{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:10:49Z","timestamp":1773969049911,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"DOI":"10.1007\/s10143-024-03056-x","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:02:39Z","timestamp":1729598559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pregnancy and lactation associated osteoporotic vertebral fracture: the neurosurgical perspective through a multicentric study"],"prefix":"10.1007","volume":"47","author":[{"given":"Teresa","family":"Somma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Mastantuoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Rispoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Bove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bocchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Stefano","family":"Salcuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Driul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Cappabianca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Tessitore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Cappelletto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"3056_CR1","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1001\/jama.1941.02820220007002","volume":"116","author":"F Albright","year":"1941","unstructured":"Albright F, Smith PAR (1941) Postmenopausal osteoporosis, its clinical features. JAMA 116:2465\u20132474. https:\/\/doi.org\/10.1001\/jama.1941.02820220007002","journal-title":"JAMA"},{"key":"3056_CR2","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.jbspin.2011.04.007","volume":"78","author":"C Alexandre","year":"2011","unstructured":"Alexandre C, Vico L (2011) Pathophysiology of bone loss in disuse osteoporosis. Joint Bone Spine 78:572\u2013576. https:\/\/doi.org\/10.1016\/j.jbspin.2011.04.007","journal-title":"Joint Bone Spine"},{"key":"3056_CR3","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1210\/clinem\/dgad548","volume":"109","author":"P Anagnostis","year":"2024","unstructured":"Anagnostis P, Lampropoulou-Adamidou K, Bosdou JK, Trovas G, Galanis P, Chronopoulos E, Goulis DG, Tournis S (2024) Comparative effectiveness of therapeutic interventions in pregnancy and lactation-associated osteoporosis: a systematic review and meta-analysis. J Clin Endocrinol Metab 109:879\u2013901. https:\/\/doi.org\/10.1210\/clinem\/dgad548","journal-title":"J Clin Endocrinol Metab"},{"key":"3056_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00402-013-1912-5","volume":"134","author":"J Bonacker","year":"2014","unstructured":"Bonacker J, Janousek M, Kr\u00f6ber M (2014) Pregnancy-associated osteoporosis with eight fractures in the vertebral column treated with kyphoplasty and bracing: a case report. Arch Orthop Trauma Surg 134:173\u2013179. https:\/\/doi.org\/10.1007\/s00402-013-1912-5","journal-title":"Arch Orthop Trauma Surg"},{"key":"3056_CR5","doi-asserted-by":"publisher","unstructured":"Carsote M, Turturea MR, Valea A, Buescu C, Nistor C, Turturea IF (2023) Bridging the gap: pregnancy-and lactation-associated osteoporosis. Diagnostics (Basel) 13. https:\/\/doi.org\/10.3390\/diagnostics13091615","DOI":"10.3390\/diagnostics13091615"},{"key":"3056_CR6","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1093\/ajcn\/nqab264","volume":"114","author":"EM Curtis","year":"2021","unstructured":"Curtis EM, Parsons C, Maslin K, D\u2019Angelo S, Moon RJ, Crozier SR, Gossiel F, Bishop NJ, Kennedy SH, Papageorghiou AT, Fraser R, Gandhi SV, Prentice A, Inskip HM, Godfrey KM, Schoenmakers I, Javaid MK, Eastell R, Cooper C, Harvey NC, Group MT (2021) Bone turnover in pregnancy, measured by urinary CTX, is influenced by vitamin D supplementation and is associated with maternal bone health: findings from the maternal vitamin D osteoporosis study (MAVIDOS) trial. Am J Clin Nutr 114:1600\u20131611. https:\/\/doi.org\/10.1093\/ajcn\/nqab264","journal-title":"Am J Clin Nutr"},{"key":"3056_CR7","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/0002-9378(93)90378-v","volume":"168","author":"TC Dahlman","year":"1993","unstructured":"Dahlman TC (1993) Osteoporotic fractures and the recurrence of thromboembolism during pregnancy and the puerperium in 184 women undergoing