{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:45:22Z","timestamp":1788875122360,"version":"build-2803163510"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epilepsy is a common neurological disease that is treated with medications; however, patients with drug-resistant epilepsy, commonly intractable temporal lobe epilepsy, tend to have better control with surgical treatment. While the mainstay of surgical treatment is anterior temporal lobectomy, it carries risk of potential adverse effects hence minimally invasive techniques are now being used as an alternative to open surgery. This systematic review and meta-analysis compare the efficacy and safety of three of the most used techniques: laser interstitial thermal therapy (LITT), radiofrequency ablation (RFA) and stereotactic radiosurgery (SRS). Multiple databases were searched and PRISMA guidelines were followed to make an indirect meta-analysis using the currently available studies for the three techniques in terms of seizure freedom, risk of major complications and reoperations. Further subgroup analyses were carried out for LITT in terms of follow up periods and seizure freedom in patients with or without hippocampal sclerosis. A total of 42 papers were included in this study with a total of 1675 patients (1303 treated by LITT, 188 treated by RFA and 184 treated by SRS). LITT had the highest rate of seizure freedom (55.0%, CI 51.5 \u2212\u200958.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.148), and the lowest rates of major complications (2.3%, CI 1.2 \u2212\u20093.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.070), and reoperations (14.3%, CI 10.4 \u2212\u200918.3%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.042) compared to RFA and SRS which had seizure freedom of 46.3% (CI 18.8 \u2212\u200973.7%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000) and 53.8% (CI 44.4 \u2212\u200963.3%; I^2\u2009=\u200940.4%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.098), major complication rate of 3.9% (CI 0.7 \u2212\u20097.0%; I^2\u2009=\u20090%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.458) and 14.3% (CI 3.1 \u2212\u200925.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000) and reoperation rate of 28.6% (CI -4.3 \u2212\u200961.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.000) and 15.4% (CI 6.1 \u2212\u200924.8%; I^2\u2009=\u20090%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.392) respectively. In conclusion, LITT showed the highest rate of seizure freedom and the lowest rate of major complications and reoperations compared to RFA and SRS in single-arm studies of intractable mesial temporal lobe epilepsy. However, the lack of direct comparisons between treatment modalities limits definitive conclusions. Despite this, LITT appears to offer a favorable safety profile, warranting further prospective, comparative studies to validate these findings.\n                  <\/jats:p>","DOI":"10.1007\/s10143-025-03215-8","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:44:19Z","timestamp":1737431059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of laser interstitial thermal therapy versus radiofrequency ablation and stereotactic radiosurgery in the treatment of intractable mesial temporal lobe epilepsy: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-1794","authenticated-orcid":false,"given":"Youstina","family":"Mohsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5474-4755","authenticated-orcid":false,"given":"Khalid","family":"Sarhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7040-2566","authenticated-orcid":false,"given":"Ibrahim Saleh","family":"Alawadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4114-0397","authenticated-orcid":false,"given":"Reem Reda","family":"Elmahdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-7309","authenticated-orcid":false,"given":"Yasmeena