{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:33:40Z","timestamp":1792272820442,"version":"4.4.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"DOI":"10.1007\/s10143-025-03217-6","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:27:22Z","timestamp":1739420842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fluid biomarkers for cervical spondylotic myelopathy"],"prefix":"10.1007","volume":"48","author":[{"given":"Michael R.","family":"Kann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Swaroop","family":"Lavadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Crane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taim","family":"Aizooky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanish","family":"Polavarapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit Prem","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rida","family":"Mitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manan","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Kojo","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"issue":"12","key":"3217_CR1","doi-asserted-by":"publisher","first-page":"E675","DOI":"10.1097\/BRS.0000000000000913","volume":"40","author":"A Nouri","year":"2015","unstructured":"Nouri A et al (2015) Degenerative cervical myelopathy: epidemiology, genetics, and pathogenesis. Spine (Phila Pa 1976) 40(12):E675-93","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"3217_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/sc.2012.165","volume":"52","author":"PW New","year":"2014","unstructured":"New PW, Cripps RA, Bonne Lee B (2014) Global maps of non-traumatic spinal cord injury epidemiology: towards a living data repository. Spinal Cord 52(2):97\u2013109","journal-title":"Spinal Cord"},{"issue":"2","key":"3217_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3122\/jabfm.2020.02.190195","volume":"33","author":"JR McCormick","year":"2020","unstructured":"McCormick JR et al (2020) Cervical spondylotic myelopathy: a guide to diagnosis and management. J Am Board Fam Med 33(2):303\u2013313","journal-title":"J Am Board Fam Med"},{"issue":"1","key":"3217_CR4","doi-asserted-by":"publisher","first-page":"E68","DOI":"10.1097\/BSD.0000000000001113","volume":"35","author":"CJ Donnally 3rd","year":"2022","unstructured":"Donnally CJ 3rd et al (2022) Current management of cervical spondylotic myelopathy. Clin Spine Surg 35(1):E68-e76","journal-title":"Clin Spine Surg"},{"issue":"1","key":"3217_CR5","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/2013.4.FOCUS13122","volume":"35","author":"JC Wu","year":"2013","unstructured":"Wu JC et al (2013) Epidemiology of cervical spondylotic myelopathy and its risk of causing spinal cord injury: a national cohort study. Neurosurg Focus 35(1):E10","journal-title":"Neurosurg Focus"},{"issue":"5","key":"3217_CR6","first-page":"1064","volume":"62","author":"WF Young","year":"2000","unstructured":"Young WF (2000) Cervical spondylotic myelopathy: a common cause of spinal cord dysfunction in older persons. Am Fam Physician 62(5):1064\u201370, 1073","journal-title":"Am Fam Physician"},{"issue":"Suppl 2","key":"3217_CR7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00586-013-2915-1","volume":"24 Suppl 2","author":"BM Ellingson","year":"2015","unstructured":"Ellingson BM, Salamon N, Holly LT (2015) Advances in MR imaging for cervical spondylotic myelopathy. Eur Spine J 24 Suppl 2(Suppl 2):197\u2013208","journal-title":"Eur Spine J"},{"key":"3217_CR8","unstructured":"(2024) Focus on biomarkers research. [cited 2024 March 10]; Available from: https:\/\/www.ninds.nih.gov\/current-research\/focus-tools-topics\/focus-biomarkers-research. Accessed 19 Jul 2024"},{"issue":"1","key":"3217_CR9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1055\/s-0041-1727421","volume":"12","author":"N Sharma","year":"2023","unstructured":"Sharma N, A R, G D, S MV (2023) Role of diffuse tensor imaging in predicting outcomes of decompressive surgery in degenerative cervical myelopathy-a prospective analysis. Indian J Neurosurg 12(1):30\u201336","journal-title":"Indian J