.3390\/cancers13020324","DOI":"10.3390\/cancers13020324"},{"key":"1986_CR16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.radonc.2015.08.023","volume":"117","author":"F Pietrantonio","year":"2015","unstructured":"Pietrantonio F, Aprile G, Rimassa L, Franco P, Lonardi S, Cremolini C, Biondani P, Sbicego EL, Pasqualetti F, Tomasello G, Niger M, Casagrande M, Ghidini M, Muni R, Montrone S, Bergamo F, Berenato R, Fontanella C, Bozzarelli S et al (2015) A new nomogram for estimating survival in patients with brain metastases secondary to colorectal cancer. Radiother Oncol 117:315\u2013321. https:\/\/doi.org\/10.1016\/j.radonc.2015.08.023","journal-title":"Radiother Oncol"},{"key":"1986_CR17","doi-asserted-by":"publisher","first-page":"713965","DOI":"10.3389\/fonc.2021.713965","volume":"11","author":"M Heimann","year":"2021","unstructured":"Heimann M, Schafer N, Bode C, Borger V, Eichhorn L, Giordano FA, Guresir E, Jacobs AH, Ko YD, Landsberg J, Lehmann F, Radbruch A, Schaub C, Schwab KS, Weller J, Herrlinger U, Vatter H, Schuss P, Schneider M (2021) Outcome of elderly patients with surgically treated brain metastases. Front Oncol 11:713965. https:\/\/doi.org\/10.3389\/fonc.2021.713965","journal-title":"Front Oncol"},{"key":"1986_CR18","doi-asserted-by":"publisher","first-page":"867462","DOI":"10.3389\/fonc.2022.867462","volume":"12","author":"M Freeman","year":"2022","unstructured":"Freeman M, Ennis M, Jerzak KJ (2022) Karnofsky Performance Status (KPS) <\/=60 is strongly associated with shorter brain-specific progression-free survival among patients with metastatic breast cancer with brain metastases. Front Oncol 12:867462. https:\/\/doi.org\/10.3389\/fonc.2022.867462","journal-title":"Front Oncol"},{"key":"1986_CR19","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.ijrobp.2016.06.009","volume":"96","author":"DM Trifiletti","year":"2016","unstructured":"Trifiletti DM, Lee CC, Kano H, Cohen J, Janopaul-Naylor J, Alonso-Basanta M, Lee JYK, Simonova G, Liscak R, Wolf A, Kvint S, Grills IS, Johnson M, Liu KD, Lin CJ, Mathieu D, Heroux F, Silva D, Sharma M et al (2016) Stereotactic radiosurgery for brainstem metastases: an international cooperative study to define response and toxicity. Int J Radiat Oncol Biol Phys 96:280\u2013288. https:\/\/doi.org\/10.1016\/j.ijrobp.2016.06.009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1986_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0021-9150(89)90008-7","volume":"77","author":"C Burks","year":"1989","unstructured":"Burks C, Hong S, Ho M, Engelman DM (1989) Limitations of the lipid state hypothesis for atherosclerosis are revealed by X-ray diffraction measurements. Atherosclerosis 77:43\u201351. https:\/\/doi.org\/10.1016\/0021-9150(89)90008-7","journal-title":"Atherosclerosis"},{"key":"1986_CR21","first-page":"89","volume":"4","author":"RT Hughes","year":"2016","unstructured":"Hughes RT, Black PJ, Page BR, Lucas JT Jr, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD (2016) Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm. Journal Radiosur SBRT 4:89\u201396","journal-title":"Journal Radiosur SBRT"},{"key":"1986_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41571-019-0320-3","volume":"17","author":"JH Suh","year":"2020","unstructured":"Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL (2020) Current approaches to the management of brain metastases. Nat Rev Clin Oncol 17:279\u2013299. https:\/\/doi.org\/10.1038\/s41571-019-0320-3","journal-title":"Nat Rev Clin Oncol"},{"key":"1986_CR23","doi-asserted-by":"publisher","first-page":"512","DOI":"10.5603\/RPOR.a2021.0060","volume":"26","author":"B Cacho-Diaz","year":"2021","unstructured":"Cacho-Diaz B, Alvarez-Alvarez A, Salmeron-Moreno K, Rodriguez-Mayoral O, Santiago-Concha BG, Arrieta Rodriguez OG (2021) Role of whole brain radiotherapy in the management of infratentorial metastases from lung and breast cancer. Rep Pract Oncol Radiother 26:512\u2013517. https:\/\/doi.org\/10.5603\/RPOR.a2021.0060","journal-title":"Rep Pract Oncol Radiother"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-023-01986-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-023-01986-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-023-01986-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T06:13:15Z","timestamp":1705903995000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-023-01986-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1986"],"URL":"https:\/\/doi.org\/10.1007\/s10143-023-01986-6","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"15 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the local ethics committee at the University of Bonn.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was not sought as a retrospective study design was used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agreed to the publication of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"80"}}