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Radiomics, by extracting quantitative features from Computed Tomograhpy (CT) scans, may reveal imaging biomarkers predictive of outcomes. This study evaluates the predictive value of radiomics in SAH for multiple outcomes and compares its performance to models based on clinical data.Radiomic features were extracted from admission CTs using segmentations of brain tissue (white and gray matter) and hemorrhage. Machine learning models with cross-validation were trained using clinical data, radiomics, or both, to predict 6-month mortality, Glasgow Outcome Scale (GOS), vasospasm, and long-term hydrocephalus. SHapley Additive exPlanations (SHAP) analysis was used to interpret feature contributions.The training dataset included 403 aneurysmal SAH patients; GOS predictions used all patients, while vasospasm and hydrocephalus predictions excluded those with incomplete data or early death, leaving 328 and 332 patients, respectively. Radiomics and clinical models demonstrated comparable performance, achieving in validation set AUCs more than 85% for six-month mortality and clinical outcome, and 75% and 86% for vasospasm and hydrocephalus, respectively. In an independent cohort of 41 patients, the combined models yielded AUCs of 89% for mortality, 87% for clinical outcome, 66% for vasospasm, and 72% for hydrocephalus. SHAP analysis highlighted significant contributions of radiomic features from brain tissue and hemorrhage segmentation, alongside key clinical variables, in predicting SAH outcomes.This study underscores the potential of radiomics-based approaches for SAH outcome prediction, demonstrating predictive power comparable to traditional clinical models and enhancing understanding of SAH-related complications.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical trial number<\/jats:bold>\n                    Not applicable.\n                  <\/jats:p>","DOI":"10.1007\/s10143-025-03679-8","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:43:17Z","timestamp":1750725797000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comprehensive predictive modeling in subarachnoid hemorrhage: integrating radiomics and clinical variables"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-996X","authenticated-orcid":false,"given":"Gemma","family":"Urbanos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-5049","authenticated-orcid":false,"given":"Ana M.","family":"Casta\u00f1o-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4623-0728","authenticated-orcid":false,"given":"M\u00f3nica","family":"Maldonado-Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-6502","authenticated-orcid":false,"given":"Elena","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-313X","authenticated-orcid":false,"given":"Ana","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3809-3241","authenticated-orcid":false,"given":"Carmen","family":"Lechuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-9132","authenticated-orcid":false,"given":"C\u00e9sar","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-1511","authenticated-orcid":false,"given":"Eduardo","family":"Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-0554","authenticated-orcid":false,"given":"Alfonso","family":"Lagares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"3679_CR1","first-page":"37","volume":"9","author":"K Psychogios","year":"2019","unstructured":"Psychogios K, Tsivgoulis G, FEAN FESO (2019) Subarachnoid hemorrhage, vasospasm, and delayed cerebral ischemia. 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