thromboprophylaxis with heparin. Am J Obstet Gynecol 168:1265\u20131270. https:\/\/doi.org\/10.1016\/0002-9378(93)90378-v","journal-title":"Am J Obstet Gynecol"},{"key":"3056_CR8","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/s0899-9007(00)00430-5","volume":"16","author":"S Di Gregorio","year":"2000","unstructured":"Di Gregorio S, Danilowicz K, Rubin Z, Mautalen C (2000) Osteoporosis with vertebral fractures associated with pregnancy and lactation. Nutrition 16:1052\u20131055. https:\/\/doi.org\/10.1016\/s0899-9007(00)00430-5","journal-title":"Nutrition"},{"key":"3056_CR9","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00223-015-0028-z","volume":"97","author":"FM Grizzo","year":"2015","unstructured":"Grizzo FM, da Silva Martins J, Pinheiro MM, Jorgetti V, Carvalho MD, Pelloso SM (2015) Pregnancy and lactation-associated osteoporosis: bone histomorphometric analysis and response to treatment with Zoledronic Acid. Calcif Tissue Int 97:421\u2013425. https:\/\/doi.org\/10.1007\/s00223-015-0028-z","journal-title":"Calcif Tissue Int"},{"key":"3056_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11657-017-0310-y","volume":"12","author":"P Hadji","year":"2017","unstructured":"Hadji P, Boekhoff J, Hahn M, Hellmeyer L, Hars O, Kyvernitakis I (2017) Pregnancy-associated transient osteoporosis of the hip: results of a case-control study. Arch Osteoporos 12:11. https:\/\/doi.org\/10.1007\/s11657-017-0310-y","journal-title":"Arch Osteoporos"},{"key":"3056_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s11657-020-00768-7","volume":"15","author":"P Jia","year":"2020","unstructured":"Jia P, Wang R, Yuan J, Chen H, Bao L, Feng F, Tang H (2020) A case of pregnancy and lactation-associated osteoporosis and a review of the literature. Arch Osteoporos 15:94. https:\/\/doi.org\/10.1007\/s11657-020-00768-7","journal-title":"Arch Osteoporos"},{"key":"3056_CR12","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3340\/jkns.2010.47.5.399","volume":"47","author":"HW Kim","year":"2010","unstructured":"Kim HW, Song JW, Kwon A, Kim IH (2010) Percutaneous vertebroplasty for pregnancy-associated osteoporotic vertebral compression fractures. J Korean Neurosurg Soc 47:399\u2013402. https:\/\/doi.org\/10.3340\/jkns.2010.47.5.399","journal-title":"J Korean Neurosurg Soc"},{"key":"3056_CR13","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1007\/s00198-017-4165-2","volume":"28","author":"M Laroche","year":"2017","unstructured":"Laroche M, Talibart M, Cormier C, Roux C, Guggenbuhl P, Degboe Y (2017) Pregnancy-related fractures: a retrospective study of a French cohort of 52 patients and review of the literature. Osteoporos Int 28:3135\u20133142. https:\/\/doi.org\/10.1007\/s00198-017-4165-2","journal-title":"Osteoporos Int"},{"key":"3056_CR14","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s00198-009-1138-0","volume":"21","author":"SR Mastaglia","year":"2010","unstructured":"Mastaglia SR, Watman NP, Oliveri B (2010) Intravenous bisphosphonate treatment and pregnancy: its effects on mother and infant bone health. Osteoporos Int 21:1959\u20131962. https:\/\/doi.org\/10.1007\/s00198-009-1138-0","journal-title":"Osteoporos Int"},{"key":"3056_CR15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19011","volume":"13","author":"B Miles","year":"2021","unstructured":"Miles B, Panchbhavi M, Mackey JD (2021) Analysis of fracture incidence in 135 patients with pregnancy and lactation osteoporosis (PLO). Cureus 13:e19011. https:\/\/doi.org\/10.7759\/cureus.19011","journal-title":"Cureus"},{"key":"3056_CR16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3346\/jkms.2013.28.4.569","volume":"28","author":"JP Myong","year":"2013","unstructured":"Myong JP, Kim HR, Koo JW, Park CY (2013) Relationship between bone mineral density and moderate to severe chronic kidney disease among general population in Korea. J Korean Med Sci 28:569\u2013574. https:\/\/doi.org\/10.3346\/jkms.2013.28.4.569","journal-title":"J Korean Med Sci"},{"key":"3056_CR17","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13018-017-0585-0","volume":"12","author":"C Neuerburg","year":"2017","unstructured":"Neuerburg C, Mittlmeier L, Schmidmaier R, Kammerlander