Abdelall","family":"Kozaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3729-9657","authenticated-orcid":false,"given":"Menna A.","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-022X","authenticated-orcid":false,"given":"Ibrahim","family":"Serag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1348-2208","authenticated-orcid":false,"given":"Mostafa","family":"Shahein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"issue":"3","key":"3215_CR1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1684\/epd.2015.0751","volume":"17","author":"E Beghi","year":"2015","unstructured":"Beghi E, Giussani G, Sander JW (2015) The natural history and prognosis of epilepsy. Epileptic Disord 17(3):243\u2013253","journal-title":"Epileptic Disord"},{"issue":"2","key":"3215_CR2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1212\/CON.0000000000000712","volume":"25","author":"ANV Moosa","year":"2019","unstructured":"Moosa ANV (2019) Antiepileptic drug treatment of Epilepsy in Children. CONTINUUM: Lifelong Learn Neurol 25(2):381\u2013407","journal-title":"CONTINUUM: Lifelong Learn Neurol"},{"key":"3215_CR3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.wneu.2016.12.074","volume":"99","author":"AA Asadi-Pooya","year":"2017","unstructured":"Asadi-Pooya AA, Stewart GR, Abrams DJ, Sharan A (2017) Prevalence and incidence of drug-resistant mesial temporal lobe Epilepsy in the United States. World Neurosurg 99:662\u2013666","journal-title":"World Neurosurg"},{"key":"3215_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.seizure.2015.01.005","volume":"26","author":"RN Menon","year":"2015","unstructured":"Menon RN, Radhakrishnan K (2015) A survey of epilepsy surgery in India. Seizure 26:1\u20134","journal-title":"Seizure"},{"issue":"5","key":"3215_CR5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJM200108023450501","volume":"345","author":"S Wiebe","year":"2001","unstructured":"Wiebe S, Blume WT, Girvin JP, Eliasziw MA, Randomized (2001) Controlled trial of surgery for temporal-lobe Epilepsy. N Engl J Med 345(5):311\u2013318","journal-title":"N Engl J Med"},{"issue":"01","key":"3215_CR6","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1017\/S031716710000069X","volume":"27","author":"A Olivier","year":"2000","unstructured":"Olivier A (2000) Transcortical selective amygdalohippocampectomy in temporal lobe Epilepsy. Can J Neurol Sci 27(01):S68\u201376","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"3215_CR7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000500136","volume":"97","author":"AG Brotis","year":"2019","unstructured":"Brotis AG, Giannis T, Kapsalaki E, Dardiotis E, Fountas KN (2019) Complications after anterior temporal lobectomy for medically intractable Epilepsy: a systematic review and Meta-analysis. Stereotact Funct Neurosurg 97(2):69\u201382","journal-title":"Stereotact Funct Neurosurg"},{"issue":"19","key":"3215_CR8","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1212\/01.wnl.0000294326.05118.d8","volume":"70","author":"F Bartolomei","year":"2008","unstructured":"Bartolomei F, Hayashi M, Tamura M, Rey M, Fischer C, Chauvel P et al (2008) Long-term efficacy of gamma knife radiosurgery in mesial temporal lobe epilepsy. Neurology 70(19):1658\u20131663","journal-title":"Neurology"},{"issue":"3","key":"3215_CR9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3171\/2018.4.JNS184","volume":"131","author":"CY Lee","year":"2019","unstructured":"Lee CY, Li HT, Wu T, Cheng MY, Lim SN, Lee ST (2019) Efficacy of limited hippocampal radiofrequency thermocoagulation for mesial temporal lobe epilepsy. J Neurosurg 131(3):781\u2013789","journal-title":"J Neurosurg"},{"issue":"4","key":"3215_CR10","doi-asserted-by":"crossref","first-page":"E366","DOI":"10.1093\/neuros\/nyz556","volume":"86","author":"BE Youngerman","year":"2020","unstructured":"Youngerman BE, Save AV, McKhann GM (2020) Magnetic resonance imaging-guided laser interstitial thermal therapy for