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The data that support the findings of this study was available from the corresponding author upon reasonable request. This manuscript is an original work. The manuscript has not been under consideration for publication in another journal and is not currently available on a preprint server. We also confirm that all the listed authors have participated actively in the study and have seen and approved the submitted manuscript. Statistics has the information reported been evaluated by an expert. The authors have no personal financial or institutional interest in any of the drugs, materials, or devices described in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"This research adheres to the principles outlined in the Declaration of Helsinki. 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