C, B\u00f6cker W, Mutschler W, Stumpf U (2017) Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis. J Orthop Surg Res 12:86. https:\/\/doi.org\/10.1186\/s13018-017-0585-0","journal-title":"J Orthop Surg Res"},{"key":"3056_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1741-7015-8-47","volume":"8","author":"R Nikander","year":"2010","unstructured":"Nikander R, Siev\u00e4nen H, Heinonen A, Daly RM, Uusi-Rasi K, Kannus P (2010) Targeted exercise against osteoporosis: a systematic review and meta-analysis for optimising bone strength throughout life. BMC Med 8:47. https:\/\/doi.org\/10.1186\/1741-7015-8-47","journal-title":"BMC Med"},{"key":"3056_CR19","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/s0140-6736(55)90214-2","volume":"268","author":"BE Nordin","year":"1955","unstructured":"Nordin BE, Roper A (1955) Post-pregnancy osteoporosis; a syndrome? Lancet 268:431\u2013434. https:\/\/doi.org\/10.1016\/s0140-6736(55)90214-2","journal-title":"Lancet"},{"key":"3056_CR20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.2165\/00007256-200737070-00003","volume":"37","author":"KS Ondrak","year":"2007","unstructured":"Ondrak KS, Morgan DW (2007) Physical activity, calcium intake and bone health in children and adolescents. Sports Med 37:587\u2013600. https:\/\/doi.org\/10.2165\/00007256-200737070-00003","journal-title":"Sports Med"},{"key":"3056_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/jog.12157","volume":"40","author":"C Ozturk","year":"2014","unstructured":"Ozturk C, Atamaz FC, Akkurt H, Akkoc Y (2014) Pregnancy-associated osteoporosis presenting severe vertebral fractures. J Obstet Gynaecol Res 40:288\u2013292. https:\/\/doi.org\/10.1111\/jog.12157","journal-title":"J Obstet Gynaecol Res"},{"key":"3056_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bone.2016.12.002","volume":"95","author":"H Park","year":"2017","unstructured":"Park H, Brannon PM, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Mehta S, Caudill MA (2017) Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus. Bone 95:183\u2013191. https:\/\/doi.org\/10.1016\/j.bone.2016.12.002","journal-title":"Bone"},{"key":"3056_CR23","doi-asserted-by":"publisher","first-page":"441","DOI":"10.5535\/arm.2018.42.3.441","volume":"42","author":"SG Park","year":"2018","unstructured":"Park SG, Jeong SU, Lee JH, Ryu SH, Jeong HJ, Sim YJ, Kim DK, Kim GC (2018) The changes of CTX, DPD, osteocalcin, and bone mineral density during the postmenopausal period. Ann Rehabil Med 42:441\u2013448. https:\/\/doi.org\/10.5535\/arm.2018.42.3.441","journal-title":"Ann Rehabil Med"},{"key":"3056_CR24","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.maturitas.2006.10.005","volume":"56","author":"M Petruzzi","year":"2007","unstructured":"Petruzzi M (2007) Tooth count in elderly women in relation to their skeletal status. Maturitas 56:335. https:\/\/doi.org\/10.1016\/j.maturitas.2006.10.005","journal-title":"Maturitas"},{"key":"3056_CR25","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1055\/s-0041-103417","volume":"140","author":"J Pfeilschifter","year":"2015","unstructured":"Pfeilschifter J (2015) [Diagnosing osteoporosis: what is new in the 2014 DVO guideline?]. Dtsch Med Wochenschr 140:1667\u20131671. https:\/\/doi.org\/10.1055\/s-0041-103417","journal-title":"Dtsch Med Wochenschr"},{"key":"3056_CR26","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s001980070113","volume":"11","author":"AJ Phillips","year":"2000","unstructured":"Phillips AJ, Ostlere SJ, Smith R (2000) Pregnancy-associated osteoporosis: does the skeleton recover? Osteoporos Int 11:449\u2013454. https:\/\/doi.org\/10.1007\/s001980070113","journal-title":"Osteoporos Int"},{"key":"3056_CR27","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1186\/s12891-021-04776-7","volume":"22","author":"Y Qian","year":"2021","unstructured":"Qian Y, Wang L, Yu L, Huang W (2021) Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review. BMC Musculoskelet Disord 22:926. https:\/\/doi.org\/10.1186\/s12891-021-04776-7","journal-title":"BMC Musculoskelet Disord"},{"key":"3056_CR28","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/s0140-6736(96)90932-0","volume":"347","author":"R Rizzoli","year":"1996","unstructured":"Rizzoli R, Bonjour JP (1996) Pregnancy-associated osteoporosis. Lancet 347:1274\u20131276. https:\/\/doi.org\/10.1016\/s0140-6736(96)90932-0","journal-title":"Lancet"},{"key":"3056_CR29","first-page":"596","volume":"60","author":"A Saraux","year":"1993","unstructured":"Saraux A, Bourgeais F, Ehrhart A, Baron D, Le Goff P (1993) [Osteoporosis during pregnancy. 