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Here, we performed a systematic review and meta-analysis of proton beam for VSs, evaluating tumor control and cranial nerve preservation rates, particularly with regard to facial and hearing preservation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We reviewed, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) articles published between 1968 and September 30, 2022. We retained 8 studies reporting 587 patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall rate of tumor control (both stability and decrease in volume) was 95.4% (range 93.5\u201397.2%, <jats:italic>p<\/jats:italic> heterogeneity= 0.77, <jats:italic>p<\/jats:italic>&lt;0.001). Overall rate of tumor progression was 4.6% (range 2.8\u20136.5%, <jats:italic>p<\/jats:italic> heterogeneity &lt; 0.77, <jats:italic>p<\/jats:italic>&lt;0.001). Overall rate of trigeminal nerve preservation (absence of numbness) was 95.6% (range 93.5\u201397.7%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 11.44%, <jats:italic>p<\/jats:italic> heterogeneity= 0.34, <jats:italic>p<\/jats:italic>&lt;0.001). Overall rate of facial nerve preservation was 93.7% (range 89.6\u201397.7%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 76.27%, <jats:italic>p<\/jats:italic> heterogeneity&lt;0.001, <jats:italic>p<\/jats:italic>&lt;0.001). Overall rate of hearing preservation was 40.6% (range 29.4\u201351.8%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 43.36%, <jats:italic>p<\/jats:italic> heterogeneity= 0.1, <jats:italic>p<\/jats:italic>&lt;0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Proton beam therapy for VSs achieves high tumor control rates, as high as\u00a095.4%. Facial rate preservation overall rates are 93%, which is lower compared to the most SRS series.  Compared with most currently reported SRS techniques, proton beam radiation therapy for VSs does not offer an advantage for facial and hearing preservation compared to most of the currently reported SRS series.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10143-023-02060-x","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T22:01:45Z","timestamp":1688508105000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Proton beam radiation therapy for vestibular schwannomas-tumor control and hearing preservation rates: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"46","author":[{"given":"Antonio","family":"Santacroce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mioara- Florentina","family":"Trandafirescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Levivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"F\u00fcrweger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iuliana","family":"Toma-Dasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercy","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy Thomas","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Maire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Faouzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Schiappacasse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Dasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Tuleasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"2060_CR1","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1227\/NEU.0b013e3181f22660","volume":"67","author":"SE Stangerup","year":"2010","unstructured":"Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P (2010) True incidence of vestibular schwannoma? 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