Epilepsy: systematic review of technique, indications, and outcomes. Neurosurgery 86(4):E366\u2013E382","journal-title":"Neurosurgery"},{"issue":"1","key":"3215_CR11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/1096-9101(2001)28:1<80::AID-LSM1020>3.0.CO;2-1","volume":"28","author":"J Heisterkamp","year":"2001","unstructured":"Heisterkamp J, van Hillegersberg R, Zondervan PE, IJzermans JNM (2001) Metabolic activity and DNA integrity in human hepatic metastases after interstitial laser coagulation (ILC). Lasers Surg Med 28(1):80\u201386","journal-title":"Lasers Surg Med"},{"issue":"2","key":"3215_CR12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.nec.2022.11.005","volume":"34","author":"JJ Van Gompel","year":"2023","unstructured":"Van Gompel JJ, Burkholder DB, Parker JJ, Grewal SS, Middlebrooks EH, Lehman VT et al (2023) Laser interstitial thermal therapy for Epilepsy. Neurosurg Clin N Am 34(2):247\u2013257","journal-title":"Neurosurg Clin N Am"},{"issue":"11","key":"3215_CR13","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00381-013-2169-6","volume":"29","author":"Z Tovar-Spinoza","year":"2013","unstructured":"Tovar-Spinoza Z, Carter D, Ferrone D, Eksioglu Y, Huckins S (2013) The use of MRI-guided laser-induced thermal ablation for epilepsy. Child\u2019s Nerv Syst 29(11):2089\u20132094","journal-title":"Child\u2019s Nerv Syst"},{"key":"3215_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2016.12.002","volume":"38","author":"H Waseem","year":"2017","unstructured":"Waseem H, Vivas AC, Vale FL (2017) MRI-guided laser interstitial thermal therapy for treatment of medically refractory non-lesional mesial temporal lobe epilepsy: outcomes, complications, and current limitations: a review. J Clin Neurosci 38:1\u20137","journal-title":"J Clin Neurosci"},{"key":"3215_CR15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.eplepsyres.2018.03.007","volume":"142","author":"J Voges","year":"2018","unstructured":"Voges J, B\u00fcntjen L, Schmitt FC (2018) Radiofrequency-thermoablation: General principle, historical overview and modern applications for epilepsy. Epilepsy Res 142:113\u2013116","journal-title":"Epilepsy Res"},{"key":"3215_CR16","doi-asserted-by":"crossref","unstructured":"Quigg M, Barbaro NM (2008) Stereotactic radiosurgery for treatment of Epilepsy. Arch Neurol.;65(2)","DOI":"10.1001\/archneurol.2007.40"},{"issue":"4","key":"3215_CR17","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/epi.16846","volume":"62","author":"K Kohlhase","year":"2021","unstructured":"Kohlhase K, Z\u00f6llner JP, Tandon N, Strzelczyk A, Rosenow F (2021) Comparison of minimally invasive and traditional surgical approaches for refractory mesial temporal lobe epilepsy: a systematic review and meta-analysis of outcomes. Epilepsia 62(4):831\u2013845","journal-title":"Epilepsia"},{"key":"3215_CR18","doi-asserted-by":"crossref","unstructured":"Marathe K, Alim-Marvasti A, Dahele K, Xiao F, Buck S, O\u2019Keeffe AG et al (2021) Resective, ablative and radiosurgical interventions for drug resistant mesial temporal lobe Epilepsy: a systematic review and Meta-analysis of outcomes. Front Neurol.;12","DOI":"10.3389\/fneur.2021.777845"},{"key":"3215_CR19","doi-asserted-by":"crossref","unstructured":"Ekman FR, Bjellvi J, Ljunggren S, Malmgren K, Nilsson D (2024) Laser Interstitial Thermal Therapy versus Open Surgery for Mesial Temporal Lobe Epilepsy: A Systematic Review and Meta-Analysis. World Neurosurg","DOI":"10.1016\/j.wneu.2024.09.090"},{"key":"3215_CR20","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ.;n71","DOI":"10.1136\/bmj.n71"},{"issue":"5","key":"3215_CR21","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/brain\/awh449","volume":"128","author":"JF T\u00e9llez-Zenteno","year":"2005","unstructured":"T\u00e9llez-Zenteno JF, Dhar R, Wiebe S (2005) Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain 128(5):1188\u20131198","journal-title":"Brain"},{"issue":"1","key":"3215_CR22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1148\/radiol.14132958","volume":"273","author":"M Ahmed","year":"2014","unstructured":"Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW et al (2014) Image-guided tumor ablation: standardization of terminology and reporting Criteria\u2014A 10-Year update. Radiology 273(1):241\u2013260","journal-title":"Radiology"},{"issue":"9","key":"3215_CR23","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","volume":"73","author":"K Slim","year":"2003","unstructured":"Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J (2003) Methodological index for non-randomized studies (MINORS): development and validation of a new instrument. ANZ J Surg 73(9):712\u2013716","journal-title":"ANZ J Surg"},{"issue":"10","key":"3215_CR24","first-page":"2127","volume":"18","author":"Z Munn","year":"2020","unstructured":"Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A et al (2020) Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth 18(10):2127\u20132133","journal-title":"JBI Evid Synth"},{"key":"3215_CR25","doi-asserted-by":"crossref","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ.;l4898","DOI":"10.1136\/bmj.l4898"},{"issue":"7109","key":"3215_CR26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"issue":"4","key":"3215_CR27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088\u20131101","journal-title":"Biometrics"},{"issue":"1","key":"3215_CR28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14(1):135","journal-title":"BMC Med Res Methodol"},{"issue":"7414","key":"3215_CR29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557\u2013560","journal-title":"BMJ"},{"issue":"8","key":"3215_CR30","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00701-014-2126-5","volume":"156","author":"Z Vojt\u011bch","year":"2014","unstructured":"Vojt\u011bch Z, Mal\u00edkov\u00e1 H, Kr\u00e1msk\u00e1 L, An\u00fd\u017e J, Syr\u016f\u010dek M, Z\u00e1me\u010dn\u00edk J et al (2014) Long-term seizure outcome after stereotactic amygdalohippocampectomy. Acta Neurochir (Wien) 156(8):1529\u20131537","journal-title":"Acta Neurochir (Wien)"},{"key":"3215_CR31","doi-asserted-by":"crossref","unstructured":"Kawamura T, Onishi H, Kohda Y, Hirose G Serious adverse effects of gamma knife radiosurgery for mesial temporal lobe epilepsy. Neurol Med Chir (Tokyo) [Internet]. 2012 [cited 2024 Aug 10];52(12):892\u20138. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/23269044\/","DOI":"10.2176\/nmc.52.892"},{"issue":"2","key":"3215_CR32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ana.21558","volume":"65","author":"NM Barbaro","year":"2009","unstructured":"Barbaro NM, Quigg M, Broshek DK, Ward MM, Lamborn KR, Laxer KD et al (2009) A multicenter, prospective pilot study of gamma knife radiosurgery for mesial temporal lobe epilepsy: seizure response, adverse events, and verbal memory. Ann Neurol 65(2):167\u2013175","journal-title":"Ann Neurol"},{"key":"3215_CR33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.seizure.2018.10.017","volume":"63","author":"M Quigg","year":"2018","unstructured":"Quigg M, Barbaro NM, Ward MM, Chang EF, Broshek DK, Langfitt JT et al (2018) Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: findings of the ROSE trial. Seizure 63:62\u201367","journal-title":"Seizure"},{"issue":"6","key":"3215_CR34","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/epi.14045","volume":"59","author":"NM Barbaro","year":"2018","unstructured":"Barbaro NM, Quigg M, Ward MM, Chang EF, Broshek DK, Langfitt JT et al (2018) Radiosurgery versus open surgery for mesial temporal lobe epilepsy: the randomized, controlled\u2009<\u2009scp\u2009>\u2009ROSE\u2009trial. Epilepsia 59(6):1198\u20131207","journal-title":"Epilepsia"},{"key":"3215_CR35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.seizure.2019.08.011","volume":"71","author":"X Fan","year":"2019","unstructured":"Fan X, Shan