4 cases]. Rev Rhum Ed Fr 60:596\u2013600","journal-title":"Rev Rhum Ed Fr"},{"key":"3056_CR30","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2147\/IJWH.S366254","volume":"15","author":"MF Scioscia","year":"2023","unstructured":"Scioscia MF, Zanchetta MB (2023) Recent insights into pregnancy and Lactation-Associated osteoporosis (PLO). Int J Womens Health 15:1227\u20131238. https:\/\/doi.org\/10.2147\/IJWH.S366254","journal-title":"Int J Womens Health"},{"key":"3056_CR31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/s0140-6736(05)65017-9","volume":"348","author":"R Smith","year":"1996","unstructured":"Smith R, Ostlere S, Athanasou N, Vipond S (1996) Pregnancy-associated osteoporosis. Lancet 348:402\u2013403. https:\/\/doi.org\/10.1016\/s0140-6736(05)65017-9","journal-title":"Lancet"},{"key":"3056_CR32","doi-asserted-by":"publisher","first-page":"189","DOI":"10.23736\/S2724-6507.21.03515-6","volume":"47","author":"T Somma","year":"2022","unstructured":"Somma T, DE Rosa A, Mastantuoni C, Esposito F, Meglio V, Romano F, Ricciardi L, de Divitiis O, DI Somma C (2022) Multidisciplinary management of osteoporotic vertebral fractures. Minerva Endocrinol (Torino) 47:189\u2013202. https:\/\/doi.org\/10.23736\/S2724-6507.21.03515-6","journal-title":"Minerva Endocrinol (Torino)"},{"key":"3056_CR33","doi-asserted-by":"publisher","first-page":"254","DOI":"10.4997\/JRCPE.2013.314","volume":"43","author":"PJ Stride","year":"2013","unstructured":"Stride PJ, Patel N, Kingston D (2013) The history of osteoporosis: why do Egyptian mummies have porotic bones? J R Coll Physicians Edinb 43:254\u2013261. https:\/\/doi.org\/10.4997\/JRCPE.2013.314","journal-title":"J R Coll Physicians Edinb"},{"key":"3056_CR34","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1530\/EC-20-0055","volume":"9","author":"EM Winter","year":"2020","unstructured":"Winter EM, Ireland A, Butterfield NC, Haffner-Luntzer M, Horcajada MN, Veldhuis-Vlug AG, Oei L, Colaianni G, Bonnet N (2020) Pregnancy and lactation, a challenge for the skeleton. Endocr Connect 9:R143\u2013R157. https:\/\/doi.org\/10.1530\/EC-20-0055","journal-title":"Endocr Connect"},{"key":"3056_CR35","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.18632\/aging.101449","volume":"10","author":"J Zhang","year":"2018","unstructured":"Zhang J, Lai Z, Shi L, Tian Y, Luo A, Xu Z, Ma X, Wang S (2018) Repeated superovulation increases the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging in mice. Aging 10:1089\u20131102. https:\/\/doi.org\/10.18632\/aging.101449","journal-title":"Aging"},{"key":"3056_CR36","doi-asserted-by":"publisher","unstructured":"Zhang Y, Li R, Zhang J, Zhou W, Yu F (2023) Changes in serum concentrations of bone turnover markers in healthy pregnant women. Int J Clin Pract 2023(8466349). https:\/\/doi.org\/10.1155\/2023\/8466349","DOI":"10.1155\/2023\/8466349"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-024-03056-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-024-03056-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-024-03056-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:45:42Z","timestamp":1741085142000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-024-03056-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3056"],"URL":"https:\/\/doi.org\/10.1007\/s10143-024-03056-x","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"29 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No ethical approval is needed for retrospective studies according to Swiss and Italian countries.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All data are anonymized, and the submission does not include images that may identify the person, thus informed consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate\/Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"811"}}