Neurosurg"},{"issue":"1","key":"3217_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1227\/neu.0000000000002183","volume":"92","author":"JK Zhang","year":"2023","unstructured":"Zhang JK, J D, S C, G JK, J S, D CF, B J, S P, S SK, R W (2023) Diffusion basis spectrum imaging provides insights into cervical spondylotic myelopathy pathology. Neurosurgery 92(1):102\u2013109","journal-title":"Neurosurgery"},{"key":"3217_CR11","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1227\/neu.0000000000002375_673","volume":"69","author":"J Zhang","year":"2023","unstructured":"Zhang J, J S, G JK, J D, S P, B J, D C, S C, S SK, R WZ (2023) Utility of diffusion basis spectrum imaging in quantifying baseline disease severity and prognosis of cervical spondylotic myelopathy. Neurosurgery 69:158","journal-title":"Neurosurgery"},{"issue":"3","key":"3217_CR12","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/jmri.27894","volume":"55","author":"MZ Zhang","year":"2022","unstructured":"Zhang MZ et al (2022) Utility of advanced DWI in the detection of spinal cord microstructural alterations and assessment of neurologic function in cervical spondylotic myelopathy patients. J Magn Reson Imaging 55(3):930\u2013940","journal-title":"J Magn Reson Imaging"},{"key":"3217_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejrad.2019.04.009","volume":"116","author":"RF Gohmann","year":"2019","unstructured":"Gohmann RF, B C, Z M, M V, C H, W M, B MA, M CA (2019) Cervical spondylotic myelopathy: Changes of fractional anisotropy in the spinal cord and magnetic resonance spectroscopy of the primary motor cortex in relation to clinical symptoms and their duration. Eur J Radiol 116:55\u201360","journal-title":"Eur J Radiol"},{"key":"3217_CR14","doi-asserted-by":"publisher","unstructured":"Ellingson BM, Salamon N, Hardy AJ, Holly LT (2015) Prediction of neurological impairment in cervical spondylotic myelopathy using a combination of diffusion mri and proton mr spectroscopy. PLoS One 10(10):e0139451. https:\/\/doi.org\/10.1371\/journal.pone.0139451","DOI":"10.1371\/journal.pone.0139451"},{"key":"3217_CR15","unstructured":"Covidence systematic review software, Veritas Health Innovation, Melbourne, Australia. Available at www.covidence.org.\u00a0Accessed 19 Jul 2024"},{"key":"3217_CR16","unstructured":"OHAT Risk of Bias Rating Tool for Human and Animal Studies. [cited 2024 March 17]; Available from: https:\/\/ntp.niehs.nih.gov\/sites\/default\/files\/ntp\/ohat\/pubs\/riskofbiastool_508.pdf.\u00a0Accessed 19 Jul 2024"},{"issue":"11","key":"3217_CR17","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.spinee.2022.06.012","volume":"22","author":"PP Tsitsopoulos","year":"2022","unstructured":"Tsitsopoulos PP et al (2022) Cerebrospinal fluid biomarkers of white matter injury and astrogliosis are associated with the severity and surgical outcome of degenerative cervical spondylotic myelopathy. Spine J 22(11):1848\u20131856","journal-title":"Spine J"},{"issue":"4","key":"3217_CR18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3171\/2020.8.SPINE20965","volume":"34","author":"PP Tsitsopoulos","year":"2021","unstructured":"Tsitsopoulos PP et al (2021) Cerebrospinal fluid biomarkers of glial and axonal injury in cervical spondylotic myelopathy. J Neurosurg Spine 34(4):632\u2013641","journal-title":"J Neurosurg Spine"},{"issue":"10","key":"3217_CR19","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/j.jocn.2015.03.047","volume":"22","author":"S Kato","year":"2015","unstructured":"Kato S, C H, O J, H K, T K, T S, O T (2015) Phosphorylated neurofilament subunit levels in the serum of cervical compressive myelopathy patients. J Clin Neurosci 22(10):1638\u20131642","journal-title":"J Clin Neurosci"},{"issue":"11","key":"3217_CR20","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s00701-009-0408-0","volume":"151","author":"G Marquardt","year":"2009","unstructured":"Marquardt G et al (2009) Significance of serial S100b and NSE serum measurements in surgically treated patients with spondylotic cervical myelopathy. Acta Neurochir (Wien) 151(11):1439\u20131443","journal-title":"Acta Neurochir (Wien)"},{"issue":"1","key":"3217_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/ANA.0b013e3181c572bd","volume":"22","author":"S Hu","year":"2010","unstructured":"Hu S et al (2010) Effects of remote ischemic preconditioning on biochemical markers and neurologic outcomes in patients undergoing elective cervical decompression surgery: a prospective randomized controlled trial. J Neurosurg Anesthesiol 22(1):46\u201352","journal-title":"J Neurosurg Anesthesiol"},{"issue":"1","key":"3217_CR22","doi-asserted-by":"publisher","first-page":"22827","DOI":"10.1038\/s41598-021-02310-2","volume":"11","author":"A Tsukahara","year":"2021","unstructured":"Tsukahara A et al (2021) Neuron-specific enolase level is a useful biomarker for distinguishing amyotrophic lateral sclerosis from cervical spondylotic myelopathy. Sci Rep 11(1):22827","journal-title":"Sci Rep"},{"issue":"12","key":"3217_CR23","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1007\/s00586-009-1069-7","volume":"18","author":"H Nagashima","year":"2009","unstructured":"Nagashima H, M Y, Y K, N Y, T R (2009) Tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy. Eur Spine J\u202f: Off Publ Eur Spine Soc Eur Spinal Deformity Soc Eur Sect Cervical Spine Res Soc 18(12):1946\u201350","journal-title":"Eur Spine J : Off Publ Eur Spine Soc Eur Spinal Deformity Soc Eur Sect Cervical Spine Res Soc"},{"key":"3217_CR24","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.12659\/MSM.912868","volume":"24","author":"S Du","year":"2018","unstructured":"Du S, S Y, Z B (2018) Interleukin-6 serum levels are elevated in individuals with degenerative cervical myelopathy and are correlated with symptom severity. Med Sci Monit 24:7405\u20137413","journal-title":"Med Sci Monit"},{"issue":"12","key":"3217_CR25","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1016\/j.jocn.2014.04.021","volume":"21","author":"H Takahashi","year":"2014","unstructured":"Takahashi H, A Y, N A, S M, T F, S M, T S, Y M, W F, F T, K M, Y MT (2014) Phosphorylated neurofilament subunit NF-H becomes elevated in the cerebrospinal fluid of patients with acutely worsening symptoms of compression myelopathy. J Clin Neurosc 21(12):2175\u20132178","journal-title":"J Clin Neurosc"},{"issue":"8","key":"3217_CR26","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s00586-018-5549-5","volume":"27","author":"H Takahashi","year":"2018","unstructured":"Takahashi H, A Y, N A, S M, T F, S M, M T, K K, Y K, F T, K M, O SY (2018) Axonal damage is remarkable in patients with acutely worsening symptoms of compression myelopathy: biomarkers in cerebrospinal fluid samples. Eur Spine J 27(8):1824\u20131830","journal-title":"Eur Spine J"},{"issue":"1","key":"3217_CR27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1186\/s12891-019-2966-5","volume":"20","author":"H Takahashi","year":"2019","unstructured":"Takahashi H et al (2019) Serum oxidative stress influences neurological recovery after surgery to treat acutely worsening symptoms of compression myelopathy: a cross-sectional human study. BMC Musculoskelet Disord 20(1):589","journal-title":"BMC Musculoskelet Disord"},{"issue":"4","key":"3217_CR28","doi-asserted-by":"publisher","first-page":"E178","DOI":"10.1097\/BSD.0000000000000952","volume":"33","author":"N Akshota","year":"2020","unstructured":"Akshota N et al (2020) Neural cell adhesion molecule (NCAM) a serum biomarker indicative for the severity of cervical spondylotic myelopathy. Clin Spine Surg 33(4):E178-e184","journal-title":"Clin Spine Surg"},{"issue":"1","key":"3217_CR29","doi-asserted-by":"publisher","first-page":"fcaa234","DOI":"10.1093\/braincomms\/fcaa234","volume":"3","author":"AM Laliberte","year":"2021","unstructured":"Laliberte AM, K SK, V PM, S K, F MG (2021) Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models. Brain Commun 3(1):fcaa234","journal-title":"Brain Commun"},{"key":"3217_CR30","doi-asserted-by":"publisher","unstructured":"Vidal PM, Ulndreaj A, Tetreault L, Hong J, Fehlings MG (2019) The changes in systemic monocytes in humans undergoing surgical decompression for degenerative cervical myelopathy may influence clinical neurological recovery. J Neuroimmunol 