Y, Lu C, An Y, Wang Y, Du J et al (2019) Optimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis. Seizure 71:304\u2013311","journal-title":"Seizure"},{"issue":"6","key":"3215_CR36","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3171\/2012.2.JNS111296","volume":"116","author":"K Usami","year":"2012","unstructured":"Usami K, Kawai K, Koga T, Shin M, Kurita H, Suzuki I et al (2012) Delayed complication after Gamma Knife surgery for mesial temporal lobe epilepsy. J Neurosurg 116(6):1221\u20131225","journal-title":"J Neurosurg"},{"issue":"7","key":"3215_CR37","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/epi.14443","volume":"59","author":"C Donos","year":"2018","unstructured":"Donos C, Breier J, Friedman E, Rollo P, Johnson J, Moss L et al (2018) Laser ablation for mesial temporal lobe epilepsy: Surgical and cognitive outcomes with and without mesial temporal sclerosis. Epilepsia 59(7):1421\u20131432","journal-title":"Epilepsia"},{"key":"3215_CR38","doi-asserted-by":"crossref","first-page":"e1121","DOI":"10.1016\/j.wneu.2019.03.057","volume":"126","author":"I Cajigas","year":"2019","unstructured":"Cajigas I, Kanner AM, Ribot R, Casabella AM, Mahavadi A, Jermakowicz W et al (2019) Magnetic resonance\u2013guided laser interstitial thermal therapy for mesial temporal Epilepsy: a Case Series Analysis of outcomes and complications at 2-Year Follow-Up. World Neurosurg 126:e1121\u2013e1129","journal-title":"World Neurosurg"},{"key":"3215_CR39","doi-asserted-by":"crossref","unstructured":"Greenway MRF, Lucas JA, Feyissa AM, Grewal S, Wharen RE, Tatum WO Neuropsychological outcomes following stereotactic laser amygdalohippocampectomy. Epilepsy Behav [Internet]. 2017 Oct 1 [cited 2024 Aug 10];75:50\u20135. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/28841472\/","DOI":"10.1016\/j.yebeh.2017.07.033"},{"issue":"5","key":"3215_CR40","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/epi.13715","volume":"58","author":"WJ Jermakowicz","year":"2017","unstructured":"Jermakowicz WJ, Kanner AM, Sur S, Bermudez C, D\u2019Haese P, Kolcun JPG et al (2017) Laser thermal ablation for mesiotemporal epilepsy: analysis of ablation volumes and trajectories. Epilepsia 58(5):801\u2013810","journal-title":"Epilepsia"},{"key":"3215_CR41","doi-asserted-by":"crossref","unstructured":"Hoggard N, Wilkinson ID, Griffiths PD, Vaughan P, Kemeny AA, Rowe JG The clinical course after stereotactic radiosurgical amygdalohippocampectomy with neuroradiological correlates. Neurosurgery [Internet]. 2008 Feb [cited 2024 Aug 10];62(2):336\u201344. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/18382311\/","DOI":"10.1227\/01.neu.0000316000.96140.12"},{"issue":"11","key":"3215_CR42","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1136\/jnnp-2022-330979","volume":"94","author":"BE Youngerman","year":"2023","unstructured":"Youngerman BE, Banu MA, Khan F, McKhann GM, Schevon CA, Jagid JR et al (2023) Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre cohort study. J Neurol Neurosurg Psychiatry 94(11):879\u2013886","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3215_CR43","doi-asserted-by":"crossref","unstructured":"Landazuri P, Shih J, Leuthardt E, Ben-Haim S, Neimat J, Tovar-Spinoza Z et al A prospective multicenter study of laser ablation for drug resistant epilepsy - One year outcomes. Epilepsy Res [Internet]. 2020 Nov 1 [cited 2024 Aug 10];167. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33045664\/","DOI":"10.1016\/j.eplepsyres.2020.106473"},{"issue":"9","key":"3215_CR44","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1007\/s00415-018-8958-9","volume":"265","author":"A Moles","year":"2018","unstructured":"Moles A, Gu\u00e9not M, Rheims S, Berthiller J, Catenoix H, Montavont A et al (2018) SEEG-guided radiofrequency coagulation (SEEG-guided RF-TC) versus anterior temporal lobectomy (ATL) in temporal lobe epilepsy. J Neurol 265(9):1998\u20132004","journal-title":"J Neurol"},{"key":"3215_CR45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.clinph.2022.12.003","volume":"146","author":"B Chen","year":"2023","unstructured":"Chen B, Grewal SS, Middlebrooks EH, Tatum WO, Ritaccio AL, Sirven JI et al (2023) Intraoperative electrocorticography during laser-interstitial thermal therapy predicts seizure outcome in mesial temporal lobe epilepsy. Clin Neurophysiol 146:118\u2013123","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"3215_CR46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/epi.12860","volume":"56","author":"DL Drane","year":"2015","unstructured":"Drane DL, Loring DW, Voets NL, Price M, Ojemann JG, Willie JT et al (2015) Better object recognition and naming outcome with <\u2009scp\u2009>\u2009MRI -guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy. Epilepsia 56(1):101\u2013113","journal-title":"Epilepsia"},{"key":"3215_CR47","doi-asserted-by":"crossref","unstructured":"Drane DL, Willie JT, Pedersen NP, Qiu D, Voets NL, Millis SR et al (2021) Superior Verbal Memory Outcome after Stereotactic Laser Amygdalohippocampotomy. Front Neurol.;12","DOI":"10.3389\/fneur.2021.779495"},{"issue":"6","key":"3215_CR48","first-page":"2055","volume":"130","author":"SS Grewal","year":"2019","unstructured":"Grewal SS, Zimmerman RS, Worrell G, Brinkmann BH, Tatum WO, Crepeau AZ et al (2019) Laser ablation for mesial temporal epilepsy: a multi-site, single institutional series. J Neurosurg 130(6):2055\u20132062","journal-title":"J Neurosurg"},{"issue":"3","key":"3215_CR49","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/ana.25180","volume":"83","author":"RE Gross","year":"2018","unstructured":"Gross RE, Stern MA, Willie JT, Fasano RE, Saindane AM, Soares BP et al (2018) Stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy. Ann Neurol 83(3):575\u2013587","journal-title":"Ann Neurol"},{"issue":"2","key":"3215_CR50","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/epi.13284","volume":"57","author":"JY Kang","year":"2016","unstructured":"Kang JY, Wu C, Tracy J, Lorenzo M, Evans J, Nei M et al (2016) Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia 57(2):325\u2013334","journal-title":"Epilepsia"},{"issue":"4","key":"3215_CR51","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/epi.17183","volume":"63","author":"AM Kanner","year":"2022","unstructured":"Kanner AM, Irving LT, Cajigas I, Saporta A, Cordeiro JG, Ribot R et al (2022) Long-term seizure and psychiatric outcomes following laser ablation of mesial temporal structures. Epilepsia 63(4):812\u2013823","journal-title":"Epilepsia"},{"key":"3215_CR52","doi-asserted-by":"crossref","unstructured":"Kim MJ, Hwang B, Mampre D, Negoita S, Tsehay Y, Sair H et al Ablation of apparent diffusion coefficient hyperintensity clusters in mesial temporal lobe epilepsy improves seizure outcomes after laser interstitial thermal therapy. Epilepsia [Internet]. 2023 Mar 1 [cited 2024 Aug 10];64(3):654\u201366. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/36196769\/","DOI":"10.1111\/epi.17432"},{"key":"3215_CR53","doi-asserted-by":"crossref","unstructured":"Le S, Ho AL, Fisher RS, Miller KJ, Henderson JM, Grant GA et al Laser interstitial thermal therapy (LITT): Seizure outcomes for refractory mesial temporal lobe epilepsy. Epilepsy Behav [Internet]. 2018 Dec 1 [cited 2024 Aug 10];89:37\u201341. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/30384097\/","DOI":"10.1016\/j.yebeh.2018.09.040"},{"issue":"1","key":"3215_CR54","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/JS9.0000000000000811","volume":"110","author":"J Mo","year":"2024","unstructured":"Mo J, Guo Z, Wang X, Zhang J, Hu W, Shao X et al (2024) Magnetic resonance-guided laser interstitial thermal therapy vs. open surgery for drug-resistant mesial temporal lobe epilepsy: a propensity score matched retrospective cohort study. Int J Surg 110(1):306\u2013314","journal-title":"Int J Surg"},{"issue":"1","key":"3215_CR55","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s41016-023-00335-2","volume":"9","author":"H Niu","year":"2023","unstructured":"Niu H, Li K, Liang X, Kong D, Li Z, Sun F et al (2023) MR-guided laser interstitial thermal therapy for drug-resistant lesional epilepsy: a single-center experience. Chin Neurosurg J 9(1):26","journal-title":"Chin Neurosurg J"},{"key":"3215_CR56","doi-asserted-by":"crossref","unstructured":"Petito GT, Wharen RE, Feyissa AM, Grewal SS, Lucas JA, Tatum WO The impact of stereotactic laser ablation at a typical epilepsy center. Epilepsy Behav [Internet]. 2018 Jan 1 [cited 2024 Aug 10];78:37\u201344. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29172137\/","DOI":"10.1016\/j.yebeh.2017.10.041"},{"key":"3215_CR57","doi-asserted-by":"crossref","unstructured":"Sun T, Wu S, Liu X, Tao JX, Wang Q Impact of intracranial subclinical seizures on seizure outcomes after SLAH in patients with mesial temporal lobe epilepsy. Clin Neurophysiol [Internet]. 2024 Apr 1 [cited 2024 Aug 10];160:121\u20139. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/38422970\/","DOI":"10.1016\/j.clinph.2024.02.013"},{"issue":"5","key":"3215_CR58","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/jnnp-2017-316833","volume":"89","author":"JX Tao","year":"2018","unstructured":"Tao JX, Wu S, Lacy M, Rose S, Issa NP, Yang CW et al (2018) Stereotactic EEG-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 89(5):542\u2013548","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"3215_CR59","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/epi.14034","volume":"59","author":"VN Vakharia","year":"2018","unstructured":"Vakharia VN, Sparks R, Li K, O\u2019Keeffe AG, Miserocchi A, McEvoy AW et al (2018) Automated trajectory planning for laser interstitial thermal therapy in mesial temporal lobe epilepsy. Epilepsia 59(4):814\u2013824","journal-title":"Epilepsia"},{"issue":"6","key":"3215_CR60","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1227\/NEU.0000000000000343","volume":"74","author":"JT Willie","year":"2014","unstructured":"Willie JT, Laxpati NG, Drane DL, Gowda A, Appin C, Hao C et al (2014) Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe Epilepsy. Neurosurgery 74(6):569\u2013585","journal-title":"Neurosurgery"},{"issue":"6","key":"3215_CR61","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/epi.15565","volume":"60","author":"C Wu","year":"2019","unstructured":"Wu C, Jermakowicz WJ, Chakravorti S, Cajigas I, Sharan AD, Jagid JR et al (2019) Effects of surgical targeting in laser interstitial thermal therapy for mesial temporal lobe epilepsy: a multicenter study of 234 patients. Epilepsia 60(6):1171\u20131183","journal-title":"Epilepsia"},{"issue":"1","key":"3215_CR62","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/epi.17451","volume":"64","author":"O Yossofzai","year":"2023","unstructured":"Yossofzai O, Stone S, Madsen J, Moineddin R, Wang S, Ragheb J et al (2023) Seizure outcome of pediatric magnetic resonance-guided laser interstitial thermal therapy versus open surgery: a matched\u2009<\u2009scp\u2009>\u2009noninferiority\u2009cohort study. Epilepsia 64(1):114\u2013126","journal-title":"Epilepsia"},{"issue":"3","key":"3215_CR63","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/epi.14004","volume":"59","author":"BE Youngerman","year":"2018","unstructured":"Youngerman BE, Oh JY, Anbarasan D, Billakota S, Casadei CH, Corrigan EK et al (2018) Laser ablation is effective for temporal lobe epilepsy with and without mesial temporal sclerosis if hippocampal seizure onsets are localized by stereoelectroencephalography. Epilepsia 59(3):595\u2013606","journal-title":"Epilepsia"},{"key":"3215_CR64","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.wneu.2023.01.061","volume":"173","author":"KH Fu","year":"2023","unstructured":"Fu KH, Wang YC, Lim SN, Cheng MY, Wu T, Chang CW