{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:46:54Z","timestamp":1788281214375,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurosurg Rev"],"DOI":"10.1007\/s10143-025-03394-4","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:00:09Z","timestamp":1741734009000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of the Japanese traditional medicine Goreisan on adverse events affecting mucosal edema in patients with subarachnoid hemorrhage treated with clazosentan"],"prefix":"10.1007","volume":"48","author":[{"given":"Yosuke","family":"Akamatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Chida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinari","family":"Misaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Koji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunrou","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kashimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniaki","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"3394_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.hest.2023.10.003","volume":"5","author":"Y Akamatsu","year":"2024","unstructured":"Akamatsu Y, Chida K, Miyoshi K et al (2024) Fluid balance management with loop diuretics in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a case series. Brain Hemorrhages 5:74\u201378. https:\/\/doi.org\/10.1016\/j.hest.2023.10.003","journal-title":"Brain Hemorrhages"},{"key":"3394_CR2","doi-asserted-by":"publisher","first-page":"G211","DOI":"10.1152\/ajpgi.2000.279.1.G211","volume":"279","author":"G Egidy","year":"2000","unstructured":"Egidy G, Juillerat-Jeanneret L, Korth P, Bosman FT, Pinet F (2000) The endothelin system in normal human colon. Am J Physiol Gastrointest Liver Physiol 279:G211\u2013222. https:\/\/doi.org\/10.1152\/ajpgi.2000.279.1.G211","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3394_CR3","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.3171\/2022.2.JNS212914","volume":"137","author":"H Endo","year":"2022","unstructured":"Endo H, Hagihara Y, Kimura N et al (2022) Effects of clazosentan on cerebral vasospasm-related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients. J Neurosurg 137:1707\u20131717. https:\/\/doi.org\/10.3171\/2022.2.JNS212914","journal-title":"J Neurosurg"},{"key":"3394_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1227\/01.neu.0000243277.86222.6c","volume":"59","author":"JA Frontera","year":"2006","unstructured":"Frontera JA, Claassen J, Schmidt JM et al (2006) Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified Fisher scale. Neurosurgery 59:21\u201327 discussion 21\u201327. https:\/\/doi.org\/10.1227\/01.neu.0000243277.86222.6c","journal-title":"Neurosurgery"},{"key":"3394_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000475824","volume":"44","author":"M Fujimura","year":"2017","unstructured":"Fujimura M, Joo JY, Kim JS, Hatta M, Yokoyama Y, Tominaga T (2017) Preventive effect of clazosentan against cerebral vasospasm after clipping surgery for aneurysmal subarachnoid hemorrhage in Japanese and Korean patients. Cerebrovasc Dis 44:59\u201367. https:\/\/doi.org\/10.1159\/000475824","journal-title":"Cerebrovasc Dis"},{"key":"3394_CR6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jjcc.2024.09.010","volume":"24","author":"T Isogai","year":"2024","unstructured":"Isogai T, Morita K, Okada A et al (2024) Association between complementary use of Goreisan (a Japanese herbal Kampo medicine) and heart failure readmission: a nationwide propensity score-matched study. J Cardiol 24:182\u2013185. https:\/\/doi.org\/10.1016\/j.jjcc.2024.09.010","journal-title":"J Cardiol"},{"key":"3394_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.hest.2023.12.001","volume":"5","author":"T Itazu","year":"2024","unstructured":"Itazu T, Ikedo T, Tsutsui T et al (2024) Impact of strict fluid management on the treatment outcome of clazosentan for cerebral vasospasm. Brain Hemorrhages 5:69\u201373. https:\/\/doi.org\/10.1016\/j.hest.2023.12.001","journal-title":"Brain Hemorrhages"},{"key":"3394_CR8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fphar.2016.00174","volume":"7","author":"N Iwata","year":"2016","unstructured":"Iwata N, Kainuma M, Kobayashi D et al (2016) The relation between Hepatotoxicity and the total coumarin intake from traditional Japanese Medicines Containing Cinnamon Bark. Front Pharmacol 7:174. https:\/\/doi.org\/10.3389\/fphar.2016.00174","journal-title":"Front Pharmacol"},{"key":"3394_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3937\/kampomed.70.57","volume":"79","author":"R