336:577024. https:\/\/doi.org\/10.1016\/j.jneuroim.2019.577024","DOI":"10.1016\/j.jneuroim.2019.577024"},{"key":"3217_CR31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.4103\/sni.sni_110_17","volume":"8","author":"J Guan","year":"2017","unstructured":"Guan J, Holland CM, Ravindra VM, Bisson EF (2017) Perioperative malnutrition and its relationship to length of stay and complications in patients undergoing surgery for cervical myelopathy. Surg Neurol Int 8:307. https:\/\/doi.org\/10.4103\/sni.sni_110_17","journal-title":"Surg Neurol Int"},{"issue":"7","key":"3217_CR32","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1097\/00007632-200204010-00010","volume":"27","author":"T Tsuji","year":"2002","unstructured":"Tsuji T et al (2002) Analysis of chondrex (YKL-40, HC gp-39) in the cerebrospinal fluid of patients with spine disease. Spine (Phila Pa 1976) 27(7):732\u20135","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"3217_CR33","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/01.bsd.0000203944.65803.17","volume":"19","author":"K Sakayama","year":"2006","unstructured":"Sakayama K et al (2006) Elevated concentration of hyaluronan in the cerebrospinal fluid is a secondary marker of spinal disorders: hyaluronan in the cerebrospinal fluid in patients with spinal disorders. J Spinal Disord Tech 19(4):262\u2013265","journal-title":"J Spinal Disord Tech"},{"issue":"2","key":"3217_CR34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/00007632-200101150-00009","volume":"26","author":"N Natsume","year":"2001","unstructured":"Natsume N et al (2001) Analysis of cartilage-derived retinoic acid-sensitive protein in cerebrospinal fluid From patients With spinal diseases. Spine (Phila Pa 1976) 26(2):157\u201360","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"3217_CR35","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/jvim.12388","volume":"28","author":"P Martin-Vaquero","year":"2014","unstructured":"Martin-Vaquero P et al (2014) Cytokine concentrations in the cerebrospinal fluid of great danes with cervical spondylomyelopathy. J Vet Intern Med 28(4):1268\u20131274","journal-title":"J Vet Intern Med"},{"issue":"9","key":"3217_CR36","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1097\/BRS.0000000000000831","volume":"40","author":"P Martin-Vaquero","year":"2015","unstructured":"Martin-Vaquero P, DC RC, A MJ, M SA, K JK, G KB (2015) Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy. Spine 40(9):601\u2013612","journal-title":"Spine"},{"issue":"2","key":"3217_CR37","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/sc.2016.174","volume":"55","author":"CH Hulme","year":"2017","unstructured":"Hulme CH et al (2017) The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood. Spinal Cord 55(2):114\u2013125","journal-title":"Spinal Cord"},{"issue":"2","key":"3217_CR38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/brainsci8020033","volume":"8","author":"A Haque","year":"2018","unstructured":"Haque A et al (2018) New insights into the role of neuron-specific enolase in neuro-inflammation, neurodegeneration, and neuroprotection. Brain Sci 8(2):33","journal-title":"Brain Sci"},{"key":"3217_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fneur.2019.00027","volume":"10","author":"AA Albayar","year":"2019","unstructured":"Albayar AA, Roche A, Swiatkowski P, Antar S, Ouda N, Emara E, Smith DH, Ozturk AK, Awad BI (2019) Biomarkers in spinal cord injury: prognostic insights and future potentials. Front Neurol 10:27. https:\/\/doi.org\/10.3389\/fneur.2019.00027","journal-title":"Front Neurol"},{"issue":"11","key":"3217_CR40","doi-asserted-by":"publisher","first-page":"9605","DOI":"10.3390\/ijms24119605","volume":"24","author":"F Michetti","year":"2023","unstructured":"Michetti F, Clementi ME, Di Liddo R, Valeriani F, Ria F, Rende M, Di Sante G, Romano Spica V (2023) The S100B protein: a multifaceted pathogenic factor more than a biomarker. Int J Mol Sci 24(11):9605. https:\/\/doi.org\/10.3390\/ijms24119605","journal-title":"Int J Mol Sci"},{"issue":"11","key":"3217_CR41","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.spinee.2022.06.012","volume":"22","author":"PP