et al (2023) Long-term outcome of seizure control and neurologic performance after limited hippocampal Radiofrequency Thermocoagulation for Mesial temporal lobe Epilepsy. World Neurosurg 173:e18\u201326","journal-title":"World Neurosurg"},{"issue":"3","key":"3215_CR65","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/epi4.12866","volume":"9","author":"K Li","year":"2024","unstructured":"Li K, Shi J, Wei P, He X, Shan Y, Zhao G (2024) Stereo-electroencephalography\u2010guided three\u2010dimensional radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis: a retrospective study with long\u2010term follow\u2010up. Epilepsia Open 9(3):918\u2013925","journal-title":"Epilepsia Open"},{"issue":"6","key":"3215_CR66","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3892\/etm.2014.1620","volume":"7","author":"Z WU","year":"2014","unstructured":"WU Z, ZHAO Q, TIAN Z, ZHANG J, XIAO X (2014) Efficacy and safety of a new robot-assisted stereotactic system for radiofrequency thermocoagulation in patients with temporal lobe epilepsy. Exp Ther Med 7(6):1728\u20131732","journal-title":"Exp Ther Med"},{"key":"3215_CR67","doi-asserted-by":"crossref","unstructured":"Zhao Q, Shi T, Cui S, Wu Z, Wang W, Jia Y et al Stereotactic bilateral transfrontal minimal radiofrequency thermocoagulation of the amygdalohippocampal complex for bilateral medial temporal lobe epilepsy: a retrospective study of 12 patients. Epileptic Disord [Internet]. 2017 Jun 1 [cited 2024 Aug 10];19(2):152\u201365. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/28637635\/","DOI":"10.1684\/epd.2017.0914"},{"issue":"1","key":"3215_CR68","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.eplepsyres.2008.03.003","volume":"80","author":"S Rheims","year":"2008","unstructured":"Rheims S, Fischer C, Ryvlin P, Isnard J, Guenot M, Tamura M et al (2008) Long-term outcome of gamma-knife surgery in temporal lobe epilepsy. Epilepsy Res 80(1):23\u201329","journal-title":"Epilepsy Res"},{"issue":"9","key":"3215_CR69","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1111\/j.1528-1167.2009.02071.x","volume":"50","author":"Z Vojt\u011bch","year":"2009","unstructured":"Vojt\u011bch Z, Vladyka V, Kalina M, Ne\u0161por E, Seltenreichov\u00e1 K, \u0160emnick\u00e1 J et al (2009) The use of radiosurgery for the treatment of mesial temporal lobe epilepsy and long-term results. Epilepsia 50(9):2061\u20132071","journal-title":"Epilepsia"},{"issue":"8","key":"3215_CR70","first-page":"1774","volume":"21","author":"XQ Wang","year":"2017","unstructured":"Wang XQ, Zhang XD, Han YM, Shi XF, Lan ZB, Men XX et al (2017) Clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy and their effects on EF-Tumt and EF-Tsmt expression. Eur Rev Med Pharmacol Sci 21(8):1774\u20131779","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3215_CR71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yebeh.2015.04.033","volume":"47","author":"EF Chang","year":"2015","unstructured":"Chang EF, Englot DJ, Vadera S (2015) Minimally invasive surgical approaches for temporal lobe epilepsy. Epilepsy Behav 47:24\u201333","journal-title":"Epilepsy Behav"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-03215-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-025-03215-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-03215-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:11:00Z","timestamp":1772082660000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-025-03215-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3215"],"URL":"https:\/\/doi.org\/10.1007\/s10143-025-03215-8","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"26 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval is not applicable to our study design.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"CRD42024594624.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Prospero registery number"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}