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Patients who presented to a neurosurgical center and two endocrinological services for outpatient follow-up after surgical treatment, as well as those under medical therapy or radiological follow-up without treatment, were invited to participate in the study. Sociodemographic, health-related quality of life and clinical data were assessed. Psychosocial factors were measured using the Distress Thermometer (DT), the Hospital Anxiety and Depression Scale (HADS), the Short Form (SF-36), and the Sino-nasal outcome test (SNOT). Thirty-two postoperative patients and thirty conservatively managed patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921 under medical treatment,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099 watch and wait), mean age 53, SD 19; 56% female participated in the study. Prolactinomas (35%) and non-functioning pituitary adenomas (21%) were the most common findings. There were no significant differences between conservative and operative groups in mean DT score (4.7 (SD 2.45) vs. 4.9 (SD 3.0),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.61), HADS anxiety score (6.4 (SD 3.9) vs. 6.0 (SD 4.3),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.76) or depression score (5.7 (SD 4.8) vs. 4.6 (SD 3.6),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.50). For patients with ACTH-producing adenomas, the mean anxiety score was significantly higher (10.3 (SD 1.9) vs. 5.9 (SD 4.0),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). The SNOT score correlated significantly with the DT, HADS-A, and HADS-D scores and therefore was associated with higher psychological distress. The level of self-reported distress in patients with sellar processes was not associated with a specific treatment strategy. ACTH-producing adenomas and manifest nasal symptoms were associated with higher psychological distress.\n                  <\/jats:p>","DOI":"10.1007\/s10143-025-03240-7","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T02:08:28Z","timestamp":1738202908000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Psychological burden in patients with sellar masses under conservative and surgical management"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-3949","authenticated-orcid":false,"given":"Darius","family":"Kalasauskas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Mireri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naureen","family":"Keric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh G.","family":"Thavarajasingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Omran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"W\u00fcster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ringel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"3240_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00019514-200304000-00005","volume":"12","author":"A Baird","year":"2003","unstructured":"Baird A, Sullivan T, Zafar S, Rock J (2003) Quality of life in patients with pituitary tumors: a preliminary study. 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