Tsitsopoulos","year":"2022","unstructured":"Tsitsopoulos PP, M S, H U, M N (2022) Cerebrospinal fluid biomarkers of white matter injury and astrogliosis are associated with the severity and surgical outcome of degenerative cervical spondylotic myelopathy. Spine J 22(11):1848\u20131856","journal-title":"Spine J"},{"issue":"4","key":"3217_CR42","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/01.wad.0000194014.43575.fd","volume":"19","author":"ER Peskind","year":"2005","unstructured":"Peskind ER et al (2005) Safety and acceptability of the research lumbar puncture. Alzheimer Dis Assoc Disord 19(4):220\u2013225","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"23","key":"3217_CR43","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1089\/neu.2020.7140","volume":"37","author":"DO Okonkwo","year":"2020","unstructured":"Okonkwo DO et al (2020) Point-of-care platform blood biomarker testing of glial fibrillary acidic protein versus S100 calcium-binding protein B for prediction of traumatic brain injuries: a transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma 37(23):2460\u20132467","journal-title":"J Neurotrauma"},{"issue":"24","key":"3217_CR44","doi-asserted-by":"publisher","first-page":"01960-0","DOI":"10.1016\/j.wneu.2024.11.098","volume":"S1878\u20138750","author":"W Rabon","year":"2024","unstructured":"Rabon W, Rode M, Taylor T, Muluk P, Krishnamoorthy A, Easow H, Stout G, Chang YF, Hamilton DK, Thirumala PD, Agarwal N (2024) Establishing indicative neurofilament gradients based on severity of spinal cord injury. World Neurosurg S1878\u20138750(24):01960\u20130. https:\/\/doi.org\/10.1016\/j.wneu.2024.11.098","journal-title":"World Neurosurg"},{"key":"3217_CR45","doi-asserted-by":"publisher","unstructured":"Ibrahim S, Adeputra Nasution IF, Danil M, Sadewo W, Widyawati T, Eyanoer PC, Ritarwan K, Riawan W, Darmajaya R (2021) Potential benefit of olive leaf extract in cervical spondylotic myelopathy model. Ann Med Surg (Lond) 73:103040. https:\/\/doi.org\/10.1016\/j.amsu.2021.103040","DOI":"10.1016\/j.amsu.2021.103040"},{"key":"3217_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.amsu.2021.102603","volume":"69","author":"SRW Ibrahim","year":"2021","unstructured":"Ibrahim SRW (2021) Progressive spinal cord compression technique in experimental rabbit animal model for cervical spondylotic myelopathy. Ann Med Surg 69:7","journal-title":"Ann Med Surg"},{"key":"3217_CR47","doi-asserted-by":"publisher","unstructured":"Desimone A, Hong J, Brockie ST, Yu W, Laliberte AM, Fehlings MG (2021) The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy. JCI Insight 6(15):e149227. https:\/\/doi.org\/10.1172\/jci.insight.149227","DOI":"10.1172\/jci.insight.149227"},{"issue":"3","key":"3217_CR48","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3171\/2022.10.SPINE22605","volume":"38","author":"MM Safaee","year":"2023","unstructured":"Safaee MM et al (2023) Association of telomere length with risk of complications in adult spinal deformity surgery: a pilot study of 43 patients. J Neurosurg Spine 38(3):331\u2013339","journal-title":"J Neurosurg Spine"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-03217-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-025-03217-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-03217-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:37Z","timestamp":1772118157000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-025-03217-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3217"],"URL":"https:\/\/doi.org\/10.1007\/s10143-025-03217-6","relation":{},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"19 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"As this is a review of previously published literature, ethical approval was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Dr. Nitin Agarwal receives royalties from Thieme Medical Publishers and Springer International Publishing, and research support from DePuy Synthes.\u00a0Dr. D. Kojo Hamilton receives research support from DePuy Synthes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Previous presentations"}}],"article-number":"232"}}