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It is known that these cystic VS bear different risk profiles compared to solid VS in surgical treatment. Still, there has not been a direct comparative study comparing both <jats:italic>SRS<\/jats:italic> and <jats:italic>SURGERY<\/jats:italic> effectiveness in cystic VS. This retrospective bi-center cohort study aims to analyze the management of cystic VS compared to solid VS in a dual center study with both microsurgery (<jats:italic>SURGERY<\/jats:italic>) and stereotactic radiosurgery (<jats:italic>SRS<\/jats:italic>). Cystic morphology was defined as presence of any T2-hyperintense and Gadolinium-contrast-negative cyst of any size in the pre-interventional MRI. A matched subgroup analysis was carried out by determining a subgroup of matched\u00a0<jats:italic>SURGERY-<\/jats:italic>treated solid VS and <jats:italic>SRS<\/jats:italic>-treated solid VS. Functional status, and post-interventional tumor volume size was then compared. From 2005 to 2011, <jats:italic>N<\/jats:italic>\u2009=\u2009901 patients with primary and solitary VS were treated in both study sites. Of these,\u00a06% showed cystic morphology. The incidence of cystic VS increased with tumor size: 1.75% in Koos I, 4.07% in Koos II, 4.84% in Koos III, and the highest incidence with 15.43% in Koos IV. Shunt-Dependency was significantly more often in cystic VS compared to solid VS (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and patients with cystic VS presented with significantly worse Charlson Comorbidity Index (CCI) compared to solid VS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The rate of GTR was 87% in cystic VS and therefore significantly lower, compared to 96% in solid VS (<jats:italic>p<\/jats:italic>\u2009=\u20090.037). The incidence of dynamic volume change (decrease and increase) after <jats:italic>SRS<\/jats:italic> was significantly more common in cystic VS compared to the matched solid VS (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). The incidence of tumor progression with <jats:italic>SRS<\/jats:italic> in cystic VS was 25%. When comparing EOR in the <jats:italic>SURGERY-<\/jats:italic>treated cystic to solid VS, the rate for tumor recurrence was significantly lower in GTR with 4% compared to STR with 50% (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). Tumor control in cystic VS is superior in <jats:italic>SURGERY<\/jats:italic>, when treated with a high extent of resection grade, compared to <jats:italic>SRS<\/jats:italic>. Therapeutic response of <jats:italic>SRS<\/jats:italic> was worse in cystic compared to solid VS. However, when cystic VS was treated surgically, the rate of GTR is lower compared to the overall, and solid VS cohort. The significantly higher number of patients with relevant post-operative facial palsy in cystic VS is accredited to the increased tumor size not its sole cystic morphology. Cystic VS should be surgically treated in specialized centers.<\/jats:p>","DOI":"10.1007\/s10143-024-02495-w","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T03:52:21Z","timestamp":1719287541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cystic vestibular schwannoma \u2013 a subgroup analysis from a comparative study between radiosurgery and microsurgery"],"prefix":"10.1007","volume":"47","author":[{"given":"Sophie Shih-Y\u00fcng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Rizk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian H.","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertus","family":"van Eck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Naros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Horstmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Tatagiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2495_CR1","doi-asserted-by":"publisher","unstructured":"Frisch CD, Jacob JT, Carlson ML et al (2017) Stereotactic radiosurgery for cystic vestibular schwannomas. 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