Kawahara","year":"2019","unstructured":"Kawahara R, Chiba K, Takahashi H et al (2019) Efficacy and dafety of Goreisan for chronic heart failurepatients with chronic kidney disease. Kampo Med 79:57\u201364. https:\/\/doi.org\/10.3937\/kampomed.70.57","journal-title":"Kampo Med"},{"key":"3394_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3923\/jms.2011.30.38","volume":"11","author":"T Kurita","year":"2011","unstructured":"Kurita T, Nakamura K, Tabuchi M, Orita M, Ooshima K, Higashino H (2011) Effects of Gorei-san: a traditional Japanese Kampo Medicine, on Aquaporin 1, 2, 3, 4 and V2R mRNA expression in rat kidney and forebrain. J Med Sci 11:30\u201338. https:\/\/scialert.net\/abstract\/?doi=jms.2011.30.38","journal-title":"J Med Sci"},{"key":"3394_CR11","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3109\/00365529709011203","volume":"32","author":"SJ Lewis","year":"1997","unstructured":"Lewis SJ, Heaton KW (1997) Stool Form Scale as a useful guide to Intestinal Transit Time. Scand J Gastroenterol 32:920\u2013924. https:\/\/doi.org\/10.3109\/00365529709011203","journal-title":"Scand J Gastroenterol"},{"key":"3394_CR12","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S1474-4422(11)70108-9","volume":"10","author":"RL Macdonald","year":"2011","unstructured":"Macdonald RL, Higashida RT, Keller E et al (2011) Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol 10:618\u2013625. https:\/\/doi.org\/10.1016\/S1474-4422(11)70108-9","journal-title":"Lancet Neurol"},{"key":"3394_CR13","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1161\/STROKEAHA.111.648980","volume":"43","author":"RL Macdonald","year":"2012","unstructured":"Macdonald RL, Higashida RT, Keller E et al (2012) Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage un dergoing endovascular coiling. Stroke 43:1463\u20131469. https:\/\/doi.org\/10.1161\/STROKEAHA.111.648980","journal-title":"Stroke"},{"key":"3394_CR14","doi-asserted-by":"publisher","first-page":"100253","DOI":"10.1016\/j.wnsx.2023.100253","volume":"21","author":"T Maeda","year":"2024","unstructured":"Maeda T, Okawara M, Osakabe M, Yamaguchi H, Maeda T, Kurita H (2024) Initial real-world experience of clazosentan for subarachnoid hemorrhage in Japan. World Neurosurg X 21:100253. https:\/\/doi.org\/10.1016\/j.wnsx.2023.100253","journal-title":"World Neurosurg X"},{"key":"3394_CR15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1227\/neu.0000000000002649","volume":"94","author":"H Matsumoto","year":"2024","unstructured":"Matsumoto H, Matsumoto A, Miyata S et al (2024) The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: a prospective Randomized Study. Neurosurgery 94:80\u201389. https:\/\/doi.org\/10.1227\/neu.0000000000002649","journal-title":"Neurosurgery"},{"key":"3394_CR16","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1046\/j.1365-2222.2000.00754.x","volume":"30","author":"J Mullol","year":"2000","unstructured":"Mullol J, Picado C (2000) Endothelin in nasal mucosa: role in nasal function and inflammation. Clin Exp Allergy 30:172\u2013177","journal-title":"Clin Exp Allergy"},{"key":"3394_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/tkm2.1276","volume":"8","author":"K Murakami","year":"2021","unstructured":"Murakami K, Horie I, Hara-Chikuma M, Shimizu T, Matsumoto C, Isohama Y (2021) Goreisan regulates AQP3 expression and improves diarrhea. Traditional Kampo Med 8:91\u201399. https:\/\/doi.org\/10.1002\/tkm2.1276","journal-title":"Traditional Kampo Med"},{"key":"3394_CR18","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s10143-023-02104-2","volume":"46","author":"S Muraoka","year":"2023","unstructured":"Muraoka S, Asai T, Fukui T et al (2023) Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: a multicenter retrospective cohort study. Neurosurg Rev 46:195. https:\/\/doi.org\/10.1007\/s10143-023-02104-2","journal-title":"Neurosurg Rev"},{"key":"3394_CR19","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.10.010","volume":"27","author":"T Nakano","year":"2018","unstructured":"Nakano T, Nishigami C, Irie K et al (2018) Goreisan prevents brain edema after cerebral ischemic stroke by inhibiting aquaporin 4 upregulation in mice. J Stroke Cerebrovasc Dis 27:758\u2013763. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2017.10.010","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"3394_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.hest.2023.11.007","volume":"5","author":"R Nishii","year":"2024","unstructured":"Nishii R, Ohta T, Fukui N et al (2024) A high cardiothoracic ratio increases the risk of severe pulmonary complications after early initiation of clazosentan in patients with aneurysmal subarachnoid hemorrhage. Brain Hemorrhages 5:85\u201390. https:\/\/doi.org\/10.1016\/j.hest.2023.11.007","journal-title":"Brain Hemorrhages"},{"key":"3394_CR21","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3171\/jns.1988.68.6.0985","volume":"68","author":"Report of World Federation of Neurological Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale","year":"1988","unstructured":"Report of World Federation of Neurological Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale (1988) J Neurosurg 68:985\u2013986. https:\/\/doi.org\/10.3171\/jns.1988.68.6.0985","journal-title":"J Neurosurg"},{"key":"3394_CR22","doi-asserted-by":"publisher","unstructured":"Schneider AG, Baldwin I, Freitag E, Glassford N, Bellomo R (2012) Estimation of fluid status changes in critically ill patients: fluid balance chart or electronic bed weight? J Crit Care 27:745.e747-712. https:\/\/doi.org\/10.1016\/j.jcrc.2011.12.017.","DOI":"10.1016\/j.jcrc.2011.12.017"},{"key":"3394_CR23","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.hest.2023.10.006","volume":"5","author":"H Suzuki","year":"2024","unstructured":"Suzuki H, Nakajima H, Ichikawa T et al (2024) Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage. Brain Hemorrhages 5:62\u201368. https:\/\/doi.org\/10.1016\/j.hest.2023.10.006","journal-title":"Brain Hemorrhages"},{"key":"3394_CR24","unstructured":"World Health Organization. About World Health Organization. Accessed Aug 25 (2024) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diarrhoeal-disease"},{"key":"3394_CR25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/332411a0","volume":"332","author":"M Yanagisawa","year":"1988","unstructured":"Yanagisawa M, Kurihara H, Kimura S et al (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411\u2013415. https:\/\/doi.org\/10.1038\/332411a0","journal-title":"Nature"},{"key":"3394_CR26","doi-asserted-by":"publisher","first-page":"3209219","DOI":"10.1155\/2017\/3209219","volume":"2017","author":"Y Yano","year":"2017","unstructured":"Yano Y, Yano H, Takahashi H et al (2017) Goreisan inhibits upregulation of aquaporin 4 and formation of cerebral edema in the rat model of fuvenile hypoxic\u2013ischemic edncephalopathy. Evid Based Complement Alternat Med 2017:3209219. https:\/\/doi.org\/10.1155\/2017\/3209219","journal-title":"Evid Based Complement Alternat Med"},{"key":"3394_CR27","doi-asserted-by":"publisher","first-page":"6298293","DOI":"10.1155\/2020\/6298293","volume":"2020","author":"N Yoshikawa","year":"2020","unstructured":"Yoshikawa N, Kajiyama H, Otsuka N et al (2020) The therapeutic effects of Goreisan, a traditional Japanese herbal medicine, on lower-limb lymphedema after lymphadenectomy in gynecologic malignancies: a case series study. Evid Based Complement Alternat Med 2020:6298293. https:\/\/doi.org\/10.1155\/2020\/6298293","journal-title":"Evid Based Complement Alternat Med"}],"container-title":["Neurosurgical Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-03394-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10143-025-03394-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10143-025-03394-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:15:22Z","timestamp":1772079322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10143-025-03394-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3394"],"URL":"https:\/\/doi.org\/10.1007\/s10143-025-03394-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4980693\/v1","asserted-by":"object"}]},"ISSN":["1437-2320"],"issn-type":[{"value":"1437-2320","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"27 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethics committee of Iwate Medical University School of Medicine reviewed and approved the study protocol (No. MH2023-106).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Each patient provided written informed consent prior to participation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Each patient provided written informed consent prior to publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no personal, financial, or institutional interests in any of the drugs, materials, or devices described in this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"None.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Previous presentations"}},{"value":"The authors declare no competing interests.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"293"}}